FI120183B - Joderad neurosond för kartläggning av monoaminåtertagningsställen - Google Patents

Joderad neurosond för kartläggning av monoaminåtertagningsställen Download PDF

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Publication number
FI120183B
FI120183B FI956261A FI956261A FI120183B FI 120183 B FI120183 B FI 120183B FI 956261 A FI956261 A FI 956261A FI 956261 A FI956261 A FI 956261A FI 120183 B FI120183 B FI 120183B
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group
neuroprobe
iodized
precursor
cnh2n
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FI956261A
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English (en)
Finnish (fi)
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FI956261A0 (sv
FI956261A (sv
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John L Neumeyer
Richard A Milius
Robert B Innis
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Ge Healthcare Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Valve-Gear Or Valve Arrangements (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Testing Or Measuring Of Semiconductors Or The Like (AREA)
  • Measuring Leads Or Probes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Window Of Vehicle (AREA)

Claims (20)

1. Jo.der.ad neuroprob f ör kartläggning mv irionoamin-äterupptagsstallen, kannetecknad av att den joderade 5 neuroproben har följande forme1: R n' C02R} H Y där R = en monofluoroalkylgrupp innefattande nF., där n = 18 eller 19;
10 R' = en CnHj^+x-grupp, där n = 0 - 6; X = en isotop av X; Y = H,
2. Joderad neuroprob enligt. patentkrav 1, kän-n e t e c k n a d av at t den är 2 -be ta-karbometoxi- 3 -beta- (4 - 15 jodofenyl) - 8·- (3-f luoroppöpyl) -nortropan. 3. : Joderad neuroprob enligt patentkrav 1 eller 2, k a n n e t e o k n a d av att X = U3T.
4. Joderad neuroprob enligt patentkrav 1 eller 2, kannet ecknad av att X = 12SI.
5. Joderad neuroprob enligt patentkrav 1 eller 2, k ä n n e t e c k n a d av att X - 131I.
6. Joderad neuroprob för kartläggning av monoamin-äterupptagsställen, kännet. ecknad av att den joderade neuroproben har följande forroel: R N H 25 där R.- en manpfluoroalkylgrupp irmefattan.de nF, där n = 18: eller 19; R' - en CnH2n+1_grupp, där n = 0 - 6; X = en isotop av I;
5 Y = H.
7 Joderad neuroprop enligt patentkrav 6, känne-tecknad a? att X - 123I.
8, Joderad neuropx'ob enligt patentkrav 6.,. kanne teckn ad av att X = U5i.
10 Joderad neuroprob enligt patentkrav 6, k an ne c e c k n a d av att X = 1311,
10. Prekursor av en radioirtäfkt neuroprob för kart-läggning av monoamin-äterupptagsställen, k ä n n e t e c k n a d av att prekursorn bar följande forrael: & V_CO.r’ 15 där R = monofluoroalkylgrupp; | R1 = CnH2n!i-grupp, där n = 0 - 6; j x = Sn (R"iR"2R"3) ; |
20 R”i = en CnH2no.-grupp, där n ~ 1 - 6, eller en arylgrupp; R"2 = en CnH2rj+]-grupp, där n = 1 - 6, eller en arylgrupp; | R'b = en GnH2n+i-grupp, där n = 1 - 6, eller en arylgrupp; | och Y = H. j
11. Prekursor av en radiomärkt neuroprob för kart- läggning av monoamin-ätertagsställen, kännetecknad av att prekursorn har följande formel: j * \ ·: R N K ΓΪ—'—co2rs H Y där R = rnonof luoroalkylgrupp; R' = en CnH2n+i-grupp , där n ·= 0 - 6;
5 X = Sn:(R"iR"2R"3>; R"i = en CnHsn+i-grupp, där n = 1 - 6, el'ler en arylgrupp; R"2= en CnHin+x-grupp, där n = 1 ~ 6, eller en arylgrupp; R"/3 = en CnHin+i-grupp* där n = 1 - 6, eller en arylgrupp; qch
10 Y = H. 12., Kit for framställning ay en joderad neui’oprob för kartläggning ay monoamin-äterupptagsställen, varvid kitet innefattär en prekursör enligt följande formel: R N*___COjtR1 15 där 1 R - en monofluoroalkylgrupp; | R' = en CnHgni-i-grupp, där n =, 0 - 6; | X = Sn(R''iR"2R“3) ; ] R”·! = en CnH2n+i-grupp, där n = 1 - 6, eller en arylgrupp; j
20 R"2 = en CnHzn+i-grupp, där n = 1 - 6, eller en arvlgrupp; Rn3 = en CnH2n+]-grupp, där n = 1 - 6, eller en arylgrupp; och | Y = H; OCh j ett: pxideringsmedel, 25 kannet e c 3c n at. ay att prekursorn och oxideringsmedlet | skall reagera x närvaro av en kalla ay radioaktivt jod. j \
13. Kit enligt patentkrav 12, kännetecknaE av att kalian av radioaktivt jod är en loaning av ett salt av eri radioaktiv jodisotop.
14. Kit för framställning av en joderad neuroprob 5 för kartläggxiing av rnonaamin-aterupptägsställen, varvi d kitet innefattar en prekursor enligt följaride formed; :R *1 H f~\ H y där R = en monofInoroalkylgrupp;
10 Rl — en CnH2n+i-grupp, där n - 0 - 6; X = Sn(R"iR"2R',:3) ; R"i = en CnH2n+i-grupp( där n = 1 - 6, eller en arylgrupp; R" 2 = en CnH2n.i~grupp, där n -- 1 - 6, eller en arylgrupp; R”3 = en CnH2mi“grupp, där n = 1 - 6, eller en arylgrupp; 15 och Y = H; och ett oxideringsmedel, kannet ecktät av att prekursorn och oxideringsinedlet skall reagera i närvaro av en kalla av radioaktivt jod.
15. Kit enligt patentkrav 14, kännetecknat av att kallan av radioaktivt jod är en lösning av ett sait av en radioaktiv jodisotop:. |
FI956261A 1992-02-25 1995-12-27 Joderad neurosond för kartläggning av monoaminåtertagningsställen FI120183B (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US07/841,617 US5310912A (en) 1992-02-25 1992-02-25 Iodinated neuroprobe for mapping monoamine reuptake sites
US84161792 1992-02-25
US9306170 1993-06-29
PCT/US1993/006170 WO1995001184A1 (en) 1992-02-25 1993-06-29 An iodinated neuroprobe for mapping monoamine reuptake sites

Publications (3)

Publication Number Publication Date
FI956261A0 FI956261A0 (sv) 1995-12-27
FI956261A FI956261A (sv) 1995-12-27
FI120183B true FI120183B (sv) 2009-07-31

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US (2) US5310912A (sv)
EP (1) EP0703791B1 (sv)
JP (1) JP3228422B2 (sv)
AT (1) ATE228858T1 (sv)
AU (1) AU674331B2 (sv)
DE (2) DE69332544T2 (sv)
DK (1) DK0703791T3 (sv)
ES (1) ES2189792T3 (sv)
FI (1) FI120183B (sv)
NL (1) NL300123I2 (sv)
PT (1) PT703791E (sv)
WO (1) WO1995001184A1 (sv)

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Publication number Publication date
DE69332544D1 (de) 2003-01-16
DE10399020I1 (de) 2003-09-18
PT703791E (pt) 2003-04-30
AU674331B2 (en) 1996-12-19
WO1995001184A1 (en) 1995-01-12
JP3228422B2 (ja) 2001-11-12
AU4655493A (en) 1995-01-24
US5439666A (en) 1995-08-08
ES2189792T3 (es) 2003-07-16
ATE228858T1 (de) 2002-12-15
JPH09503745A (ja) 1997-04-15
DK0703791T3 (da) 2003-03-24
EP0703791A4 (en) 1996-05-22
NL300123I1 (nl) 2003-06-02
FI956261A0 (sv) 1995-12-27
NL300123I2 (nl) 2003-08-01
DE69332544T2 (de) 2003-08-14
US5310912A (en) 1994-05-10
DE10399020I2 (de) 2005-05-04
EP0703791B1 (en) 2002-12-04
FI956261A (sv) 1995-12-27
EP0703791A1 (en) 1996-04-03

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