FI117940B - Menetelmä ihmisen kudosplasminogeeniaktivaattorinmuunnelman (t-PA-muunnelman) valmistamiseksi - Google Patents

Menetelmä ihmisen kudosplasminogeeniaktivaattorinmuunnelman (t-PA-muunnelman) valmistamiseksi Download PDF

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Publication number
FI117940B
FI117940B FI943632A FI943632A FI117940B FI 117940 B FI117940 B FI 117940B FI 943632 A FI943632 A FI 943632A FI 943632 A FI943632 A FI 943632A FI 117940 B FI117940 B FI 117940B
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FI
Finland
Prior art keywords
variant
amino acid
human
wild
acid sequence
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Application number
FI943632A
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English (en)
Finnish (fi)
Swedish (sv)
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FI943632A (fi
FI943632A0 (fi
Inventor
William F Bennett
Bruce Alan Keyt
Nicholas F Paoni
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Genentech Inc
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Publication of FI943632A0 publication Critical patent/FI943632A0/fi
Publication of FI943632A publication Critical patent/FI943632A/fi
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Publication of FI117940B publication Critical patent/FI117940B/fi

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
FI943632A 1992-06-03 1994-08-04 Menetelmä ihmisen kudosplasminogeeniaktivaattorinmuunnelman (t-PA-muunnelman) valmistamiseksi FI117940B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US89421392A 1992-06-03 1992-06-03
US89421392 1992-06-03
US9305109 1993-05-28
PCT/US1993/005109 WO1993024635A1 (en) 1992-06-03 1993-05-28 Tissue plasminogen activator glycosylation variants with improved therapeutic properties

Publications (3)

Publication Number Publication Date
FI943632A0 FI943632A0 (fi) 1994-08-04
FI943632A FI943632A (fi) 1994-10-04
FI117940B true FI117940B (fi) 2007-04-30

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Family Applications (1)

Application Number Title Priority Date Filing Date
FI943632A FI117940B (fi) 1992-06-03 1994-08-04 Menetelmä ihmisen kudosplasminogeeniaktivaattorinmuunnelman (t-PA-muunnelman) valmistamiseksi

Country Status (20)

Country Link
US (1) US5612029A (et)
EP (2) EP0643772B1 (et)
JP (1) JP3559559B2 (et)
AT (2) ATE246000T1 (et)
AU (1) AU664469B2 (et)
CA (1) CA2129660C (et)
DE (3) DE69333127T2 (et)
DK (2) DK0643772T3 (et)
EE (1) EE03128B1 (et)
ES (2) ES2203668T3 (et)
FI (1) FI117940B (et)
GE (1) GEP20012448B (et)
GR (1) GR3024806T3 (et)
HK (2) HK1000449A1 (et)
IL (1) IL105883A (et)
LU (1) LU90800I2 (et)
NL (1) NL300050I2 (et)
NZ (1) NZ253556A (et)
PT (1) PT786257E (et)
WO (1) WO1993024635A1 (et)

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US20130122076A1 (en) * 2011-11-11 2013-05-16 Mathew Gelfand Transdermal Patch Having Ultrasound Transducer for Administering Thrombolytic Reagents to Patients Having a Protein Misfolding Disease
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Also Published As

Publication number Publication date
NL300050I2 (nl) 2001-11-01
GEP20012448B (en) 2001-05-25
EP0643772A1 (en) 1995-03-22
US5612029A (en) 1997-03-18
FI943632A (fi) 1994-10-04
JPH07507448A (ja) 1995-08-24
DE10199044I2 (de) 2006-02-09
NL300050I1 (nl) 2001-10-01
DE69312493D1 (de) 1997-09-04
DE10199044I1 (de) 2002-02-21
ATE246000T1 (de) 2003-08-15
CA2129660A1 (en) 1993-12-09
FI943632A0 (fi) 1994-08-04
IL105883A (en) 2003-04-10
DE69333127D1 (de) 2003-09-04
WO1993024635A1 (en) 1993-12-09
DK0643772T3 (da) 1998-02-02
EP0643772B1 (en) 1997-07-23
AU4397393A (en) 1993-12-30
DE69312493T2 (de) 1998-01-15
HK1001190A1 (en) 1998-05-29
AU664469B2 (en) 1995-11-16
HK1000449A1 (en) 2004-03-05
CA2129660C (en) 2005-06-28
EE03128B1 (et) 1998-10-15
ATE155816T1 (de) 1997-08-15
DE69333127T2 (de) 2004-05-06
ES2107041T3 (es) 1997-11-16
DK0786257T3 (da) 2003-10-06
NZ253556A (en) 1995-11-27
ES2203668T3 (es) 2004-04-16
PT786257E (pt) 2003-12-31
JP3559559B2 (ja) 2004-09-02
LU90800I2 (fr) 2001-10-08
GR3024806T3 (en) 1998-01-30
EP0786257A1 (en) 1997-07-30
EP0786257B1 (en) 2003-07-30
IL105883A0 (en) 1993-10-20

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