DE69941298D1 - Radiomarkierte neurokinin-1 rezeptor antagonisten - Google Patents

Radiomarkierte neurokinin-1 rezeptor antagonisten

Info

Publication number
DE69941298D1
DE69941298D1 DE69941298T DE69941298T DE69941298D1 DE 69941298 D1 DE69941298 D1 DE 69941298D1 DE 69941298 T DE69941298 T DE 69941298T DE 69941298 T DE69941298 T DE 69941298T DE 69941298 D1 DE69941298 D1 DE 69941298D1
Authority
DE
Germany
Prior art keywords
radiolabeled
receptor antagonists
neukoquin
neurokinin
mammals
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69941298T
Other languages
English (en)
Inventor
H Donald Burns
Raymond E Gibson
Terence G Hamill
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE69941298D1 publication Critical patent/DE69941298D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/804—Radioisotope, e.g. radioimmunoassay

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DE69941298T 1998-09-29 1999-09-24 Radiomarkierte neurokinin-1 rezeptor antagonisten Expired - Lifetime DE69941298D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10233498P 1998-09-29 1998-09-29
PCT/US1999/022163 WO2000018403A1 (en) 1998-09-29 1999-09-24 Radiolabeled neurokinin-1 receptor antagonists

Publications (1)

Publication Number Publication Date
DE69941298D1 true DE69941298D1 (de) 2009-10-01

Family

ID=22289321

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69941298T Expired - Lifetime DE69941298D1 (de) 1998-09-29 1999-09-24 Radiomarkierte neurokinin-1 rezeptor antagonisten

Country Status (8)

Country Link
US (1) US6241964B1 (de)
EP (1) EP1119356B1 (de)
JP (1) JP2002525325A (de)
AT (1) ATE439838T1 (de)
AU (1) AU1309100A (de)
CA (1) CA2343106A1 (de)
DE (1) DE69941298D1 (de)
WO (1) WO2000018403A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7344702B2 (en) 2004-02-13 2008-03-18 Bristol-Myers Squibb Pharma Company Contrast agents for myocardial perfusion imaging
EP1457487A4 (de) * 2001-12-21 2005-06-22 Toray Finechemicals Co Ltd Verfahren zur herstellung optisch aktiver cis-piperidinderivate
CA2499825C (en) * 2002-09-24 2011-11-01 Merck & Co., Inc. Radiolabeled neurokinin-1 receptor antagonists
JP2006528648A (ja) * 2003-07-24 2006-12-21 ザ クイーンズ メディカル センター アルキル化剤の調製及び使用
US7579480B2 (en) 2003-08-01 2009-08-25 Toyo Kasei Kogyo Company Limited Alkoxy-(tetrazol-1-yl)benzaldehyde compound and process for producing the same
US7485283B2 (en) * 2004-04-28 2009-02-03 Lantheus Medical Imaging Contrast agents for myocardial perfusion imaging
KR100808547B1 (ko) 2005-06-22 2008-02-29 재단법인서울대학교산학협력재단 펩타이드 수용체 영상용 제제로 사용할 수 있는 ｆ－１８－플로로벤질리덴하이드라존－니코틴아마이드－펩타이드 유도체 및 펩타이드에 방사성불소를 효율적으로 표지하기 위한 방법
US7824659B2 (en) 2005-08-10 2010-11-02 Lantheus Medical Imaging, Inc. Methods of making radiolabeled tracers and precursors thereof
EP1942733B1 (de) * 2005-09-29 2012-03-21 Merck Sharp & Dohme Corp. Radioaktiv markierte glycintransporter-hemmer
US8506928B2 (en) * 2007-09-07 2013-08-13 The Regents Of The University Of California Methods and compounds for targeting tissues
EP2257315B1 (de) 2008-02-29 2019-10-23 Lantheus Medical Imaging, Inc. Kontrastmittel für anwendungen einschliesslich perfusionsbildgebung
CA2737699A1 (en) * 2008-09-16 2010-03-25 Merck Sharp & Dohme Corp. Phthalimide derivative metabotropic glutamate r4 ligands
US8592454B2 (en) 2008-09-19 2013-11-26 Takeda Pharmaceutical Company Limited Nitrogen-containing heterocyclic compound and use of same
US9687571B2 (en) 2009-04-15 2017-06-27 Lantheus Medical Imaging, Inc. Stabilization of radiopharmaceutical compositions using ascorbic acid
PT2534136T (pt) 2010-02-08 2017-12-15 Lantheus Medical Imaging Inc Métodos para sintetizar agentes de imagiologia, e seus intermediários
AU2013203000B9 (en) 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
EP2774930A1 (de) 2013-03-07 2014-09-10 Aptenia S.R.L. Metallocenverbindungen und markierte Moleküle damit für In-vivo-Bildgebung

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4437896A (en) * 1995-01-12 1996-07-31 Glaxo Group Limited Piperidine derivatives having tachykinin antagonist activity
GB9505692D0 (en) * 1995-03-21 1995-05-10 Glaxo Group Ltd Chemical compounds
JPH08325169A (ja) * 1995-03-29 1996-12-10 Nkk Corp フッ素放射性同位元素標識有機化合物の製造方法
US5719156A (en) * 1995-05-02 1998-02-17 Schering Corporation Piperazino derivatives as neurokinin antagonists
FI104048B1 (fi) 1997-06-16 1999-11-15 Map Medical Technologies Oy Prosessi tuottaa radiojodattuja reseptoriaineita in vivo käyttöön

Also Published As

Publication number Publication date
JP2002525325A (ja) 2002-08-13
CA2343106A1 (en) 2000-04-06
AU1309100A (en) 2000-04-17
WO2000018403A1 (en) 2000-04-06
US6241964B1 (en) 2001-06-05
ATE439838T1 (de) 2009-09-15
EP1119356A4 (de) 2008-01-09
EP1119356B1 (de) 2009-08-19
EP1119356A1 (de) 2001-08-01

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Legal Events

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