FI963452A0 - Menetelmä epoxidin valmistamiseksi - Google Patents

Menetelmä epoxidin valmistamiseksi

Info

Publication number
FI963452A0
FI963452A0 FI963452A FI963452A FI963452A0 FI 963452 A0 FI963452 A0 FI 963452A0 FI 963452 A FI963452 A FI 963452A FI 963452 A FI963452 A FI 963452A FI 963452 A0 FI963452 A0 FI 963452A0
Authority
FI
Finland
Prior art keywords
epoxide
preparing epoxide
preparing
renin
proteases
Prior art date
Application number
FI963452A
Other languages
English (en)
Swedish (sv)
Other versions
FI963452A (fi
FI120259B (fi
Inventor
David Askin
Kan K Eng
Peter E Maligres
Paul J Reider
Kai Rossen
Ralph P Volante
Veena Upadhyay
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22764868&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI963452(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of FI963452A0 publication Critical patent/FI963452A0/fi
Publication of FI963452A publication Critical patent/FI963452A/fi
Application granted granted Critical
Publication of FI120259B publication Critical patent/FI120259B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
FI963452A 1994-03-04 1996-09-03 Menetelmä epoksidin valmistamiseksi FI120259B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US20607494A 1994-03-04 1994-03-04
US20607494 1994-03-04
US9502347 1995-02-27
PCT/US1995/002347 WO1995023797A1 (en) 1994-03-04 1995-02-27 Process for making an epoxide

Publications (3)

Publication Number Publication Date
FI963452A0 true FI963452A0 (fi) 1996-09-03
FI963452A FI963452A (fi) 1996-09-03
FI120259B FI120259B (fi) 2009-08-31

Family

ID=22764868

Family Applications (1)

Application Number Title Priority Date Filing Date
FI963452A FI120259B (fi) 1994-03-04 1996-09-03 Menetelmä epoksidin valmistamiseksi

Country Status (25)

Country Link
EP (1) EP0748319B1 (fi)
JP (1) JP3871705B2 (fi)
KR (1) KR100387741B1 (fi)
CN (1) CN1066728C (fi)
AT (1) ATE210662T1 (fi)
AU (1) AU690231B2 (fi)
BR (1) BR9506977A (fi)
CA (1) CA2183976C (fi)
CZ (1) CZ291816B6 (fi)
DE (1) DE69524578T2 (fi)
DK (1) DK0748319T3 (fi)
ES (1) ES2167419T3 (fi)
FI (1) FI120259B (fi)
HR (1) HRP950096B1 (fi)
HU (1) HU222750B1 (fi)
MX (1) MX9603871A (fi)
NZ (1) NZ281866A (fi)
PT (1) PT748319E (fi)
RO (1) RO117696B1 (fi)
RU (1) RU2137769C1 (fi)
SK (1) SK283067B6 (fi)
TW (1) TW380137B (fi)
UA (1) UA45968C2 (fi)
WO (1) WO1995023797A1 (fi)
YU (1) YU49010B (fi)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728840A (en) * 1994-03-04 1998-03-17 Merck & Co., Inc. Process for making an epoxide
TW415948B (en) * 1995-10-30 2000-12-21 Merck & Co Inc Process for synthesizing epoxide and halohydrin
US5981759A (en) * 1997-06-20 1999-11-09 Merck & Co., Inc. Process for indinavir intermediate
PT1948678E (pt) 2005-11-09 2013-07-16 Onyx Therapeutics Inc Compostos para inibição de enzimas
ES2415632T3 (es) 2006-06-19 2013-07-26 Onyx Therapeutics, Inc. Epoxicetonas peptídicas para la inhibición del proteosoma
EP2207791B2 (en) * 2007-10-04 2019-08-07 Onyx Therapeutics, Inc. Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides
BRPI0919668A2 (pt) 2008-10-21 2018-05-29 Onyx Therapeutics, Inc. terapia de combinação com epóxi-cetonas de peptídeo
TWI504598B (zh) 2009-03-20 2015-10-21 Onyx Therapeutics Inc 結晶性三肽環氧酮蛋白酶抑制劑
JP5919196B2 (ja) 2009-11-13 2016-05-18 オニキス セラピューティクス， インク．Ｏｎｙｘ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． 転移抑制のためのペプチドエポキシケトンの使用
KR20130075723A (ko) 2010-03-01 2013-07-05 오닉스 세라퓨틱스, 인크. 면역프로테아좀 저해를 위한 화합물
AU2011245302A1 (en) * 2010-04-30 2012-11-22 Indiana University Research And Technology Corporation Processes for preparing linezolid
JP2015524394A (ja) 2012-07-09 2015-08-24 オニキス セラピューティクス， インク．Ｏｎｙｘ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． ペプチドエポキシケトンプロテアーゼ阻害剤のプロドラッグ
CN104692987B (zh) * 2015-01-22 2017-05-17 北京大学 卤代醇及其衍生物的廉价高效合成方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2072237A1 (en) * 1991-07-02 1993-01-03 Merck & Co., Inc. Stereoselective production of hydroxyamide compounds from chiral –-amino epoxides
ES2112880T3 (es) * 1991-11-08 1998-04-16 Merck & Co Inc Inhibidores de la proteasa de vih utiles para el tratamiento del sida.

Also Published As

Publication number Publication date
AU690231B2 (en) 1998-04-23
HUT75611A (en) 1997-05-28
EP0748319B1 (en) 2001-12-12
MX9603871A (es) 1997-07-31
CN1066728C (zh) 2001-06-06
RU2137769C1 (ru) 1999-09-20
BR9506977A (pt) 1997-09-02
PT748319E (pt) 2002-05-31
HU9602412D0 (en) 1996-11-28
NZ281866A (en) 1998-05-27
ATE210662T1 (de) 2001-12-15
SK112296A3 (en) 1997-02-05
CA2183976A1 (en) 1995-09-08
JPH09509929A (ja) 1997-10-07
HRP950096B1 (en) 2002-06-30
HRP950096A2 (en) 1997-06-30
CA2183976C (en) 2005-02-01
JP3871705B2 (ja) 2007-01-24
CN1146768A (zh) 1997-04-02
WO1995023797A1 (en) 1995-09-08
AU1882895A (en) 1995-09-18
KR970701714A (ko) 1997-04-12
DK0748319T3 (da) 2002-03-18
YU14595A (sh) 1997-12-05
FI963452A (fi) 1996-09-03
DE69524578D1 (de) 2002-01-24
KR100387741B1 (ko) 2003-10-04
DE69524578T2 (de) 2002-07-18
YU49010B (sh) 2003-04-30
HU222750B1 (hu) 2003-09-29
FI120259B (fi) 2009-08-31
EP0748319A1 (en) 1996-12-18
UA45968C2 (uk) 2002-05-15
SK283067B6 (sk) 2003-02-04
CZ291816B6 (cs) 2003-06-18
TW380137B (en) 2000-01-21
ES2167419T3 (es) 2002-05-16
RO117696B1 (ro) 2002-06-28
CZ254396A3 (en) 1997-01-15

Similar Documents

Publication Publication Date Title
DK0443449T3 (da) Fremgangsmåde til fremstilling af oxetanoner
FI963452A (fi) Menetelmä epoxidin valmistamiseksi
MXPA04002067A (es) Nuevas dihidropteridinonas, procedimientos para su preparacion y su uso como medicamento.
UA50730C2 (uk) Спосіб одержання 1-(тіометил)циклопропаноцтової кислоти та проміжних сполук для її одержання
HU9601857D0 (en) New benzyl-piperidine- or -tetrahydro-pyridine derivatives and processes for producing them
WO2001057014A3 (en) Synthesis of 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one
DE60100238D1 (de) Synthese von 3,6-Dialkyl-5,6-Dihydro-4-Hydroxy-2H-Pyran-2-one
AR000813A1 (es) Procedimiento para la obtencion de n-aril y n-heteroarilhidroxilaminas
MXPA02012471A (es) Procedimiento de fabricacion del oxirano que comprende la separacion del oxirano del medio de reaccion.
YU45896A (sh) Postupak za dobijanje epoksida
ATE233249T1 (de) Verfahren zur herstellung von hiv protease inhibitoren
LV12825B (en) Process for making hiv protease inhibitors
EA199900772A1 (ru) Способ селективного эпоксидирования для получения лекарственных соединений
HUP9903318A2 (hu) Intermedierek taxol előállítására
GB2369356B (en) Process
MXPA04004537A (es) Derivados de gabusectina, metodo para produccion de los mismos y uso de los mismos.
TW200611691A (en) Retroviral protease inhibiting compounds

Legal Events

Date Code Title Description
FG Patent granted

Ref document number: 120259

Country of ref document: FI

PC Transfer of assignment of patent

Owner name: MERCK SHARP & DOHME CORP.

Free format text: MERCK SHARP & DOHME CORP.

MM Patent lapsed