KR950703367A - 생분해성 공중합체로 제조된 미립자 제제(Micropartide Preparations Made from Biodegradable Copolymers) - Google Patents
생분해성 공중합체로 제조된 미립자 제제(Micropartide Preparations Made from Biodegradable Copolymers) Download PDFInfo
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- KR950703367A KR950703367A KR1019950701155A KR19950701155A KR950703367A KR 950703367 A KR950703367 A KR 950703367A KR 1019950701155 A KR1019950701155 A KR 1019950701155A KR 19950701155 A KR19950701155 A KR 19950701155A KR 950703367 A KR950703367 A KR 950703367A
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- 238000002360 preparation method Methods 0.000 title claims abstract 4
- 229920001577 copolymer Polymers 0.000 title claims abstract 3
- 238000000034 method Methods 0.000 claims abstract 4
- 239000011859 microparticle Substances 0.000 claims abstract 2
- 239000003094 microcapsule Substances 0.000 claims 13
- 229920001222 biopolymer Polymers 0.000 claims 9
- 239000000463 material Substances 0.000 claims 8
- 239000002775 capsule Substances 0.000 claims 4
- 125000000524 functional group Chemical group 0.000 claims 4
- 239000007789 gas Substances 0.000 claims 4
- 229920001059 synthetic polymer Polymers 0.000 claims 4
- 239000004480 active ingredient Substances 0.000 claims 3
- 239000002872 contrast media Substances 0.000 claims 3
- 239000003446 ligand Substances 0.000 claims 3
- 229910021645 metal ion Inorganic materials 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 claims 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims 2
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims 2
- 102000016359 Fibronectins Human genes 0.000 claims 2
- 108010067306 Fibronectins Proteins 0.000 claims 2
- 239000000178 monomer Substances 0.000 claims 2
- 238000006116 polymerization reaction Methods 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- MDNRBNZIOBQHHK-KWBADKCTSA-N (2s)-2-[[(2s)-2-[[2-[[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]-3-carboxypropanoyl]amino]-3-methylbutanoic acid Chemical compound CC(C)[C@@H](C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCN=C(N)N MDNRBNZIOBQHHK-KWBADKCTSA-N 0.000 claims 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 claims 1
- 102000009027 Albumins Human genes 0.000 claims 1
- 108010088751 Albumins Proteins 0.000 claims 1
- 102000004506 Blood Proteins Human genes 0.000 claims 1
- 108010017384 Blood Proteins Proteins 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- 102400001368 Epidermal growth factor Human genes 0.000 claims 1
- 101800003838 Epidermal growth factor Proteins 0.000 claims 1
- 102000008946 Fibrinogen Human genes 0.000 claims 1
- 108010049003 Fibrinogen Proteins 0.000 claims 1
- 229910052688 Gadolinium Inorganic materials 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 1
- 102000004895 Lipoproteins Human genes 0.000 claims 1
- 108090001030 Lipoproteins Proteins 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- 102000015636 Oligopeptides Human genes 0.000 claims 1
- 108010038807 Oligopeptides Proteins 0.000 claims 1
- 108010002885 Polygeline Proteins 0.000 claims 1
- 241000702660 Rice gall dwarf virus Species 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
- 102000011409 Transcobalamins Human genes 0.000 claims 1
- 108010023603 Transcobalamins Proteins 0.000 claims 1
- 102000004338 Transferrin Human genes 0.000 claims 1
- 108090000901 Transferrin Proteins 0.000 claims 1
- HFBMWMNUJJDEQZ-UHFFFAOYSA-N acryloyl chloride Chemical compound ClC(=O)C=C HFBMWMNUJJDEQZ-UHFFFAOYSA-N 0.000 claims 1
- 239000003570 air Substances 0.000 claims 1
- 150000001299 aldehydes Chemical class 0.000 claims 1
- 150000001413 amino acids Chemical group 0.000 claims 1
- 239000008346 aqueous phase Substances 0.000 claims 1
- 229910052786 argon Inorganic materials 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
- 229920002988 biodegradable polymer Polymers 0.000 claims 1
- 239000004621 biodegradable polymer Substances 0.000 claims 1
- 239000001569 carbon dioxide Substances 0.000 claims 1
- 229910002092 carbon dioxide Inorganic materials 0.000 claims 1
- 238000005119 centrifugation Methods 0.000 claims 1
- 239000013522 chelant Substances 0.000 claims 1
- 150000004697 chelate complex Chemical group 0.000 claims 1
- 239000002738 chelating agent Substances 0.000 claims 1
- 230000011382 collagen catabolic process Effects 0.000 claims 1
- 150000004696 coordination complex Chemical class 0.000 claims 1
- 239000007857 degradation product Substances 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 238000000502 dialysis Methods 0.000 claims 1
- 239000006185 dispersion Substances 0.000 claims 1
- 229940116977 epidermal growth factor Drugs 0.000 claims 1
- 229940012952 fibrinogen Drugs 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 239000010419 fine particle Substances 0.000 claims 1
- 238000005188 flotation Methods 0.000 claims 1
- 238000004108 freeze drying Methods 0.000 claims 1
- -1 gadolinium ions Chemical class 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 239000001307 helium Substances 0.000 claims 1
- 229910052734 helium Inorganic materials 0.000 claims 1
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 claims 1
- 229960002897 heparin Drugs 0.000 claims 1
- 229920000669 heparin Polymers 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229910001449 indium ion Inorganic materials 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- 229910052743 krypton Inorganic materials 0.000 claims 1
- DNNSSWSSYDEUBZ-UHFFFAOYSA-N krypton atom Chemical compound [Kr] DNNSSWSSYDEUBZ-UHFFFAOYSA-N 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 239000006249 magnetic particle Substances 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 229910052754 neon Inorganic materials 0.000 claims 1
- GKAOGPIIYCISHV-UHFFFAOYSA-N neon atom Chemical compound [Ne] GKAOGPIIYCISHV-UHFFFAOYSA-N 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 108010014241 oxypolygelatine Proteins 0.000 claims 1
- 230000005298 paramagnetic effect Effects 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 229920000729 poly(L-lysine) polymer Polymers 0.000 claims 1
- 229960004250 polygeline Drugs 0.000 claims 1
- 239000002861 polymer material Substances 0.000 claims 1
- 238000001556 precipitation Methods 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 150000005846 sugar alcohols Polymers 0.000 claims 1
- 239000000375 suspending agent Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 229910052713 technetium Inorganic materials 0.000 claims 1
- GKLVYJBZJHMRIY-UHFFFAOYSA-N technetium atom Chemical compound [Tc] GKLVYJBZJHMRIY-UHFFFAOYSA-N 0.000 claims 1
- 239000012581 transferrin Substances 0.000 claims 1
- 238000002604 ultrasonography Methods 0.000 claims 1
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 239000008215 water for injection Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
- A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
- A61K49/226—Solutes, emulsions, suspensions, dispersions, semi-solid forms, e.g. hydrogels
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- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Radiology & Medical Imaging (AREA)
- Physics & Mathematics (AREA)
- Acoustics & Sound (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dispersion Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Polyesters Or Polycarbonates (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Abstract
본 발명은 진단 치료용, 특히 초음파 진단용 생분해성 공중합체로 제조된 미립자 제재, 및 그의 제조 방법에 관한 것이다.
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (17)
- 캡슐의 벽 재료가 1종 이상의 합성 중합 물질과, a) 위치-특이성, 구조-특이성 또는 조직-특이성을 나타내거나 또는 b) 임의로 킬레이트화 리간드 또는 그의 금속 착화합물 및(또는) 위치-특이성, 구조-특이성 또는 조직-특이성 물질을 결합시키는 관능기를 갖고, 임의로 1종 이상의 제약학상 활성성분을 더 함유하는, 1종 이상의 생중합체로 제조된 공중합체로 이루어지고, 캡슐의 코어가 a) 기체 또는 기체 혼합물 및(또는) b) 제약학상 활성 성분 또는 활성 성분 혼합물 또는 c) 캡슐 벽과 동일한 물질로 이루어지고, 합성 중합체 물질이 증합가능한 알데히드로 제조된 것이 아니고, 합성 중합체에 대한 생중합체의 중량비가 10:90 내지 80:20 범위이고, 캡슐의 크기가 0.5 내지 8㎛인 것을 특징으로 하는, 생분해성 중합체의 진단 및(또는)치료용 미세 캡슐.
- 제1항에 있어서, 합성 중합체가 아크릴산, 아크릴아미드, 아크릴산 클로라이드, 아크릴산 글리시드에스테르 또는 알킬시아노아크릴레이트 단량체로 제조된 것인 미세 캡슐.
- 제1항에 있어서, 생중합체가 임의로 글리코실화 폴리펩티드, 바람직하게는 알부민, 피브리노겐, 피브로넥틴 또는 교원질 분해 생성물, 바람직하게는 젤라틴, 폴리젤린, 옥시폴리젤라틴 또는 폴리-L-리신인 미세 캡슐.
- 제1항에 있어서, 임의로 생중합체의 관능기에 의하여 결합되는 위치-특이성, 구조-특이성 및 조직-특이성 물질이 항체, 공액 항체, 호르몬, 트랜스페린, 피브로넥틴, 헤파린, 트랜스코발라민, 표피 성장 인자, 지방단백질, 혈정 단백질, 펩티드 또는 올리고펩티드이고, 바람직하게는 아미노산 서열 RGD, RGDA, RGDV 또는 RGDT를 함유하는 것인 미세 캡슐.
- 제1항에 있어서, 생중합체가 위치-특이성, 구조-특이성 및 조직-특이성의 폴리펩티드인 미세 캡슐.
- 제1항 내지 제5항중 어느 한 항에 있어서, 벽 재료가 기체, 바람직하게는 공기, 질소, 이산화탄소, 산소, 헬륨, 네온, 아르곤, 크립론 또는 2종 이상의 이들 기체의 혼합물을 함유하는 것인 초음파 진단용 미세 캡슐.
- 제1항 내지 제5항중 어느 한 항에 있어서, 생중합체의 관능기에 의해 결합되는 라디칼이 킬레이트화 리간드인 미세 캡슐.
- 제1항 내지 제5항 및 제7항 중 어느 한 항에 있어서, 킬레이트화 리간드로서 에틸렌디아민펜타아세트산 라디칼 또는 그의 유도체를 포함하는 미세 캡슐.
- 제1항 내지 제5항 및 제7항 및 제8항 중 어느 한 항에 있어서, 생중합체의 관능기에 의해 결합되는 라디칼이 금속 이온의 킬레이트 착화합물인 미세 캡슐.
- 제1항 내지 제5항 및 제7항 내지 제9항 중 어느 한 항에 있어서, 착화합물 결합 금속 이온이 상자성 이온, 바람직하게는 가도리늄 이온인 미세 캡슐.
- NMR 진단에 사용되기 위한 제9항 또는 제10항에 따른 미세 캡슐.
- 제1항 내지 제5항 및 제7항 내지 제9항 중 어느 한 항에 있어서, 착화합물 결합 금속 이온이 방사성 동위원소, 바람직하게는99m테크네튬 또는111인듐 이온인 미세 캡슐.
- 신티그래피에 사용되기 위한 제12항에 따른 미세 캡슐.
- 단량체를 제조 용액의 총 부피에 대해 0.01 내지 10%(m/V), 바람직하게는 0.1 내지 10%의 농도로, 0.5 내지 20%(m/V), 바람직하게는 1 내지 15%(m/V)의 농도로 용해된 생중합체 및 임의로 또한 자성 입자를 함유하는, 기체-포화된, 임의로 압열 멸균된 수상 분산액과 합성 중합체에 대한 생중합체의 중량비가 10:90 내지 80:20이라는 조건하에, 중합 반응시키고, 중합 반응을 완결한 후, 생성된 미립자를 원심분리법, 여과법, 침전법 또는 부유법을 1회 또는 수회 반복하여 밀도와 입자 크기에 따라 분리하고, 임의로 투석에 의해 더 정제하고, 생리 적합성 현탁제로 현탁시킨 다음, 임의로 킬레이트화제, 금속 킬레이트 및(또는) 위치-특이성, 구조-특이성 또는 조직-특이성 물질과 반응시키고, 이 현탁액을 바람직하게는 골격 형성제를 첨가하여 동결-건조시키는 것으로 이루어진 제1항에 따른 미세캡슐의 제조 방법.
- 제1항에 따른 미립자를 제약상 허용되는 현탁 매질에 재현탁시킨 조영 매질.
- 제15항에 있어서, 제약상 허용되는 현탁 매질로서, 임의로 식염, 글루코스, 만니톨 및(또는) 락토스 및 임의로 또한 다가 알콜을 더 함유하는 주사용 물이 사용된 조영 매질.
- 최종의 동결-건조 단계를 거치지 않고, 제14항에 기재한 방법에 따라 제조할 수 있는 조영 매질.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4232755A DE4232755A1 (de) | 1992-09-26 | 1992-09-26 | Mikropartikelpräparationen aus biologisch abbaubaren Mischpolymeren |
| DEP4232755.5 | 1992-09-26 | ||
| PCT/EP1993/002422 WO1994007539A1 (de) | 1992-09-26 | 1993-09-08 | Mikropartikelpräparationen aus biologisch abbaubaren mischpolymeren |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR950703367A true KR950703367A (ko) | 1995-09-20 |
| KR100287975B1 KR100287975B1 (ko) | 2001-05-02 |
Family
ID=6469216
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019950701155A KR100287975B1 (ko) | 1992-09-26 | 1993-09-08 | 생분해성 공중합체로 제조된 미립자 제제 |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0662005B1 (ko) |
| JP (1) | JPH08504398A (ko) |
| KR (1) | KR100287975B1 (ko) |
| CN (1) | CN1078815C (ko) |
| AT (1) | ATE165517T1 (ko) |
| AU (1) | AU687360B2 (ko) |
| CA (1) | CA2145505C (ko) |
| DE (2) | DE4232755A1 (ko) |
| DK (1) | DK0662005T3 (ko) |
| ES (1) | ES2118251T3 (ko) |
| FI (1) | FI117124B (ko) |
| HU (1) | HU221972B1 (ko) |
| IL (1) | IL107108A (ko) |
| NO (1) | NO307692B1 (ko) |
| NZ (1) | NZ255409A (ko) |
| TW (1) | TW394688B (ko) |
| WO (1) | WO1994007539A1 (ko) |
| ZA (1) | ZA937099B (ko) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100845010B1 (ko) * | 2007-08-29 | 2008-07-08 | 한국생명공학연구원 | Ｎｉｒ／ｍｒ 이중모드 분자영상용 고분자 입자 및 그제조방법 |
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| US5922304A (en) * | 1989-12-22 | 1999-07-13 | Imarx Pharmaceutical Corp. | Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents |
| US6333021B1 (en) * | 1994-11-22 | 2001-12-25 | Bracco Research S.A. | Microcapsules, method of making and their use |
| EP0727225A3 (en) * | 1995-02-14 | 1997-01-15 | Sonus Pharma Inc | Compositions and methods for directed ultrasonic imaging |
| DE19510690A1 (de) * | 1995-03-14 | 1996-09-19 | Schering Ag | Polymere Nano- und/oder Mikropartikel, Verfahren zu deren Herstellung, sowie Verwendung in medizinischen Diagnostik und Therapie |
| ATE265863T1 (de) * | 1995-06-07 | 2004-05-15 | Imarx Pharmaceutical Corp | Neue zielgerichtete mittel zur diagnostischen und therapeutischen verwendung |
| US6548046B1 (en) | 1995-06-08 | 2003-04-15 | Barnes-Jewish Hospital | Site specific binding system, imaging compositions and methods |
| US6821506B2 (en) | 1995-06-08 | 2004-11-23 | Barnes-Jewish Hospital | Site specific binding system, imaging compositions and methods |
| US5780010A (en) * | 1995-06-08 | 1998-07-14 | Barnes-Jewish Hospital | Method of MRI using avidin-biotin conjugated emulsions as a site specific binding system |
| WO1997022409A1 (en) * | 1995-12-21 | 1997-06-26 | Drexel University | Hollow polymer microcapsules and method of producing |
| US5849727A (en) * | 1996-06-28 | 1998-12-15 | Board Of Regents Of The University Of Nebraska | Compositions and methods for altering the biodistribution of biological agents |
| US6331289B1 (en) | 1996-10-28 | 2001-12-18 | Nycomed Imaging As | Targeted diagnostic/therapeutic agents having more than one different vectors |
| EP0963209A2 (en) * | 1996-10-28 | 1999-12-15 | Marsden, John Christopher | Improvements in or relating to diagnostic/therapeutic agents |
| KR20000052829A (ko) | 1996-10-28 | 2000-08-25 | 조오지 디빈센조, 토브 아스 헬지, 에바 요한손 | 진단/치료제 또는 그와 관련된 개선 |
| US6261537B1 (en) | 1996-10-28 | 2001-07-17 | Nycomed Imaging As | Diagnostic/therapeutic agents having microbubbles coupled to one or more vectors |
| US20010003580A1 (en) | 1998-01-14 | 2001-06-14 | Poh K. Hui | Preparation of a lipid blend and a phospholipid suspension containing the lipid blend |
| DE19925311B4 (de) * | 1999-05-27 | 2004-06-09 | Schering Ag | Mehrstufen-Verfahren zur Herstellung von gasgefüllten Mikrokapseln |
| US7220401B2 (en) | 1999-09-24 | 2007-05-22 | Barnes-Jewish Hospital | Blood clot-targeted nanoparticles |
| DE10013850A1 (de) * | 2000-03-15 | 2001-09-20 | Schering Ag | Gasgefüllte Mikrokapseln enthaltend funktionalisiertes Polyalkylcyanacrylat, sowie Verfahren zu deren Herstellung |
| DE10119522A1 (de) * | 2001-04-20 | 2002-12-05 | Innovacell Biotechnologie Gmbh | Herstellung und Anwendung einer Suspensionszusammensetzung mit einem Ultraschall-Kontrastmittel |
| US7462366B2 (en) | 2002-03-29 | 2008-12-09 | Boston Scientific Scimed, Inc. | Drug delivery particle |
| US7842377B2 (en) | 2003-08-08 | 2010-11-30 | Boston Scientific Scimed, Inc. | Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient |
| US8012454B2 (en) | 2002-08-30 | 2011-09-06 | Boston Scientific Scimed, Inc. | Embolization |
| US7883490B2 (en) | 2002-10-23 | 2011-02-08 | Boston Scientific Scimed, Inc. | Mixing and delivery of therapeutic compositions |
| US7976823B2 (en) | 2003-08-29 | 2011-07-12 | Boston Scientific Scimed, Inc. | Ferromagnetic particles and methods |
| US7901770B2 (en) | 2003-11-04 | 2011-03-08 | Boston Scientific Scimed, Inc. | Embolic compositions |
| US7736671B2 (en) | 2004-03-02 | 2010-06-15 | Boston Scientific Scimed, Inc. | Embolization |
| US8173176B2 (en) | 2004-03-30 | 2012-05-08 | Boston Scientific Scimed, Inc. | Embolization |
| US7311861B2 (en) | 2004-06-01 | 2007-12-25 | Boston Scientific Scimed, Inc. | Embolization |
| ATE530666T1 (de) | 2004-11-03 | 2011-11-15 | Iris Molecular Diagnostics Inc | Mikrobläschen zur affinitätstrennung |
| WO2006137932A2 (en) | 2004-11-03 | 2006-12-28 | Leucadia Technologies, Inc. | Homogeneous analyte detection |
| US7858183B2 (en) | 2005-03-02 | 2010-12-28 | Boston Scientific Scimed, Inc. | Particles |
| US7727555B2 (en) | 2005-03-02 | 2010-06-01 | Boston Scientific Scimed, Inc. | Particles |
| US7963287B2 (en) | 2005-04-28 | 2011-06-21 | Boston Scientific Scimed, Inc. | Tissue-treatment methods |
| US9463426B2 (en) | 2005-06-24 | 2016-10-11 | Boston Scientific Scimed, Inc. | Methods and systems for coating particles |
| US7947368B2 (en) | 2005-12-21 | 2011-05-24 | Boston Scientific Scimed, Inc. | Block copolymer particles |
| CN101518780B (zh) * | 2008-12-31 | 2011-09-14 | 广东省生态环境与土壤研究所 | 一种用于植物修复土壤的络合剂微胶囊及其制备方法 |
| EP2474327A1 (en) * | 2011-01-07 | 2012-07-11 | RWTH Aachen | Microdosing of ultrasound contrast agents |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2068917T3 (es) * | 1988-02-05 | 1995-05-01 | Schering Ag | Medios de contraste por ultrasonido, procedimiento para su obtencion y utilizacion de los mismos como productos de diagnostico y terapeuticos. |
| DE4004430A1 (de) * | 1990-02-09 | 1991-08-14 | Schering Ag | Aus polyaldehyden aufgebaute kontrastmittel |
| AU636481B2 (en) * | 1990-05-18 | 1993-04-29 | Bracco International B.V. | Polymeric gas or air filled microballoons usable as suspensions in liquid carriers for ultrasonic echography |
| GB9106686D0 (en) * | 1991-03-28 | 1991-05-15 | Hafslund Nycomed As | Improvements in or relating to contrast agents |
-
1992
- 1992-09-26 DE DE4232755A patent/DE4232755A1/de not_active Ceased
-
1993
- 1993-09-08 WO PCT/EP1993/002422 patent/WO1994007539A1/de active IP Right Grant
- 1993-09-08 KR KR1019950701155A patent/KR100287975B1/ko not_active IP Right Cessation
- 1993-09-08 AT AT93919293T patent/ATE165517T1/de not_active IP Right Cessation
- 1993-09-08 CA CA002145505A patent/CA2145505C/en not_active Expired - Fee Related
- 1993-09-08 DK DK93919293T patent/DK0662005T3/da active
- 1993-09-08 JP JP6508620A patent/JPH08504398A/ja not_active Ceased
- 1993-09-08 HU HU9500876A patent/HU221972B1/hu not_active IP Right Cessation
- 1993-09-08 NZ NZ255409A patent/NZ255409A/en unknown
- 1993-09-08 ES ES93919293T patent/ES2118251T3/es not_active Expired - Lifetime
- 1993-09-08 AU AU49592/93A patent/AU687360B2/en not_active Ceased
- 1993-09-08 EP EP93919293A patent/EP0662005B1/de not_active Expired - Lifetime
- 1993-09-08 DE DE59308479T patent/DE59308479D1/de not_active Expired - Fee Related
- 1993-09-24 ZA ZA937099A patent/ZA937099B/xx unknown
- 1993-09-25 CN CN93118159A patent/CN1078815C/zh not_active Expired - Fee Related
- 1993-09-26 IL IL107108A patent/IL107108A/en not_active IP Right Cessation
- 1993-10-04 TW TW082108177A patent/TW394688B/zh not_active IP Right Cessation
-
1995
- 1995-03-23 FI FI951379A patent/FI117124B/fi not_active IP Right Cessation
- 1995-03-24 NO NO951138A patent/NO307692B1/no unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100845010B1 (ko) * | 2007-08-29 | 2008-07-08 | 한국생명공학연구원 | Ｎｉｒ／ｍｒ 이중모드 분자영상용 고분자 입자 및 그제조방법 |
Also Published As
| Publication number | Publication date |
|---|---|
| IL107108A0 (en) | 1993-12-28 |
| DE59308479D1 (de) | 1998-06-04 |
| NO951138L (no) | 1995-03-24 |
| TW394688B (en) | 2000-06-21 |
| ATE165517T1 (de) | 1998-05-15 |
| FI117124B (fi) | 2006-06-30 |
| IL107108A (en) | 1998-01-04 |
| CN1089508A (zh) | 1994-07-20 |
| NZ255409A (en) | 1997-02-24 |
| HU9500876D0 (en) | 1995-05-29 |
| WO1994007539A1 (de) | 1994-04-14 |
| ES2118251T3 (es) | 1998-09-16 |
| NO307692B1 (no) | 2000-05-15 |
| KR100287975B1 (ko) | 2001-05-02 |
| CA2145505A1 (en) | 1994-04-14 |
| HU221972B1 (hu) | 2003-03-28 |
| AU687360B2 (en) | 1998-02-26 |
| AU4959293A (en) | 1994-04-26 |
| EP0662005B1 (de) | 1998-04-29 |
| HUT71683A (en) | 1996-01-29 |
| JPH08504398A (ja) | 1996-05-14 |
| FI951379A (fi) | 1995-03-23 |
| EP0662005A1 (de) | 1995-07-12 |
| DK0662005T3 (da) | 1999-02-22 |
| ZA937099B (en) | 1995-03-24 |
| NO951138D0 (no) | 1995-03-24 |
| FI951379A0 (fi) | 1995-03-23 |
| CN1078815C (zh) | 2002-02-06 |
| DE4232755A1 (de) | 1994-03-31 |
| CA2145505C (en) | 2004-02-17 |
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