FI115444B - Nytt förfarande för att framställa ett läkemedel - Google Patents

Nytt förfarande för att framställa ett läkemedel Download PDF

Info

Publication number
FI115444B
FI115444B FI961221A FI961221A FI115444B FI 115444 B FI115444 B FI 115444B FI 961221 A FI961221 A FI 961221A FI 961221 A FI961221 A FI 961221A FI 115444 B FI115444 B FI 115444B
Authority
FI
Finland
Prior art keywords
progesterone
att
levels
polymer
serum
Prior art date
Application number
FI961221A
Other languages
English (en)
Finnish (fi)
Other versions
FI961221A0 (sv
FI961221A (sv
Inventor
William Joseph Bologna
Howard Leslie Levine
Original Assignee
Columbia Lab Bermuda Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22402302&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI115444(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Columbia Lab Bermuda Ltd filed Critical Columbia Lab Bermuda Ltd
Publication of FI961221A0 publication Critical patent/FI961221A0/sv
Publication of FI961221A publication Critical patent/FI961221A/sv
Application granted granted Critical
Publication of FI115444B publication Critical patent/FI115444B/sv

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Gynecology & Obstetrics (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
FI961221A 1993-09-15 1996-03-15 Nytt förfarande för att framställa ett läkemedel FI115444B (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US12237193 1993-09-15
US08/122,371 US5543150A (en) 1993-09-15 1993-09-15 Method of progesterone delivery and affect thereof
US9410270 1994-09-13
PCT/US1994/010270 WO1995007699A1 (en) 1993-09-15 1994-09-13 Novel method of progesterone delivery and affect thereof

Publications (3)

Publication Number Publication Date
FI961221A0 FI961221A0 (sv) 1996-03-15
FI961221A FI961221A (sv) 1996-05-14
FI115444B true FI115444B (sv) 2005-05-13

Family

ID=22402302

Family Applications (1)

Application Number Title Priority Date Filing Date
FI961221A FI115444B (sv) 1993-09-15 1996-03-15 Nytt förfarande för att framställa ett läkemedel

Country Status (27)

Country Link
US (1) US5543150A (sv)
EP (1) EP0719146B1 (sv)
JP (1) JP3143474B2 (sv)
KR (1) KR100278553B1 (sv)
AT (1) ATE174796T1 (sv)
BR (1) BR9407475A (sv)
CA (1) CA2171939C (sv)
CO (1) CO4290332A1 (sv)
DE (1) DE69415543T2 (sv)
DK (1) DK0719146T3 (sv)
ES (1) ES2126783T3 (sv)
FI (1) FI115444B (sv)
GR (1) GR3029314T3 (sv)
HU (1) HU221583B (sv)
IL (1) IL110972A (sv)
LT (1) LT4072B (sv)
LV (1) LV11527B (sv)
MA (1) MA23329A1 (sv)
MY (1) MY111484A (sv)
NO (1) NO308585B1 (sv)
NZ (1) NZ273816A (sv)
PE (1) PE50795A1 (sv)
PH (1) PH30813A (sv)
RU (1) RU2148393C1 (sv)
UA (1) UA37244C2 (sv)
WO (1) WO1995007699A1 (sv)
ZA (1) ZA947073B (sv)

Families Citing this family (73)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5869081A (en) * 1996-06-28 1999-02-09 The Population Council Progesterone vaginal ring for treatment of infertility
US5985861A (en) * 1996-11-04 1999-11-16 Columbia Laboratories, Inc. Progesterone for treating or reducing ischemia
US6056972A (en) * 1997-02-26 2000-05-02 Dimera, Llc Method for reducing coronary artery reactivity
US6602487B1 (en) 1997-02-26 2003-08-05 Dimera Incorporated Methods and tests for producing and for inhibiting coronary artery vasospasms
US20040234606A1 (en) * 1997-09-12 2004-11-25 Levine Howard L. Localized vaginal delivery without detrimental blood levels
EP1356806A1 (en) * 1997-09-12 2003-10-29 Columbia Laboratories (Bermuda) Limited A pharmaceutical composition for treating dysmenorrhea and premature labor
US8765177B2 (en) * 1997-09-12 2014-07-01 Columbia Laboratories, Inc. Bioadhesive progressive hydration tablets
DE69819748T2 (de) * 1997-09-12 2004-09-30 Columbia Laboratories (Bermuda) Ltd. Arzneimittel zur behandlung von dysmenorrhöe und verfrühten wehen
US6248358B1 (en) * 1998-08-25 2001-06-19 Columbia Laboratories, Inc. Bioadhesive progressive hydration tablets and methods of making and using the same
US7153845B2 (en) * 1998-08-25 2006-12-26 Columbia Laboratories, Inc. Bioadhesive progressive hydration tablets
JP2001519381A (ja) * 1997-10-10 2001-10-23 インペリアル・カレッジ・イノベイションズ・リミテッド 子宮収縮管理のためのｃｓａｉｄｔｍ化合物の使用
US6306914B1 (en) * 1997-10-21 2001-10-23 Columbia Laboratories, Inc. Progestin therapy for maintaining amenorrhea
AU4406899A (en) * 1998-05-20 1999-12-06 Bent Formby Progesterone treatment of cancer
US20070178139A1 (en) * 1998-11-18 2007-08-02 Yankov Vladimir I Vaginally administratable progesterone-containing tablets and method for preparing same
IL127129A (en) 1998-11-18 2004-06-01 Ferring Bv Method for preparation of progesterone tablets for vaginal delivery and tablets so prepared
US6479045B2 (en) 1999-12-22 2002-11-12 Columbia Laboratories, Inc. Vaginal pH buffering for preventing miscarriage and premature labor, by treating or preventing bacterial vaginosis
US6544553B1 (en) 1999-12-28 2003-04-08 Watson Pharmaceuticals, Inc. Dosage forms and methods for oral delivery of progesterone
GB0001449D0 (en) * 2000-01-21 2000-03-08 Cortendo Ab Compositions
GB0009914D0 (en) 2000-04-20 2000-06-07 Metris Therapeutics Limited Device
EP1363600B1 (en) * 2001-02-15 2008-10-01 Access Pharmaceuticals, Inc. Liquid formulations for the prevention and treatment of mucosal diseases and disorders
US7544348B2 (en) * 2001-02-15 2009-06-09 Access Pharmaceuticals, Inc. Liquid formulations for the prevention and treatment of mucosal diseases and disorders
US20060073174A1 (en) * 2001-08-16 2006-04-06 Access Pharmaceuticals, Inc. Adherent and erodible film to treat a moist surface of a body tissue
US6585997B2 (en) 2001-08-16 2003-07-01 Access Pharmaceuticals, Inc. Mucoadhesive erodible drug delivery device for controlled administration of pharmaceuticals and other active compounds
US20080182841A1 (en) * 2001-10-29 2008-07-31 Levine Howard L Vaginally administered anti-dysrhythmic agents for treating pelvic pain
US20030114394A1 (en) * 2001-10-29 2003-06-19 Levine Howard L. Vaginally administered anti-dysrhythmic agents for treating pelvic pain
US7709026B2 (en) 2001-10-29 2010-05-04 Columbia Laboratories, Inc. Low concentration of peroxide for treating or preventing vaginal infections
US8425892B2 (en) 2001-10-29 2013-04-23 Columbia Laboratories, Inc. Extended, controlled-release pharmaceutical compositions using charged polymers
US7572780B2 (en) 2003-01-21 2009-08-11 Dimera, Incorporated Method and kit for reducing the symptoms of peripheral vascular disease
EP1620060B1 (en) * 2003-04-29 2010-03-24 The General Hospital Corporation Methods and devices for the sustained release of multiple drugs
ES2237298B1 (es) * 2003-07-16 2006-11-01 Italfarmaco, S.A. Formulaciones mucoadhesivas semisolidas.
KR101285137B1 (ko) 2003-09-03 2013-07-11 미스콘 트레이딩 에스.에이. 자궁 내막증의 치료 방법
UA90095C2 (en) * 2003-09-03 2010-04-12 Мискон Трейдинг С.А. Method for the treatment of endometriosis
CA2612456C (en) * 2005-06-16 2017-06-06 Warner Chilcott Company, Inc. Gel compositions for topical administration
CA2612380C (en) * 2005-06-16 2017-06-06 Warner Chilcott Company, Inc. Estrogen compositions for vaginal administration
KR20090029237A (ko) * 2006-06-02 2009-03-20 피어 트리 파머슈티칼스 인코포레이티드 위축성 질염을 치료하는 방법
US8828981B2 (en) 2007-02-06 2014-09-09 George Creasy Progesterone for the treatment or prevention of spontaneous preterm birth
ES2310968B1 (es) 2007-06-25 2010-02-08 Italfarmaco, S.A. Uso de estriol en bajas dosis.
US8003621B2 (en) * 2007-09-14 2011-08-23 Nitto Denko Corporation Drug carriers
GB0723882D0 (en) * 2007-12-07 2008-01-23 Univ Leicester Methods for the detection of a threatened miscarriage
KR20100133969A (ko) * 2008-02-04 2010-12-22 테바 위민즈 헬스 인코포레이티드 프로게스테론 함유 단일형 질내 링 및 그의 제조방법과 용도
US9107696B2 (en) 2008-08-06 2015-08-18 Emory University Method of embryo transfer that eliminates transferred air while hormonally inducing implantation and apparatus
ES2344673B1 (es) 2008-08-07 2011-05-03 Italfarmaco, S.A. Uso de estriol en la preparacion de una formulacion farmaceutica parael tratamiento de atrofia vaginal en mujeres con riesgo de potologiatumoral.
US8421747B2 (en) 2008-09-24 2013-04-16 Microsoft Corporation Object detection and user settings
ES2344675B1 (es) 2008-12-19 2011-04-28 Italfarmaco, S.A. Uso de estriol en la preparacion de una formulacion farrmaceutica para el tratamiento de atrofia vaginal en mujeres con riesgo de patologiacardiovascular.
MY164622A (en) * 2010-03-22 2018-01-30 Repros Therapeutics Inc Compositions and methods for non-toxic delivery of antiprogestins
US9375437B2 (en) 2010-06-18 2016-06-28 Lipocine Inc. Progesterone containing oral dosage forms and kits
US8435972B2 (en) 2010-09-02 2013-05-07 Emory University Method for the treatment of central nervous system cancers and compositions related thereto
WO2013010915A1 (en) * 2011-07-15 2013-01-24 Universiteit Gent Intravaginal delivery system
US8951996B2 (en) 2011-07-28 2015-02-10 Lipocine Inc. 17-hydroxyprogesterone ester-containing oral compositions and related methods
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
BR112014012444B1 (pt) 2011-11-23 2021-12-14 Therapeuticsmd, Inc Composição farmacêutica compreendendo estradiol solubilizado, progesterona e um agente de solubilização, bem como usos desta para tratar um sintoma relacionado à menopausa em uma mulher
BR112014018439A8 (pt) * 2012-01-26 2017-07-11 Therapeuticsmd Inc Terapias de reposição de hormônio transdérmica
NZ702467A (en) 2012-05-31 2016-07-29 Repros Therapeutics Inc Formulations and methods for vaginal delivery of antiprogestins
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
CA2888377C (en) 2012-11-02 2021-02-02 Repros Therapeutics Inc. Methods and compositions for treating progesterone-dependent conditions
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
CN103239389A (zh) * 2013-06-03 2013-08-14 南京泽恒医药技术开发有限公司 一种治疗先兆性流产的黄体酮缓释凝胶的制备方法
AU2015264003A1 (en) 2014-05-22 2016-11-17 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
MX2016013693A (es) 2014-07-29 2017-10-31 Therapeuticsmd Inc Crema transdermica.
EP3310359A4 (en) 2015-06-22 2019-04-03 Lipocine Inc. ORAL COMPOSITIONS CONTAINING 17-HYDROXYPROGESTERONE ESTER AND METHODS RELATING THERETO
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
WO2017173044A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd Inc. Steroid hormone compositions in medium chain oils
BR112018070199A2 (pt) 2016-04-01 2019-01-29 Therapeuticsmd Inc composição farmacêutica de hormônio esteroide
BR112019027366A2 (pt) * 2017-06-22 2020-08-18 Viramal Limited composições para entrega de drogas e métodos de uso
US11633405B2 (en) 2020-02-07 2023-04-25 Therapeuticsmd, Inc. Steroid hormone pharmaceutical formulations

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3588620A (en) * 1969-08-06 1971-06-28 Gen Electric Electrical control device panel assembly with multifunctional insulating support means
DE3486448T2 (de) * 1983-11-14 1997-10-09 Columbia Lab Inc Bioadhäsive Mittel
FR2558373B1 (fr) * 1984-01-20 1987-07-03 Mauvais Jarvis Pierre Medicament antioestrogene a base de 4-hydroxytamoxifene pour administration percutanee
US4916574A (en) * 1989-06-06 1990-04-10 Siemens Energy & Automation, Inc. Panelboard bus bar arrangement
DK0431719T3 (da) * 1989-10-31 1995-02-27 Columbia Lab Inc Vaginalt vævsbefugtende præparat
EP0599888A1 (de) * 1991-08-05 1994-06-08 Trawöger, Werner Mittel gegen beläge an benetzten oberflächen
TWI354439B (en) 2007-06-04 2011-12-11 Holtek Semiconductor Inc Ac signal producer and method thereof
US7862282B2 (en) 2008-07-24 2011-01-04 Autoliv Asp, Inc. Separation fastener with segmented washer

Also Published As

Publication number Publication date
NO308585B1 (no) 2000-10-02
AU7726194A (en) 1995-04-03
RU2148393C1 (ru) 2000-05-10
JP3143474B2 (ja) 2001-03-07
NO961044L (no) 1996-05-14
WO1995007699A1 (en) 1995-03-23
NO961044D0 (no) 1996-03-14
JPH09502724A (ja) 1997-03-18
LV11527A (lv) 1996-10-20
CA2171939C (en) 2002-01-01
CO4290332A1 (es) 1996-04-17
IL110972A (en) 1998-03-10
LT4072B (en) 1996-11-25
HU9600669D0 (en) 1996-05-28
EP0719146A1 (en) 1996-07-03
FI961221A0 (sv) 1996-03-15
BR9407475A (pt) 1996-11-12
FI961221A (sv) 1996-05-14
ES2126783T3 (es) 1999-04-01
PH30813A (en) 1997-10-17
IL110972A0 (en) 1994-11-28
MA23329A1 (fr) 1995-04-01
DK0719146T3 (da) 1999-08-23
AU689133B2 (en) 1998-03-26
HUT76824A (en) 1997-11-28
ZA947073B (en) 1995-05-02
EP0719146B1 (en) 1998-12-23
GR3029314T3 (en) 1999-05-28
DE69415543D1 (de) 1999-02-04
ATE174796T1 (de) 1999-01-15
US5543150A (en) 1996-08-06
NZ273816A (en) 2007-09-28
KR100278553B1 (ko) 2001-01-15
UA37244C2 (uk) 2001-05-15
HU221583B (hu) 2002-11-28
LT96027A (en) 1996-07-25
DE69415543T2 (de) 1999-06-17
PE50795A1 (es) 1996-01-19
CA2171939A1 (en) 1995-03-23
LV11527B (en) 1997-02-20
MY111484A (en) 2000-06-30

Similar Documents

Publication Publication Date Title
FI115444B (sv) Nytt förfarande för att framställa ett läkemedel
RU2330667C2 (ru) Прогестинотерапия с регулируемым кровотечением
US4816257A (en) Method for producing an in vivo environment suitable for human embryo transfer
RU2340345C2 (ru) Схема восполнения эстрогена
EP2741824B1 (en) Use of estetrol as emergency contraceptive
RU96108813A (ru) Новый способ доставки прогестерона и его влияние
JPH10510825A (ja) １７β−エストラジオール前駆体の投与のための膣内薬剤送出製剤
HU208487B (en) Process for producing composition for inhibiting human ovulation and for preventinvg mammal cancer
KR20070006543A (ko) 확장된 경피 피임제 투약 계획
WO2020247653A1 (en) Hormonal contraception using a vaginal ring which releases estriol and trimegestone
JP2023508606A (ja) 排卵を誘発し、黄体期支持を提供するプロゲステロン製剤
JP4851057B2 (ja) 萎縮性膣炎の治療のためのエストロゲンを含有する組成物の製造におけるエストロゲンの使用
AU689133C (en) Novel method of progesterone delivery and affect thereof
WEBSTER et al. Induction of abortion in early first trimester human pregnancy using epostane
Davey Hormone replacement therapy
Ng et al. The use of hormonal intrauterine systems in menopausal women
UA79421C2 (en) Progestin therapy with regular menstrual bleeding

Legal Events

Date Code Title Description
GB Transfer or assigment of application

Owner name: COLUMBIA LABORATORIES (BERMUDA) LIMITED

FG Patent granted

Ref document number: 115444

Country of ref document: FI

MA Patent expired