FI119246B - Menetelmä (2R-3S)-(4-asetoksi-2alfa-bentsoyylioksi-5beta,20-epoksi-1,7beta,10beta-trihydroksi-9-oksotaks-11-en-13alfa-yyli)-3-tert-butoksikarbonyyliamino-3-fenyyli-2-hydroksipropionaatin trihydraatinvalmistamiseksi - Google Patents

Menetelmä (2R-3S)-(4-asetoksi-2alfa-bentsoyylioksi-5beta,20-epoksi-1,7beta,10beta-trihydroksi-9-oksotaks-11-en-13alfa-yyli)-3-tert-butoksikarbonyyliamino-3-fenyyli-2-hydroksipropionaatin trihydraatinvalmistamiseksi Download PDF

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Publication number
FI119246B
FI119246B FI970069A FI970069A FI119246B FI 119246 B FI119246 B FI 119246B FI 970069 A FI970069 A FI 970069A FI 970069 A FI970069 A FI 970069A FI 119246 B FI119246 B FI 119246B
Authority
FI
Finland
Prior art keywords
acetoxy
epoxy
tert
benzoyloxy
trihydroxy
Prior art date
Application number
FI970069A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI970069A (fi
FI970069A0 (fi
Inventor
Elie Fouque
Jean-Rene Authelin
Isabelle Taillepied
Jacques Doveze
Bernadette Mandard
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9465183&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI119246(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of FI970069A publication Critical patent/FI970069A/fi
Publication of FI970069A0 publication Critical patent/FI970069A0/fi
Application granted granted Critical
Publication of FI119246B publication Critical patent/FI119246B/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
FI970069A 1994-07-08 1997-01-07 Menetelmä (2R-3S)-(4-asetoksi-2alfa-bentsoyylioksi-5beta,20-epoksi-1,7beta,10beta-trihydroksi-9-oksotaks-11-en-13alfa-yyli)-3-tert-butoksikarbonyyliamino-3-fenyyli-2-hydroksipropionaatin trihydraatinvalmistamiseksi FI119246B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR9408479A FR2722191B1 (fr) 1994-07-08 1994-07-08 Procede de preparation du trihydrate du (2r,3s)-3-tertbutoxycarbonylamino-2-hydroxy-3-phenylpropionate de 4-acetoxy2alpha-benzoyloxy-5beta,20epoxy-1,7beta,10beta trihydroxy-9-oxo-tax-11-en-13alpha-yle
FR9408479 1994-07-08
PCT/FR1995/000910 WO1996001815A1 (fr) 1994-07-08 1995-07-07 PROCEDE DE PREPARATION DU TRIHYDRATE DU (2R,3S)-3-TERT-BUTOXYCARBONYLAMINO-2-HYDROXY-3-PHENYLPROPIONATE DE 4-ACETOXY-2α-BENZOYLOXY-5β,20-EPOXY-1,7β,10β-TRIHYDROXY-9-OXO-TAX-11-EN-13α-YLE
FR9500910 1995-07-07

Publications (3)

Publication Number Publication Date
FI970069A FI970069A (fi) 1997-01-07
FI970069A0 FI970069A0 (fi) 1997-01-07
FI119246B true FI119246B (fi) 2008-09-15

Family

ID=9465183

Family Applications (1)

Application Number Title Priority Date Filing Date
FI970069A FI119246B (fi) 1994-07-08 1997-01-07 Menetelmä (2R-3S)-(4-asetoksi-2alfa-bentsoyylioksi-5beta,20-epoksi-1,7beta,10beta-trihydroksi-9-oksotaks-11-en-13alfa-yyli)-3-tert-butoksikarbonyyliamino-3-fenyyli-2-hydroksipropionaatin trihydraatinvalmistamiseksi

Country Status (38)

Country Link
US (1) US6022985A (cs)
EP (1) EP0770070B1 (cs)
JP (1) JP3753155B2 (cs)
KR (1) KR100391753B1 (cs)
CN (1) CN1067996C (cs)
AT (1) ATE171702T1 (cs)
AU (1) AU706519B2 (cs)
BR (1) BR9508789A (cs)
CA (1) CA2193531C (cs)
CO (1) CO4410189A1 (cs)
CZ (1) CZ284695B6 (cs)
DE (1) DE69505128T2 (cs)
DK (1) DK0770070T3 (cs)
DZ (1) DZ1905A1 (cs)
ES (1) ES2121404T3 (cs)
FI (1) FI119246B (cs)
FR (1) FR2722191B1 (cs)
GR (1) GR3027558T3 (cs)
HU (1) HU220634B1 (cs)
IL (1) IL114274A (cs)
IN (1) IN183947B (cs)
IS (1) IS2032B (cs)
MA (1) MA23606A1 (cs)
MX (1) MX9700173A (cs)
MY (1) MY118481A (cs)
NO (1) NO314500B1 (cs)
NZ (1) NZ289455A (cs)
PE (1) PE8697A1 (cs)
PL (1) PL179876B1 (cs)
RU (1) RU2126397C1 (cs)
SI (1) SI0770070T1 (cs)
SK (1) SK280520B6 (cs)
TN (1) TNSN95071A1 (cs)
TW (1) TW419473B (cs)
UA (1) UA51624C2 (cs)
UY (1) UY23991A1 (cs)
WO (1) WO1996001815A1 (cs)
ZA (1) ZA955646B (cs)

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FR2794771B1 (fr) 1999-06-11 2001-08-10 Aventis Pharma Sa Adenovirus recombinants codant pour le transporteur specifique de l'iode (nis)
US6266619B1 (en) * 1999-07-20 2001-07-24 Halliburton Energy Services, Inc. System and method for real time reservoir management
US6853921B2 (en) 1999-07-20 2005-02-08 Halliburton Energy Services, Inc. System and method for real time reservoir management
GB9920548D0 (en) * 1999-08-31 1999-11-03 Rhone Poulenc Rorer Sa Treatment of hepatocellular carcinoma
US6891050B2 (en) * 2001-08-10 2005-05-10 Dabur India Limited Process for the preparation of taxanes such as paclitaxel, docetaxel and structurally similar analogs
US6881852B2 (en) * 2002-02-05 2005-04-19 Dabur India Limited Process of purification of paclitaxel and docetaxel
US7247738B2 (en) * 2002-05-07 2007-07-24 Dabur India Limited Method of preparation of anticancer taxanes using 3-[(substituted-2-trialkylsilyl) ethoxycarbonyl]-5-oxazolidine carboxylic acids
US6900342B2 (en) * 2002-05-10 2005-05-31 Dabur India Limited Anticancer taxanes such as paclitaxel, docetaxel and their structural analogs, and a method for the preparation thereof
US6838569B2 (en) * 2002-12-16 2005-01-04 Dabur India Limited Process for preparation of paclitaxel trihydrate and docetaxel trihydrate
US7584165B2 (en) * 2003-01-30 2009-09-01 Landmark Graphics Corporation Support apparatus, method and system for real time operations and maintenance
US8703982B2 (en) 2003-03-17 2014-04-22 Phyton Holdings Llc Purification of taxanes
CN1268619C (zh) * 2003-05-08 2006-08-09 上海迪赛诺化学制药有限公司 多烯紫杉醇三水化合物的制备方法
EP1947094A3 (en) 2003-12-12 2009-02-18 Quiral Quimica Do Brasil Process for the preparation of taxane derivatives
US7142986B2 (en) * 2005-02-01 2006-11-28 Smith International, Inc. System for optimizing drilling in real time
CN100420681C (zh) * 2005-04-29 2008-09-24 上海奥锐特国际贸易有限公司 多烯紫杉醇三水物的制备方法
TWI417114B (zh) * 2005-08-31 2013-12-01 Abraxis Bioscience Llc 具有增強穩定性之弱水溶性藥物之組合物及其製備方法
CN101291658B (zh) 2005-08-31 2014-04-16 阿布拉科斯生物科学有限公司 用于制备稳定性增加的水难溶性药物的组合物和方法
KR20070088784A (ko) * 2005-10-12 2007-08-29 시코르, 인크. 도세탁셀의 결정형 및 이의 제조 방법
KR100995390B1 (ko) 2006-01-02 2010-11-19 주식회사 삼양제넥스 무정형, 무수결정형 또는 수화 결정형 도세탁셀의 제조방법
WO2007084611A2 (en) * 2006-01-20 2007-07-26 Landmark Graphics Corporation Dynamic production system management
JP2009533330A (ja) * 2006-03-21 2009-09-17 ドクター レディズ ラボラトリーズ リミテッド ドセタキセルの多形体およびプロセス
CA2667416C (en) * 2006-10-20 2013-12-17 Scinopharm Singapore Pte, Ltd. Process for making crystalline anhydrous docetaxel
KR100868116B1 (ko) * 2007-04-09 2008-11-10 한미약품 주식회사 도세탁셀·모노프로필렌글라이콜 내포화합물 및 이의제조방법
KR100878455B1 (ko) * 2007-04-10 2009-01-13 한미약품 주식회사 안정한 무수결정형 도세탁셀 및 이의 제조방법
WO2009006590A2 (en) * 2007-07-04 2009-01-08 Dr. Reddy's Laboratories Ltd. Docetaxel process and polymorphs
EP2080763A1 (en) * 2008-01-18 2009-07-22 INDENA S.p.A. Crystalline form I of ortataxel
ES2389518T3 (es) 2008-01-18 2012-10-26 Indena S.P.A. Formas sólidas de ortataxel
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
US8686165B2 (en) * 2009-11-04 2014-04-01 Emcure Pharmaceuticals Limited Process for preparation of taxane derivatives
MX341082B (es) 2010-05-03 2016-08-08 Teikoku Pharma Usa Inc Formulaciones de pro-emulsion de taxano no acuosas y metodos para hacer y usar las mismas.
WO2012160568A1 (en) * 2011-05-23 2012-11-29 Shilpa Medicare Limited Process for preparing docetaxel trihydrate polymorph
HUE041799T2 (hu) 2011-09-08 2019-05-28 Univ New York Onkolitikus Herpes simplex vírus és terápiás alkalmazásai
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EA031986B1 (ru) 2012-04-04 2019-03-29 Галозим, Инк. Способ и комбинация для лечения солидной раковой опухоли и набор, содержащий комбинацию
WO2013177426A2 (en) 2012-05-24 2013-11-28 Dana-Farber Cancer Institute, Inc. Targeting the glutamine to pyruvate pathway for treatment of oncogenic kras-associated cancer
WO2014014518A1 (en) 2012-07-18 2014-01-23 Dana-Farber Cancer Institute, Inc. Methods for treating, preventing and predicting risk of developing breast cancer
JO3685B1 (ar) 2012-10-01 2020-08-27 Teikoku Pharma Usa Inc صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها
WO2014149871A1 (en) 2013-03-14 2014-09-25 Icahn School Of Medicine At Mount Sinai Autologous tumor lysate-loaded dendritic cell vaccine for treatment of liver cancer
WO2015050844A1 (en) 2013-10-01 2015-04-09 Dana-Farber Cancer Institute, Inc. Methods of treating cancer with atovaquone-related compounds
WO2015149006A2 (en) 2014-03-27 2015-10-01 Dana-Farber Cancer Institute, Inc. Compositions and methods for modulating ncoa4-mediated autophagic targeting of ferritin
MA39818A (fr) 2014-03-30 2017-02-08 Benevir Biopharm Inc Virus oncolytiques « armés » comprenant un inhibiteur de tap exogène et leurs utilisations thérapeutiques
US10967015B2 (en) 2015-06-15 2021-04-06 New York University Method of treatment using oncolytic viruses
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FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides

Also Published As

Publication number Publication date
KR100391753B1 (ko) 2004-02-11
HU9700041D0 (en) 1997-02-28
IL114274A0 (en) 1995-10-31
SK697A3 (en) 1997-06-04
CZ3597A3 (en) 1997-04-16
TNSN95071A1 (fr) 1996-02-06
NZ289455A (en) 1997-12-19
WO1996001815A1 (fr) 1996-01-25
JPH10502627A (ja) 1998-03-10
AU706519B2 (en) 1999-06-17
DZ1905A1 (fr) 2002-02-17
IN183947B (cs) 2000-05-20
SI0770070T1 (en) 1998-12-31
EP0770070A1 (fr) 1997-05-02
DE69505128D1 (de) 1998-11-05
UY23991A1 (es) 1995-09-20
DE69505128T2 (de) 1999-04-01
TW419473B (en) 2001-01-21
MY118481A (en) 2004-11-30
ATE171702T1 (de) 1998-10-15
CN1067996C (zh) 2001-07-04
BR9508789A (pt) 1997-10-21
FI970069A (fi) 1997-01-07
AU2930595A (en) 1996-02-09
HUT76833A (en) 1997-11-28
FR2722191B1 (fr) 1996-08-23
KR970704721A (ko) 1997-09-06
DK0770070T3 (da) 1999-03-01
EP0770070B1 (fr) 1998-09-30
CA2193531C (fr) 2006-12-05
IS2032B (is) 2005-08-15
US6022985A (en) 2000-02-08
GR3027558T3 (en) 1998-11-30
FI970069A0 (fi) 1997-01-07
FR2722191A1 (fr) 1996-01-12
ES2121404T3 (es) 1998-11-16
PL179876B1 (pl) 2000-11-30
ZA955646B (en) 1996-02-21
IS4411A (is) 1997-01-07
HU220634B1 (hu) 2002-03-28
MA23606A1 (fr) 1996-04-01
NO314500B1 (no) 2003-03-31
CA2193531A1 (fr) 1996-01-25
CZ284695B6 (cs) 1999-02-17
MX9700173A (es) 1997-04-30
UA51624C2 (uk) 2002-12-16
PE8697A1 (es) 1997-03-26
CO4410189A1 (es) 1997-01-09
CN1151741A (zh) 1997-06-11
NO970007D0 (no) 1997-01-02
PL318195A1 (en) 1997-05-26
JP3753155B2 (ja) 2006-03-08
SK280520B6 (sk) 2000-03-13
NO970007L (no) 1997-01-02
RU2126397C1 (ru) 1999-02-20
IL114274A (en) 1999-04-11

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