IL114274A - Process for the preparation of 4-acetoxy -2alpha-bezoyloxy-5beta, 20-epoxy-1,7beta, 10beta-trihydroxy-9-oxo-tax-11-en 13alpha-yl (2r,3s)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate trihydrate - Google Patents

Process for the preparation of 4-acetoxy -2alpha-bezoyloxy-5beta, 20-epoxy-1,7beta, 10beta-trihydroxy-9-oxo-tax-11-en 13alpha-yl (2r,3s)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate trihydrate

Info

Publication number
IL114274A
IL114274A IL11427495A IL11427495A IL114274A IL 114274 A IL114274 A IL 114274A IL 11427495 A IL11427495 A IL 11427495A IL 11427495 A IL11427495 A IL 11427495A IL 114274 A IL114274 A IL 114274A
Authority
IL
Israel
Prior art keywords
beta
butoxycarbonylamino
trihydroxy
tax
acetoxy
Prior art date
Application number
IL11427495A
Other languages
English (en)
Other versions
IL114274A0 (en
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9465183&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IL114274(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of IL114274A0 publication Critical patent/IL114274A0/xx
Publication of IL114274A publication Critical patent/IL114274A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
IL11427495A 1994-07-08 1995-06-22 Process for the preparation of 4-acetoxy -2alpha-bezoyloxy-5beta, 20-epoxy-1,7beta, 10beta-trihydroxy-9-oxo-tax-11-en 13alpha-yl (2r,3s)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate trihydrate IL114274A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9408479A FR2722191B1 (fr) 1994-07-08 1994-07-08 Procede de preparation du trihydrate du (2r,3s)-3-tertbutoxycarbonylamino-2-hydroxy-3-phenylpropionate de 4-acetoxy2alpha-benzoyloxy-5beta,20epoxy-1,7beta,10beta trihydroxy-9-oxo-tax-11-en-13alpha-yle

Publications (2)

Publication Number Publication Date
IL114274A0 IL114274A0 (en) 1995-10-31
IL114274A true IL114274A (en) 1999-04-11

Family

ID=9465183

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11427495A IL114274A (en) 1994-07-08 1995-06-22 Process for the preparation of 4-acetoxy -2alpha-bezoyloxy-5beta, 20-epoxy-1,7beta, 10beta-trihydroxy-9-oxo-tax-11-en 13alpha-yl (2r,3s)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropionate trihydrate

Country Status (38)

Country Link
US (1) US6022985A (cs)
EP (1) EP0770070B1 (cs)
JP (1) JP3753155B2 (cs)
KR (1) KR100391753B1 (cs)
CN (1) CN1067996C (cs)
AT (1) ATE171702T1 (cs)
AU (1) AU706519B2 (cs)
BR (1) BR9508789A (cs)
CA (1) CA2193531C (cs)
CO (1) CO4410189A1 (cs)
CZ (1) CZ284695B6 (cs)
DE (1) DE69505128T2 (cs)
DK (1) DK0770070T3 (cs)
DZ (1) DZ1905A1 (cs)
ES (1) ES2121404T3 (cs)
FI (1) FI119246B (cs)
FR (1) FR2722191B1 (cs)
GR (1) GR3027558T3 (cs)
HU (1) HU220634B1 (cs)
IL (1) IL114274A (cs)
IN (1) IN183947B (cs)
IS (1) IS2032B (cs)
MA (1) MA23606A1 (cs)
MX (1) MX9700173A (cs)
MY (1) MY118481A (cs)
NO (1) NO314500B1 (cs)
NZ (1) NZ289455A (cs)
PE (1) PE8697A1 (cs)
PL (1) PL179876B1 (cs)
RU (1) RU2126397C1 (cs)
SI (1) SI0770070T1 (cs)
SK (1) SK280520B6 (cs)
TN (1) TNSN95071A1 (cs)
TW (1) TW419473B (cs)
UA (1) UA51624C2 (cs)
UY (1) UY23991A1 (cs)
WO (1) WO1996001815A1 (cs)
ZA (1) ZA955646B (cs)

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BR9808697A (pt) 1997-04-28 2000-07-11 Rhone Poulenc Rorer Sa Processo para inibir o crescimento de um tumor, vetor de adenovìrus defeituoso, vetor de vìrus, uso do mesmo, e, composição farmacêutica
SE510650C2 (sv) * 1997-05-30 1999-06-14 Astra Ab Ny förening
FR2794771B1 (fr) 1999-06-11 2001-08-10 Aventis Pharma Sa Adenovirus recombinants codant pour le transporteur specifique de l'iode (nis)
US6266619B1 (en) * 1999-07-20 2001-07-24 Halliburton Energy Services, Inc. System and method for real time reservoir management
US6853921B2 (en) 1999-07-20 2005-02-08 Halliburton Energy Services, Inc. System and method for real time reservoir management
GB9920548D0 (en) * 1999-08-31 1999-11-03 Rhone Poulenc Rorer Sa Treatment of hepatocellular carcinoma
US6891050B2 (en) * 2001-08-10 2005-05-10 Dabur India Limited Process for the preparation of taxanes such as paclitaxel, docetaxel and structurally similar analogs
US6881852B2 (en) * 2002-02-05 2005-04-19 Dabur India Limited Process of purification of paclitaxel and docetaxel
US7247738B2 (en) * 2002-05-07 2007-07-24 Dabur India Limited Method of preparation of anticancer taxanes using 3-[(substituted-2-trialkylsilyl) ethoxycarbonyl]-5-oxazolidine carboxylic acids
US6900342B2 (en) * 2002-05-10 2005-05-31 Dabur India Limited Anticancer taxanes such as paclitaxel, docetaxel and their structural analogs, and a method for the preparation thereof
US6838569B2 (en) * 2002-12-16 2005-01-04 Dabur India Limited Process for preparation of paclitaxel trihydrate and docetaxel trihydrate
US7584165B2 (en) * 2003-01-30 2009-09-01 Landmark Graphics Corporation Support apparatus, method and system for real time operations and maintenance
US8703982B2 (en) 2003-03-17 2014-04-22 Phyton Holdings Llc Purification of taxanes
CN1268619C (zh) * 2003-05-08 2006-08-09 上海迪赛诺化学制药有限公司 多烯紫杉醇三水化合物的制备方法
WO2005061474A1 (en) 2003-12-12 2005-07-07 Quiral Química Do Brasil Process for the preparation of anhydrous and hydrated active pharmaceutical ingredients (apis); stable pharmaceutical compositions prepared from the same and uses of said compositions
US7142986B2 (en) * 2005-02-01 2006-11-28 Smith International, Inc. System for optimizing drilling in real time
CN100420681C (zh) * 2005-04-29 2008-09-24 上海奥锐特国际贸易有限公司 多烯紫杉醇三水物的制备方法
NZ592132A (en) 2005-08-31 2012-12-21 Abraxis Bioscience Llc Composition comprising nanoparticles of docitaxel and a citrate
CN103054798B (zh) * 2005-08-31 2021-03-16 阿布拉科斯生物科学有限公司 用于制备稳定性增加的水难溶性药物的组合物和方法
US20070142457A1 (en) * 2005-10-12 2007-06-21 Alessandro Pontiroli Crystalline forms of docetaxel and processes for their preparation
KR100995390B1 (ko) 2006-01-02 2010-11-19 주식회사 삼양제넥스 무정형, 무수결정형 또는 수화 결정형 도세탁셀의 제조방법
AU2007207497B8 (en) * 2006-01-20 2013-05-16 Landmark Graphics Corporation Dynamic production system management
AU2007226937A1 (en) * 2006-03-21 2007-09-27 Dr. Reddy's Laboratories Ltd. Docetaxel polymorphs and processes
NZ576355A (en) * 2006-10-20 2012-04-27 Scinopharm Singapore Pte Ltd Process for making crystalline anhydrous docetaxel
KR100868116B1 (ko) * 2007-04-09 2008-11-10 한미약품 주식회사 도세탁셀·모노프로필렌글라이콜 내포화합물 및 이의제조방법
KR100878455B1 (ko) * 2007-04-10 2009-01-13 한미약품 주식회사 안정한 무수결정형 도세탁셀 및 이의 제조방법
US20100197944A1 (en) * 2007-07-04 2010-08-05 Dr. Reddy's Laboratories Limited Docetaxel process and polymorphs
EP2080763A1 (en) * 2008-01-18 2009-07-22 INDENA S.p.A. Crystalline form I of ortataxel
ES2389518T3 (es) * 2008-01-18 2012-10-26 Indena S.P.A. Formas sólidas de ortataxel
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
EP2330100B1 (en) 2009-11-04 2017-01-11 Emcure Pharmaceuticals Limited An improved process for preparation of taxane derivatives
CA2798180A1 (en) 2010-05-03 2011-11-10 Teikoku Pharma Usa, Inc. Non-aqueous taxane pro-emulsion formulations and methods of making and using the same
WO2012160568A1 (en) * 2011-05-23 2012-11-29 Shilpa Medicare Limited Process for preparing docetaxel trihydrate polymorph
PT2753355T (pt) 2011-09-08 2019-02-01 Univ New York Vírus herpes simplex oncolítico e suas utilizações terapêuticas
US9745631B2 (en) 2011-12-20 2017-08-29 Dana-Farber Cancer Institute, Inc. Methods for diagnosing and treating oncogenic kras-associated cancer
JP6042527B2 (ja) 2012-04-04 2016-12-14 ハロザイム インコーポレイテッド 抗ヒアルロナン剤と腫瘍標的タキサンの組み合わせ治療
CA2874521A1 (en) 2012-05-24 2013-11-28 Dana-Farber Cancer Institute, Inc. Targeting the glutamine to pyruvate pathway for treatment of oncogenic kras-associated cancer
WO2014014518A1 (en) 2012-07-18 2014-01-23 Dana-Farber Cancer Institute, Inc. Methods for treating, preventing and predicting risk of developing breast cancer
JO3685B1 (ar) 2012-10-01 2020-08-27 Teikoku Pharma Usa Inc صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها
EP2968406A4 (en) 2013-03-14 2016-10-26 Icahn School Med Mount Sinai AUTOLOGOUS TUMOR LYSAT-FILLED DENDRITIC CELL VACCINE FOR THE TREATMENT OF LIVER CANCER
WO2015050844A1 (en) 2013-10-01 2015-04-09 Dana-Farber Cancer Institute, Inc. Methods of treating cancer with atovaquone-related compounds
WO2015149006A2 (en) 2014-03-27 2015-10-01 Dana-Farber Cancer Institute, Inc. Compositions and methods for modulating ncoa4-mediated autophagic targeting of ferritin
MA39818A (fr) 2014-03-30 2017-02-08 Benevir Biopharm Inc Virus oncolytiques « armés » comprenant un inhibiteur de tap exogène et leurs utilisations thérapeutiques
US10967015B2 (en) 2015-06-15 2021-04-06 New York University Method of treatment using oncolytic viruses
WO2019222435A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides

Also Published As

Publication number Publication date
TW419473B (en) 2001-01-21
JP3753155B2 (ja) 2006-03-08
ATE171702T1 (de) 1998-10-15
IN183947B (cs) 2000-05-20
AU2930595A (en) 1996-02-09
IL114274A0 (en) 1995-10-31
HU220634B1 (hu) 2002-03-28
FI970069A0 (fi) 1997-01-07
ES2121404T3 (es) 1998-11-16
FR2722191B1 (fr) 1996-08-23
FI970069A (fi) 1997-01-07
CN1151741A (zh) 1997-06-11
UY23991A1 (es) 1995-09-20
RU2126397C1 (ru) 1999-02-20
CN1067996C (zh) 2001-07-04
HUT76833A (en) 1997-11-28
DE69505128T2 (de) 1999-04-01
NO970007D0 (no) 1997-01-02
KR970704721A (ko) 1997-09-06
CA2193531C (fr) 2006-12-05
JPH10502627A (ja) 1998-03-10
MA23606A1 (fr) 1996-04-01
NO314500B1 (no) 2003-03-31
AU706519B2 (en) 1999-06-17
KR100391753B1 (ko) 2004-02-11
TNSN95071A1 (fr) 1996-02-06
FR2722191A1 (fr) 1996-01-12
WO1996001815A1 (fr) 1996-01-25
SK280520B6 (sk) 2000-03-13
DE69505128D1 (de) 1998-11-05
CA2193531A1 (fr) 1996-01-25
FI119246B (fi) 2008-09-15
DK0770070T3 (da) 1999-03-01
GR3027558T3 (en) 1998-11-30
EP0770070A1 (fr) 1997-05-02
NO970007L (no) 1997-01-02
CO4410189A1 (es) 1997-01-09
SK697A3 (en) 1997-06-04
SI0770070T1 (en) 1998-12-31
BR9508789A (pt) 1997-10-21
NZ289455A (en) 1997-12-19
MX9700173A (es) 1997-04-30
IS2032B (is) 2005-08-15
ZA955646B (en) 1996-02-21
UA51624C2 (uk) 2002-12-16
PL318195A1 (en) 1997-05-26
DZ1905A1 (fr) 2002-02-17
IS4411A (is) 1997-01-07
US6022985A (en) 2000-02-08
PE8697A1 (es) 1997-03-26
EP0770070B1 (fr) 1998-09-30
HU9700041D0 (en) 1997-02-28
PL179876B1 (pl) 2000-11-30
MY118481A (en) 2004-11-30
CZ3597A3 (en) 1997-04-16
CZ284695B6 (cs) 1999-02-17

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