ATE284852T1 - Verfahren zur herstellung von mit radioaktivem iod markierten, neurorezeptor-wirksamen mitteln - Google Patents

Verfahren zur herstellung von mit radioaktivem iod markierten, neurorezeptor-wirksamen mitteln

Info

Publication number
ATE284852T1
ATE284852T1 AT98925677T AT98925677T ATE284852T1 AT E284852 T1 ATE284852 T1 AT E284852T1 AT 98925677 T AT98925677 T AT 98925677T AT 98925677 T AT98925677 T AT 98925677T AT E284852 T1 ATE284852 T1 AT E284852T1
Authority
AT
Austria
Prior art keywords
neuroreceptor
products
producing
active agents
chromatographic separation
Prior art date
Application number
AT98925677T
Other languages
English (en)
Inventor
Jukka Hiltunen
Tuomo Nikula
Original Assignee
Map Medical Technologies Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Map Medical Technologies Oy filed Critical Map Medical Technologies Oy
Application granted granted Critical
Publication of ATE284852T1 publication Critical patent/ATE284852T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Saccharide Compounds (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Inorganic Compounds Of Heavy Metals (AREA)
AT98925677T 1997-06-16 1998-06-15 Verfahren zur herstellung von mit radioaktivem iod markierten, neurorezeptor-wirksamen mitteln ATE284852T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI972550A FI104048B (fi) 1997-06-16 1997-06-16 Prosessi tuottaa radiojodattuja reseptoriaineita in vivo käyttöön
PCT/FI1998/000514 WO1998057909A1 (en) 1997-06-16 1998-06-15 Process for the production of radioiodinated neuroreceptor agents

Publications (1)

Publication Number Publication Date
ATE284852T1 true ATE284852T1 (de) 2005-01-15

Family

ID=8549059

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98925677T ATE284852T1 (de) 1997-06-16 1998-06-15 Verfahren zur herstellung von mit radioaktivem iod markierten, neurorezeptor-wirksamen mitteln

Country Status (10)

Country Link
US (1) US6365125B1 (de)
EP (1) EP0988263B1 (de)
AT (1) ATE284852T1 (de)
AU (1) AU7770098A (de)
CA (1) CA2293317A1 (de)
DE (1) DE69828166T2 (de)
ES (1) ES2232947T3 (de)
FI (1) FI104048B (de)
PT (1) PT988263E (de)
WO (1) WO1998057909A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002525325A (ja) 1998-09-29 2002-08-13 メルク エンド カムパニー インコーポレーテッド 放射標識化ニューロキニン−１受容体拮抗薬
US8435492B2 (en) * 2003-05-02 2013-05-07 University Of Western Ontario Prosthetic groups attached to stannyl polymer in the synthesis of radiopharmaceuticals
ITMC20070196A1 (it) * 2007-10-10 2008-01-09 A C O M Advanced Ct Oncology M Sintesi chimica di i-124betacit iodine-124[2beta-carbomethoxy-3beta-(4-iodophenyl)-tropane] per indagini pet e per la radioterapia.
DE102009016493A1 (de) * 2009-04-06 2010-10-14 ITM Isotopen Technologien München AG Verfahren zur Reinigung kleiner Mengen chemischer Substanzen
US20120264949A1 (en) * 2011-04-13 2012-10-18 Atomic Energy Council-Institute Of Nuclear Energy Research Method of Labeling Dopamine D2 Receptor Using Radiosynthesized Ligand of Iodine-123-Epidepride
US20140079634A1 (en) * 2012-09-18 2014-03-20 Navidea Biopharmaceuticals Inc. Labeled pe2i formulation and method
AU2014326601B2 (en) * 2013-09-25 2018-01-18 SpecGx LLC Preparation of radioiodinated 3-fluoropropyl-nor-beta-CIT
CN110582494A (zh) * 2017-03-17 2019-12-17 日本医事物理股份有限公司 碘氟潘的制造方法
WO2021148598A1 (en) 2020-01-24 2021-07-29 Rotop Radiopharmacy Gmbh Method for the preparation of n-monofluoroalkyl tropanes and their use

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5310912A (en) * 1992-02-25 1994-05-10 Research Biochemicals Limited Partnership Iodinated neuroprobe for mapping monoamine reuptake sites
US5911970A (en) 1993-05-06 1999-06-15 Research Corporation Technologies, Inc. Methods for cancer imaging and therapy using benzamine compounds
US5569447A (en) 1994-04-19 1996-10-29 The United States Of America Represented By The Secretary Department Of Health And Human Services Stannylated 3-quinuclidinyl benzilates and methods of preparing radiohalogenated derivatives
US5723103A (en) 1994-12-09 1998-03-03 Vanderbilt University Substituted benzamides and radioligand analogs and methods of use
BE1009833A3 (fr) 1995-12-12 1997-10-07 Quivy Jacques Irenee Charles Nouveau marqueur, son procede d'obtention et son utilisation.
CA2270242A1 (en) 1996-10-29 1998-05-07 Guilford Pharmaceuticals Inc. Process for the preparation of radiopharmaceuticals
US5976497A (en) * 1997-08-04 1999-11-02 Resolution Pharmaceuticals, Inc. Dopamine D4 receptor ligands

Also Published As

Publication number Publication date
FI972550A (fi) 1998-12-17
FI104048B1 (fi) 1999-11-15
ES2232947T3 (es) 2005-06-01
AU7770098A (en) 1999-01-04
CA2293317A1 (en) 1998-12-23
US6365125B1 (en) 2002-04-02
PT988263E (pt) 2005-03-31
DE69828166D1 (de) 2005-01-20
FI972550A0 (fi) 1997-06-16
EP0988263A1 (de) 2000-03-29
FI104048B (fi) 1999-11-15
DE69828166T2 (de) 2005-12-22
EP0988263B1 (de) 2004-12-15
WO1998057909A1 (en) 1998-12-23

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