FI120183B - Jodattu neurokoetin monoamiinin takaisinottokohtien kartoittamiseksi - Google Patents

Jodattu neurokoetin monoamiinin takaisinottokohtien kartoittamiseksi Download PDF

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Publication number
FI120183B
FI120183B FI956261A FI956261A FI120183B FI 120183 B FI120183 B FI 120183B FI 956261 A FI956261 A FI 956261A FI 956261 A FI956261 A FI 956261A FI 120183 B FI120183 B FI 120183B
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FI
Finland
Prior art keywords
group
neuroprobe
iodized
precursor
cnh2n
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Application number
FI956261A
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English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI956261A0 (fi
FI956261A (fi
Inventor
John L Neumeyer
Richard A Milius
Robert B Innis
Original Assignee
Ge Healthcare Ltd
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Publication of FI956261A0 publication Critical patent/FI956261A0/fi
Publication of FI956261A publication Critical patent/FI956261A/fi
Application granted granted Critical
Publication of FI120183B publication Critical patent/FI120183B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Valve-Gear Or Valve Arrangements (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Window Of Vehicle (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Testing Or Measuring Of Semiconductors Or The Like (AREA)
  • Measuring Leads Or Probes (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
FI956261A 1992-02-25 1995-12-27 Jodattu neurokoetin monoamiinin takaisinottokohtien kartoittamiseksi FI120183B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US84161792 1992-02-25
US07/841,617 US5310912A (en) 1992-02-25 1992-02-25 Iodinated neuroprobe for mapping monoamine reuptake sites
US9306170 1993-06-29
PCT/US1993/006170 WO1995001184A1 (fr) 1992-02-25 1993-06-29 Neurosonde iodee destinee a la cartographie de sites de reabsorption de monoamines

Publications (3)

Publication Number Publication Date
FI956261A0 FI956261A0 (fi) 1995-12-27
FI956261A FI956261A (fi) 1995-12-27
FI120183B true FI120183B (fi) 2009-07-31

Family

ID=25285315

Family Applications (1)

Application Number Title Priority Date Filing Date
FI956261A FI120183B (fi) 1992-02-25 1995-12-27 Jodattu neurokoetin monoamiinin takaisinottokohtien kartoittamiseksi

Country Status (12)

Country Link
US (2) US5310912A (fr)
EP (1) EP0703791B1 (fr)
JP (1) JP3228422B2 (fr)
AT (1) ATE228858T1 (fr)
AU (1) AU674331B2 (fr)
DE (2) DE69332544T2 (fr)
DK (1) DK0703791T3 (fr)
ES (1) ES2189792T3 (fr)
FI (1) FI120183B (fr)
NL (1) NL300123I2 (fr)
PT (1) PT703791E (fr)
WO (1) WO1995001184A1 (fr)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5496953A (en) * 1990-08-09 1996-03-05 Research Triangle Institute Cocaine receptor binding ligands
US5128118A (en) * 1990-08-09 1992-07-07 Research Triangle Institute Cocaine receptor binding ligands
US7189737B2 (en) 1991-08-09 2007-03-13 Research Triangle Institute Cocaine receptor binding ligands
US5736123A (en) * 1990-08-09 1998-04-07 Research Triangle Institute Cocaine receptor binding ligands
US5750089A (en) * 1996-01-11 1998-05-12 Neuro Imaging Technologies, Llc Halogenated neuroprobe for mapping monoamine reuptake sites
US5770180A (en) * 1992-08-24 1998-06-23 Organix, Inc. Bridge-substituted tropanes for methods of imaging and therapy
US5493026A (en) * 1993-10-25 1996-02-20 Organix, Inc. Substituted 2-carboxyalkyl-3-(fluorophenyl)-8-(3-halopropen-2-yl) nortropanes and their use as imaging for agents for neurodegenerative disorders
AU6159796A (en) * 1995-06-06 1996-12-24 Research Biochemicals Iodinated neuroprobes for mapping monoamine reuptake sites
US5864038A (en) * 1995-08-17 1999-01-26 Emory University Labeled cocaine analogs
US5948933A (en) * 1997-07-11 1999-09-07 Organix, Inc. Tropane analogs and methods for inhibition of monoamine transport
US7105678B2 (en) 1995-11-03 2006-09-12 Organix, Inc. Boat tropanes
US6171576B1 (en) * 1995-11-03 2001-01-09 Organix Inc. Dopamine transporter imaging agent
FR2748475B1 (fr) * 1996-05-10 1999-04-16 Cis Bio Int Derives du tropane utilisables en particulier pour la detection in vivo des transporteurs de la dopamine
AU5194798A (en) * 1996-10-29 1998-05-22 Guilford Pharmaceuticals Inc. Process for the preparation of radiopharmaceuticals
FI104048B (fi) * 1997-06-16 1999-11-15 Map Medical Technologies Oy Prosessi tuottaa radiojodattuja reseptoriaineita in vivo käyttöön
US6358492B1 (en) * 1997-10-07 2002-03-19 Research Triangle Institute Dopamine transporter imaging ligand
US6013242A (en) * 1998-01-13 2000-01-11 Wake Forest University Tropane derivatives with selective binding to the serotonin reuptake transporters for treatment of mental illness and as intermediates in the formation of imaging diagnostic agents for depression
US6843979B2 (en) 1999-04-26 2005-01-18 Emory University 4-haloethenylphenyl tropane:serotonin transporter imaging agents
WO2000064491A1 (fr) * 1999-04-26 2000-11-02 Emory University 4-fluoroalkyl-3-halophenyl nortropanes
CA2285516C (fr) * 1999-05-12 2010-12-07 President And Fellows Of Harvard College Agents d'imagerie pour transporteur de dopamine
US6555581B1 (en) 2001-02-15 2003-04-29 Jones Pharma, Inc. Levothyroxine compositions and methods
US20030224047A1 (en) * 2001-02-15 2003-12-04 Franz G. Andrew Levothyroxine compositions and methods
US20030032675A1 (en) * 2001-02-15 2003-02-13 Franz G. Andrew Manufacture of thyroid hormone tablets having consistent active moiety amounts
BR0207297A (pt) * 2001-02-15 2005-04-19 King Pharmaceuticals Inc Composição farmacêutica em forma sólida e método de preparar uma forma de dosagem sólida de um ingrediente farmaceuticamente ativo
JP4497815B2 (ja) * 2001-02-16 2010-07-07 アベンティス・ファーマスーティカルズ・インコーポレイテツド 新規な複素環式アミド誘導体およびドーパミンｄ３受容体リガンドとしてのその使用
US20030198667A1 (en) * 2001-08-10 2003-10-23 Franz Andrew G. Methods of producing dispersible pharmaceutical compositions
US20030190349A1 (en) * 2001-08-10 2003-10-09 Franz G. Andrew Methods of stabilizing pharmaceutical compositions
US20030180353A1 (en) * 2001-08-10 2003-09-25 Franz G. Andrew Stabilized pharmaceutical compositions
US20030203967A1 (en) * 2001-08-14 2003-10-30 Franz G. Andrew Levothyroxine compositions having unique Tmax properties
US20030195253A1 (en) * 2001-08-14 2003-10-16 Franz G. Andrew Unadsorbed levothyroxine pharmaceutical compositions, methods of making and methods of administration
US20030199586A1 (en) * 2001-08-14 2003-10-23 Franz G. Andrew Unique levothyroxine aqueous materials
US20030198672A1 (en) * 2001-08-14 2003-10-23 Franz G. Andrew Levothyroxine compositions having unique triidothyronine plasma AUC properties
US7101569B2 (en) 2001-08-14 2006-09-05 Franz G Andrew Methods of administering levothyroxine pharmaceutical compositions
US20030199587A1 (en) * 2001-08-14 2003-10-23 Franz G. Andrew Levothyroxine compositions having unique Cmax properties
DE20120708U1 (de) 2001-10-09 2002-08-01 Meltzer Peter C Tropan-Analoga zur Inhibierung des Monoamin-Transports
US20030190359A1 (en) * 2001-10-29 2003-10-09 Franz G. Andrew Levothyroxine compositions having unique triiodothyronine Tmax properties
WO2003093412A2 (fr) * 2002-04-30 2003-11-13 Emory University Composes pour l'imagerie de tumeurs
JP2005154374A (ja) * 2003-11-27 2005-06-16 Hamamatsu Photonics Kk 放射性トロパンアルカロイド誘導体、トロパンアルカロイド誘導体、及びそれらの製造方法。
CA2612186A1 (fr) 2005-06-23 2007-01-04 Emory University Agents pour l'imagerie
EP1893246A4 (fr) * 2005-06-23 2009-05-06 Univ Emory Synthèse stéréo-sélective d'analogues d'acides aminés pour l'imagerie des tumeurs
JP2011500857A (ja) 2007-10-31 2011-01-06 アルセレス ファーマシューティカルズ， インコーポレイテッド 標識ヨウ化トロパン処方物
US8246752B2 (en) 2008-01-25 2012-08-21 Clear Catheter Systems, Inc. Methods and devices to clear obstructions from medical tubes
WO2018168643A1 (fr) * 2017-03-17 2018-09-20 日本メジフィジックス株式会社 Procédé de fabrication d'ioflupane
WO2021148598A1 (fr) 2020-01-24 2021-07-29 Rotop Radiopharmacy Gmbh Procédé de préparation de n-monofluoroalkyl-tropanes et leur utilisation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3813404A (en) * 1972-11-15 1974-05-28 Sterling Drug Inc Tropane-2-carboxylates and derivatives
US4942231A (en) * 1984-05-24 1990-07-17 Mallinckrodt, Inc. Method of preparing a chlorinated, brominated, radio-brominated, iodinated and/or radioiodinated aromatic or heteroaromatic compound
US5098996A (en) * 1984-10-26 1992-03-24 The United States Of America As Represented By The Department Of Health And Human Services Process for introducing fluorine into biologically active materials
US5200169A (en) * 1987-04-16 1993-04-06 Neorx Corporation Vinyl substituted radiohalogen conjugates for protein labeling
US5186921A (en) * 1989-04-17 1993-02-16 Trustees Of The University Of Pennsylvania Dopamine receptor ligands and image agents
US5128118A (en) * 1990-08-09 1992-07-07 Research Triangle Institute Cocaine receptor binding ligands
US5104638A (en) * 1990-10-29 1992-04-14 Mallinckrodt Medical, Inc. Method of making a radiopharmaceutical complex from a kit

Also Published As

Publication number Publication date
AU674331B2 (en) 1996-12-19
PT703791E (pt) 2003-04-30
DE69332544T2 (de) 2003-08-14
JP3228422B2 (ja) 2001-11-12
EP0703791A1 (fr) 1996-04-03
US5439666A (en) 1995-08-08
EP0703791B1 (fr) 2002-12-04
FI956261A0 (fi) 1995-12-27
EP0703791A4 (fr) 1996-05-22
NL300123I1 (nl) 2003-06-02
FI956261A (fi) 1995-12-27
DE69332544D1 (de) 2003-01-16
JPH09503745A (ja) 1997-04-15
DE10399020I1 (de) 2003-09-18
WO1995001184A1 (fr) 1995-01-12
DE10399020I2 (de) 2005-05-04
US5310912A (en) 1994-05-10
AU4655493A (en) 1995-01-24
ES2189792T3 (es) 2003-07-16
NL300123I2 (nl) 2003-08-01
ATE228858T1 (de) 2002-12-15
DK0703791T3 (da) 2003-03-24

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