DE69507253D1 - Verfahren zur Herstellung von 4'-Bromomethyl-2-cyanobiphenyl - Google Patents

Verfahren zur Herstellung von 4'-Bromomethyl-2-cyanobiphenyl

Info

Publication number
DE69507253D1
DE69507253D1 DE69507253T DE69507253T DE69507253D1 DE 69507253 D1 DE69507253 D1 DE 69507253D1 DE 69507253 T DE69507253 T DE 69507253T DE 69507253 T DE69507253 T DE 69507253T DE 69507253 D1 DE69507253 D1 DE 69507253D1
Authority
DE
Germany
Prior art keywords
cyanobiphenyl
bromomethyl
preparation
solvent
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69507253T
Other languages
English (en)
Other versions
DE69507253T2 (de
Inventor
Tadashi Katsura
Hiroshi Shiratani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumika Fine Chemicals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumika Fine Chemicals Co Ltd filed Critical Sumika Fine Chemicals Co Ltd
Application granted granted Critical
Publication of DE69507253D1 publication Critical patent/DE69507253D1/de
Publication of DE69507253T2 publication Critical patent/DE69507253T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69507253T 1994-10-27 1995-10-24 Verfahren zur Herstellung von 4'-Bromomethyl-2-cyanobiphenyl Expired - Lifetime DE69507253T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6289079A JP2928982B2 (ja) 1994-10-27 1994-10-27 ４’−ブロモメチル−２−シアノビフェニルの製造法

Publications (2)

Publication Number Publication Date
DE69507253D1 true DE69507253D1 (de) 1999-02-25
DE69507253T2 DE69507253T2 (de) 1999-05-27

Family

ID=17738558

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69507253T Expired - Lifetime DE69507253T2 (de) 1994-10-27 1995-10-24 Verfahren zur Herstellung von 4'-Bromomethyl-2-cyanobiphenyl

Country Status (7)

Country Link
US (1) US5621134A (de)
EP (1) EP0709369B1 (de)
JP (1) JP2928982B2 (de)
AT (1) ATE175663T1 (de)
DE (1) DE69507253T2 (de)
DK (1) DK0709369T3 (de)
ES (1) ES2127479T3 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5892094A (en) * 1997-01-08 1999-04-06 Sumika Fine Chemicals Co., Ltd. Process for preparing 4'-methyl-2-cyanobiphenyl
DE19712339C1 (de) * 1997-03-25 1998-04-09 Clariant Gmbh Verfahren zur Herstellung von in 2'-Stellung substituierten 4-Brommethyl-biphenyl-Verbindungen
FR2771090B1 (fr) * 1997-11-17 2000-02-04 Sanofi Sa Procede de preparation de derives de bromomethyl-biphenyle
DE19757995A1 (de) * 1997-12-29 1999-07-08 Great Lakes Chem Konstanz Gmbh Verfahren zur Herstellung von aromatischen Brommethyl-Verbindungen
ATE388136T1 (de) * 2002-06-12 2008-03-15 Sumitomo Chemical Co Verfahren zur herstellung von 4'-brommethyl-2- cyanobiphenyl
EP1784398A1 (de) * 2004-09-02 2007-05-16 Teva Pharmaceutical Industries Ltd Aufreinigung von olmesartan-medoxomil
US20070054948A1 (en) * 2004-09-02 2007-03-08 Lilach Hedvati Purification of olmesartan medoxomil
JP4511550B2 (ja) * 2004-09-02 2010-07-28 テバ ファーマシューティカル インダストリーズ リミティド オルメサルタンメドキソミルの調製法
CN101094849A (zh) * 2004-12-30 2007-12-26 特瓦制药工业有限公司 在ph高于2.5的情况下制备奥美沙坦酯的方法
US7563814B2 (en) * 2005-01-03 2009-07-21 Teva Pharmaceutical Industries Ltd. Olmesartan medoxomil with reduced levels of impurities
US20060258727A1 (en) * 2005-01-03 2006-11-16 Lilach Hedvati Olmesartan medoxomil with reduced levels of impurities
EP1705168A1 (de) * 2005-03-21 2006-09-27 Helm AG Verbessertes Verfahren zur Bromierung der Seitenkette von Alkylbenzolen
WO2008078340A1 (en) * 2006-12-27 2008-07-03 Calyx Chemicals And Pharmaceuticals Ltd. Process for the separation of 4-bromomethyl-2'-substituted biphenyls from 4,4,-dibromomethyl-2'-substituted biphenyls
CN102557987A (zh) * 2010-12-09 2012-07-11 宜昌长江药业有限公司 一种沙坦类抗高血压药物侧链的制备方法
CN103626677B (zh) * 2013-12-05 2015-07-15 天津大学 制备高纯度溴代沙坦联苯的结晶方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4087473A (en) * 1976-11-03 1978-05-02 The Dow Chemical Company Preferential aliphatic halogenation of ar-substituted alkylbenzenes
DE3044564A1 (de) * 1980-11-26 1982-07-15 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung von (alpha)-bromacetophenonoximethern
ZA875052B (en) 1986-07-11 1989-03-29 Du Pont Angiotensin ii receptor blocking imidazoles
GB9017480D0 (en) 1990-08-09 1990-09-26 Ici Plc Chemical process
GB9017482D0 (en) 1990-08-09 1990-09-26 Ici Plc Manufacturing process
JP2859791B2 (ja) 1992-01-31 1999-02-24 吉富製薬株式会社 ４−ブロモメチルビフェニル化合物の製造法
US5312958A (en) * 1992-01-31 1994-05-17 Takeda Chemical Industries, Ltd. Process for producing 4-bromomethylbiphenyl compounds
FR2689887B1 (fr) 1992-04-13 1995-06-23 Sanofi Elf Procede de preparation d'un derive de biphenyle.

Also Published As

Publication number Publication date
JP2928982B2 (ja) 1999-08-03
ATE175663T1 (de) 1999-01-15
ES2127479T3 (es) 1999-04-16
DE69507253T2 (de) 1999-05-27
EP0709369A1 (de) 1996-05-01
DK0709369T3 (da) 1999-08-30
US5621134A (en) 1997-04-15
JPH08127562A (ja) 1996-05-21
EP0709369B1 (de) 1999-01-13

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: SUMITOMO CHEMICAL CO. LTD., TOKIO/TOKYO, JP