HK1000449A1 - Tissue plasminogen activator glycosylation variants with improved therapeutic properties - Google Patents

Tissue plasminogen activator glycosylation variants with improved therapeutic properties

Info

Publication number
HK1000449A1
HK1000449A1 HK97101814A HK97101814A HK1000449A1 HK 1000449 A1 HK1000449 A1 HK 1000449A1 HK 97101814 A HK97101814 A HK 97101814A HK 97101814 A HK97101814 A HK 97101814A HK 1000449 A1 HK1000449 A1 HK 1000449A1
Authority
HK
Hong Kong
Prior art keywords
plasminogen activator
tissue plasminogen
therapeutic properties
improved therapeutic
glycosylation variants
Prior art date
Application number
HK97101814A
Other languages
English (en)
Inventor
William F Bennett
Bruce Alan Keyt
Nicholas F Paoni
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of HK1000449A1 publication Critical patent/HK1000449A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
HK97101814A 1992-06-03 1997-09-23 Tissue plasminogen activator glycosylation variants with improved therapeutic properties HK1000449A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US89421392A 1992-06-03 1992-06-03

Publications (1)

Publication Number Publication Date
HK1000449A1 true HK1000449A1 (en) 2004-03-05

Family

ID=25402765

Family Applications (2)

Application Number Title Priority Date Filing Date
HK97101814A HK1000449A1 (en) 1992-06-03 1997-09-23 Tissue plasminogen activator glycosylation variants with improved therapeutic properties
HK98100124A HK1001190A1 (en) 1992-06-03 1998-01-07 Tissue plasminogen activator glycosylation variants with improved therapeutic properties

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK98100124A HK1001190A1 (en) 1992-06-03 1998-01-07 Tissue plasminogen activator glycosylation variants with improved therapeutic properties

Country Status (20)

Country Link
US (1) US5612029A (et)
EP (2) EP0643772B1 (et)
JP (1) JP3559559B2 (et)
AT (2) ATE246000T1 (et)
AU (1) AU664469B2 (et)
CA (1) CA2129660C (et)
DE (3) DE69333127T2 (et)
DK (2) DK0643772T3 (et)
EE (1) EE03128B1 (et)
ES (2) ES2203668T3 (et)
FI (1) FI117940B (et)
GE (1) GEP20012448B (et)
GR (1) GR3024806T3 (et)
HK (2) HK1000449A1 (et)
IL (1) IL105883A (et)
LU (1) LU90800I2 (et)
NL (1) NL300050I2 (et)
NZ (1) NZ253556A (et)
PT (1) PT786257E (et)
WO (1) WO1993024635A1 (et)

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EP2289542A1 (en) 2009-08-31 2011-03-02 PAION Deutschland GmbH Treatment of neurological or neurodegenerative disorders
US20130122076A1 (en) * 2011-11-11 2013-05-16 Mathew Gelfand Transdermal Patch Having Ultrasound Transducer for Administering Thrombolytic Reagents to Patients Having a Protein Misfolding Disease
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WO2014089327A1 (en) 2012-12-05 2014-06-12 National Jewish Health Treatment for airway cast obstruction
CN103159860B (zh) * 2013-04-07 2014-09-24 旭华（上海）生物研发中心有限公司 重组组织型纤溶酶原激活剂及其制备方法与用途
US10220008B2 (en) 2013-08-14 2019-03-05 Stc.Unm Treatment and prevention of stroke and other neurological disorders
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JP2020520386A (ja) 2017-05-16 2020-07-09 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 急性虚血性脳卒中の処置のための方法及び医薬組成物
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WO2021148439A1 (en) 2020-01-21 2021-07-29 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for stimulating cerebrovascular function
US20240207190A1 (en) 2020-06-09 2024-06-27 INSERM (Institut National de la Santé et de la Recherche Médicale) Fucoidan-functionalized polysaccharide particles with t-pa for targeted thrombolytic therapy
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Also Published As

Publication number Publication date
FI117940B (fi) 2007-04-30
NL300050I2 (nl) 2001-11-01
GEP20012448B (en) 2001-05-25
EP0643772A1 (en) 1995-03-22
US5612029A (en) 1997-03-18
FI943632A (fi) 1994-10-04
JPH07507448A (ja) 1995-08-24
DE10199044I2 (de) 2006-02-09
NL300050I1 (nl) 2001-10-01
DE69312493D1 (de) 1997-09-04
DE10199044I1 (de) 2002-02-21
ATE246000T1 (de) 2003-08-15
CA2129660A1 (en) 1993-12-09
FI943632A0 (fi) 1994-08-04
IL105883A (en) 2003-04-10
DE69333127D1 (de) 2003-09-04
WO1993024635A1 (en) 1993-12-09
DK0643772T3 (da) 1998-02-02
EP0643772B1 (en) 1997-07-23
AU4397393A (en) 1993-12-30
DE69312493T2 (de) 1998-01-15
HK1001190A1 (en) 1998-05-29
AU664469B2 (en) 1995-11-16
CA2129660C (en) 2005-06-28
EE03128B1 (et) 1998-10-15
ATE155816T1 (de) 1997-08-15
DE69333127T2 (de) 2004-05-06
ES2107041T3 (es) 1997-11-16
DK0786257T3 (da) 2003-10-06
NZ253556A (en) 1995-11-27
ES2203668T3 (es) 2004-04-16
PT786257E (pt) 2003-12-31
JP3559559B2 (ja) 2004-09-02
LU90800I2 (fr) 2001-10-08
GR3024806T3 (en) 1998-01-30
EP0786257A1 (en) 1997-07-30
EP0786257B1 (en) 2003-07-30
IL105883A0 (en) 1993-10-20

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