DE69303935D1 - Process for the preparation of 4-bromomethylbiphenyl compounds - Google Patents

Process for the preparation of 4-bromomethylbiphenyl compounds

Info

Publication number
DE69303935D1
DE69303935D1 DE69303935T DE69303935T DE69303935D1 DE 69303935 D1 DE69303935 D1 DE 69303935D1 DE 69303935 T DE69303935 T DE 69303935T DE 69303935 T DE69303935 T DE 69303935T DE 69303935 D1 DE69303935 D1 DE 69303935D1
Authority
DE
Germany
Prior art keywords
preparation
compound
bromomethylbiphenyl
compounds
brominating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69303935T
Other languages
German (de)
Other versions
DE69303935T2 (en
Inventor
Syuji Suenaga
Hitoshi - Kawaguchi
Takeshi Kato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of DE69303935D1 publication Critical patent/DE69303935D1/en
Publication of DE69303935T2 publication Critical patent/DE69303935T2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B39/00—Halogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

A process for the production of a compound of general formula <CHEM> , wherein R represents cyano, carboxy which may be esterified or amidated or tetrazolyl which may be substituted, comprising brominating the corresponding methyl compound with a brominating agent such as N-bromoacetamide, N-bromophtalimide, N-bromosuccinimide and so on in a halogenated hydrocarbon solvent in the presence of an azobis compound.
DE69303935T 1992-01-31 1993-01-29 Process for the preparation of 4-bromomethylbiphenyl compounds Expired - Lifetime DE69303935T2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP4607892 1992-01-31
JP32483192 1992-11-09

Publications (2)

Publication Number Publication Date
DE69303935D1 true DE69303935D1 (en) 1996-09-19
DE69303935T2 DE69303935T2 (en) 1996-12-19

Family

ID=26386198

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69303935T Expired - Lifetime DE69303935T2 (en) 1992-01-31 1993-01-29 Process for the preparation of 4-bromomethylbiphenyl compounds

Country Status (6)

Country Link
US (1) US5312958A (en)
EP (1) EP0553879B1 (en)
AT (1) ATE141256T1 (en)
CA (1) CA2088431C (en)
DE (1) DE69303935T2 (en)
ES (1) ES2093288T3 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2928982B2 (en) * 1994-10-27 1999-08-03 住化ファインケム株式会社 Method for producing 4'-bromomethyl-2-cyanobiphenyl
DE19712339C1 (en) * 1997-03-25 1998-04-09 Clariant Gmbh Preparation of 2'-substituted 4-bromo-methyl-bi:phenyl compounds
IT1291551B1 (en) * 1997-04-11 1999-01-11 Luso Farmaco Inst PROCESS FOR THE PREPARATION OF 4-BROMOMETHL BIPHENYL COMPOUNDS
US6177587B1 (en) * 1997-05-26 2001-01-23 Takeda Chemical Industries, Ltd. Production method of aminobenzene compound
DE19732693C1 (en) * 1997-07-30 1999-03-11 Basf Ag Process for the preparation of substituted benzyl bromides
DE19757995A1 (en) * 1997-12-29 1999-07-08 Great Lakes Chem Konstanz Gmbh Process for the preparation of aromatic bromomethyl compounds
DE19917025A1 (en) * 1999-04-15 2000-10-19 Boehringer Ingelheim Pharma Rapid preparation of 4-bromomethyl-biphenyl derivatives from 4-methyl compounds, using N-bromo-imide or -amide in carboxylic acid ester solvent, used as pharmaceutical intermediates
CA2430934C (en) 2000-12-01 2011-06-21 Takeda Chemical Industries, Ltd. A method of producing sustained-release preparations of a bioactive substance using high-pressure gas
US7812044B2 (en) 2001-11-13 2010-10-12 Takeda Pharmaceutical Company Limited Anticancer agents
EP1699765A1 (en) * 2004-10-15 2006-09-13 Teva Pharmaceutical Industries Ltd Process for preparing telmisartan
WO2008078340A1 (en) * 2006-12-27 2008-07-03 Calyx Chemicals And Pharmaceuticals Ltd. Process for the separation of 4-bromomethyl-2'-substituted biphenyls from 4,4,-dibromomethyl-2'-substituted biphenyls
EP4119564A1 (en) 2012-09-28 2023-01-18 Takeda Pharmaceutical Company Limited Production method of thienopyrimidine derivative
CN109776355A (en) * 2018-09-28 2019-05-21 浙江工业大学 The preparation method of smooth hypotensor important intermediate 2- cyano-the 4 '-bromomethylbiphenyl of one seed sand

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU190007B (en) * 1982-05-06 1986-08-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu Process for producing new aromatic prostacylin analogues
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
US4820843A (en) * 1987-05-22 1989-04-11 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
IL94390A (en) * 1989-05-30 1996-03-31 Merck & Co Inc Di-substituted imidazo fused 6-membered nitrogen-containing heterocycles and pharmaceutical compositions containing them
GB9005354D0 (en) * 1990-03-09 1990-05-02 Glaxo Group Ltd Chemical compounds
GB9017480D0 (en) * 1990-08-09 1990-09-26 Ici Plc Chemical process
EP0505098A1 (en) * 1991-03-19 1992-09-23 Merck & Co. Inc. Imidazole derivatives bearing acidic functional groups as angiotensin II antagonists

Also Published As

Publication number Publication date
ES2093288T3 (en) 1996-12-16
CA2088431C (en) 2003-12-16
ATE141256T1 (en) 1996-08-15
EP0553879B1 (en) 1996-08-14
DE69303935T2 (en) 1996-12-19
CA2088431A1 (en) 1993-08-01
US5312958A (en) 1994-05-17
EP0553879A2 (en) 1993-08-04
EP0553879A3 (en) 1993-11-03

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Legal Events

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Owner name: TAKEDA PHARMACEUTICAL CO. LTD., OSAKA, JP

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