FI118428B - BMP-mutantteja koodaavat yhdistelmä-DNA-molekyylit sekä menetelmät BMP-mutanttien ja niitä käsittävien farmaseuttisten valmisteiden valmistamiseksi - Google Patents

BMP-mutantteja koodaavat yhdistelmä-DNA-molekyylit sekä menetelmät BMP-mutanttien ja niitä käsittävien farmaseuttisten valmisteiden valmistamiseksi Download PDF

Info

Publication number
FI118428B
FI118428B FI962349A FI962349A FI118428B FI 118428 B FI118428 B FI 118428B FI 962349 A FI962349 A FI 962349A FI 962349 A FI962349 A FI 962349A FI 118428 B FI118428 B FI 118428B
Authority
FI
Finland
Prior art keywords
bmp
amino acid
seq
sequence
encoding
Prior art date
Application number
FI962349A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI962349A (fi
FI962349A0 (fi
Inventor
Neil M Wolfman
John Mccoy
Original Assignee
Genetics Inst Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Inst Llc filed Critical Genetics Inst Llc
Publication of FI962349A0 publication Critical patent/FI962349A0/fi
Publication of FI962349A publication Critical patent/FI962349A/fi
Application granted granted Critical
Publication of FI118428B publication Critical patent/FI118428B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
FI962349A 1993-12-07 1996-06-06 BMP-mutantteja koodaavat yhdistelmä-DNA-molekyylit sekä menetelmät BMP-mutanttien ja niitä käsittävien farmaseuttisten valmisteiden valmistamiseksi FI118428B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US16387793 1993-12-07
US08/163,877 US5399677A (en) 1993-12-07 1993-12-07 Mutants of bone morphogenetic proteins
PCT/US1994/013181 WO1995016034A1 (fr) 1993-12-07 1994-11-15 Mutants des proteines morphogenetiques osseuses
US9413181 1994-11-15

Publications (3)

Publication Number Publication Date
FI962349A0 FI962349A0 (fi) 1996-06-06
FI962349A FI962349A (fi) 1996-07-16
FI118428B true FI118428B (fi) 2007-11-15

Family

ID=22591964

Family Applications (1)

Application Number Title Priority Date Filing Date
FI962349A FI118428B (fi) 1993-12-07 1996-06-06 BMP-mutantteja koodaavat yhdistelmä-DNA-molekyylit sekä menetelmät BMP-mutanttien ja niitä käsittävien farmaseuttisten valmisteiden valmistamiseksi

Country Status (16)

Country Link
US (3) US5399677A (fr)
EP (1) EP0733108B1 (fr)
JP (1) JP3704350B2 (fr)
KR (1) KR100361058B1 (fr)
AT (1) ATE200515T1 (fr)
AU (1) AU682238B2 (fr)
CA (1) CA2176943C (fr)
DE (1) DE69427093T2 (fr)
DK (1) DK0733108T3 (fr)
ES (1) ES2157313T3 (fr)
FI (1) FI118428B (fr)
GR (1) GR3035769T3 (fr)
NO (1) NO317800B1 (fr)
OA (1) OA10294A (fr)
PT (1) PT733108E (fr)
WO (1) WO1995016034A1 (fr)

Families Citing this family (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6150328A (en) * 1986-07-01 2000-11-21 Genetics Institute, Inc. BMP products
DE69233022T2 (de) 1991-11-04 2004-02-12 Genetics Institute, LLC, Cambridge Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung
US20080139474A1 (en) * 1991-11-04 2008-06-12 David Israel Recombinant bone morphogenetic protein heterodimers, compositions and methods of use
US6291206B1 (en) * 1993-09-17 2001-09-18 Genetics Institute, Inc. BMP receptor proteins
EP0733109B9 (fr) * 1993-12-07 2006-07-05 Genetics Institute, LLC Bmp-12, bmp-13 et compositions de celles-ci pour l'induction de tendons
US5942496A (en) 1994-02-18 1999-08-24 The Regent Of The University Of Michigan Methods and compositions for multiple gene transfer into bone cells
US6551618B2 (en) * 1994-03-15 2003-04-22 University Of Birmingham Compositions and methods for delivery of agents for neuronal regeneration and survival
BR9608019A (pt) 1995-04-19 1999-11-30 Hoechst Japan Uma nova proteína e um processo para a preparação da mesma'
US6040431A (en) * 1995-06-07 2000-03-21 Stryker Corporation Single chain analogs of the TGF-β superfamily (morphons)
US6048964A (en) * 1995-12-12 2000-04-11 Stryker Corporation Compositions and therapeutic methods using morphogenic proteins and stimulatory factors
US7026292B1 (en) 1995-12-12 2006-04-11 Stryker Corporation Compositions and therapeutic methods using morphogenic proteins and stimulatory factors
US5869041A (en) * 1996-01-12 1999-02-09 The Miriam Hospital Delivery of bioactive compounds to an organism
US7811793B2 (en) * 1996-12-25 2010-10-12 Biopharma Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh Process for preparing purified active monomer of bone-derived factor
US20040019185A1 (en) * 1996-12-25 2004-01-29 Hidetoshi Andou Process for preparing purified active monomer of bone-derived factor
ZA9711580B (en) * 1996-12-25 1999-09-23 Hoechst Marion Roussel Ltd Process for the production of purified dimeric bone morphogenetic factors.
US20020052026A1 (en) * 1997-10-08 2002-05-02 Steven M. Vicik Methods of refolding proteins
US6391311B1 (en) 1998-03-17 2002-05-21 Genentech, Inc. Polypeptides having homology to vascular endothelial cell growth factor and bone morphogenetic protein 1
US6455283B1 (en) * 1998-03-17 2002-09-24 Genentech, Inc. Nucleic acids encoding vascular endothelial cell growth factor-E (VEGF-E)
EP2050762A3 (fr) 1998-03-10 2009-07-08 Genentech, Inc. Nouvelles polypeptides et acides nucléiques les codant
US6677432B1 (en) 1998-10-07 2004-01-13 Stryker Corporation Mutations of the C-terminal portion of TGF-β superfamily proteins
JP3762222B2 (ja) 1998-10-07 2006-04-05 ストライカー・コーポレーション 改変型ＴＧＦ−βスーパーファミリータンパク質
US6846906B1 (en) 1998-10-07 2005-01-25 Stryker Corporation Modified proteins of the TGF-β superfamily, including morphogenic proteins
US6727224B1 (en) * 1999-02-01 2004-04-27 Genetics Institute, Llc. Methods and compositions for healing and repair of articular cartilage
DE19906096A1 (de) 1999-02-13 2000-08-17 Walter Sebald Protein mit einem Heparin-bindenden Epitop
DE19944626A1 (de) * 1999-09-17 2001-03-22 Knoell Hans Forschung Ev Verfahren zur Herstellung von dimeren, biologisch aktiven knochenmorphogenetischen Proteinen
WO2001028602A1 (fr) 1999-10-15 2001-04-26 Genetics Institute, Inc. Formulations a base d'acide hyaluronique aux fins de l'administration de proteines osteogenes
US7740841B1 (en) * 2000-01-28 2010-06-22 Sunnybrook Health Science Center Therapeutic method for reducing angiogenesis
US20030104977A1 (en) * 2000-03-31 2003-06-05 Ugo Ripamonti Methods for inducing angiogenesis using morphogenic proteins and stimulatory factors
DE10026713A1 (de) * 2000-05-30 2001-12-06 Walter Sebald Mutein einer Kette eines Proteins aus der Superfamilie des Wachstumsfaktors TGF-beta
US20030082233A1 (en) * 2000-12-01 2003-05-01 Lyons Karen M. Method and composition for modulating bone growth
ATE393573T1 (de) * 2001-06-01 2008-05-15 Wyeth Corp Zusammensetzungen für die systemische verabreichung von sequenzen, die für knochenmorphogenese-proteinen kodieren
TWI267378B (en) * 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
FI117667B (fi) * 2001-07-05 2007-01-15 Univ Zuerich Farmaseuttinen koostumus, joka soveltuu käytettäväksi ortopediassa ja hammaslääketieteessä
NZ536478A (en) * 2002-05-17 2008-02-29 Wyeth Corp Injectable or implantable solid, rod- shaped compositions for intraosseous delivery of osteogenic proteins
US20040023322A1 (en) * 2002-08-01 2004-02-05 Goodheart Clyde R. Method of producing non-recombinant BMP-2 and use thereof
US20060194279A1 (en) * 2003-07-09 2006-08-31 Fujio Mizukami Protein-refolding material
PT1675608E (pt) * 2003-09-12 2007-05-31 Etex Corp Barras sólidas e pastas de fosfato de cálcio injectável para a libertação de proteínas osteogénicas.
EP1677735B1 (fr) 2003-10-17 2014-07-23 Joslin Diabetes Center, Inc. Methodes et compositions pour moduler la fonction des adipocytes
US20070066525A1 (en) * 2004-02-04 2007-03-22 Lee John C Compositions and therapeutic methods using morphogenic proteins
JP2008501042A (ja) * 2004-05-19 2008-01-17 ワイス 免疫グロブリン産生の調節とアトピー性疾患
KR20070057789A (ko) * 2004-08-05 2007-06-07 와이어쓰 인터루킨-21 수용체 활성의 상쇄
AU2006214384A1 (en) * 2005-02-14 2006-08-24 University Of Pittsburgh Of The Commonwealth System Of Higher Education Use of IL-17F in diagnosis and therapy of airway inflammation
AU2006214473A1 (en) * 2005-02-14 2006-08-24 Wyeth Interleukin-17F antibodies and other IL-17F signaling antagonists and uses therefor
WO2006105359A2 (fr) * 2005-03-30 2006-10-05 Wyeth Methodes pour stimuler la pousse des cheveux par administration de proteines bmp
GT200600148A (es) 2005-04-14 2006-11-22 Metodos para el tratamiento y la prevencion de fibrosis
WO2006125868A1 (fr) 2005-05-27 2006-11-30 Bbs-Bioactive Bone Substitutes Oy Proteines morphogenetiques d’os contenant un site liant pour l’heparine et dispositifs osteogeniques et produits pharmaceutiques les contenant
US7807627B2 (en) 2005-05-27 2010-10-05 Bbs-Bioactive Bone Substitutes Oy Bone morphogenetic protein 4 and osteogenic devices and pharmaceutical products containing thereof
WO2006125866A1 (fr) 2005-05-27 2006-11-30 Bbs-Bioactive Bone Substitutes Oy Proteine morphogenetique d'os 3 et dispositifs osteogeniques et produits pharmaceutiques les contenant
WO2006130690A2 (fr) 2005-06-01 2006-12-07 Joslin Diabetes Center, Inc. Methodes et compositions permettant d'induire l'adipogenese brune
GB0604964D0 (en) * 2006-03-11 2006-04-19 Renovo Ltd Protein folding
GB0604938D0 (en) 2006-03-11 2006-04-19 Renovo Ltd Proteins, nucleic acids and medicaments
GB0604966D0 (en) 2006-03-11 2006-04-19 Renovo Ltd Medicaments and proteins
WO2007139972A2 (fr) * 2006-05-25 2007-12-06 Wyeth Expression de la cystéine protéase légumaïne dans des maladies vasculaires et inflammatoires
CA2668771C (fr) * 2006-11-08 2016-03-15 Wyeth Milieux concus rationnellement pour une culture cellulaire
AU2007339280B2 (en) 2006-12-21 2013-12-05 Stryker Corporation Sustained-release formulations comprising crystals, macromolecular gels, and particulate suspensions of biologic agents
CL2008000883A1 (es) * 2007-03-28 2008-10-03 Wyeth6 3 Metodo de deteccion de compuestos capaces de antagonizar la senalizacion de il-17f/il-17a; compuesto identificado por dicho metodo; uso de una cantidad de un antagonista de senalizacion de il-17f/il-17a, composicion farmaceutica que comprende dicho a
TW200902708A (en) * 2007-04-23 2009-01-16 Wyeth Corp Methods of protein production using anti-senescence compounds
EP2019117A1 (fr) * 2007-07-27 2009-01-28 BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH Procédé de purification optimisé de la protéine recombinante du facteur de croissance
US20090042253A1 (en) * 2007-08-09 2009-02-12 Wyeth Use of perfusion to enhance production of fed-batch cell culture in bioreactors
WO2010051360A1 (fr) * 2008-10-31 2010-05-06 Wyeth Llc Purification de protéines acides à l’aide d’une chromatographie sur hydroxyapatite en céramique
JP5819733B2 (ja) 2009-02-12 2015-11-24 ストライカー コーポレイションＳｔｒｙｋｅｒ Ｃｏｒｐｏｒａｔｉｏｎ 障害および疾患に対する全身治療のためのＴＧＦ−βスーパーファミリーメンバー含有タンパク質の末梢投与
AU2010213591B2 (en) 2009-02-12 2013-11-21 Stryker Corporation Compositions and methods for minimally-invasive systemic delivery of proteins including TGF-beta superfamily members
US20120148539A1 (en) 2009-03-24 2012-06-14 Moulay Hicham Alaoui-Ismaili Methods and Compositions for Tissue Engineering
WO2011031856A1 (fr) 2009-09-09 2011-03-17 Stryker Corporation Bmp-7 à utiliser dans le traitement de la douleur induite par les lésions et les maladies d'articulation
ES2387379T3 (es) 2009-09-17 2012-09-21 Stryker Corporation Tampones para controlar el pH de las proteínas morfogenéticas óseas
WO2011087768A1 (fr) 2009-12-22 2011-07-21 Stryker Corporation Variants de la bmp-7 dotés d'une immunogénicité réduite
KR20190005239A (ko) * 2016-05-31 2019-01-15 재단법인 목암생명과학연구소 Tgf-베타 슈퍼패밀리의 ab6 패밀리 디자이너 리간드를 포함하는 간질환 치료용 조성물 및 그의 이용
US11512126B2 (en) 2016-05-31 2022-11-29 Mogam Institute For Biomedicak Research AB6 family designer ligands of TGF-β superfamily
WO2017209523A1 (fr) * 2016-05-31 2017-12-07 Mogam Institute For Biomedical Research Composition comprenant un ligand de conception de la famille ab6 de la super-famille des tgf-bêta pour le traitement de maladies osseuses et cartilagineuses et son utilisation
EP4126919A1 (fr) * 2020-03-24 2023-02-08 Bio-Techne Corporation Méthodes d'utilisation d'une lignée cellulaire knock-out tgf-bêta et compositions obtenues à partir de celle-ci

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR79124B (fr) * 1982-12-22 1984-10-02 Genentech Inc
US5106748A (en) * 1986-07-01 1992-04-21 Genetics Institute, Inc. Dna sequences encoding 5 proteins
ZA874681B (en) * 1986-07-01 1988-04-27 Genetics Inst Novel osteoinductive factors
US5187076A (en) * 1986-07-01 1993-02-16 Genetics Institute, Inc. DNA sequences encoding BMP-6 proteins
US5013649A (en) * 1986-07-01 1991-05-07 Genetics Institute, Inc. DNA sequences encoding osteoinductive products
GB8927546D0 (en) * 1989-12-06 1990-02-07 Ciba Geigy Process for the production of biologically active tgf-beta
ES2168091T3 (es) * 1990-05-16 2002-06-01 Genetics Inst Proteinas de induccion osea y cartilaginosa.
WO1992015323A1 (fr) * 1991-03-11 1992-09-17 Creative Biomolecules, Inc. Morphogenese induite par des proteines
KR100255415B1 (ko) * 1991-06-25 2000-05-01 브루스 엠. 에이센 비엠피-9 조성물
DE69233022T2 (de) * 1991-11-04 2004-02-12 Genetics Institute, LLC, Cambridge Rekombinante knochenmorphogenetische protein heterodimere, zusammensetzungen und verfahren zur verwendung

Also Published As

Publication number Publication date
KR100361058B1 (ko) 2003-04-10
DE69427093D1 (de) 2001-05-17
JP3704350B2 (ja) 2005-10-12
AU1209395A (en) 1995-06-27
FI962349A (fi) 1996-07-16
NO317800B1 (no) 2004-12-13
ES2157313T3 (es) 2001-08-16
JPH09506259A (ja) 1997-06-24
DK0733108T3 (da) 2001-06-18
AU682238B2 (en) 1997-09-25
DE69427093T2 (de) 2001-11-15
GR3035769T3 (en) 2001-07-31
NO962303D0 (no) 1996-06-04
ATE200515T1 (de) 2001-04-15
CA2176943A1 (fr) 1995-06-15
EP0733108A1 (fr) 1996-09-25
PT733108E (pt) 2001-08-30
KR960706558A (ko) 1996-12-09
US5804416A (en) 1998-09-08
WO1995016034A1 (fr) 1995-06-15
US5399677A (en) 1995-03-21
CA2176943C (fr) 2007-04-03
OA10294A (en) 1997-10-07
NO962303L (no) 1996-06-04
FI962349A0 (fi) 1996-06-06
EP0733108B1 (fr) 2001-04-11
US5756308A (en) 1998-05-26

Similar Documents

Publication Publication Date Title
FI118428B (fi) BMP-mutantteja koodaavat yhdistelmä-DNA-molekyylit sekä menetelmät BMP-mutanttien ja niitä käsittävien farmaseuttisten valmisteiden valmistamiseksi
FI119816B (fi) Eristetyt DNA-sekvenssit, jotka koodaavat jänteen/nivelsiteen kaltaisen kudoksen muodostumista indusoivaa BMP-12- tai BMP-13-proteiinia, sekä niiden sovellukset
CA2055963C (fr) Facteur de croissance chimerique de fibroblastes
Fox et al. Production, biological activity, and structure of recombinant basic fibroblast growth factor and an analog with cysteine replaced by serine.
US6593106B1 (en) Methods of refolding proteins
AU763470B2 (en) Bone morphogenetic protein (BMP)-17 and BMP-18 compositions
JPH08506247A (ja) 組換えｃｔｌａ４ポリペプチドおよびその製造方法
IL101024A (en) Process for activation of recombinant proteins
JP2002516098A (ja) 新規な骨誘導活性を有する単量体蛋白質およびそれらからなる骨・軟骨疾患の予防および治療薬
HU222830B1 (hu) Eljárás biológiailag aktív dimer TGF-béta protein előállítására
WO2007122975A1 (fr) Mutant de la protéine précurseur du hgf et sa forme activée
EP0496833A1 (fr) CONSTRUCTIONS BIOSYNTHETIQUES DE TGF-$g(b)
CA1339757C (fr) Methode de production bacteriologique de csf-1 humain recombinant biologiquement actif pur
Yuan et al. Optimized expression and refolding of human keratoepithelin in BL21 (DE3)
CA2574929C (fr) Proteine morphogenetique osseuse (bmp)-17 et bmp-18 et compositions
MXPA00003436A (es) Metodo para el repliegue de proteinas mediante el uso de agentes zwitterionicos de bajo peso molecular
MXPA00005709A (en) Bone morphogenetic protein (bmp)-17 and bmp-18 compositions
IE84354B1 (en) Purified, biologically active, bacterially produced recombinant human CSF-1
MXPA99003874A (es) Agonistas del receptor de eritropoyetina circularmente permutados

Legal Events

Date Code Title Description
FG Patent granted

Ref document number: 118428

Country of ref document: FI