PT703791E - Neuro-sonda iodada para o mapeamento dos locais de reincorporacao de monoaminas - Google Patents
Neuro-sonda iodada para o mapeamento dos locais de reincorporacao de monoaminasInfo
- Publication number
- PT703791E PT703791E PT93916836T PT93916836T PT703791E PT 703791 E PT703791 E PT 703791E PT 93916836 T PT93916836 T PT 93916836T PT 93916836 T PT93916836 T PT 93916836T PT 703791 E PT703791 E PT 703791E
- Authority
- PT
- Portugal
- Prior art keywords
- group
- isotope
- cnh2n
- mapping
- ioded
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
- Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Valve-Gear Or Valve Arrangements (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Testing Or Measuring Of Semiconductors Or The Like (AREA)
- Measuring Leads Or Probes (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Management, Administration, Business Operations System, And Electronic Commerce (AREA)
- Apparatus For Radiation Diagnosis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Window Of Vehicle (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/841,617 US5310912A (en) | 1992-02-25 | 1992-02-25 | Iodinated neuroprobe for mapping monoamine reuptake sites |
PCT/US1993/006170 WO1995001184A1 (en) | 1992-02-25 | 1993-06-29 | An iodinated neuroprobe for mapping monoamine reuptake sites |
Publications (1)
Publication Number | Publication Date |
---|---|
PT703791E true PT703791E (pt) | 2003-04-30 |
Family
ID=25285315
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT93916836T PT703791E (pt) | 1992-02-25 | 1993-06-29 | Neuro-sonda iodada para o mapeamento dos locais de reincorporacao de monoaminas |
Country Status (12)
Country | Link |
---|---|
US (2) | US5310912A (pt) |
EP (1) | EP0703791B1 (pt) |
JP (1) | JP3228422B2 (pt) |
AT (1) | ATE228858T1 (pt) |
AU (1) | AU674331B2 (pt) |
DE (2) | DE69332544T2 (pt) |
DK (1) | DK0703791T3 (pt) |
ES (1) | ES2189792T3 (pt) |
FI (1) | FI120183B (pt) |
NL (1) | NL300123I2 (pt) |
PT (1) | PT703791E (pt) |
WO (1) | WO1995001184A1 (pt) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5736123A (en) * | 1990-08-09 | 1998-04-07 | Research Triangle Institute | Cocaine receptor binding ligands |
US7189737B2 (en) * | 1991-08-09 | 2007-03-13 | Research Triangle Institute | Cocaine receptor binding ligands |
US5496953A (en) * | 1990-08-09 | 1996-03-05 | Research Triangle Institute | Cocaine receptor binding ligands |
US5128118A (en) * | 1990-08-09 | 1992-07-07 | Research Triangle Institute | Cocaine receptor binding ligands |
US5750089A (en) * | 1996-01-11 | 1998-05-12 | Neuro Imaging Technologies, Llc | Halogenated neuroprobe for mapping monoamine reuptake sites |
US5770180A (en) * | 1992-08-24 | 1998-06-23 | Organix, Inc. | Bridge-substituted tropanes for methods of imaging and therapy |
US5493026A (en) * | 1993-10-25 | 1996-02-20 | Organix, Inc. | Substituted 2-carboxyalkyl-3-(fluorophenyl)-8-(3-halopropen-2-yl) nortropanes and their use as imaging for agents for neurodegenerative disorders |
EP0831941B1 (en) * | 1995-06-06 | 2012-04-04 | GE Healthcare Limited | Iodinated neuroprobes for mapping monoamine reuptake sites |
US5864038A (en) * | 1995-08-17 | 1999-01-26 | Emory University | Labeled cocaine analogs |
US6171576B1 (en) * | 1995-11-03 | 2001-01-09 | Organix Inc. | Dopamine transporter imaging agent |
US5948933A (en) | 1997-07-11 | 1999-09-07 | Organix, Inc. | Tropane analogs and methods for inhibition of monoamine transport |
US7105678B2 (en) | 1995-11-03 | 2006-09-12 | Organix, Inc. | Boat tropanes |
FR2748475B1 (fr) * | 1996-05-10 | 1999-04-16 | Cis Bio Int | Derives du tropane utilisables en particulier pour la detection in vivo des transporteurs de la dopamine |
CA2270242A1 (en) * | 1996-10-29 | 1998-05-07 | Guilford Pharmaceuticals Inc. | Process for the preparation of radiopharmaceuticals |
FI104048B (fi) * | 1997-06-16 | 1999-11-15 | Map Medical Technologies Oy | Prosessi tuottaa radiojodattuja reseptoriaineita in vivo käyttöön |
US6358492B1 (en) * | 1997-10-07 | 2002-03-19 | Research Triangle Institute | Dopamine transporter imaging ligand |
US6013242A (en) * | 1998-01-13 | 2000-01-11 | Wake Forest University | Tropane derivatives with selective binding to the serotonin reuptake transporters for treatment of mental illness and as intermediates in the formation of imaging diagnostic agents for depression |
US6399042B1 (en) * | 1999-04-26 | 2002-06-04 | Emory University | 4-fluoroalkyl-3-halophenyl nortropanes |
US6843979B2 (en) | 1999-04-26 | 2005-01-18 | Emory University | 4-haloethenylphenyl tropane:serotonin transporter imaging agents |
CA2285516C (en) * | 1999-05-12 | 2010-12-07 | President And Fellows Of Harvard College | Dopamine transporter imaging agents |
US20030032675A1 (en) * | 2001-02-15 | 2003-02-13 | Franz G. Andrew | Manufacture of thyroid hormone tablets having consistent active moiety amounts |
US6555581B1 (en) | 2001-02-15 | 2003-04-29 | Jones Pharma, Inc. | Levothyroxine compositions and methods |
BR0207297A (pt) * | 2001-02-15 | 2005-04-19 | King Pharmaceuticals Inc | Composição farmacêutica em forma sólida e método de preparar uma forma de dosagem sólida de um ingrediente farmaceuticamente ativo |
US20030224047A1 (en) * | 2001-02-15 | 2003-12-04 | Franz G. Andrew | Levothyroxine compositions and methods |
CA2438318A1 (en) * | 2001-02-16 | 2002-08-29 | Aventis Pharmaceuticals Inc. | Novel heterocyclic amide derivatives and their use as dopamine d3 receptor ligands |
US20030180353A1 (en) * | 2001-08-10 | 2003-09-25 | Franz G. Andrew | Stabilized pharmaceutical compositions |
US20030190349A1 (en) * | 2001-08-10 | 2003-10-09 | Franz G. Andrew | Methods of stabilizing pharmaceutical compositions |
US20030198667A1 (en) * | 2001-08-10 | 2003-10-23 | Franz Andrew G. | Methods of producing dispersible pharmaceutical compositions |
US20030198672A1 (en) * | 2001-08-14 | 2003-10-23 | Franz G. Andrew | Levothyroxine compositions having unique triidothyronine plasma AUC properties |
US7101569B2 (en) | 2001-08-14 | 2006-09-05 | Franz G Andrew | Methods of administering levothyroxine pharmaceutical compositions |
US20030195253A1 (en) * | 2001-08-14 | 2003-10-16 | Franz G. Andrew | Unadsorbed levothyroxine pharmaceutical compositions, methods of making and methods of administration |
US20030199586A1 (en) * | 2001-08-14 | 2003-10-23 | Franz G. Andrew | Unique levothyroxine aqueous materials |
US20030199587A1 (en) * | 2001-08-14 | 2003-10-23 | Franz G. Andrew | Levothyroxine compositions having unique Cmax properties |
US20030203967A1 (en) * | 2001-08-14 | 2003-10-30 | Franz G. Andrew | Levothyroxine compositions having unique Tmax properties |
DE20120708U1 (de) | 2001-10-09 | 2002-08-01 | Meltzer Peter C | Tropan-Analoga zur Inhibierung des Monoamin-Transports |
US20030171436A1 (en) * | 2001-10-29 | 2003-09-11 | Franz G. Andrew | Levothyroxine compositions having unique triiodothyronine Tmax properties |
ES2349528T3 (es) * | 2002-04-30 | 2011-01-04 | Emory University | Compuestos para la imagen de tumores. |
JP2005154374A (ja) * | 2003-11-27 | 2005-06-16 | Hamamatsu Photonics Kk | 放射性トロパンアルカロイド誘導体、トロパンアルカロイド誘導体、及びそれらの製造方法。 |
WO2007001958A2 (en) * | 2005-06-23 | 2007-01-04 | Emory University | Stereoselective synthesis of amino acid analogs for tumor imaging |
JP2009505947A (ja) * | 2005-06-23 | 2009-02-12 | エモリー・ユニバーシティ | 画像化剤 |
CA2704104C (en) * | 2007-10-31 | 2016-02-02 | Alseres Pharmaceuticals, Inc. | Labeled iodinated tropane formulation |
US8246752B2 (en) | 2008-01-25 | 2012-08-21 | Clear Catheter Systems, Inc. | Methods and devices to clear obstructions from medical tubes |
CN110582494A (zh) * | 2017-03-17 | 2019-12-17 | 日本医事物理股份有限公司 | 碘氟潘的制造方法 |
BR112022014569A2 (pt) | 2020-01-24 | 2022-09-13 | Rotop Radiopharmacy Gmbh | Método para preparação de n-monofluoroalquil tropanos e seu uso |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3813404A (en) * | 1972-11-15 | 1974-05-28 | Sterling Drug Inc | Tropane-2-carboxylates and derivatives |
US4942231A (en) * | 1984-05-24 | 1990-07-17 | Mallinckrodt, Inc. | Method of preparing a chlorinated, brominated, radio-brominated, iodinated and/or radioiodinated aromatic or heteroaromatic compound |
US5098996A (en) * | 1984-10-26 | 1992-03-24 | The United States Of America As Represented By The Department Of Health And Human Services | Process for introducing fluorine into biologically active materials |
US5200169A (en) * | 1987-04-16 | 1993-04-06 | Neorx Corporation | Vinyl substituted radiohalogen conjugates for protein labeling |
US5186921A (en) * | 1989-04-17 | 1993-02-16 | Trustees Of The University Of Pennsylvania | Dopamine receptor ligands and image agents |
US5128118A (en) * | 1990-08-09 | 1992-07-07 | Research Triangle Institute | Cocaine receptor binding ligands |
US5104638A (en) * | 1990-10-29 | 1992-04-14 | Mallinckrodt Medical, Inc. | Method of making a radiopharmaceutical complex from a kit |
-
1992
- 1992-02-25 US US07/841,617 patent/US5310912A/en not_active Expired - Lifetime
-
1993
- 1993-06-29 WO PCT/US1993/006170 patent/WO1995001184A1/en active IP Right Grant
- 1993-06-29 EP EP93916836A patent/EP0703791B1/en not_active Expired - Lifetime
- 1993-06-29 AT AT93916836T patent/ATE228858T1/de active
- 1993-06-29 ES ES93916836T patent/ES2189792T3/es not_active Expired - Lifetime
- 1993-06-29 DE DE69332544T patent/DE69332544T2/de not_active Expired - Lifetime
- 1993-06-29 JP JP50343995A patent/JP3228422B2/ja not_active Expired - Lifetime
- 1993-06-29 PT PT93916836T patent/PT703791E/pt unknown
- 1993-06-29 AU AU46554/93A patent/AU674331B2/en not_active Expired
- 1993-06-29 DK DK93916836T patent/DK0703791T3/da active
- 1993-06-29 DE DE2003199020 patent/DE10399020I2/de active Active
-
1994
- 1994-01-24 US US08/185,689 patent/US5439666A/en not_active Expired - Lifetime
-
1995
- 1995-12-27 FI FI956261A patent/FI120183B/fi not_active IP Right Cessation
-
2003
- 2003-04-09 NL NL300123C patent/NL300123I2/nl unknown
Also Published As
Publication number | Publication date |
---|---|
DE69332544D1 (de) | 2003-01-16 |
DE10399020I1 (de) | 2003-09-18 |
AU674331B2 (en) | 1996-12-19 |
WO1995001184A1 (en) | 1995-01-12 |
JP3228422B2 (ja) | 2001-11-12 |
AU4655493A (en) | 1995-01-24 |
US5439666A (en) | 1995-08-08 |
ES2189792T3 (es) | 2003-07-16 |
FI120183B (fi) | 2009-07-31 |
ATE228858T1 (de) | 2002-12-15 |
JPH09503745A (ja) | 1997-04-15 |
DK0703791T3 (da) | 2003-03-24 |
EP0703791A4 (en) | 1996-05-22 |
NL300123I1 (nl) | 2003-06-02 |
FI956261A0 (fi) | 1995-12-27 |
NL300123I2 (nl) | 2003-08-01 |
DE69332544T2 (de) | 2003-08-14 |
US5310912A (en) | 1994-05-10 |
DE10399020I2 (de) | 2005-05-04 |
EP0703791B1 (en) | 2002-12-04 |
FI956261A (fi) | 1995-12-27 |
EP0703791A1 (en) | 1996-04-03 |
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