FI962349A0 - Luun morfogeneettisten proteiinien mutantit - Google Patents

Luun morfogeneettisten proteiinien mutantit

Info

Publication number
FI962349A0
FI962349A0 FI962349A FI962349A FI962349A0 FI 962349 A0 FI962349 A0 FI 962349A0 FI 962349 A FI962349 A FI 962349A FI 962349 A FI962349 A FI 962349A FI 962349 A0 FI962349 A0 FI 962349A0
Authority
FI
Finland
Prior art keywords
bone morphogenetic
morphogenetic proteins
mutants
bmp
disclosed
Prior art date
Application number
FI962349A
Other languages
English (en)
Swedish (sv)
Other versions
FI962349A (fi
FI118428B (fi
Inventor
Neil M Wolfman
John Mccoy
Original Assignee
Genetics Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Inst filed Critical Genetics Inst
Publication of FI962349A0 publication Critical patent/FI962349A0/fi
Publication of FI962349A publication Critical patent/FI962349A/fi
Application granted granted Critical
Publication of FI118428B publication Critical patent/FI118428B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
FI962349A 1993-12-07 1996-06-06 BMP-mutantteja koodaavat yhdistelmä-DNA-molekyylit sekä menetelmät BMP-mutanttien ja niitä käsittävien farmaseuttisten valmisteiden valmistamiseksi FI118428B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US16387793 1993-12-07
US08/163,877 US5399677A (en) 1993-12-07 1993-12-07 Mutants of bone morphogenetic proteins
PCT/US1994/013181 WO1995016034A1 (en) 1993-12-07 1994-11-15 Mutants of bone morphogenetic proteins
US9413181 1994-11-15

Publications (3)

Publication Number Publication Date
FI962349A0 true FI962349A0 (fi) 1996-06-06
FI962349A FI962349A (fi) 1996-07-16
FI118428B FI118428B (fi) 2007-11-15

Family

ID=22591964

Family Applications (1)

Application Number Title Priority Date Filing Date
FI962349A FI118428B (fi) 1993-12-07 1996-06-06 BMP-mutantteja koodaavat yhdistelmä-DNA-molekyylit sekä menetelmät BMP-mutanttien ja niitä käsittävien farmaseuttisten valmisteiden valmistamiseksi

Country Status (16)

Country Link
US (3) US5399677A (fi)
EP (1) EP0733108B1 (fi)
JP (1) JP3704350B2 (fi)
KR (1) KR100361058B1 (fi)
AT (1) ATE200515T1 (fi)
AU (1) AU682238B2 (fi)
CA (1) CA2176943C (fi)
DE (1) DE69427093T2 (fi)
DK (1) DK0733108T3 (fi)
ES (1) ES2157313T3 (fi)
FI (1) FI118428B (fi)
GR (1) GR3035769T3 (fi)
NO (1) NO317800B1 (fi)
OA (1) OA10294A (fi)
PT (1) PT733108E (fi)
WO (1) WO1995016034A1 (fi)

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BR9608019A (pt) 1995-04-19 1999-11-30 Hoechst Japan Uma nova proteína e um processo para a preparação da mesma'
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US6048964A (en) * 1995-12-12 2000-04-11 Stryker Corporation Compositions and therapeutic methods using morphogenic proteins and stimulatory factors
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US6677432B1 (en) 1998-10-07 2004-01-13 Stryker Corporation Mutations of the C-terminal portion of TGF-β superfamily proteins
JP3762222B2 (ja) 1998-10-07 2006-04-05 ストライカー・コーポレーション 改変型ＴＧＦ−βスーパーファミリータンパク質
US6846906B1 (en) 1998-10-07 2005-01-25 Stryker Corporation Modified proteins of the TGF-β superfamily, including morphogenic proteins
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DE10026713A1 (de) * 2000-05-30 2001-12-06 Walter Sebald Mutein einer Kette eines Proteins aus der Superfamilie des Wachstumsfaktors TGF-beta
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TWI267378B (en) * 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
FI117667B (fi) * 2001-07-05 2007-01-15 Univ Zuerich Farmaseuttinen koostumus, joka soveltuu käytettäväksi ortopediassa ja hammaslääketieteessä
NZ536478A (en) * 2002-05-17 2008-02-29 Wyeth Corp Injectable or implantable solid, rod- shaped compositions for intraosseous delivery of osteogenic proteins
US20040023322A1 (en) * 2002-08-01 2004-02-05 Goodheart Clyde R. Method of producing non-recombinant BMP-2 and use thereof
US20060194279A1 (en) * 2003-07-09 2006-08-31 Fujio Mizukami Protein-refolding material
PT1675608E (pt) * 2003-09-12 2007-05-31 Etex Corp Barras sólidas e pastas de fosfato de cálcio injectável para a libertação de proteínas osteogénicas.
EP1677735B1 (en) 2003-10-17 2014-07-23 Joslin Diabetes Center, Inc. Methods and compositions for modulating adipocyte function
US20070066525A1 (en) * 2004-02-04 2007-03-22 Lee John C Compositions and therapeutic methods using morphogenic proteins
JP2008501042A (ja) * 2004-05-19 2008-01-17 ワイス 免疫グロブリン産生の調節とアトピー性疾患
KR20070057789A (ko) * 2004-08-05 2007-06-07 와이어쓰 인터루킨-21 수용체 활성의 상쇄
AU2006214384A1 (en) * 2005-02-14 2006-08-24 University Of Pittsburgh Of The Commonwealth System Of Higher Education Use of IL-17F in diagnosis and therapy of airway inflammation
AU2006214473A1 (en) * 2005-02-14 2006-08-24 Wyeth Interleukin-17F antibodies and other IL-17F signaling antagonists and uses therefor
WO2006105359A2 (en) * 2005-03-30 2006-10-05 Wyeth Methods for stimulating hair growth by administering bmps
GT200600148A (es) 2005-04-14 2006-11-22 Metodos para el tratamiento y la prevencion de fibrosis
WO2006125868A1 (en) 2005-05-27 2006-11-30 Bbs-Bioactive Bone Substitutes Oy Bone morphogenetic proteins containing a heparin binding site and osteogenic devices and pharmaceutical products containing thereof
US7807627B2 (en) 2005-05-27 2010-10-05 Bbs-Bioactive Bone Substitutes Oy Bone morphogenetic protein 4 and osteogenic devices and pharmaceutical products containing thereof
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TW200902708A (en) * 2007-04-23 2009-01-16 Wyeth Corp Methods of protein production using anti-senescence compounds
EP2019117A1 (en) * 2007-07-27 2009-01-28 BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH Optimized purification process of recombinant growth factor protein
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JP5819733B2 (ja) 2009-02-12 2015-11-24 ストライカー コーポレイションＳｔｒｙｋｅｒ Ｃｏｒｐｏｒａｔｉｏｎ 障害および疾患に対する全身治療のためのＴＧＦ−βスーパーファミリーメンバー含有タンパク質の末梢投与
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Also Published As

Publication number Publication date
KR100361058B1 (ko) 2003-04-10
DE69427093D1 (de) 2001-05-17
JP3704350B2 (ja) 2005-10-12
AU1209395A (en) 1995-06-27
FI962349A (fi) 1996-07-16
NO317800B1 (no) 2004-12-13
ES2157313T3 (es) 2001-08-16
JPH09506259A (ja) 1997-06-24
DK0733108T3 (da) 2001-06-18
AU682238B2 (en) 1997-09-25
DE69427093T2 (de) 2001-11-15
GR3035769T3 (en) 2001-07-31
NO962303D0 (no) 1996-06-04
ATE200515T1 (de) 2001-04-15
CA2176943A1 (en) 1995-06-15
EP0733108A1 (en) 1996-09-25
PT733108E (pt) 2001-08-30
KR960706558A (ko) 1996-12-09
US5804416A (en) 1998-09-08
WO1995016034A1 (en) 1995-06-15
US5399677A (en) 1995-03-21
CA2176943C (en) 2007-04-03
OA10294A (en) 1997-10-07
FI118428B (fi) 2007-11-15
NO962303L (no) 1996-06-04
EP0733108B1 (en) 2001-04-11
US5756308A (en) 1998-05-26

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