FI120081B - Mikrokapslar, förfarande för deras framställning, och deras användning - Google Patents
Mikrokapslar, förfarande för deras framställning, och deras användning Download PDFInfo
- Publication number
- FI120081B FI120081B FI962917A FI962917A FI120081B FI 120081 B FI120081 B FI 120081B FI 962917 A FI962917 A FI 962917A FI 962917 A FI962917 A FI 962917A FI 120081 B FI120081 B FI 120081B
- Authority
- FI
- Finland
- Prior art keywords
- microcapsules
- biodegradable
- water
- group
- microcapsules according
- Prior art date
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- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 claims abstract description 32
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Landscapes
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Claims (30)
1. Fas ta mikrokapsiarsoin har en medelstorlek av 1 μπι - 1000 |±m och som har en bionedbrytfoar membran, som 5 inkapslar en luft- ellei, gaskärna, känneteclnade därsv, att membranen omfattar minst 25 vikt-% av en eller flera, i vatten olösliga bionedbrytbara lipider, som är fasta vid rumstemperatur ooh som är valda ur gruppen mono-, di- och tri glycerider, fettsyror med minst 12 kolatomer 10 och estrar av dessa fettsyror, steroler,, vax och bland- hingar av dessa.
2. Mikrokapsiar enligt patentkrav 1, känne-tecknade tecknade därav, att glyceriden är mono-, di-eller trimyristin, -palmitin, -stearin, eller blandningar 15 av dessa ooh företrädesvis fcripalmitin eller tristearin.
3. Mikrokapsiar enligt patentkrav 1, kanne - tecknade därav, att fettsyrorna är valda ur gruppen jordnöts-, behen-, palmitin-, stearin-, sebacin-, myristun- , och erukasyra, och företrädesvis ur gruppen stearin-, 20 palmitin-, sebacin- och myristinsyra.
4. Mikrokapsiar enligt patentkrav 1, k anne- tecknade därav, att sterolen är vald ur gruppen koles-terol, fytosteroi, lanosterol, ergosterol, och estrar av steroler med fettsyror enligt patentkrav 3, och är fcre- 25 trädesvis kolesterol.
5. Mikrokapsiar enligt patentkrav 1, kanne- t e c k n a d e därav, att membranen är ätminstone delvis kristallin eller semikristallin.
6. Mikrokapsiar enligt patentkrav 1, k ä n n e - 30 tecknade därav, att membranen omfattar ytterligare högst 75 vikt-% toionedbrytbara polymerer.
7. Mikrokapsiar enligt patentkrav 6, kännetecknade därav, att membranen omfattar högst 50 vikt-%, företrädesvis högst 20 vikt-% och mera fördelaktigt högst 10 vikt-% 35 bionedbrytbara polymerer. 29
8. Mikrokapslar enligt patentkrav 1, 2 eller 3, k a n n e t e c k n a d e därav, att mikrokapslarna har en ge-nomsnittlig storieksfördelning 0,1 - 100 μτα.
9. Mikrokapslar enligt patentkrav 1, 2 eller 3, 5 kännetecknade därav, att mikrokapslarna är porösa och har en porositet av 20 - 2 000 run. 1-0» Mikrokapslar enligt patentkrav 1, känne tecknade därav, att mikrokapslarna är i'Gke^s.axnmansm^l-· tande, toria och ögohblickligen dispergerbara i ett väts-10 keformigt medium.
11. Mikrokapslar enligt patentkrav 10, känne tecknade därav, att mikrokapslarna omfatcar ytterliga-re ett äterdispergeringsmedel.
12. Mikrokapslar enligt patentkrav 11, kanne- 15 tecknade därav, att aterdispergeringsmedlet är valt ur gruppen albumin, polyvinylalkohol och polyetylenglykol.
13. Mikrokapslar enligt patentkrav 6 eller 7, kännetecknade därav, att den bionedbrytbafa polyme-ren är vald ur gruppen pol yarainosvror, polylaktider och 20 polyglykolider och kopolymerer av dessa, kopolymerer av laktider och laktoner, polypeptider, poly(orto)estrar, po~ lydioxanon, poly-p-aminoketoner, polyfosfazener, polyan-hydrider, polyhydroxibutvrat och polyalkyl(cyan)akrylater,
14. Mikrokapslar enligt nagot av föregäende pa- 25 tentkrav, kännetecknade därav, att mikrokapslarna omfattar ytterligare ett ytaktivt medel, som är valt ur gruppen polyoxietylen-polyoxipropylen-block-kopolymerer och fosfolipider.
15. Mikrokapslar enligt nägot av föregäende pa- 30 tentkrav, klnne t ecknade därav, att membranen omf attar ytterligare ett lipofilt aktivt medel.
16. Mikrokapslar enligt patentkrav 15, kännetecknade därav, att det lipoilla aktiva medlet är valt ur gruppen vitamin E, prednisolon, kloramfenikolpalmitat 35 och salbutamol. il 30
17. Mikrokapslar enligt patentkrav 1 - 15, k anne t e c k n a ά e därav, att kärnan omfattar ett icke-jpniskt joderat kontragtmedel eller MRl-kontrastmedel.
18. Mikrokapslar enligt patentkrav 1 - IS:, kan-5 netecknade därav, att kärnan omfattar insulin.
19. Förfarande för framställning av ett kontrast- medel, k ä n n e t ;e c k n a t därav, att mikrokapslar enligt patentkrav 17 suspenderas i en fysiologiskt godtagbar mediumia s .
20. Injekterbar komposition, kanneteeknad därav, att den innehäller en suspension av en effektiv mängd av mikrokapslar enligt nägot av patentkraven 1 - 18 i ett farmaceutiskt godtagbart medium med konventionella ti 1.1-satsmedel ooh stabilisatorer- 15 21. Förfarande för framställning av fas ta·, mikrokapslar enligt patentkraven 1 - 16 , k ä n n e t e c k n a t där av, att det omfattar s teg, där: man: a) löser en bxonedbrytbar lipid och eventuellt en bxonedbrytbar polymer i ett lösningsmedel eller lösnings- 20 medelsblandning, b) blandar med en vattenfas, c) emulgerar blandningen med för bildande av en oija-i-va11en-emu1si on, d) tiilsätter ett äterdispergeringsmedel, 25 e) nedfryser, f) lyofiliserar för bildande av ett pulver inne-häilande semisfäriskä eller sfäriska mikrokapslar, g) dispergerar pulvret i ett vattenbaserat medium, h} separerar mlkr okaps lama inhehällande luft el- 30 ler gas medelst dekantering frän en rest, och i) torkar de tillvaratagna mikrokapslama,
22. Förfarande enligt patentkrav 21, kanne tecknafc därav, att en del av det organiska lösnings-medlet avdunstas efter bildande av vatten-i-olja-emulsio- 35 nen. 31
23. Förfarande enligt pa tent kr av 21, kanne teckn at därav, att lösningsmedelsblanänirigen är en blandning av vattenlösliga och i vatten olösliga organiska lösningsmedel. 5 24. Förfarande enligt patent, kr av 23, kan ne tecknat därav, att det i vatteri olösliga lösnings-medlet är vai t ur gruppen alkanen , cykloalkanex:, ar omat is kä korvaten, etrar och halogenerade koIvaten.
25. Förfarande enligt patent kr av 24, kän- 10. e t e c k n a t därav, att lösningsmedlet är vai t ur gruppen toinen, xylen, cyklooktan, cyklohexan, kloroform, tetra-klormetan, difluortetrakloretan, dibutyleter, diisopropy-leter, isobutylmetylkaton och blandningar därav.
26. Förfarande enligt patentkrav 21, k ä n - 15 ne teckn at däräv, att mikrokapslarna ofattar ytterliga- re ett ytaktivt medel, som är valt ur gruppen gruppen po-lyoxietylen-polyoxipropylen-block-kopolyinerer och fosfoli-pider.
27. Förfarande enligt patentkrav 21, kän- 20 ne tecknat därav, att ett lipofilt aktivt sätts tili lösningen av lipiderna fore blandning med vattenfasen.
28. Mikrokapslar enlig patentkraven 1 -· 14 för användning ultraljudsavbildrling av organ i mänsko- eller dj urkropp.
29. Användning av mikrokapslar enligt patentkrav 1 - 18 för framställning av injekterbara, terapeutiskt ef~ fektiva kotipos i t ioner.
30. Användning av mikrokapslar enligt patentkrav 1 - 14 för framställning av medel för ultraljudsavbild-30 ning.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP94810660 | 1994-11-22 | ||
| EP94810660 | 1994-11-22 | ||
| IB9501029 | 1995-11-21 | ||
| PCT/IB1995/001029 WO1996015815A1 (en) | 1994-11-22 | 1995-11-21 | Microcapsules, method of making and their use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI962917A0 FI962917A0 (sv) | 1996-07-19 |
| FI962917A FI962917A (sv) | 1996-07-19 |
| FI120081B true FI120081B (sv) | 2009-06-30 |
Family
ID=8218339
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI962917A FI120081B (sv) | 1994-11-22 | 1996-07-19 | Mikrokapslar, förfarande för deras framställning, och deras användning |
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| US (2) | US6333021B1 (sv) |
| EP (1) | EP0755270B1 (sv) |
| JP (1) | JP4202414B2 (sv) |
| KR (1) | KR100416163B1 (sv) |
| CN (1) | CN1066964C (sv) |
| AT (1) | ATE337795T1 (sv) |
| AU (1) | AU709240B2 (sv) |
| CA (1) | CA2178602C (sv) |
| CZ (1) | CZ291178B6 (sv) |
| DE (1) | DE69535203T2 (sv) |
| ES (1) | ES2271947T3 (sv) |
| FI (1) | FI120081B (sv) |
| HU (1) | HU226896B1 (sv) |
| IL (1) | IL116081A (sv) |
| MX (1) | MX9602697A (sv) |
| NO (1) | NO315692B1 (sv) |
| PL (1) | PL182989B1 (sv) |
| RU (1) | RU2139046C1 (sv) |
| WO (1) | WO1996015815A1 (sv) |
| ZA (1) | ZA959941B (sv) |
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| DE4232755A1 (de) * | 1992-09-26 | 1994-03-31 | Schering Ag | Mikropartikelpräparationen aus biologisch abbaubaren Mischpolymeren |
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1995
- 1995-11-08 US US08/555,147 patent/US6333021B1/en not_active Expired - Fee Related
- 1995-11-21 CZ CZ19962140A patent/CZ291178B6/cs not_active IP Right Cessation
- 1995-11-21 JP JP51671596A patent/JP4202414B2/ja not_active Expired - Fee Related
- 1995-11-21 DE DE69535203T patent/DE69535203T2/de not_active Expired - Lifetime
- 1995-11-21 RU RU96117128A patent/RU2139046C1/ru not_active IP Right Cessation
- 1995-11-21 AT AT95936064T patent/ATE337795T1/de active
- 1995-11-21 IL IL11608195A patent/IL116081A/xx not_active IP Right Cessation
- 1995-11-21 WO PCT/IB1995/001029 patent/WO1996015815A1/en active IP Right Grant
- 1995-11-21 KR KR1019960703921A patent/KR100416163B1/ko not_active IP Right Cessation
- 1995-11-21 CN CN95191307A patent/CN1066964C/zh not_active Expired - Fee Related
- 1995-11-21 HU HU9601996A patent/HU226896B1/hu not_active IP Right Cessation
- 1995-11-21 PL PL95315585A patent/PL182989B1/pl unknown
- 1995-11-21 CA CA002178602A patent/CA2178602C/en not_active Expired - Fee Related
- 1995-11-21 AU AU38144/95A patent/AU709240B2/en not_active Ceased
- 1995-11-21 EP EP95936064A patent/EP0755270B1/en not_active Expired - Lifetime
- 1995-11-21 ES ES95936064T patent/ES2271947T3/es not_active Expired - Lifetime
- 1995-11-22 ZA ZA959941A patent/ZA959941B/xx unknown
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1996
- 1996-07-05 NO NO19962843A patent/NO315692B1/no not_active IP Right Cessation
- 1996-07-09 MX MX9602697A patent/MX9602697A/es unknown
- 1996-07-19 FI FI962917A patent/FI120081B/sv not_active IP Right Cessation
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Also Published As
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| NO315692B1 (no) | 2003-10-13 |
| CA2178602C (en) | 2004-03-30 |
| PL182989B1 (pl) | 2002-05-31 |
| IL116081A0 (en) | 1996-01-31 |
| CZ214096A3 (en) | 1996-10-16 |
| CN1066964C (zh) | 2001-06-13 |
| WO1996015815A1 (en) | 1996-05-30 |
| AU3814495A (en) | 1996-06-17 |
| PL315585A1 (en) | 1996-11-12 |
| HU226896B1 (en) | 2010-01-28 |
| NO962843L (no) | 1996-07-05 |
| DE69535203D1 (de) | 2006-10-12 |
| NO962843D0 (no) | 1996-07-05 |
| AU709240B2 (en) | 1999-08-26 |
| CA2178602A1 (en) | 1996-05-30 |
| ZA959941B (en) | 1996-06-10 |
| ES2271947T3 (es) | 2007-04-16 |
| HU9601996D0 (en) | 1996-09-30 |
| ATE337795T1 (de) | 2006-09-15 |
| RU2139046C1 (ru) | 1999-10-10 |
| US6403057B1 (en) | 2002-06-11 |
| FI962917A0 (sv) | 1996-07-19 |
| US6333021B1 (en) | 2001-12-25 |
| CZ291178B6 (cs) | 2003-01-15 |
| CN1139386A (zh) | 1997-01-01 |
| JPH09511762A (ja) | 1997-11-25 |
| FI962917A (sv) | 1996-07-19 |
| DE69535203T2 (de) | 2007-07-19 |
| HUT74912A (en) | 1997-03-28 |
| KR100416163B1 (ko) | 2004-03-19 |
| EP0755270A1 (en) | 1997-01-29 |
| IL116081A (en) | 2003-04-10 |
| MX9602697A (es) | 1998-06-28 |
| JP4202414B2 (ja) | 2008-12-24 |
| EP0755270B1 (en) | 2006-08-30 |
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