FI956261A - Joderad neurosond för kartläggning av monoaminåtertagningsställen - Google Patents

Joderad neurosond för kartläggning av monoaminåtertagningsställen Download PDF

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Publication number
FI956261A
FI956261A FI956261A FI956261A FI956261A FI 956261 A FI956261 A FI 956261A FI 956261 A FI956261 A FI 956261A FI 956261 A FI956261 A FI 956261A FI 956261 A FI956261 A FI 956261A
Authority
FI
Finland
Prior art keywords
group
isotope
cnh2n
neurotestor
iodized
Prior art date
Application number
FI956261A
Other languages
English (en)
Finnish (fi)
Other versions
FI956261A0 (sv
FI120183B (sv
Inventor
John L Neumeyer
Richard A Milius
Robert B Innis
Original Assignee
Res Biochemicals Limited Partn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Res Biochemicals Limited Partn filed Critical Res Biochemicals Limited Partn
Publication of FI956261A0 publication Critical patent/FI956261A0/sv
Publication of FI956261A publication Critical patent/FI956261A/sv
Application granted granted Critical
Publication of FI120183B publication Critical patent/FI120183B/sv

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
  • Valve-Gear Or Valve Arrangements (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Window Of Vehicle (AREA)
  • Testing Or Measuring Of Semiconductors Or The Like (AREA)
  • Measuring Leads Or Probes (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Management, Administration, Business Operations System, And Electronic Commerce (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
FI956261A 1992-02-25 1995-12-27 Joderad neurosond för kartläggning av monoaminåtertagningsställen FI120183B (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US07/841,617 US5310912A (en) 1992-02-25 1992-02-25 Iodinated neuroprobe for mapping monoamine reuptake sites
US84161792 1992-02-25
PCT/US1993/006170 WO1995001184A1 (en) 1992-02-25 1993-06-29 An iodinated neuroprobe for mapping monoamine reuptake sites
US9306170 1993-06-29

Publications (3)

Publication Number Publication Date
FI956261A0 FI956261A0 (sv) 1995-12-27
FI956261A true FI956261A (sv) 1995-12-27
FI120183B FI120183B (sv) 2009-07-31

Family

ID=25285315

Family Applications (1)

Application Number Title Priority Date Filing Date
FI956261A FI120183B (sv) 1992-02-25 1995-12-27 Joderad neurosond för kartläggning av monoaminåtertagningsställen

Country Status (12)

Country Link
US (2) US5310912A (sv)
EP (1) EP0703791B1 (sv)
JP (1) JP3228422B2 (sv)
AT (1) ATE228858T1 (sv)
AU (1) AU674331B2 (sv)
DE (2) DE10399020I2 (sv)
DK (1) DK0703791T3 (sv)
ES (1) ES2189792T3 (sv)
FI (1) FI120183B (sv)
NL (1) NL300123I2 (sv)
PT (1) PT703791E (sv)
WO (1) WO1995001184A1 (sv)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
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US5496953A (en) * 1990-08-09 1996-03-05 Research Triangle Institute Cocaine receptor binding ligands
US5128118A (en) * 1990-08-09 1992-07-07 Research Triangle Institute Cocaine receptor binding ligands
US5736123A (en) * 1990-08-09 1998-04-07 Research Triangle Institute Cocaine receptor binding ligands
US7189737B2 (en) * 1991-08-09 2007-03-13 Research Triangle Institute Cocaine receptor binding ligands
US5750089A (en) * 1996-01-11 1998-05-12 Neuro Imaging Technologies, Llc Halogenated neuroprobe for mapping monoamine reuptake sites
US5770180A (en) * 1992-08-24 1998-06-23 Organix, Inc. Bridge-substituted tropanes for methods of imaging and therapy
US5493026A (en) * 1993-10-25 1996-02-20 Organix, Inc. Substituted 2-carboxyalkyl-3-(fluorophenyl)-8-(3-halopropen-2-yl) nortropanes and their use as imaging for agents for neurodegenerative disorders
ES2385202T3 (es) 1995-06-06 2012-07-19 Ge Healthcare Limited Sondas neurológicas yodadas para el mapeo de sitios de recaptación de monoamina
US5864038A (en) * 1995-08-17 1999-01-26 Emory University Labeled cocaine analogs
US6171576B1 (en) * 1995-11-03 2001-01-09 Organix Inc. Dopamine transporter imaging agent
US5948933A (en) 1997-07-11 1999-09-07 Organix, Inc. Tropane analogs and methods for inhibition of monoamine transport
US7105678B2 (en) 1995-11-03 2006-09-12 Organix, Inc. Boat tropanes
FR2748475B1 (fr) * 1996-05-10 1999-04-16 Cis Bio Int Derives du tropane utilisables en particulier pour la detection in vivo des transporteurs de la dopamine
EP0946204A1 (en) * 1996-10-29 1999-10-06 Guilford Pharmaceuticals Inc. Process for the preparation of radiopharmaceuticals
FI104048B (sv) * 1997-06-16 1999-11-15 Map Medical Technologies Oy Process för framställnig av radiojoderade reseptorämnen för in vivo-bruk
US6358492B1 (en) * 1997-10-07 2002-03-19 Research Triangle Institute Dopamine transporter imaging ligand
US6013242A (en) * 1998-01-13 2000-01-11 Wake Forest University Tropane derivatives with selective binding to the serotonin reuptake transporters for treatment of mental illness and as intermediates in the formation of imaging diagnostic agents for depression
EP1212103B1 (en) * 1999-04-26 2004-11-03 Emory University 4-fluoroalkyl-3-halophenyl nortropanes
US6843979B2 (en) 1999-04-26 2005-01-18 Emory University 4-haloethenylphenyl tropane:serotonin transporter imaging agents
CA2721484A1 (en) 1999-05-12 2000-11-12 President And Fellows Of Harvard College Dopamine transporter imaging agents
US20030224047A1 (en) * 2001-02-15 2003-12-04 Franz G. Andrew Levothyroxine compositions and methods
WO2002064093A2 (en) * 2001-02-15 2002-08-22 King Pharmaceuticals, Inc. Stabilized pharmaceutical and thyroid hormone compositions and method of preparation
US20030032675A1 (en) * 2001-02-15 2003-02-13 Franz G. Andrew Manufacture of thyroid hormone tablets having consistent active moiety amounts
US6555581B1 (en) 2001-02-15 2003-04-29 Jones Pharma, Inc. Levothyroxine compositions and methods
EP1361875A2 (en) * 2001-02-16 2003-11-19 Aventis Pharmaceuticals Inc. Novel heterocyclic amide derivatives and their use as dopamine d3 receptor ligands
US20030198667A1 (en) * 2001-08-10 2003-10-23 Franz Andrew G. Methods of producing dispersible pharmaceutical compositions
US20030190349A1 (en) * 2001-08-10 2003-10-09 Franz G. Andrew Methods of stabilizing pharmaceutical compositions
US20030180353A1 (en) * 2001-08-10 2003-09-25 Franz G. Andrew Stabilized pharmaceutical compositions
US20030203967A1 (en) * 2001-08-14 2003-10-30 Franz G. Andrew Levothyroxine compositions having unique Tmax properties
US7101569B2 (en) 2001-08-14 2006-09-05 Franz G Andrew Methods of administering levothyroxine pharmaceutical compositions
US20030198672A1 (en) * 2001-08-14 2003-10-23 Franz G. Andrew Levothyroxine compositions having unique triidothyronine plasma AUC properties
US20030199586A1 (en) * 2001-08-14 2003-10-23 Franz G. Andrew Unique levothyroxine aqueous materials
US20030199587A1 (en) * 2001-08-14 2003-10-23 Franz G. Andrew Levothyroxine compositions having unique Cmax properties
US20030195253A1 (en) * 2001-08-14 2003-10-16 Franz G. Andrew Unadsorbed levothyroxine pharmaceutical compositions, methods of making and methods of administration
DE20120708U1 (de) 2001-10-09 2002-08-01 Blundell, Paul, Sommerville, Mass. Tropan-Analoga zur Inhibierung des Monoamin-Transports
US20030181524A1 (en) * 2001-10-29 2003-09-25 Franz G. Andrew Levothyroxine compositions having unique triiodothyronine Tmax properties
DE60333830D1 (de) * 2002-04-30 2010-09-30 Univ Emory Verbindungen zur abbildung von tumoren
JP2005154374A (ja) * 2003-11-27 2005-06-16 Hamamatsu Photonics Kk 放射性トロパンアルカロイド誘導体、トロパンアルカロイド誘導体、及びそれらの製造方法。
JP5349960B2 (ja) * 2005-06-23 2013-11-20 エモリー ユニバーシティー 腫瘍画像化のためのアミノ酸類似体の立体選択的合成
US7837982B2 (en) * 2005-06-23 2010-11-23 Emory University Imaging agents
WO2009055922A1 (en) 2007-10-31 2009-05-07 Alseres Pharmaceuticals, Inc. Labeled iodinated tropane formulation
US8246752B2 (en) 2008-01-25 2012-08-21 Clear Catheter Systems, Inc. Methods and devices to clear obstructions from medical tubes
WO2018168643A1 (ja) * 2017-03-17 2018-09-20 日本メジフィジックス株式会社 イオフルパンの製造方法
EP3880674A1 (en) 2020-01-24 2021-09-22 Rotop Radiopharmacy Gmbh Method for the preparation of n-monofluoroalkyl tropanes and their use

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Publication number Priority date Publication date Assignee Title
US3813404A (en) * 1972-11-15 1974-05-28 Sterling Drug Inc Tropane-2-carboxylates and derivatives
US4942231A (en) * 1984-05-24 1990-07-17 Mallinckrodt, Inc. Method of preparing a chlorinated, brominated, radio-brominated, iodinated and/or radioiodinated aromatic or heteroaromatic compound
US5098996A (en) * 1984-10-26 1992-03-24 The United States Of America As Represented By The Department Of Health And Human Services Process for introducing fluorine into biologically active materials
US5200169A (en) * 1987-04-16 1993-04-06 Neorx Corporation Vinyl substituted radiohalogen conjugates for protein labeling
US5186921A (en) * 1989-04-17 1993-02-16 Trustees Of The University Of Pennsylvania Dopamine receptor ligands and image agents
US5128118A (en) * 1990-08-09 1992-07-07 Research Triangle Institute Cocaine receptor binding ligands
US5104638A (en) * 1990-10-29 1992-04-14 Mallinckrodt Medical, Inc. Method of making a radiopharmaceutical complex from a kit

Also Published As

Publication number Publication date
EP0703791B1 (en) 2002-12-04
EP0703791A1 (en) 1996-04-03
ES2189792T3 (es) 2003-07-16
FI956261A0 (sv) 1995-12-27
US5310912A (en) 1994-05-10
DE69332544T2 (de) 2003-08-14
PT703791E (pt) 2003-04-30
JP3228422B2 (ja) 2001-11-12
AU674331B2 (en) 1996-12-19
JPH09503745A (ja) 1997-04-15
DE10399020I2 (de) 2005-05-04
NL300123I1 (nl) 2003-06-02
DK0703791T3 (da) 2003-03-24
FI120183B (sv) 2009-07-31
DE69332544D1 (de) 2003-01-16
NL300123I2 (nl) 2003-08-01
AU4655493A (en) 1995-01-24
DE10399020I1 (de) 2003-09-18
US5439666A (en) 1995-08-08
WO1995001184A1 (en) 1995-01-12
ATE228858T1 (de) 2002-12-15
EP0703791A4 (en) 1996-05-22

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