CA2167183C - Methode pour l'obtention d'inhibiteurs de la protease du vih - Google Patents

Methode pour l'obtention d'inhibiteurs de la protease du vih Download PDF

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Publication number
CA2167183C
CA2167183C CA002167183A CA2167183A CA2167183C CA 2167183 C CA2167183 C CA 2167183C CA 002167183 A CA002167183 A CA 002167183A CA 2167183 A CA2167183 A CA 2167183A CA 2167183 C CA2167183 C CA 2167183C
Authority
CA
Canada
Prior art keywords
substituted
alkyl
unsubstituted
group
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002167183A
Other languages
English (en)
Other versions
CA2167183A1 (fr
Inventor
David Askin
Ralph P. Volante
Kan K. Eng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/187,664 external-priority patent/US5463067A/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Priority claimed from PCT/US1994/007706 external-priority patent/WO1995002584A2/fr
Publication of CA2167183A1 publication Critical patent/CA2167183A1/fr
Application granted granted Critical
Publication of CA2167183C publication Critical patent/CA2167183C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Abstract

On peut obtenir des intermédiaires de la formule structurelle (IV) en faisant réagir avec un amide du glycidol ou l'un de ses dérivés activés. Ce procédé et les intermédiaires qu'il permet d'obtenir sont utiles pour synthétiser des composés inhibiteurs de la protéase de VIH.
CA002167183A 1993-07-16 1994-07-11 Methode pour l'obtention d'inhibiteurs de la protease du vih Expired - Fee Related CA2167183C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US9322593A 1993-07-16 1993-07-16
US093,225 1993-07-16
US08/187,664 US5463067A (en) 1993-07-16 1994-01-26 Process for making HIV protease inhibitors
US187,664 1994-01-26
PCT/US1994/007706 WO1995002584A2 (fr) 1993-07-16 1994-07-11 Procede de fabrication d'inhibiteurs de la protease de vih

Publications (2)

Publication Number Publication Date
CA2167183A1 CA2167183A1 (fr) 1995-01-26
CA2167183C true CA2167183C (fr) 2005-11-15

Family

ID=35520898

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002167183A Expired - Fee Related CA2167183C (fr) 1993-07-16 1994-07-11 Methode pour l'obtention d'inhibiteurs de la protease du vih

Country Status (1)

Country Link
CA (1) CA2167183C (fr)

Also Published As

Publication number Publication date
CA2167183A1 (fr) 1995-01-26

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