ATE228858T1 - Jodierte neurosonde zum erfassen von monoamin- wiederaufnahme-orten - Google Patents

Jodierte neurosonde zum erfassen von monoamin- wiederaufnahme-orten

Info

Publication number
ATE228858T1
ATE228858T1 AT93916836T AT93916836T ATE228858T1 AT E228858 T1 ATE228858 T1 AT E228858T1 AT 93916836 T AT93916836 T AT 93916836T AT 93916836 T AT93916836 T AT 93916836T AT E228858 T1 ATE228858 T1 AT E228858T1
Authority
AT
Austria
Prior art keywords
group
isotope
cnh2n
neuroprobe
sites
Prior art date
Application number
AT93916836T
Other languages
English (en)
Inventor
John L Neumeyer
Richard A Milius
Robert B Innis
Original Assignee
Res Biochemicals Ltd Paterners
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Res Biochemicals Ltd Paterners filed Critical Res Biochemicals Ltd Paterners
Application granted granted Critical
Publication of ATE228858T1 publication Critical patent/ATE228858T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Valve-Gear Or Valve Arrangements (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Window Of Vehicle (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Measuring Leads Or Probes (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Testing Or Measuring Of Semiconductors Or The Like (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
AT93916836T 1992-02-25 1993-06-29 Jodierte neurosonde zum erfassen von monoamin- wiederaufnahme-orten ATE228858T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/841,617 US5310912A (en) 1992-02-25 1992-02-25 Iodinated neuroprobe for mapping monoamine reuptake sites
PCT/US1993/006170 WO1995001184A1 (en) 1992-02-25 1993-06-29 An iodinated neuroprobe for mapping monoamine reuptake sites

Publications (1)

Publication Number Publication Date
ATE228858T1 true ATE228858T1 (de) 2002-12-15

Family

ID=25285315

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93916836T ATE228858T1 (de) 1992-02-25 1993-06-29 Jodierte neurosonde zum erfassen von monoamin- wiederaufnahme-orten

Country Status (12)

Country Link
US (2) US5310912A (de)
EP (1) EP0703791B1 (de)
JP (1) JP3228422B2 (de)
AT (1) ATE228858T1 (de)
AU (1) AU674331B2 (de)
DE (2) DE10399020I2 (de)
DK (1) DK0703791T3 (de)
ES (1) ES2189792T3 (de)
FI (1) FI120183B (de)
NL (1) NL300123I2 (de)
PT (1) PT703791E (de)
WO (1) WO1995001184A1 (de)

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US7189737B2 (en) 1991-08-09 2007-03-13 Research Triangle Institute Cocaine receptor binding ligands
US5736123A (en) * 1990-08-09 1998-04-07 Research Triangle Institute Cocaine receptor binding ligands
US5496953A (en) * 1990-08-09 1996-03-05 Research Triangle Institute Cocaine receptor binding ligands
US5128118A (en) * 1990-08-09 1992-07-07 Research Triangle Institute Cocaine receptor binding ligands
US5750089A (en) * 1996-01-11 1998-05-12 Neuro Imaging Technologies, Llc Halogenated neuroprobe for mapping monoamine reuptake sites
US5770180A (en) * 1992-08-24 1998-06-23 Organix, Inc. Bridge-substituted tropanes for methods of imaging and therapy
US5493026A (en) * 1993-10-25 1996-02-20 Organix, Inc. Substituted 2-carboxyalkyl-3-(fluorophenyl)-8-(3-halopropen-2-yl) nortropanes and their use as imaging for agents for neurodegenerative disorders
ES2385202T3 (es) * 1995-06-06 2012-07-19 Ge Healthcare Limited Sondas neurológicas yodadas para el mapeo de sitios de recaptación de monoamina
US5864038A (en) * 1995-08-17 1999-01-26 Emory University Labeled cocaine analogs
US5948933A (en) * 1997-07-11 1999-09-07 Organix, Inc. Tropane analogs and methods for inhibition of monoamine transport
US7105678B2 (en) 1995-11-03 2006-09-12 Organix, Inc. Boat tropanes
US6171576B1 (en) * 1995-11-03 2001-01-09 Organix Inc. Dopamine transporter imaging agent
FR2748475B1 (fr) * 1996-05-10 1999-04-16 Cis Bio Int Derives du tropane utilisables en particulier pour la detection in vivo des transporteurs de la dopamine
WO1998018499A1 (en) * 1996-10-29 1998-05-07 Guilford Pharmaceuticals Inc. Process for the preparation of radiopharmaceuticals
FI104048B1 (fi) * 1997-06-16 1999-11-15 Map Medical Technologies Oy Prosessi tuottaa radiojodattuja reseptoriaineita in vivo käyttöön
US6358492B1 (en) * 1997-10-07 2002-03-19 Research Triangle Institute Dopamine transporter imaging ligand
US6013242A (en) * 1998-01-13 2000-01-11 Wake Forest University Tropane derivatives with selective binding to the serotonin reuptake transporters for treatment of mental illness and as intermediates in the formation of imaging diagnostic agents for depression
US6399042B1 (en) * 1999-04-26 2002-06-04 Emory University 4-fluoroalkyl-3-halophenyl nortropanes
US6843979B2 (en) 1999-04-26 2005-01-18 Emory University 4-haloethenylphenyl tropane:serotonin transporter imaging agents
CA2285516C (en) 1999-05-12 2010-12-07 President And Fellows Of Harvard College Dopamine transporter imaging agents
US20030032675A1 (en) * 2001-02-15 2003-02-13 Franz G. Andrew Manufacture of thyroid hormone tablets having consistent active moiety amounts
CA2438641A1 (en) * 2001-02-15 2002-08-22 King Pharmaceuticals, Inc. Stabilized pharmaceutical and thyroid hormone compositions and method of preparation
US6555581B1 (en) 2001-02-15 2003-04-29 Jones Pharma, Inc. Levothyroxine compositions and methods
US20030224047A1 (en) * 2001-02-15 2003-12-04 Franz G. Andrew Levothyroxine compositions and methods
MXPA03006524A (es) * 2001-02-16 2003-09-25 Aventis Pharma Inc Derivados heterociclicos novedosos de amidas y su uso como ligandos para receptor d3 de dopamina.
US20030190349A1 (en) * 2001-08-10 2003-10-09 Franz G. Andrew Methods of stabilizing pharmaceutical compositions
US20030198667A1 (en) * 2001-08-10 2003-10-23 Franz Andrew G. Methods of producing dispersible pharmaceutical compositions
US20030180353A1 (en) * 2001-08-10 2003-09-25 Franz G. Andrew Stabilized pharmaceutical compositions
US20030199586A1 (en) * 2001-08-14 2003-10-23 Franz G. Andrew Unique levothyroxine aqueous materials
US20030198672A1 (en) * 2001-08-14 2003-10-23 Franz G. Andrew Levothyroxine compositions having unique triidothyronine plasma AUC properties
US20030199587A1 (en) * 2001-08-14 2003-10-23 Franz G. Andrew Levothyroxine compositions having unique Cmax properties
US20030195253A1 (en) * 2001-08-14 2003-10-16 Franz G. Andrew Unadsorbed levothyroxine pharmaceutical compositions, methods of making and methods of administration
US20030203967A1 (en) * 2001-08-14 2003-10-30 Franz G. Andrew Levothyroxine compositions having unique Tmax properties
US7101569B2 (en) 2001-08-14 2006-09-05 Franz G Andrew Methods of administering levothyroxine pharmaceutical compositions
DE20120708U1 (de) 2001-10-09 2002-08-01 Meltzer Peter C Tropan-Analoga zur Inhibierung des Monoamin-Transports
US20030191185A1 (en) * 2001-10-29 2003-10-09 Franz G. Andrew Levothyroxine compositions having unique triiodothyronine Tmax properties
DE60333830D1 (de) * 2002-04-30 2010-09-30 Univ Emory Verbindungen zur abbildung von tumoren
JP2005154374A (ja) * 2003-11-27 2005-06-16 Hamamatsu Photonics Kk 放射性トロパンアルカロイド誘導体、トロパンアルカロイド誘導体、及びそれらの製造方法。
EP1893244A4 (de) * 2005-06-23 2009-06-24 Univ Emory Kontrastmittel
WO2007001958A2 (en) * 2005-06-23 2007-01-04 Emory University Stereoselective synthesis of amino acid analogs for tumor imaging
CA2704104C (en) 2007-10-31 2016-02-02 Alseres Pharmaceuticals, Inc. Labeled iodinated tropane formulation
US8246752B2 (en) 2008-01-25 2012-08-21 Clear Catheter Systems, Inc. Methods and devices to clear obstructions from medical tubes
JP7241013B2 (ja) * 2017-03-17 2023-03-16 日本メジフィジックス株式会社 イオフルパンの製造方法
WO2021148598A1 (en) 2020-01-24 2021-07-29 Rotop Radiopharmacy Gmbh Method for the preparation of n-monofluoroalkyl tropanes and their use

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US3813404A (en) * 1972-11-15 1974-05-28 Sterling Drug Inc Tropane-2-carboxylates and derivatives
US4942231A (en) * 1984-05-24 1990-07-17 Mallinckrodt, Inc. Method of preparing a chlorinated, brominated, radio-brominated, iodinated and/or radioiodinated aromatic or heteroaromatic compound
US5098996A (en) * 1984-10-26 1992-03-24 The United States Of America As Represented By The Department Of Health And Human Services Process for introducing fluorine into biologically active materials
US5200169A (en) * 1987-04-16 1993-04-06 Neorx Corporation Vinyl substituted radiohalogen conjugates for protein labeling
US5186921A (en) * 1989-04-17 1993-02-16 Trustees Of The University Of Pennsylvania Dopamine receptor ligands and image agents
US5128118A (en) * 1990-08-09 1992-07-07 Research Triangle Institute Cocaine receptor binding ligands
US5104638A (en) * 1990-10-29 1992-04-14 Mallinckrodt Medical, Inc. Method of making a radiopharmaceutical complex from a kit

Also Published As

Publication number Publication date
FI120183B (fi) 2009-07-31
NL300123I1 (nl) 2003-06-02
AU4655493A (en) 1995-01-24
DE10399020I1 (de) 2003-09-18
PT703791E (pt) 2003-04-30
EP0703791B1 (de) 2002-12-04
ES2189792T3 (es) 2003-07-16
DK0703791T3 (da) 2003-03-24
EP0703791A4 (de) 1996-05-22
AU674331B2 (en) 1996-12-19
NL300123I2 (nl) 2003-08-01
DE10399020I2 (de) 2005-05-04
DE69332544T2 (de) 2003-08-14
FI956261A0 (fi) 1995-12-27
FI956261A (fi) 1995-12-27
JP3228422B2 (ja) 2001-11-12
DE69332544D1 (de) 2003-01-16
US5439666A (en) 1995-08-08
EP0703791A1 (de) 1996-04-03
WO1995001184A1 (en) 1995-01-12
JPH09503745A (ja) 1997-04-15
US5310912A (en) 1994-05-10

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