ES2093288T3 - Procedimiento para producir compuestos de 4-bromometil-bifenilo. - Google Patents

Procedimiento para producir compuestos de 4-bromometil-bifenilo.

Info

Publication number
ES2093288T3
ES2093288T3 ES93101455T ES93101455T ES2093288T3 ES 2093288 T3 ES2093288 T3 ES 2093288T3 ES 93101455 T ES93101455 T ES 93101455T ES 93101455 T ES93101455 T ES 93101455T ES 2093288 T3 ES2093288 T3 ES 2093288T3
Authority
ES
Spain
Prior art keywords
bromomethyl
procedure
producing
biphenyl compounds
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93101455T
Other languages
English (en)
Inventor
Syuji Suenaga
Hitoshi - Oaza-Koinu Kawaguchi
Takeshi Kato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ES2093288T3 publication Critical patent/ES2093288T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B39/00—Halogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE DESCRIBE UN PROCESO PARA LA PRODUCCION DE UN COMPUESTO DE LA FORMULA GENERAL DONDE R REPRESENTA CIANO, CARBOXI QUE PUEDE SER ESTERIFICADO O AMIDATADO O TETRAZOLIL QUE PUEDE SER SUSTITUIDO, COMPRENDIENDO LA BROMINACION DEL COMPUESTO METIL CORRESPONDIENTE CON UN AGENTE DE BROMINACION TAL COMO N ETAMIDA, N UN COMPUESTO DE AZOBE.
ES93101455T 1992-01-31 1993-01-29 Procedimiento para producir compuestos de 4-bromometil-bifenilo. Expired - Lifetime ES2093288T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP4607892 1992-01-31
JP32483192 1992-11-09

Publications (1)

Publication Number Publication Date
ES2093288T3 true ES2093288T3 (es) 1996-12-16

Family

ID=26386198

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93101455T Expired - Lifetime ES2093288T3 (es) 1992-01-31 1993-01-29 Procedimiento para producir compuestos de 4-bromometil-bifenilo.

Country Status (6)

Country Link
US (1) US5312958A (es)
EP (1) EP0553879B1 (es)
AT (1) ATE141256T1 (es)
CA (1) CA2088431C (es)
DE (1) DE69303935T2 (es)
ES (1) ES2093288T3 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2928982B2 (ja) * 1994-10-27 1999-08-03 住化ファインケム株式会社 ４’−ブロモメチル−２−シアノビフェニルの製造法
DE19712339C1 (de) * 1997-03-25 1998-04-09 Clariant Gmbh Verfahren zur Herstellung von in 2'-Stellung substituierten 4-Brommethyl-biphenyl-Verbindungen
IT1291551B1 (it) * 1997-04-11 1999-01-11 Luso Farmaco Inst Processo per la preparazione di composti 4-bromometil bifenilici
US6177587B1 (en) 1997-05-26 2001-01-23 Takeda Chemical Industries, Ltd. Production method of aminobenzene compound
DE19732693C1 (de) * 1997-07-30 1999-03-11 Basf Ag Verfahren zur Herstellung von substituierten Benzylbromiden
DE19757995A1 (de) * 1997-12-29 1999-07-08 Great Lakes Chem Konstanz Gmbh Verfahren zur Herstellung von aromatischen Brommethyl-Verbindungen
DE19917025A1 (de) * 1999-04-15 2000-10-19 Boehringer Ingelheim Pharma Verfahren zur Seitenkettenbromierung von in 2'-Stellung substituierten 4-Methylbiphenyl-derivaten
AU2002224124A1 (en) 2000-12-01 2002-06-11 Takeda Chemical Industries Ltd. Method for producing preparation containing bioactive substance
WO2003041739A1 (en) 2001-11-13 2003-05-22 Takeda Chemical Industries, Ltd. Anticaner agents
CA2581723A1 (en) * 2004-10-15 2006-04-27 Teva Pharmaceutical Industries Ltd. Process for preparing telmisartan
WO2008078340A1 (en) * 2006-12-27 2008-07-03 Calyx Chemicals And Pharmaceuticals Ltd. Process for the separation of 4-bromomethyl-2'-substituted biphenyls from 4,4,-dibromomethyl-2'-substituted biphenyls
AR092707A1 (es) 2012-09-28 2015-04-29 Takeda Pharmaceuticals Co Metodo de produccion de derivado de tienopirimidina
CN109776355A (zh) * 2018-09-28 2019-05-21 浙江工业大学 一种沙坦类降压药重要中间体2-氰基-4’-溴甲基联苯的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU190007B (en) * 1982-05-06 1986-08-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu Process for producing new aromatic prostacylin analogues
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
US4820843A (en) * 1987-05-22 1989-04-11 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
IL94390A (en) * 1989-05-30 1996-03-31 Merck & Co Inc The 6-membered trans-nitrogen-containing heterocycles are compressed with imidazo and pharmaceutical preparations containing them
GB9005354D0 (en) * 1990-03-09 1990-05-02 Glaxo Group Ltd Chemical compounds
GB9017480D0 (en) * 1990-08-09 1990-09-26 Ici Plc Chemical process
EP0505098A1 (en) * 1991-03-19 1992-09-23 Merck & Co. Inc. Imidazole derivatives bearing acidic functional groups as angiotensin II antagonists

Also Published As

Publication number Publication date
CA2088431C (en) 2003-12-16
CA2088431A1 (en) 1993-08-01
EP0553879A3 (en) 1993-11-03
US5312958A (en) 1994-05-17
EP0553879B1 (en) 1996-08-14
DE69303935T2 (de) 1996-12-19
DE69303935D1 (de) 1996-09-19
EP0553879A2 (en) 1993-08-04
ATE141256T1 (de) 1996-08-15

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