DE69303935D1 - Verfahren zur Herstellung von 4-Bromomethylbiphenyl-Verbindungen - Google Patents

Verfahren zur Herstellung von 4-Bromomethylbiphenyl-Verbindungen

Info

Publication number
DE69303935D1
DE69303935D1 DE69303935T DE69303935T DE69303935D1 DE 69303935 D1 DE69303935 D1 DE 69303935D1 DE 69303935 T DE69303935 T DE 69303935T DE 69303935 T DE69303935 T DE 69303935T DE 69303935 D1 DE69303935 D1 DE 69303935D1
Authority
DE
Germany
Prior art keywords
preparation
compound
bromomethylbiphenyl
compounds
brominating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69303935T
Other languages
English (en)
Other versions
DE69303935T2 (de
Inventor
Syuji Suenaga
Hitoshi - Kawaguchi
Takeshi Kato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of DE69303935D1 publication Critical patent/DE69303935D1/de
Application granted granted Critical
Publication of DE69303935T2 publication Critical patent/DE69303935T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B39/00—Halogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69303935T 1992-01-31 1993-01-29 Verfahren zur Herstellung von 4-Bromomethylbiphenyl-Verbindungen Expired - Lifetime DE69303935T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP4607892 1992-01-31
JP32483192 1992-11-09

Publications (2)

Publication Number Publication Date
DE69303935D1 true DE69303935D1 (de) 1996-09-19
DE69303935T2 DE69303935T2 (de) 1996-12-19

Family

ID=26386198

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69303935T Expired - Lifetime DE69303935T2 (de) 1992-01-31 1993-01-29 Verfahren zur Herstellung von 4-Bromomethylbiphenyl-Verbindungen

Country Status (6)

Country Link
US (1) US5312958A (de)
EP (1) EP0553879B1 (de)
AT (1) ATE141256T1 (de)
CA (1) CA2088431C (de)
DE (1) DE69303935T2 (de)
ES (1) ES2093288T3 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2928982B2 (ja) * 1994-10-27 1999-08-03 住化ファインケム株式会社 ４’−ブロモメチル−２−シアノビフェニルの製造法
DE19712339C1 (de) * 1997-03-25 1998-04-09 Clariant Gmbh Verfahren zur Herstellung von in 2'-Stellung substituierten 4-Brommethyl-biphenyl-Verbindungen
IT1291551B1 (it) * 1997-04-11 1999-01-11 Luso Farmaco Inst Processo per la preparazione di composti 4-bromometil bifenilici
US6177587B1 (en) 1997-05-26 2001-01-23 Takeda Chemical Industries, Ltd. Production method of aminobenzene compound
DE19732693C1 (de) * 1997-07-30 1999-03-11 Basf Ag Verfahren zur Herstellung von substituierten Benzylbromiden
DE19757995A1 (de) * 1997-12-29 1999-07-08 Great Lakes Chem Konstanz Gmbh Verfahren zur Herstellung von aromatischen Brommethyl-Verbindungen
DE19917025A1 (de) * 1999-04-15 2000-10-19 Boehringer Ingelheim Pharma Verfahren zur Seitenkettenbromierung von in 2'-Stellung substituierten 4-Methylbiphenyl-derivaten
CA2430934C (en) 2000-12-01 2011-06-21 Takeda Chemical Industries, Ltd. A method of producing sustained-release preparations of a bioactive substance using high-pressure gas
US7812044B2 (en) 2001-11-13 2010-10-12 Takeda Pharmaceutical Company Limited Anticancer agents
JP2008503595A (ja) * 2004-10-15 2008-02-07 テバ ファーマシューティカル インダストリーズ リミティド テルミサルタンの調製方法
WO2008078340A1 (en) * 2006-12-27 2008-07-03 Calyx Chemicals And Pharmaceuticals Ltd. Process for the separation of 4-bromomethyl-2'-substituted biphenyls from 4,4,-dibromomethyl-2'-substituted biphenyls
TWI602819B (zh) 2012-09-28 2017-10-21 武田藥品工業股份有限公司 噻吩并嘧啶衍生物之製造方法
CN109776355A (zh) * 2018-09-28 2019-05-21 浙江工业大学 一种沙坦类降压药重要中间体2-氰基-4’-溴甲基联苯的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU190007B (en) * 1982-05-06 1986-08-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu Process for producing new aromatic prostacylin analogues
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
US4820843A (en) * 1987-05-22 1989-04-11 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
IL94390A (en) * 1989-05-30 1996-03-31 Merck & Co Inc The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them
GB9005354D0 (en) * 1990-03-09 1990-05-02 Glaxo Group Ltd Chemical compounds
GB9017480D0 (en) * 1990-08-09 1990-09-26 Ici Plc Chemical process
EP0505098A1 (de) * 1991-03-19 1992-09-23 Merck & Co. Inc. Imidazolderivate mit funktionelle Säuregruppen als Angiotensin-II-Antagoniste

Also Published As

Publication number Publication date
ES2093288T3 (es) 1996-12-16
US5312958A (en) 1994-05-17
EP0553879A3 (en) 1993-11-03
ATE141256T1 (de) 1996-08-15
EP0553879B1 (de) 1996-08-14
CA2088431A1 (en) 1993-08-01
CA2088431C (en) 2003-12-16
EP0553879A2 (de) 1993-08-04
DE69303935T2 (de) 1996-12-19

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Owner name: TAKEDA PHARMACEUTICAL CO. LTD., OSAKA, JP

R071 Expiry of right

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