FI104048B1 - Prosessi tuottaa radiojodattuja reseptoriaineita in vivo käyttöön - Google Patents
Prosessi tuottaa radiojodattuja reseptoriaineita in vivo käyttöönInfo
- Publication number
- FI104048B1 FI104048B1 FI972550A FI972550A FI104048B1 FI 104048 B1 FI104048 B1 FI 104048B1 FI 972550 A FI972550 A FI 972550A FI 972550 A FI972550 A FI 972550A FI 104048 B1 FI104048 B1 FI 104048B1
- Authority
- FI
- Finland
- Prior art keywords
- products
- neuroreceptor
- chromatographic separation
- radioiodinated
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Inorganic Compounds Of Heavy Metals (AREA)
- Saccharide Compounds (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Cephalosporin Compounds (AREA)
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI972550A FI104048B1 (fi) | 1997-06-16 | 1997-06-16 | Prosessi tuottaa radiojodattuja reseptoriaineita in vivo käyttöön |
DK98925677T DK0988263T3 (da) | 1997-06-16 | 1998-06-15 | Fremgangsmåde til fremstilling af radioioderede neuroreceptormidler |
SI9830744T SI0988263T1 (en) | 1997-06-16 | 1998-06-15 | Process for the production of radioiodinated neuroreceptor agents |
DE69828166T DE69828166T2 (de) | 1997-06-16 | 1998-06-15 | Verfahren zur herstellung von mit radioaktivem iod markierten, neurorezeptor-wirksamen mitteln |
AU77700/98A AU7770098A (en) | 1997-06-16 | 1998-06-15 | Process for the production of radioiodinated neuroreceptor agents |
AT98925677T ATE284852T1 (de) | 1997-06-16 | 1998-06-15 | Verfahren zur herstellung von mit radioaktivem iod markierten, neurorezeptor-wirksamen mitteln |
PT98925677T PT988263E (pt) | 1997-06-16 | 1998-06-15 | Processo para a producao de agentes neurorreceptores radioiodados |
EP98925677A EP0988263B1 (en) | 1997-06-16 | 1998-06-15 | Process for the production of radioiodinated neuroreceptor agents |
PCT/FI1998/000514 WO1998057909A1 (en) | 1997-06-16 | 1998-06-15 | Process for the production of radioiodinated neuroreceptor agents |
ES98925677T ES2232947T3 (es) | 1997-06-16 | 1998-06-15 | Procedimiento para la produccion de agentes neurorrecepetores marcados con yodo radioactio. |
CA002293317A CA2293317A1 (en) | 1997-06-16 | 1998-06-15 | Process for the production of radioiodinated neuroreceptor agents |
US09/445,962 US6365125B1 (en) | 1997-06-16 | 1998-06-15 | Process for the production of radioiodinated neuroreceptor agents |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FI972550A FI104048B1 (fi) | 1997-06-16 | 1997-06-16 | Prosessi tuottaa radiojodattuja reseptoriaineita in vivo käyttöön |
Publications (4)
Publication Number | Publication Date |
---|---|
FI972550A0 FI972550A0 (fi) | 1997-06-16 |
FI972550A FI972550A (fi) | 1998-12-17 |
FI104048B FI104048B (fi) | 1999-11-15 |
FI104048B1 true FI104048B1 (fi) | 1999-11-15 |
Family
ID=8549059
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI972550A FI104048B1 (fi) | 1997-06-16 | 1997-06-16 | Prosessi tuottaa radiojodattuja reseptoriaineita in vivo käyttöön |
Country Status (10)
Country | Link |
---|---|
US (1) | US6365125B1 (fi) |
EP (1) | EP0988263B1 (fi) |
AT (1) | ATE284852T1 (fi) |
AU (1) | AU7770098A (fi) |
CA (1) | CA2293317A1 (fi) |
DE (1) | DE69828166T2 (fi) |
ES (1) | ES2232947T3 (fi) |
FI (1) | FI104048B1 (fi) |
PT (1) | PT988263E (fi) |
WO (1) | WO1998057909A1 (fi) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE439838T1 (de) | 1998-09-29 | 2009-09-15 | Merck & Co Inc | Radiomarkierte neurokinin-1 rezeptor antagonisten |
CN100536926C (zh) | 2003-05-02 | 2009-09-09 | 西安大略省大学 | 合成放射性药物中连接至甲锡烷基聚合物的辅基 |
ITMC20070196A1 (it) * | 2007-10-10 | 2008-01-09 | A C O M Advanced Ct Oncology M | Sintesi chimica di i-124betacit iodine-124[2beta-carbomethoxy-3beta-(4-iodophenyl)-tropane] per indagini pet e per la radioterapia. |
DE102009016493A1 (de) * | 2009-04-06 | 2010-10-14 | ITM Isotopen Technologien München AG | Verfahren zur Reinigung kleiner Mengen chemischer Substanzen |
US20120264949A1 (en) * | 2011-04-13 | 2012-10-18 | Atomic Energy Council-Institute Of Nuclear Energy Research | Method of Labeling Dopamine D2 Receptor Using Radiosynthesized Ligand of Iodine-123-Epidepride |
US20140079634A1 (en) * | 2012-09-18 | 2014-03-20 | Navidea Biopharmaceuticals Inc. | Labeled pe2i formulation and method |
WO2015048250A1 (en) * | 2013-09-25 | 2015-04-02 | Mallinckrodt Llc | Preparation of radioiodinated 3-fluoropropyl-nor-beta-cit |
JP7241013B2 (ja) * | 2017-03-17 | 2023-03-16 | 日本メジフィジックス株式会社 | イオフルパンの製造方法 |
DE112021000702T5 (de) | 2020-01-24 | 2022-11-03 | Rotop Radiopharmacy Gmbh | Verfahren zur Herstellung von N-Monofluoralkyltropanen und deren Verwendung |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5310912A (en) * | 1992-02-25 | 1994-05-10 | Research Biochemicals Limited Partnership | Iodinated neuroprobe for mapping monoamine reuptake sites |
US5911970A (en) | 1993-05-06 | 1999-06-15 | Research Corporation Technologies, Inc. | Methods for cancer imaging and therapy using benzamine compounds |
US5569447A (en) | 1994-04-19 | 1996-10-29 | The United States Of America Represented By The Secretary Department Of Health And Human Services | Stannylated 3-quinuclidinyl benzilates and methods of preparing radiohalogenated derivatives |
US5723103A (en) | 1994-12-09 | 1998-03-03 | Vanderbilt University | Substituted benzamides and radioligand analogs and methods of use |
BE1009833A3 (fr) | 1995-12-12 | 1997-10-07 | Quivy Jacques Irenee Charles | Nouveau marqueur, son procede d'obtention et son utilisation. |
AU5194798A (en) | 1996-10-29 | 1998-05-22 | Guilford Pharmaceuticals Inc. | Process for the preparation of radiopharmaceuticals |
US5976497A (en) * | 1997-08-04 | 1999-11-02 | Resolution Pharmaceuticals, Inc. | Dopamine D4 receptor ligands |
-
1997
- 1997-06-16 FI FI972550A patent/FI104048B1/fi active
-
1998
- 1998-06-15 ES ES98925677T patent/ES2232947T3/es not_active Expired - Lifetime
- 1998-06-15 CA CA002293317A patent/CA2293317A1/en not_active Abandoned
- 1998-06-15 EP EP98925677A patent/EP0988263B1/en not_active Expired - Lifetime
- 1998-06-15 AT AT98925677T patent/ATE284852T1/de not_active IP Right Cessation
- 1998-06-15 DE DE69828166T patent/DE69828166T2/de not_active Expired - Fee Related
- 1998-06-15 US US09/445,962 patent/US6365125B1/en not_active Expired - Fee Related
- 1998-06-15 WO PCT/FI1998/000514 patent/WO1998057909A1/en active IP Right Grant
- 1998-06-15 PT PT98925677T patent/PT988263E/pt unknown
- 1998-06-15 AU AU77700/98A patent/AU7770098A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
FI972550A0 (fi) | 1997-06-16 |
PT988263E (pt) | 2005-03-31 |
EP0988263B1 (en) | 2004-12-15 |
DE69828166T2 (de) | 2005-12-22 |
ATE284852T1 (de) | 2005-01-15 |
FI104048B (fi) | 1999-11-15 |
FI972550A (fi) | 1998-12-17 |
CA2293317A1 (en) | 1998-12-23 |
WO1998057909A1 (en) | 1998-12-23 |
US6365125B1 (en) | 2002-04-02 |
AU7770098A (en) | 1999-01-04 |
ES2232947T3 (es) | 2005-06-01 |
EP0988263A1 (en) | 2000-03-29 |
DE69828166D1 (de) | 2005-01-20 |
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