DE69427093T2 - Mutanten von knochen-morphogeneseproteinen - Google Patents

Mutanten von knochen-morphogeneseproteinen

Info

Publication number
DE69427093T2
DE69427093T2 DE69427093T DE69427093T DE69427093T2 DE 69427093 T2 DE69427093 T2 DE 69427093T2 DE 69427093 T DE69427093 T DE 69427093T DE 69427093 T DE69427093 T DE 69427093T DE 69427093 T2 DE69427093 T2 DE 69427093T2
Authority
DE
Germany
Prior art keywords
mutants
bmp
bone morphogenesis
disclosed
morphogenesis proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69427093T
Other languages
English (en)
Other versions
DE69427093D1 (de
Inventor
M Wolfman
John Mccoy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genetics Institute LLC
Original Assignee
Genetics Institute LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genetics Institute LLC filed Critical Genetics Institute LLC
Publication of DE69427093D1 publication Critical patent/DE69427093D1/de
Application granted granted Critical
Publication of DE69427093T2 publication Critical patent/DE69427093T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
DE69427093T 1993-12-07 1994-11-15 Mutanten von knochen-morphogeneseproteinen Expired - Lifetime DE69427093T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/163,877 US5399677A (en) 1993-12-07 1993-12-07 Mutants of bone morphogenetic proteins
PCT/US1994/013181 WO1995016034A1 (en) 1993-12-07 1994-11-15 Mutants of bone morphogenetic proteins

Publications (2)

Publication Number Publication Date
DE69427093D1 DE69427093D1 (de) 2001-05-17
DE69427093T2 true DE69427093T2 (de) 2001-11-15

Family

ID=22591964

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69427093T Expired - Lifetime DE69427093T2 (de) 1993-12-07 1994-11-15 Mutanten von knochen-morphogeneseproteinen

Country Status (16)

Country Link
US (3) US5399677A (de)
EP (1) EP0733108B1 (de)
JP (1) JP3704350B2 (de)
KR (1) KR100361058B1 (de)
AT (1) ATE200515T1 (de)
AU (1) AU682238B2 (de)
CA (1) CA2176943C (de)
DE (1) DE69427093T2 (de)
DK (1) DK0733108T3 (de)
ES (1) ES2157313T3 (de)
FI (1) FI118428B (de)
GR (1) GR3035769T3 (de)
NO (1) NO317800B1 (de)
OA (1) OA10294A (de)
PT (1) PT733108E (de)
WO (1) WO1995016034A1 (de)

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DE19944626A1 (de) * 1999-09-17 2001-03-22 Knoell Hans Forschung Ev Verfahren zur Herstellung von dimeren, biologisch aktiven knochenmorphogenetischen Proteinen
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DE10026713A1 (de) * 2000-05-30 2001-12-06 Walter Sebald Mutein einer Kette eines Proteins aus der Superfamilie des Wachstumsfaktors TGF-beta
US20030082233A1 (en) * 2000-12-01 2003-05-01 Lyons Karen M. Method and composition for modulating bone growth
ATE393573T1 (de) * 2001-06-01 2008-05-15 Wyeth Corp Zusammensetzungen für die systemische verabreichung von sequenzen, die für knochenmorphogenese-proteinen kodieren
TWI267378B (en) * 2001-06-08 2006-12-01 Wyeth Corp Calcium phosphate delivery vehicles for osteoinductive proteins
FI117667B (fi) * 2001-07-05 2007-01-15 Univ Zuerich Farmaseuttinen koostumus, joka soveltuu käytettäväksi ortopediassa ja hammaslääketieteessä
TW200638946A (en) * 2002-05-17 2006-11-16 Wyeth Corp Injectable solid hyaluronic acid carriers for delivery of osteogenic proteins
US20040023322A1 (en) * 2002-08-01 2004-02-05 Goodheart Clyde R. Method of producing non-recombinant BMP-2 and use thereof
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EP1677735B1 (de) 2003-10-17 2014-07-23 Joslin Diabetes Center, Inc. Verfahren und zusammensetzungen zur modulierung der adipozyten-funktion
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AU2006230434A1 (en) * 2005-03-30 2006-10-05 Wyeth Methods for stimulating hair growth by administering BMPs
GT200600148A (es) 2005-04-14 2006-11-22 Metodos para el tratamiento y la prevencion de fibrosis
WO2006125868A1 (en) 2005-05-27 2006-11-30 Bbs-Bioactive Bone Substitutes Oy Bone morphogenetic proteins containing a heparin binding site and osteogenic devices and pharmaceutical products containing thereof
EP1885749B1 (de) 2005-05-27 2017-08-23 BBS-Bioactive Bone Substitutes Oy Knochenmorphogenetisches protein 3 und osteogene vorrichtungen und pharmazeutische produkte, die dieses enthalten
US7807627B2 (en) 2005-05-27 2010-10-05 Bbs-Bioactive Bone Substitutes Oy Bone morphogenetic protein 4 and osteogenic devices and pharmaceutical products containing thereof
US20100150885A1 (en) 2005-06-01 2010-06-17 Joslin Diabetes Center, Inc. Methods and compositions for inducing brown adipogenesis
GB0604964D0 (en) 2006-03-11 2006-04-19 Renovo Ltd Protein folding
GB0604938D0 (en) 2006-03-11 2006-04-19 Renovo Ltd Proteins, nucleic acids and medicaments
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US20070274987A1 (en) * 2006-05-25 2007-11-29 Valerie Clerin Expression of the cysteine protease legumain in vascular and inflammatory diseases
KR101523782B1 (ko) * 2006-11-08 2015-05-28 와이어쓰 엘엘씨 세포 배양을 위한 합리적으로 설계된 배지
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TW200902708A (en) * 2007-04-23 2009-01-16 Wyeth Corp Methods of protein production using anti-senescence compounds
EP2019117A1 (de) * 2007-07-27 2009-01-28 BIOPHARM GESELLSCHAFT ZUR BIOTECHNOLOGISCHEN ENTWICKLUNG VON PHARMAKA mbH Optimiertes Reinigungsverfahren für rekombinantes Wachstumsfaktorprotein
EP3327132A3 (de) 2007-08-09 2018-07-18 Wyeth LLC Verwendung von perfusion zur erhöhung der produktion von fed-batch-zellkulturen in bioreaktoren
ES2699434T3 (es) * 2008-10-31 2019-02-11 Wyeth Llc Purificación de proteínas ácidas utilizando cromatografía de hidroxiapatita cerámica
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US20120148539A1 (en) 2009-03-24 2012-06-14 Moulay Hicham Alaoui-Ismaili Methods and Compositions for Tissue Engineering
WO2011031856A1 (en) 2009-09-09 2011-03-17 Stryker Corporation Bmp -7 for use in treating pain induced by injuries and diseases of an articular joint
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JP2013514811A (ja) 2009-12-22 2013-05-02 ストライカー コーポレイション 免疫原性が抑制されたｂｍｐ−７変異体
KR102404717B1 (ko) 2016-05-31 2022-05-31 재단법인 목암생명과학연구소 Tgf-베타 슈퍼패밀리의 ab6 패밀리 디자이너 리간드
KR20190005239A (ko) * 2016-05-31 2019-01-15 재단법인 목암생명과학연구소 Tgf-베타 슈퍼패밀리의 ab6 패밀리 디자이너 리간드를 포함하는 간질환 치료용 조성물 및 그의 이용
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Also Published As

Publication number Publication date
AU682238B2 (en) 1997-09-25
DK0733108T3 (da) 2001-06-18
KR100361058B1 (ko) 2003-04-10
JP3704350B2 (ja) 2005-10-12
ES2157313T3 (es) 2001-08-16
OA10294A (en) 1997-10-07
PT733108E (pt) 2001-08-30
CA2176943A1 (en) 1995-06-15
ATE200515T1 (de) 2001-04-15
US5756308A (en) 1998-05-26
FI962349A0 (fi) 1996-06-06
KR960706558A (ko) 1996-12-09
FI962349A (fi) 1996-07-16
DE69427093D1 (de) 2001-05-17
JPH09506259A (ja) 1997-06-24
US5804416A (en) 1998-09-08
NO317800B1 (no) 2004-12-13
EP0733108A1 (de) 1996-09-25
CA2176943C (en) 2007-04-03
EP0733108B1 (de) 2001-04-11
WO1995016034A1 (en) 1995-06-15
AU1209395A (en) 1995-06-27
US5399677A (en) 1995-03-21
NO962303L (no) 1996-06-04
FI118428B (fi) 2007-11-15
GR3035769T3 (en) 2001-07-31
NO962303D0 (no) 1996-06-04

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Legal Events

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Owner name: GENETICS INSTITUTE, LLC, CAMBRIDGE, MASS., US