ATE141256T1 - Verfahren zur herstellung von 4- bromomethylbiphenyl-verbindungen - Google Patents
Verfahren zur herstellung von 4- bromomethylbiphenyl-verbindungenInfo
- Publication number
- ATE141256T1 ATE141256T1 AT93101455T AT93101455T ATE141256T1 AT E141256 T1 ATE141256 T1 AT E141256T1 AT 93101455 T AT93101455 T AT 93101455T AT 93101455 T AT93101455 T AT 93101455T AT E141256 T1 ATE141256 T1 AT E141256T1
- Authority
- AT
- Austria
- Prior art keywords
- producing
- compound
- bromomethylbiphenyl
- compounds
- brominating
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- HZQLUIZFUXNFHK-UHFFFAOYSA-N 1-(bromomethyl)-4-phenylbenzene Chemical class C1=CC(CBr)=CC=C1C1=CC=CC=C1 HZQLUIZFUXNFHK-UHFFFAOYSA-N 0.000 title 1
- PCLIMKBDDGJMGD-UHFFFAOYSA-N N-bromosuccinimide Chemical compound BrN1C(=O)CCC1=O PCLIMKBDDGJMGD-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- -1 cyano, carboxy Chemical group 0.000 abstract 2
- MARXMDRWROUXMD-UHFFFAOYSA-N 2-bromoisoindole-1,3-dione Chemical compound C1=CC=C2C(=O)N(Br)C(=O)C2=C1 MARXMDRWROUXMD-UHFFFAOYSA-N 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000008282 halocarbons Chemical class 0.000 abstract 1
- VBTQNRFWXBXZQR-UHFFFAOYSA-N n-bromoacetamide Chemical compound CC(=O)NBr VBTQNRFWXBXZQR-UHFFFAOYSA-N 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 125000003831 tetrazolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B39/00—Halogenation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4607892 | 1992-01-31 | ||
| JP32483192 | 1992-11-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE141256T1 true ATE141256T1 (de) | 1996-08-15 |
Family
ID=26386198
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT93101455T ATE141256T1 (de) | 1992-01-31 | 1993-01-29 | Verfahren zur herstellung von 4- bromomethylbiphenyl-verbindungen |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5312958A (de) |
| EP (1) | EP0553879B1 (de) |
| AT (1) | ATE141256T1 (de) |
| CA (1) | CA2088431C (de) |
| DE (1) | DE69303935T2 (de) |
| ES (1) | ES2093288T3 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2928982B2 (ja) * | 1994-10-27 | 1999-08-03 | 住化ファインケム株式会社 | ４’−ブロモメチル−２−シアノビフェニルの製造法 |
| DE19712339C1 (de) * | 1997-03-25 | 1998-04-09 | Clariant Gmbh | Verfahren zur Herstellung von in 2'-Stellung substituierten 4-Brommethyl-biphenyl-Verbindungen |
| IT1291551B1 (it) * | 1997-04-11 | 1999-01-11 | Luso Farmaco Inst | Processo per la preparazione di composti 4-bromometil bifenilici |
| US6177587B1 (en) * | 1997-05-26 | 2001-01-23 | Takeda Chemical Industries, Ltd. | Production method of aminobenzene compound |
| DE19732693C1 (de) * | 1997-07-30 | 1999-03-11 | Basf Ag | Verfahren zur Herstellung von substituierten Benzylbromiden |
| DE19757995A1 (de) * | 1997-12-29 | 1999-07-08 | Great Lakes Chem Konstanz Gmbh | Verfahren zur Herstellung von aromatischen Brommethyl-Verbindungen |
| DE19917025A1 (de) * | 1999-04-15 | 2000-10-19 | Boehringer Ingelheim Pharma | Verfahren zur Seitenkettenbromierung von in 2'-Stellung substituierten 4-Methylbiphenyl-derivaten |
| ATE416784T1 (de) | 2000-12-01 | 2008-12-15 | Takeda Pharmaceutical | Verfahren zur herstellung einer zubereitung mit einer bioaktiven substanz |
| CA2466659A1 (en) | 2001-11-13 | 2003-05-22 | Takeda Chemical Industries, Ltd. | Anticancer agents |
| US7501448B2 (en) * | 2004-10-15 | 2009-03-10 | Teva Pharmaceutical Industries, Ltd. | Process for preparing telmisartan |
| WO2008078340A1 (en) * | 2006-12-27 | 2008-07-03 | Calyx Chemicals And Pharmaceuticals Ltd. | Process for the separation of 4-bromomethyl-2'-substituted biphenyls from 4,4,-dibromomethyl-2'-substituted biphenyls |
| SMT202200255T1 (it) | 2012-09-28 | 2022-07-21 | Takeda Pharmaceuticals Co | Forma cristallina di 1-(4-1-(2,6-difluorobenzil)-5-dimetilamminometil-3-(6-metossipiridazin-3-il)-2,4-diosso-1,2,3,4-tetraidrotieno(2,3-d)-pirimidin-6il)fenil)-3-metossiurea |
| CN109776355A (zh) * | 2018-09-28 | 2019-05-21 | 浙江工业大学 | 一种沙坦类降压药重要中间体2-氰基-4’-溴甲基联苯的制备方法 |
| WO2021069711A1 (en) | 2019-10-10 | 2021-04-15 | Myovant Sciences Gmbh | Crystalline forms of n-(4-(1-(2,6-difluorobenzyl)-5- ((dimethylamino)methyl)-3-(6-methoxy-3-pyridazinyl)-2,4-dioxo- 1,2,3,4-tetrahydrothieno[2,3-d]pyrimidin-6-yl)phenyl)-n'- methoxyurea |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU190007B (en) * | 1982-05-06 | 1986-08-28 | Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu | Process for producing new aromatic prostacylin analogues |
| CA1334092C (en) * | 1986-07-11 | 1995-01-24 | David John Carini | Angiotensin ii receptor blocking imidazoles |
| US4820843A (en) * | 1987-05-22 | 1989-04-11 | E. I. Du Pont De Nemours And Company | Tetrazole intermediates to antihypertensive compounds |
| IL94390A (en) * | 1989-05-30 | 1996-03-31 | Merck & Co Inc | The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them |
| GB9005354D0 (en) * | 1990-03-09 | 1990-05-02 | Glaxo Group Ltd | Chemical compounds |
| GB9017480D0 (en) * | 1990-08-09 | 1990-09-26 | Ici Plc | Chemical process |
| EP0505098A1 (de) * | 1991-03-19 | 1992-09-23 | Merck & Co. Inc. | Imidazolderivate mit funktionelle Säuregruppen als Angiotensin-II-Antagoniste |
-
1993
- 1993-01-26 US US08/009,101 patent/US5312958A/en not_active Expired - Lifetime
- 1993-01-29 ES ES93101455T patent/ES2093288T3/es not_active Expired - Lifetime
- 1993-01-29 DE DE69303935T patent/DE69303935T2/de not_active Expired - Lifetime
- 1993-01-29 CA CA002088431A patent/CA2088431C/en not_active Expired - Lifetime
- 1993-01-29 EP EP93101455A patent/EP0553879B1/de not_active Expired - Lifetime
- 1993-01-29 AT AT93101455T patent/ATE141256T1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69303935T2 (de) | 1996-12-19 |
| EP0553879A3 (en) | 1993-11-03 |
| US5312958A (en) | 1994-05-17 |
| CA2088431C (en) | 2003-12-16 |
| ES2093288T3 (es) | 1996-12-16 |
| EP0553879B1 (de) | 1996-08-14 |
| CA2088431A1 (en) | 1993-08-01 |
| DE69303935D1 (de) | 1996-09-19 |
| EP0553879A2 (de) | 1993-08-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |