FI116055B - Menetelmä terapeuttisesti käyttökelpoisten 9-[(substituoitu glysyyli)amido]-6-demetyyli-6-deoksitetrasykliinien valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisten 9-[(substituoitu glysyyli)amido]-6-demetyyli-6-deoksitetrasykliinien valmistamiseksi Download PDF

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Publication number
FI116055B
FI116055B FI933568A FI933568A FI116055B FI 116055 B FI116055 B FI 116055B FI 933568 A FI933568 A FI 933568A FI 933568 A FI933568 A FI 933568A FI 116055 B FI116055 B FI 116055B
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FI
Finland
Prior art keywords
amino
dimethylamino
group
dioxo
octahydro
Prior art date
Application number
FI933568A
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English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI933568A0 (fi
FI933568A (fi
Inventor
Raymond Thomas Testa
Phaik-Eng Sum
Ving J Lee
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Wyeth Corp
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Publication of FI933568A publication Critical patent/FI933568A/fi
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
    • C07C239/08—Hydroxylamino compounds or their ethers or esters
    • C07C239/18—Hydroxylamino compounds or their ethers or esters having nitrogen atoms of hydroxylamino groups further bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
    • C07C239/08—Hydroxylamino compounds or their ethers or esters
    • C07C239/20—Hydroxylamino compounds or their ethers or esters having oxygen atoms of hydroxylamino groups etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
FI933568A 1992-08-13 1993-08-12 Menetelmä terapeuttisesti käyttökelpoisten 9-[(substituoitu glysyyli)amido]-6-demetyyli-6-deoksitetrasykliinien valmistamiseksi FI116055B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92859092 1992-08-13
US07/928,590 US5442059A (en) 1992-08-13 1992-08-13 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines

Publications (3)

Publication Number Publication Date
FI933568A0 FI933568A0 (fi) 1993-08-12
FI933568A FI933568A (fi) 1994-02-14
FI116055B true FI116055B (fi) 2005-09-15

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
FI933568A FI116055B (fi) 1992-08-13 1993-08-12 Menetelmä terapeuttisesti käyttökelpoisten 9-[(substituoitu glysyyli)amido]-6-demetyyli-6-deoksitetrasykliinien valmistamiseksi

Country Status (28)

Country Link
US (3) US5442059A (ja)
EP (1) EP0582829B1 (ja)
JP (1) JP3633640B2 (ja)
KR (1) KR100309541B1 (ja)
CN (1) CN1033971C (ja)
AT (1) ATE205472T1 (ja)
AU (1) AU680616B2 (ja)
BR (1) BR1100987A (ja)
CA (1) CA2103845C (ja)
CZ (1) CZ288174B6 (ja)
DE (1) DE69330733T2 (ja)
DK (1) DK0582829T3 (ja)
ES (1) ES2161220T3 (ja)
FI (1) FI116055B (ja)
HK (1) HK1009960A1 (ja)
HU (3) HU212265B (ja)
IL (3) IL106672A (ja)
MX (1) MX9304756A (ja)
NO (1) NO304884B1 (ja)
NZ (1) NZ248342A (ja)
PH (1) PH30006A (ja)
PL (3) PL174108B1 (ja)
PT (1) PT582829E (ja)
RU (1) RU2123999C1 (ja)
SG (1) SG52326A1 (ja)
SK (1) SK281974B6 (ja)
TW (1) TW269678B (ja)
ZA (1) ZA935890B (ja)

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Also Published As

Publication number Publication date
ZA935890B (en) 1994-03-11
CZ157493A3 (en) 1994-03-16
BR1100987A (pt) 1999-12-07
MX9304756A (es) 1994-02-28
PL174073B1 (pl) 1998-06-30
RU2123999C1 (ru) 1998-12-27
KR940003908A (ko) 1994-03-14
HU9302335D0 (en) 1993-10-28
HUT66660A (en) 1994-12-28
AU680616B2 (en) 1997-08-07
DE69330733D1 (de) 2001-10-18
FI933568A0 (fi) 1993-08-12
HUT71594A (en) 1996-01-29
SK281974B6 (sk) 2001-09-11
AU4461193A (en) 1994-02-17
ES2161220T3 (es) 2001-12-01
DE69330733T2 (de) 2002-07-04
PL300068A1 (en) 1994-02-21
PT582829E (pt) 2002-01-30
NZ248342A (en) 1995-07-26
HU215445B (hu) 2000-12-28
SG52326A1 (en) 1998-09-28
HU211501A9 (en) 1995-11-28
ATE205472T1 (de) 2001-09-15
EP0582829A1 (en) 1994-02-16
SK84893A3 (en) 1994-06-08
CN1033971C (zh) 1997-02-05
EP0582829B1 (en) 2001-09-12
FI933568A (fi) 1994-02-14
US5567692A (en) 1996-10-22
HU212265B (en) 1996-04-29
CZ288174B6 (en) 2001-05-16
DK0582829T3 (da) 2001-10-15
IL119698A0 (en) 1997-02-18
HU9401974D0 (en) 1994-09-28
IL106672A0 (en) 1993-12-08
JP3633640B2 (ja) 2005-03-30
IL106672A (en) 1998-02-22
CA2103845C (en) 2005-05-17
PL174108B1 (pl) 1998-06-30
TW269678B (ja) 1996-02-01
PL173448B1 (pl) 1998-03-31
CA2103845A1 (en) 1994-02-14
NO932873D0 (no) 1993-08-12
NO932873L (no) 1994-02-14
JPH06199758A (ja) 1994-07-19
US5495030A (en) 1996-02-27
KR100309541B1 (ko) 2002-08-31
NO304884B1 (no) 1999-03-01
IL119698A (en) 1998-09-24
CN1087899A (zh) 1994-06-15
PH30006A (en) 1996-10-29
HK1009960A1 (en) 1999-06-11
US5442059A (en) 1995-08-15

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