DE69828166D1 - Verfahren zur herstellung von mit radioaktivem iod markierten, neurorezeptor-wirksamen mitteln - Google Patents

Verfahren zur herstellung von mit radioaktivem iod markierten, neurorezeptor-wirksamen mitteln

Info

Publication number
DE69828166D1
DE69828166D1 DE69828166T DE69828166T DE69828166D1 DE 69828166 D1 DE69828166 D1 DE 69828166D1 DE 69828166 T DE69828166 T DE 69828166T DE 69828166 T DE69828166 T DE 69828166T DE 69828166 D1 DE69828166 D1 DE 69828166D1
Authority
DE
Germany
Prior art keywords
products
neuroreepeptor
iod
marked
neuroreceptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69828166T
Other languages
English (en)
Other versions
DE69828166T2 (de
Inventor
Jukka Hiltunen
Tuomo Nikula
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Map Medical Technologies Oy
Original Assignee
Map Medical Technologies Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Map Medical Technologies Oy filed Critical Map Medical Technologies Oy
Publication of DE69828166D1 publication Critical patent/DE69828166D1/de
Application granted granted Critical
Publication of DE69828166T2 publication Critical patent/DE69828166T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
DE69828166T 1997-06-16 1998-06-15 Verfahren zur herstellung von mit radioaktivem iod markierten, neurorezeptor-wirksamen mitteln Expired - Fee Related DE69828166T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FI972550 1997-06-16
FI972550A FI104048B (fi) 1997-06-16 1997-06-16 Prosessi tuottaa radiojodattuja reseptoriaineita in vivo käyttöön
PCT/FI1998/000514 WO1998057909A1 (en) 1997-06-16 1998-06-15 Process for the production of radioiodinated neuroreceptor agents

Publications (2)

Publication Number Publication Date
DE69828166D1 true DE69828166D1 (de) 2005-01-20
DE69828166T2 DE69828166T2 (de) 2005-12-22

Family

ID=8549059

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69828166T Expired - Fee Related DE69828166T2 (de) 1997-06-16 1998-06-15 Verfahren zur herstellung von mit radioaktivem iod markierten, neurorezeptor-wirksamen mitteln

Country Status (10)

Country Link
US (1) US6365125B1 (de)
EP (1) EP0988263B1 (de)
AT (1) ATE284852T1 (de)
AU (1) AU7770098A (de)
CA (1) CA2293317A1 (de)
DE (1) DE69828166T2 (de)
ES (1) ES2232947T3 (de)
FI (1) FI104048B (de)
PT (1) PT988263E (de)
WO (1) WO1998057909A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69941298D1 (de) 1998-09-29 2009-10-01 Merck & Co Inc Radiomarkierte neurokinin-1 rezeptor antagonisten
AU2004237155B2 (en) * 2003-05-02 2008-02-28 The University Of Western Ontario Prosthetic groups attached to stannyl polymer in the synthesis of radiopharmaceuticals
ITMC20070196A1 (it) * 2007-10-10 2008-01-09 A C O M Advanced Ct Oncology M Sintesi chimica di i-124betacit iodine-124[2beta-carbomethoxy-3beta-(4-iodophenyl)-tropane] per indagini pet e per la radioterapia.
DE102009016493A1 (de) * 2009-04-06 2010-10-14 ITM Isotopen Technologien München AG Verfahren zur Reinigung kleiner Mengen chemischer Substanzen
US20120264949A1 (en) * 2011-04-13 2012-10-18 Atomic Energy Council-Institute Of Nuclear Energy Research Method of Labeling Dopamine D2 Receptor Using Radiosynthesized Ligand of Iodine-123-Epidepride
US20140079634A1 (en) * 2012-09-18 2014-03-20 Navidea Biopharmaceuticals Inc. Labeled pe2i formulation and method
CA2922723C (en) * 2013-09-25 2022-04-19 Mallinckrodt Llc Improved process for the preparation of radioiodinated 3-fluoropropyl-nor-b-cit
CN110582494A (zh) * 2017-03-17 2019-12-17 日本医事物理股份有限公司 碘氟潘的制造方法
BR112022014569A2 (pt) 2020-01-24 2022-09-13 Rotop Radiopharmacy Gmbh Método para preparação de n-monofluoroalquil tropanos e seu uso

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5310912A (en) * 1992-02-25 1994-05-10 Research Biochemicals Limited Partnership Iodinated neuroprobe for mapping monoamine reuptake sites
US5911970A (en) 1993-05-06 1999-06-15 Research Corporation Technologies, Inc. Methods for cancer imaging and therapy using benzamine compounds
US5569447A (en) * 1994-04-19 1996-10-29 The United States Of America Represented By The Secretary Department Of Health And Human Services Stannylated 3-quinuclidinyl benzilates and methods of preparing radiohalogenated derivatives
US5723103A (en) 1994-12-09 1998-03-03 Vanderbilt University Substituted benzamides and radioligand analogs and methods of use
BE1009833A3 (fr) 1995-12-12 1997-10-07 Quivy Jacques Irenee Charles Nouveau marqueur, son procede d'obtention et son utilisation.
CA2270242A1 (en) 1996-10-29 1998-05-07 Guilford Pharmaceuticals Inc. Process for the preparation of radiopharmaceuticals
US5976497A (en) * 1997-08-04 1999-11-02 Resolution Pharmaceuticals, Inc. Dopamine D4 receptor ligands

Also Published As

Publication number Publication date
FI104048B1 (fi) 1999-11-15
PT988263E (pt) 2005-03-31
WO1998057909A1 (en) 1998-12-23
US6365125B1 (en) 2002-04-02
ATE284852T1 (de) 2005-01-15
CA2293317A1 (en) 1998-12-23
EP0988263B1 (de) 2004-12-15
DE69828166T2 (de) 2005-12-22
FI972550A0 (fi) 1997-06-16
FI972550A (fi) 1998-12-17
EP0988263A1 (de) 2000-03-29
ES2232947T3 (es) 2005-06-01
AU7770098A (en) 1999-01-04
FI104048B (fi) 1999-11-15

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee