DE69332544D1 - Jodierte neurosonde zum erfassen von monoamin-wiederaufnahme-orten - Google Patents

Jodierte neurosonde zum erfassen von monoamin-wiederaufnahme-orten

Info

Publication number
DE69332544D1
DE69332544D1 DE69332544T DE69332544T DE69332544D1 DE 69332544 D1 DE69332544 D1 DE 69332544D1 DE 69332544 T DE69332544 T DE 69332544T DE 69332544 T DE69332544 T DE 69332544T DE 69332544 D1 DE69332544 D1 DE 69332544D1
Authority
DE
Germany
Prior art keywords
group
isotope
cnh2n
iodated
neuroprobe
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69332544T
Other languages
English (en)
Other versions
DE69332544T2 (de
Inventor
John L Neumeyer
Richard A Milius
Robert B Innis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RES BIOMEDICALS Ltd PARTNERSHI
Original Assignee
RES BIOMEDICALS Ltd PARTNERSHI
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by RES BIOMEDICALS Ltd PARTNERSHI filed Critical RES BIOMEDICALS Ltd PARTNERSHI
Publication of DE69332544D1 publication Critical patent/DE69332544D1/de
Application granted granted Critical
Publication of DE69332544T2 publication Critical patent/DE69332544T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
DE69332544T 1992-02-25 1993-06-29 Jodierte neurosonde zum erfassen von monoamin-wiederaufnahme-orten Expired - Lifetime DE69332544T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/841,617 US5310912A (en) 1992-02-25 1992-02-25 Iodinated neuroprobe for mapping monoamine reuptake sites
PCT/US1993/006170 WO1995001184A1 (en) 1992-02-25 1993-06-29 An iodinated neuroprobe for mapping monoamine reuptake sites

Publications (2)

Publication Number Publication Date
DE69332544D1 true DE69332544D1 (de) 2003-01-16
DE69332544T2 DE69332544T2 (de) 2003-08-14

Family

ID=25285315

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69332544T Expired - Lifetime DE69332544T2 (de) 1992-02-25 1993-06-29 Jodierte neurosonde zum erfassen von monoamin-wiederaufnahme-orten
DE2003199020 Active DE10399020I2 (de) 1992-02-25 1993-06-29 Jodierte Neurosonde zum erfassen von Monoamin-wiederaufnahme-orten.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE2003199020 Active DE10399020I2 (de) 1992-02-25 1993-06-29 Jodierte Neurosonde zum erfassen von Monoamin-wiederaufnahme-orten.

Country Status (12)

Country Link
US (2) US5310912A (de)
EP (1) EP0703791B1 (de)
JP (1) JP3228422B2 (de)
AT (1) ATE228858T1 (de)
AU (1) AU674331B2 (de)
DE (2) DE69332544T2 (de)
DK (1) DK0703791T3 (de)
ES (1) ES2189792T3 (de)
FI (1) FI120183B (de)
NL (1) NL300123I2 (de)
PT (1) PT703791E (de)
WO (1) WO1995001184A1 (de)

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US5736123A (en) * 1990-08-09 1998-04-07 Research Triangle Institute Cocaine receptor binding ligands
US5128118A (en) * 1990-08-09 1992-07-07 Research Triangle Institute Cocaine receptor binding ligands
US7189737B2 (en) * 1991-08-09 2007-03-13 Research Triangle Institute Cocaine receptor binding ligands
US5496953A (en) * 1990-08-09 1996-03-05 Research Triangle Institute Cocaine receptor binding ligands
US5750089A (en) * 1996-01-11 1998-05-12 Neuro Imaging Technologies, Llc Halogenated neuroprobe for mapping monoamine reuptake sites
US5770180A (en) * 1992-08-24 1998-06-23 Organix, Inc. Bridge-substituted tropanes for methods of imaging and therapy
US5493026A (en) * 1993-10-25 1996-02-20 Organix, Inc. Substituted 2-carboxyalkyl-3-(fluorophenyl)-8-(3-halopropen-2-yl) nortropanes and their use as imaging for agents for neurodegenerative disorders
WO1996039198A1 (en) 1995-06-06 1996-12-12 RESEARCH BIOCHEMICALS, LIMITED PARTNERSHIP, doing business as RESEARCH BIOCHEMICALS INTERNATIONAL, A MASSACHUSETTS LIMITED PARTNERSHIP, WHOSE SOLE GENERAL PARTNER IS RBI MANAGEMENT, INC. Iodinated neuroprobes for mapping monoamine reuptake sites
US5864038A (en) * 1995-08-17 1999-01-26 Emory University Labeled cocaine analogs
US5948933A (en) * 1997-07-11 1999-09-07 Organix, Inc. Tropane analogs and methods for inhibition of monoamine transport
US6171576B1 (en) * 1995-11-03 2001-01-09 Organix Inc. Dopamine transporter imaging agent
US7105678B2 (en) 1995-11-03 2006-09-12 Organix, Inc. Boat tropanes
FR2748475B1 (fr) * 1996-05-10 1999-04-16 Cis Bio Int Derives du tropane utilisables en particulier pour la detection in vivo des transporteurs de la dopamine
EP0946204A1 (de) * 1996-10-29 1999-10-06 Guilford Pharmaceuticals Inc. Verfahren zur herstellung von radiopharmazeutischen mittel
FI104048B1 (fi) * 1997-06-16 1999-11-15 Map Medical Technologies Oy Prosessi tuottaa radiojodattuja reseptoriaineita in vivo käyttöön
US6358492B1 (en) * 1997-10-07 2002-03-19 Research Triangle Institute Dopamine transporter imaging ligand
US6013242A (en) * 1998-01-13 2000-01-11 Wake Forest University Tropane derivatives with selective binding to the serotonin reuptake transporters for treatment of mental illness and as intermediates in the formation of imaging diagnostic agents for depression
US6843979B2 (en) 1999-04-26 2005-01-18 Emory University 4-haloethenylphenyl tropane:serotonin transporter imaging agents
DE60015576T2 (de) * 1999-04-26 2005-11-10 Emory University 4-Fluoralkyl-3-halogenphenylnortropane
CA2721484A1 (en) 1999-05-12 2000-11-12 President And Fellows Of Harvard College Dopamine transporter imaging agents
US20030032675A1 (en) * 2001-02-15 2003-02-13 Franz G. Andrew Manufacture of thyroid hormone tablets having consistent active moiety amounts
US7067148B2 (en) * 2001-02-15 2006-06-27 King Pharmaceutical Research & Development, Inc. Stabilized pharmaceutical and thyroid hormone compositions and method of preparation
US20030224047A1 (en) * 2001-02-15 2003-12-04 Franz G. Andrew Levothyroxine compositions and methods
US6555581B1 (en) 2001-02-15 2003-04-29 Jones Pharma, Inc. Levothyroxine compositions and methods
MXPA03006524A (es) * 2001-02-16 2003-09-25 Aventis Pharma Inc Derivados heterociclicos novedosos de amidas y su uso como ligandos para receptor d3 de dopamina.
US20030198667A1 (en) * 2001-08-10 2003-10-23 Franz Andrew G. Methods of producing dispersible pharmaceutical compositions
US20030190349A1 (en) * 2001-08-10 2003-10-09 Franz G. Andrew Methods of stabilizing pharmaceutical compositions
US20030180353A1 (en) * 2001-08-10 2003-09-25 Franz G. Andrew Stabilized pharmaceutical compositions
US20030198672A1 (en) * 2001-08-14 2003-10-23 Franz G. Andrew Levothyroxine compositions having unique triidothyronine plasma AUC properties
US7101569B2 (en) 2001-08-14 2006-09-05 Franz G Andrew Methods of administering levothyroxine pharmaceutical compositions
US20030203967A1 (en) * 2001-08-14 2003-10-30 Franz G. Andrew Levothyroxine compositions having unique Tmax properties
US20030199586A1 (en) * 2001-08-14 2003-10-23 Franz G. Andrew Unique levothyroxine aqueous materials
US20030195253A1 (en) * 2001-08-14 2003-10-16 Franz G. Andrew Unadsorbed levothyroxine pharmaceutical compositions, methods of making and methods of administration
US20030199587A1 (en) * 2001-08-14 2003-10-23 Franz G. Andrew Levothyroxine compositions having unique Cmax properties
DE20120708U1 (de) 2001-10-09 2002-08-01 Meltzer Peter C Tropan-Analoga zur Inhibierung des Monoamin-Transports
US20030190359A1 (en) * 2001-10-29 2003-10-09 Franz G. Andrew Levothyroxine compositions having unique triiodothyronine Tmax properties
ES2349528T3 (es) * 2002-04-30 2011-01-04 Emory University Compuestos para la imagen de tumores.
JP2005154374A (ja) * 2003-11-27 2005-06-16 Hamamatsu Photonics Kk 放射性トロパンアルカロイド誘導体、トロパンアルカロイド誘導体、及びそれらの製造方法。
US7837982B2 (en) * 2005-06-23 2010-11-23 Emory University Imaging agents
RU2376282C2 (ru) * 2005-06-23 2009-12-20 Эмори Юниверсити Стереоселективный синтез аминокислот для получения изображения опухоли
EP2212319B1 (de) 2007-10-31 2018-07-18 Alseres Pharmaceuticals, Inc. Formulierung von markiertem, iodiertem tropan
US8246752B2 (en) 2008-01-25 2012-08-21 Clear Catheter Systems, Inc. Methods and devices to clear obstructions from medical tubes
CN110582494A (zh) * 2017-03-17 2019-12-17 日本医事物理股份有限公司 碘氟潘的制造方法
WO2021148598A1 (en) 2020-01-24 2021-07-29 Rotop Radiopharmacy Gmbh Method for the preparation of n-monofluoroalkyl tropanes and their use

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US3813404A (en) * 1972-11-15 1974-05-28 Sterling Drug Inc Tropane-2-carboxylates and derivatives
US4942231A (en) * 1984-05-24 1990-07-17 Mallinckrodt, Inc. Method of preparing a chlorinated, brominated, radio-brominated, iodinated and/or radioiodinated aromatic or heteroaromatic compound
US5098996A (en) * 1984-10-26 1992-03-24 The United States Of America As Represented By The Department Of Health And Human Services Process for introducing fluorine into biologically active materials
US5200169A (en) * 1987-04-16 1993-04-06 Neorx Corporation Vinyl substituted radiohalogen conjugates for protein labeling
US5186921A (en) * 1989-04-17 1993-02-16 Trustees Of The University Of Pennsylvania Dopamine receptor ligands and image agents
US5128118A (en) * 1990-08-09 1992-07-07 Research Triangle Institute Cocaine receptor binding ligands
US5104638A (en) * 1990-10-29 1992-04-14 Mallinckrodt Medical, Inc. Method of making a radiopharmaceutical complex from a kit

Also Published As

Publication number Publication date
AU674331B2 (en) 1996-12-19
FI956261A (fi) 1995-12-27
NL300123I1 (nl) 2003-06-02
EP0703791A4 (de) 1996-05-22
JPH09503745A (ja) 1997-04-15
US5439666A (en) 1995-08-08
DE10399020I1 (de) 2003-09-18
DE69332544T2 (de) 2003-08-14
JP3228422B2 (ja) 2001-11-12
EP0703791A1 (de) 1996-04-03
AU4655493A (en) 1995-01-24
DE10399020I2 (de) 2005-05-04
US5310912A (en) 1994-05-10
EP0703791B1 (de) 2002-12-04
FI956261A0 (fi) 1995-12-27
FI120183B (fi) 2009-07-31
NL300123I2 (nl) 2003-08-01
ES2189792T3 (es) 2003-07-16
PT703791E (pt) 2003-04-30
ATE228858T1 (de) 2002-12-15
WO1995001184A1 (en) 1995-01-12
DK0703791T3 (da) 2003-03-24

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