RU96108813A - Новый способ доставки прогестерона и его влияние - Google Patents
Новый способ доставки прогестерона и его влияниеInfo
- Publication number
- RU96108813A RU96108813A RU96108813/14A RU96108813A RU96108813A RU 96108813 A RU96108813 A RU 96108813A RU 96108813/14 A RU96108813/14 A RU 96108813/14A RU 96108813 A RU96108813 A RU 96108813A RU 96108813 A RU96108813 A RU 96108813A
- Authority
- RU
- Russia
- Prior art keywords
- progesterone
- polymer
- use according
- vagina
- cross
- Prior art date
Links
- RJKFOVLPORLFTN-LEKSSAKUSA-N Syngestrets Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 title claims 11
- RJKFOVLPORLFTN-STHVQZNPSA-N Progesterone Natural products O=C(C)[C@@H]1[C@@]2(C)[C@H]([C@H]3[C@@H]([C@]4(C)C(=CC(=O)CC4)CC3)CC2)CC1 RJKFOVLPORLFTN-STHVQZNPSA-N 0.000 claims 10
- 229960003387 progesterone Drugs 0.000 claims 10
- 239000000186 progesterone Substances 0.000 claims 10
- 229920000642 polymer Polymers 0.000 claims 5
- 210000002966 Serum Anatomy 0.000 claims 4
- 210000001215 Vagina Anatomy 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 238000004132 cross linking Methods 0.000 claims 3
- 229940079593 drugs Drugs 0.000 claims 3
- 206010000234 Abortion spontaneous Diseases 0.000 claims 2
- 206010006232 Breast disease Diseases 0.000 claims 2
- 206010013908 Dysfunctional uterine bleeding Diseases 0.000 claims 2
- 206010014733 Endometrial cancer Diseases 0.000 claims 2
- 206010049513 Luteal phase deficiency Diseases 0.000 claims 2
- 206010027514 Metrorrhagia Diseases 0.000 claims 2
- 229950005134 Polycarbophil Drugs 0.000 claims 2
- 229920000148 Polycarbophil calcium Polymers 0.000 claims 2
- 208000000995 Spontaneous Abortion Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 201000006828 endometrial hyperplasia Diseases 0.000 claims 2
- 201000009273 endometriosis Diseases 0.000 claims 2
- 238000009164 estrogen replacement therapy Methods 0.000 claims 2
- 201000011461 pre-eclampsia Diseases 0.000 claims 2
- 230000003248 secreting Effects 0.000 claims 2
- 230000001131 transforming Effects 0.000 claims 2
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims 1
- 206010067647 Delivery Diseases 0.000 claims 1
- 210000004696 Endometrium Anatomy 0.000 claims 1
- 229960005309 Estradiol Drugs 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
Claims (16)
1. Применение поликарбоксиального полимера с поперечными сшивками и прогестерона для производства лекарственного средства, пригодного для поддержания уровня прогестерона в сыворотке приблизительно от 1,0 до 6,0 нг/мл при вагинальной доставке, для лечения или предупреждения клинических нарушений у пациентов женского пола, которые поддаются лечению прогестероном.
2. Применение по п.1, отличающееся тем, что указанные клинические нарушения представляют дефицит лютеальной фазы, дисфункциональное маточное кровотечение, эндометриоз, рак эндометрия, доброкачественное заболевание молочной железы, преэклампсию, самопроизвольный аборт и гиперплазию эндометрия при заместительной терапии эстрогенами.
3. Применение по п.1, отличающееся тем, что указанное клиническое нарушение является нарушением эндометрия.
4. Применение по п.1, отличающееся тем, что указанное лечение включает стимулирование секреторной трансформации влагалища.
5. Применение по любому из пп.1 - 4, отличающееся тем, что указанное лекарственное средство находится в форме дозированной единицы.
6. Применение по п.5, отличающееся тем, что указанное лекарственное средство содержит приблизительно от 10 до 200 мг прогестерона.
7. Применение по любому из пп.1 - 6, отличающееся тем, что указанный полимер представляет собой поликарбофил.
8. Способ доставки прогестерона в организм женщин, включающий введение полимера с поперечными сшивками совместно с прогестероном во влагалище в количестве, достаточном для того, чтобы вызвать секреторную трансформацию влагалища, и в то же время поддерживающем уровни прогестерона в сыворотке ниже 6,0 нг/мл в течение периода времени по меньшей мере в 48 ч.
9. Способ по п.8, отличающийся тем, что количество указанного прогестерона составляет 10 - 200 мг.
10. Способ по п.8 или 9, отличающийся тем, что указанный уровень прогестерона в сыворотке составляет от 1 до 4 нг/мл.
11. Способ по пп.8, 9 или 10, отличающийся тем, что указанный полимер представляет собой поликарбофил.
12. Способ по любому из пп.8 или 9, отличающийся тем, что влагалище предварительно подвергают воздействию эстрадиола.
13. Способ по любому из пп.8 - 12, отличающийся тем, что указанные уровни прогестерона в сыворотке поддерживают на уровне от 1 до 6 нг/мл.
14. Способ по любому из пп.8 - 13, отличающийся тем, что система доставки лекарственного средства дополнительно включает по меньшей мере одно вспомогательное вещество.
15. Способ по любому из пп.8 - 14, отличающийся тем, что поперечные сшивки в полимере обеспечиваются 0,1 - 6,0 весовыми процентами агента, образующего поперечные сшивки.
16. Способ по любому из пп.8 - 15 для лечения дефицита лютеальной фазы, дисфункционального маточного кровотечения, эндометриоза, рака эндометрия, доброкачественного заболевания молочной железы, преэклампсии, самопроизвольного аборта и гиперплазии эндометрия при заместительной терапии эстрогенами.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/122.371 | 1993-09-15 | ||
| US08/122,371 | 1993-09-15 | ||
| US08/122,371 US5543150A (en) | 1993-09-15 | 1993-09-15 | Method of progesterone delivery and affect thereof |
| PCT/US1994/010270 WO1995007699A1 (en) | 1993-09-15 | 1994-09-13 | Novel method of progesterone delivery and affect thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU96108813A true RU96108813A (ru) | 1998-07-10 |
| RU2148393C1 RU2148393C1 (ru) | 2000-05-10 |
Family
ID=22402302
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU96108813A RU2148393C1 (ru) | 1993-09-15 | 1994-09-13 | Новый способ доставки прогестерона и его влияние |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US5543150A (ru) |
| EP (1) | EP0719146B1 (ru) |
| JP (1) | JP3143474B2 (ru) |
| KR (1) | KR100278553B1 (ru) |
| AT (1) | ATE174796T1 (ru) |
| BR (1) | BR9407475A (ru) |
| CA (1) | CA2171939C (ru) |
| CO (1) | CO4290332A1 (ru) |
| DE (1) | DE69415543T2 (ru) |
| DK (1) | DK0719146T3 (ru) |
| ES (1) | ES2126783T3 (ru) |
| FI (1) | FI115444B (ru) |
| GR (1) | GR3029314T3 (ru) |
| HU (1) | HU221583B (ru) |
| IL (1) | IL110972A (ru) |
| LT (1) | LT4072B (ru) |
| LV (1) | LV11527B (ru) |
| MA (1) | MA23329A1 (ru) |
| MY (1) | MY111484A (ru) |
| NO (1) | NO308585B1 (ru) |
| NZ (1) | NZ273816A (ru) |
| PE (1) | PE50795A1 (ru) |
| PH (1) | PH30813A (ru) |
| RU (1) | RU2148393C1 (ru) |
| UA (1) | UA37244C2 (ru) |
| WO (1) | WO1995007699A1 (ru) |
| ZA (1) | ZA947073B (ru) |
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| BR112014018439A8 (pt) * | 2012-01-26 | 2017-07-11 | Therapeuticsmd Inc | Terapias de reposição de hormônio transdérmica |
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| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| CN103239389A (zh) * | 2013-06-03 | 2013-08-14 | 南京泽恒医药技术开发有限公司 | 一种治疗先兆性流产的黄体酮缓释凝胶的制备方法 |
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-
1993
- 1993-09-15 US US08/122,371 patent/US5543150A/en not_active Expired - Lifetime
-
1994
- 1994-09-13 HU HU9600669A patent/HU221583B/hu unknown
- 1994-09-13 DE DE69415543T patent/DE69415543T2/de not_active Expired - Lifetime
- 1994-09-13 AT AT94928089T patent/ATE174796T1/de active
- 1994-09-13 DK DK94928089T patent/DK0719146T3/da active
- 1994-09-13 KR KR1019960701325A patent/KR100278553B1/ko not_active IP Right Cessation
- 1994-09-13 EP EP94928089A patent/EP0719146B1/en not_active Expired - Lifetime
- 1994-09-13 JP JP07509291A patent/JP3143474B2/ja not_active Expired - Lifetime
- 1994-09-13 RU RU96108813A patent/RU2148393C1/ru active
- 1994-09-13 ES ES94928089T patent/ES2126783T3/es not_active Expired - Lifetime
- 1994-09-13 NZ NZ273816A patent/NZ273816A/en not_active IP Right Cessation
- 1994-09-13 UA UA96030993A patent/UA37244C2/ru unknown
- 1994-09-13 BR BR9407475A patent/BR9407475A/pt not_active Application Discontinuation
- 1994-09-13 CA CA002171939A patent/CA2171939C/en not_active Expired - Lifetime
- 1994-09-13 WO PCT/US1994/010270 patent/WO1995007699A1/en active IP Right Grant
- 1994-09-14 ZA ZA947073A patent/ZA947073B/xx unknown
- 1994-09-14 MA MA23649A patent/MA23329A1/fr unknown
- 1994-09-14 IL IL110972A patent/IL110972A/en not_active IP Right Cessation
- 1994-09-14 MY MYPI94002436A patent/MY111484A/en unknown
- 1994-09-15 CO CO94041745A patent/CO4290332A1/es unknown
- 1994-09-15 PH PH49001A patent/PH30813A/en unknown
- 1994-09-15 PE PE1994250745A patent/PE50795A1/es not_active IP Right Cessation
-
1996
- 1996-03-11 LT LT96-027A patent/LT4072B/lt not_active IP Right Cessation
- 1996-03-14 NO NO961044A patent/NO308585B1/no not_active IP Right Cessation
- 1996-03-15 FI FI961221A patent/FI115444B/fi not_active IP Right Cessation
- 1996-04-15 LV LVP-96-113A patent/LV11527B/en unknown
-
1999
- 1999-02-10 GR GR990400400T patent/GR3029314T3/el unknown
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