FI117124B - Biohajoavista kopolymeereistä koostuvia mikrohiukkasvalmisteita - Google Patents
Biohajoavista kopolymeereistä koostuvia mikrohiukkasvalmisteita Download PDFInfo
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- FI117124B FI117124B FI951379A FI951379A FI117124B FI 117124 B FI117124 B FI 117124B FI 951379 A FI951379 A FI 951379A FI 951379 A FI951379 A FI 951379A FI 117124 B FI117124 B FI 117124B
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- microcapsules according
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- microcapsules
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- 238000009472 formulation Methods 0.000 description 1
- 238000004108 freeze drying Methods 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 229910052595 hematite Inorganic materials 0.000 description 1
- 239000011019 hematite Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 102000006495 integrins Human genes 0.000 description 1
- 108010044426 integrins Proteins 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- LIKBJVNGSGBSGK-UHFFFAOYSA-N iron(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[Fe+3].[Fe+3] LIKBJVNGSGBSGK-UHFFFAOYSA-N 0.000 description 1
- 229910052743 krypton Inorganic materials 0.000 description 1
- DNNSSWSSYDEUBZ-UHFFFAOYSA-N krypton atom Chemical compound [Kr] DNNSSWSSYDEUBZ-UHFFFAOYSA-N 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 230000005291 magnetic effect Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 238000002493 microarray Methods 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 239000012778 molding material Substances 0.000 description 1
- 150000002763 monocarboxylic acids Chemical class 0.000 description 1
- 210000001616 monocyte Anatomy 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 210000000865 mononuclear phagocyte system Anatomy 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- ZMPMYPQIIMYNGA-UHFFFAOYSA-N n'-(2-aminoethyl)ethane-1,2-diamine;dihydrochloride Chemical compound Cl.Cl.NCCNCCN ZMPMYPQIIMYNGA-UHFFFAOYSA-N 0.000 description 1
- FODKGEZSOSELEJ-UHFFFAOYSA-N n-ethyl-n'-(2-methylbutan-2-yl)methanediimine;hydrochloride Chemical compound Cl.CCN=C=NC(C)(C)CC FODKGEZSOSELEJ-UHFFFAOYSA-N 0.000 description 1
- 125000005487 naphthalate group Chemical group 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- RPQRDASANLAFCM-UHFFFAOYSA-N oxiran-2-ylmethyl prop-2-enoate Chemical compound C=CC(=O)OCC1CO1 RPQRDASANLAFCM-UHFFFAOYSA-N 0.000 description 1
- 230000000242 pagocytic effect Effects 0.000 description 1
- 210000000496 pancreas Anatomy 0.000 description 1
- 239000000813 peptide hormone Substances 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 229920000771 poly (alkylcyanoacrylate) Polymers 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 239000004626 polylactic acid Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- SQGOMFWCSGKGEP-UHFFFAOYSA-N propan-2-yl 2-cyanoprop-2-enoate Chemical compound CC(C)OC(=O)C(=C)C#N SQGOMFWCSGKGEP-UHFFFAOYSA-N 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000008347 soybean phospholipid Substances 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
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- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000012581 transferrin Substances 0.000 description 1
- 238000012285 ultrasound imaging Methods 0.000 description 1
- 238000009281 ultraviolet germicidal irradiation Methods 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/226—Solutes, emulsions, suspensions, dispersions, semi-solid forms, e.g. hydrogels
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acoustics & Sound (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Chemical & Material Sciences (AREA)
- Dispersion Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Polyesters Or Polycarbonates (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4232755 | 1992-09-26 | ||
DE4232755A DE4232755A1 (de) | 1992-09-26 | 1992-09-26 | Mikropartikelpräparationen aus biologisch abbaubaren Mischpolymeren |
PCT/EP1993/002422 WO1994007539A1 (de) | 1992-09-26 | 1993-09-08 | Mikropartikelpräparationen aus biologisch abbaubaren mischpolymeren |
EP9302422 | 1993-09-08 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI951379A0 FI951379A0 (fi) | 1995-03-23 |
FI951379A FI951379A (fi) | 1995-03-23 |
FI117124B true FI117124B (fi) | 2006-06-30 |
Family
ID=6469216
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI951379A FI117124B (fi) | 1992-09-26 | 1995-03-23 | Biohajoavista kopolymeereistä koostuvia mikrohiukkasvalmisteita |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP0662005B1 (zh) |
JP (1) | JPH08504398A (zh) |
KR (1) | KR100287975B1 (zh) |
CN (1) | CN1078815C (zh) |
AT (1) | ATE165517T1 (zh) |
AU (1) | AU687360B2 (zh) |
CA (1) | CA2145505C (zh) |
DE (2) | DE4232755A1 (zh) |
DK (1) | DK0662005T3 (zh) |
ES (1) | ES2118251T3 (zh) |
FI (1) | FI117124B (zh) |
HU (1) | HU221972B1 (zh) |
IL (1) | IL107108A (zh) |
NO (1) | NO307692B1 (zh) |
NZ (1) | NZ255409A (zh) |
TW (1) | TW394688B (zh) |
WO (1) | WO1994007539A1 (zh) |
ZA (1) | ZA937099B (zh) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5922304A (en) * | 1989-12-22 | 1999-07-13 | Imarx Pharmaceutical Corp. | Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents |
US6333021B1 (en) * | 1994-11-22 | 2001-12-25 | Bracco Research S.A. | Microcapsules, method of making and their use |
EP0727225A3 (en) * | 1995-02-14 | 1997-01-15 | Sonus Pharma Inc | Compositions and methods for directed ultrasonic imaging |
DE19510690A1 (de) * | 1995-03-14 | 1996-09-19 | Schering Ag | Polymere Nano- und/oder Mikropartikel, Verfahren zu deren Herstellung, sowie Verwendung in medizinischen Diagnostik und Therapie |
EP0831932B1 (en) * | 1995-06-07 | 2004-05-06 | Imarx Pharmaceutical Corp. | Novel targeted compositions for diagnostic and therapeutic use |
US5780010A (en) * | 1995-06-08 | 1998-07-14 | Barnes-Jewish Hospital | Method of MRI using avidin-biotin conjugated emulsions as a site specific binding system |
US6821506B2 (en) | 1995-06-08 | 2004-11-23 | Barnes-Jewish Hospital | Site specific binding system, imaging compositions and methods |
US6548046B1 (en) | 1995-06-08 | 2003-04-15 | Barnes-Jewish Hospital | Site specific binding system, imaging compositions and methods |
US5955143A (en) * | 1995-12-21 | 1999-09-21 | Drexel University | Hollow polymer microcapsules and method of producing the same |
US5849727A (en) * | 1996-06-28 | 1998-12-15 | Board Of Regents Of The University Of Nebraska | Compositions and methods for altering the biodistribution of biological agents |
DE69735354T2 (de) | 1996-10-28 | 2006-11-30 | Amersham Health As | Verbesserungen an oder in verbindung mit diagnostischen/therapeutischen verbindungen |
WO1998018498A2 (en) * | 1996-10-28 | 1998-05-07 | Marsden, John, Christopher | Improvements in or relating to diagnostic/therapeutic agents |
US6261537B1 (en) | 1996-10-28 | 2001-07-17 | Nycomed Imaging As | Diagnostic/therapeutic agents having microbubbles coupled to one or more vectors |
US6331289B1 (en) | 1996-10-28 | 2001-12-18 | Nycomed Imaging As | Targeted diagnostic/therapeutic agents having more than one different vectors |
US20010003580A1 (en) | 1998-01-14 | 2001-06-14 | Poh K. Hui | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
DE19925311B4 (de) * | 1999-05-27 | 2004-06-09 | Schering Ag | Mehrstufen-Verfahren zur Herstellung von gasgefüllten Mikrokapseln |
US7220401B2 (en) | 1999-09-24 | 2007-05-22 | Barnes-Jewish Hospital | Blood clot-targeted nanoparticles |
DE10013850A1 (de) * | 2000-03-15 | 2001-09-20 | Schering Ag | Gasgefüllte Mikrokapseln enthaltend funktionalisiertes Polyalkylcyanacrylat, sowie Verfahren zu deren Herstellung |
DE10119522A1 (de) * | 2001-04-20 | 2002-12-05 | Innovacell Biotechnologie Gmbh | Herstellung und Anwendung einer Suspensionszusammensetzung mit einem Ultraschall-Kontrastmittel |
US7462366B2 (en) | 2002-03-29 | 2008-12-09 | Boston Scientific Scimed, Inc. | Drug delivery particle |
US7842377B2 (en) | 2003-08-08 | 2010-11-30 | Boston Scientific Scimed, Inc. | Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient |
US8012454B2 (en) | 2002-08-30 | 2011-09-06 | Boston Scientific Scimed, Inc. | Embolization |
US7883490B2 (en) | 2002-10-23 | 2011-02-08 | Boston Scientific Scimed, Inc. | Mixing and delivery of therapeutic compositions |
US7976823B2 (en) | 2003-08-29 | 2011-07-12 | Boston Scientific Scimed, Inc. | Ferromagnetic particles and methods |
US7901770B2 (en) | 2003-11-04 | 2011-03-08 | Boston Scientific Scimed, Inc. | Embolic compositions |
US7736671B2 (en) | 2004-03-02 | 2010-06-15 | Boston Scientific Scimed, Inc. | Embolization |
US8173176B2 (en) | 2004-03-30 | 2012-05-08 | Boston Scientific Scimed, Inc. | Embolization |
US7311861B2 (en) | 2004-06-01 | 2007-12-25 | Boston Scientific Scimed, Inc. | Embolization |
CA2585781A1 (en) | 2004-11-03 | 2006-12-28 | Iris Molecular Diagnostics, Inc. | Homogeneous analyte detection |
PT1815028E (pt) | 2004-11-03 | 2012-01-24 | Iris Molecular Diagnostics Inc | Microbolhas para separação por afinidade |
US7858183B2 (en) | 2005-03-02 | 2010-12-28 | Boston Scientific Scimed, Inc. | Particles |
US7727555B2 (en) | 2005-03-02 | 2010-06-01 | Boston Scientific Scimed, Inc. | Particles |
US7963287B2 (en) | 2005-04-28 | 2011-06-21 | Boston Scientific Scimed, Inc. | Tissue-treatment methods |
US9463426B2 (en) | 2005-06-24 | 2016-10-11 | Boston Scientific Scimed, Inc. | Methods and systems for coating particles |
US7947368B2 (en) | 2005-12-21 | 2011-05-24 | Boston Scientific Scimed, Inc. | Block copolymer particles |
KR100845010B1 (ko) * | 2007-08-29 | 2008-07-08 | 한국생명공학연구원 | Nir/mr 이중모드 분자영상용 고분자 입자 및 그제조방법 |
CN101518780B (zh) * | 2008-12-31 | 2011-09-14 | 广东省生态环境与土壤研究所 | 一种用于植物修复土壤的络合剂微胶囊及其制备方法 |
EP2474327A1 (en) * | 2011-01-07 | 2012-07-11 | RWTH Aachen | Microdosing of ultrasound contrast agents |
EP4247537A4 (en) * | 2020-11-20 | 2024-10-23 | Encapsys Llc | BIODEGRADABLE CONTROLLED RELEASE MICROCAPSULES |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1989006978A1 (en) * | 1988-02-05 | 1989-08-10 | Schering Aktiengesellschaft Berlin Und Bergkamen | Ultrasonic contrast agents, process for producing them and their use as diagnostic and therapeutic agents |
DE4004430A1 (de) * | 1990-02-09 | 1991-08-14 | Schering Ag | Aus polyaldehyden aufgebaute kontrastmittel |
AU636481B2 (en) * | 1990-05-18 | 1993-04-29 | Bracco International B.V. | Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography |
GB9106686D0 (en) * | 1991-03-28 | 1991-05-15 | Hafslund Nycomed As | Improvements in or relating to contrast agents |
-
1992
- 1992-09-26 DE DE4232755A patent/DE4232755A1/de not_active Ceased
-
1993
- 1993-09-08 EP EP93919293A patent/EP0662005B1/de not_active Expired - Lifetime
- 1993-09-08 JP JP6508620A patent/JPH08504398A/ja not_active Ceased
- 1993-09-08 HU HU9500876A patent/HU221972B1/hu not_active IP Right Cessation
- 1993-09-08 DK DK93919293T patent/DK0662005T3/da active
- 1993-09-08 AT AT93919293T patent/ATE165517T1/de not_active IP Right Cessation
- 1993-09-08 KR KR1019950701155A patent/KR100287975B1/ko not_active IP Right Cessation
- 1993-09-08 AU AU49592/93A patent/AU687360B2/en not_active Ceased
- 1993-09-08 WO PCT/EP1993/002422 patent/WO1994007539A1/de active IP Right Grant
- 1993-09-08 NZ NZ255409A patent/NZ255409A/en unknown
- 1993-09-08 DE DE59308479T patent/DE59308479D1/de not_active Expired - Fee Related
- 1993-09-08 ES ES93919293T patent/ES2118251T3/es not_active Expired - Lifetime
- 1993-09-08 CA CA002145505A patent/CA2145505C/en not_active Expired - Fee Related
- 1993-09-24 ZA ZA937099A patent/ZA937099B/xx unknown
- 1993-09-25 CN CN93118159A patent/CN1078815C/zh not_active Expired - Fee Related
- 1993-09-26 IL IL107108A patent/IL107108A/en not_active IP Right Cessation
- 1993-10-04 TW TW082108177A patent/TW394688B/zh not_active IP Right Cessation
-
1995
- 1995-03-23 FI FI951379A patent/FI117124B/fi not_active IP Right Cessation
- 1995-03-24 NO NO951138A patent/NO307692B1/no unknown
Also Published As
Publication number | Publication date |
---|---|
DE59308479D1 (de) | 1998-06-04 |
DK0662005T3 (da) | 1999-02-22 |
FI951379A0 (fi) | 1995-03-23 |
HU221972B1 (hu) | 2003-03-28 |
AU4959293A (en) | 1994-04-26 |
ZA937099B (en) | 1995-03-24 |
KR100287975B1 (ko) | 2001-05-02 |
AU687360B2 (en) | 1998-02-26 |
CA2145505C (en) | 2004-02-17 |
HUT71683A (en) | 1996-01-29 |
KR950703367A (ko) | 1995-09-20 |
CN1089508A (zh) | 1994-07-20 |
EP0662005A1 (de) | 1995-07-12 |
JPH08504398A (ja) | 1996-05-14 |
NO951138L (no) | 1995-03-24 |
NO307692B1 (no) | 2000-05-15 |
CN1078815C (zh) | 2002-02-06 |
DE4232755A1 (de) | 1994-03-31 |
CA2145505A1 (en) | 1994-04-14 |
IL107108A0 (en) | 1993-12-28 |
EP0662005B1 (de) | 1998-04-29 |
ATE165517T1 (de) | 1998-05-15 |
ES2118251T3 (es) | 1998-09-16 |
HU9500876D0 (en) | 1995-05-29 |
IL107108A (en) | 1998-01-04 |
NZ255409A (en) | 1997-02-24 |
NO951138D0 (no) | 1995-03-24 |
WO1994007539A1 (de) | 1994-04-14 |
TW394688B (en) | 2000-06-21 |
FI951379A (fi) | 1995-03-23 |
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