DE69415543D1 - Neue verfahren zur progesteronabgabe - Google Patents

Neue verfahren zur progesteronabgabe

Info

Publication number
DE69415543D1
DE69415543D1 DE69415543T DE69415543T DE69415543D1 DE 69415543 D1 DE69415543 D1 DE 69415543D1 DE 69415543 T DE69415543 T DE 69415543T DE 69415543 T DE69415543 T DE 69415543T DE 69415543 D1 DE69415543 D1 DE 69415543D1
Authority
DE
Germany
Prior art keywords
progesterone
serum
low levels
delivery procedure
serum progesterone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69415543T
Other languages
English (en)
Other versions
DE69415543T2 (de
Inventor
William Bologna
Howard Levine
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Columbia Laboratories Bermuda Ltd
Original Assignee
Columbia Laboratories Bermuda Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22402302&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69415543(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Columbia Laboratories Bermuda Ltd filed Critical Columbia Laboratories Bermuda Ltd
Publication of DE69415543D1 publication Critical patent/DE69415543D1/de
Application granted granted Critical
Publication of DE69415543T2 publication Critical patent/DE69415543T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Gynecology & Obstetrics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE69415543T 1993-09-15 1994-09-13 Neue verfahren zur progesteronabgabe Expired - Lifetime DE69415543T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/122,371 US5543150A (en) 1993-09-15 1993-09-15 Method of progesterone delivery and affect thereof
PCT/US1994/010270 WO1995007699A1 (en) 1993-09-15 1994-09-13 Novel method of progesterone delivery and affect thereof

Publications (2)

Publication Number Publication Date
DE69415543D1 true DE69415543D1 (de) 1999-02-04
DE69415543T2 DE69415543T2 (de) 1999-06-17

Family

ID=22402302

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69415543T Expired - Lifetime DE69415543T2 (de) 1993-09-15 1994-09-13 Neue verfahren zur progesteronabgabe

Country Status (27)

Country Link
US (1) US5543150A (de)
EP (1) EP0719146B1 (de)
JP (1) JP3143474B2 (de)
KR (1) KR100278553B1 (de)
AT (1) ATE174796T1 (de)
BR (1) BR9407475A (de)
CA (1) CA2171939C (de)
CO (1) CO4290332A1 (de)
DE (1) DE69415543T2 (de)
DK (1) DK0719146T3 (de)
ES (1) ES2126783T3 (de)
FI (1) FI115444B (de)
GR (1) GR3029314T3 (de)
HU (1) HU221583B (de)
IL (1) IL110972A (de)
LT (1) LT4072B (de)
LV (1) LV11527B (de)
MA (1) MA23329A1 (de)
MY (1) MY111484A (de)
NO (1) NO308585B1 (de)
NZ (1) NZ273816A (de)
PE (1) PE50795A1 (de)
PH (1) PH30813A (de)
RU (1) RU2148393C1 (de)
UA (1) UA37244C2 (de)
WO (1) WO1995007699A1 (de)
ZA (1) ZA947073B (de)

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US6602487B1 (en) 1997-02-26 2003-08-05 Dimera Incorporated Methods and tests for producing and for inhibiting coronary artery vasospasms
US6056972A (en) 1997-02-26 2000-05-02 Dimera, Llc Method for reducing coronary artery reactivity
DE69819748T2 (de) * 1997-09-12 2004-09-30 Columbia Laboratories (Bermuda) Ltd. Arzneimittel zur behandlung von dysmenorrhöe und verfrühten wehen
EP1356806A1 (de) * 1997-09-12 2003-10-29 Columbia Laboratories (Bermuda) Limited Arzneimittel zur Behandlung von Dysmenorrhöe und verfrühten Wehen
US8765177B2 (en) * 1997-09-12 2014-07-01 Columbia Laboratories, Inc. Bioadhesive progressive hydration tablets
US7153845B2 (en) * 1998-08-25 2006-12-26 Columbia Laboratories, Inc. Bioadhesive progressive hydration tablets
US6248358B1 (en) * 1998-08-25 2001-06-19 Columbia Laboratories, Inc. Bioadhesive progressive hydration tablets and methods of making and using the same
US20040234606A1 (en) * 1997-09-12 2004-11-25 Levine Howard L. Localized vaginal delivery without detrimental blood levels
EP1021173A1 (de) * 1997-10-10 2000-07-26 Imperial College Innovations Limited Verwendung von cytokin-unterdrückenden verbindungen (csaid) zur behandlung von gebärmutterkontraktionen
US6306914B1 (en) * 1997-10-21 2001-10-23 Columbia Laboratories, Inc. Progestin therapy for maintaining amenorrhea
WO1999059595A1 (en) * 1998-05-20 1999-11-25 Wiley Teresa S Progesterone treatment of cancer
IL127129A (en) 1998-11-18 2004-06-01 Ferring Bv Method for preparation of progesterone tablets for vaginal delivery and tablets so prepared
US20070178139A1 (en) * 1998-11-18 2007-08-02 Yankov Vladimir I Vaginally administratable progesterone-containing tablets and method for preparing same
US6479045B2 (en) 1999-12-22 2002-11-12 Columbia Laboratories, Inc. Vaginal pH buffering for preventing miscarriage and premature labor, by treating or preventing bacterial vaginosis
US6544553B1 (en) * 1999-12-28 2003-04-08 Watson Pharmaceuticals, Inc. Dosage forms and methods for oral delivery of progesterone
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BRPI0711525A2 (pt) * 2006-06-02 2011-11-01 Pear Tree Women S Health Care composição farmacêutica e método para tratar sintomas de vaginite atrófica
US8828981B2 (en) * 2007-02-06 2014-09-09 George Creasy Progesterone for the treatment or prevention of spontaneous preterm birth
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DK2359807T3 (en) 2008-02-04 2017-10-16 Ferring Bv Monolithic vaginal rings comprising progesterone and methods of preparation and use thereof
US9107696B2 (en) * 2008-08-06 2015-08-18 Emory University Method of embryo transfer that eliminates transferred air while hormonally inducing implantation and apparatus
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US8421747B2 (en) 2008-09-24 2013-04-16 Microsoft Corporation Object detection and user settings
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CN102906103A (zh) * 2010-03-22 2013-01-30 利普生物药剂公司 用于抗孕酮的非毒性递送的组合物和方法
US9375437B2 (en) 2010-06-18 2016-06-28 Lipocine Inc. Progesterone containing oral dosage forms and kits
US8435972B2 (en) 2010-09-02 2013-05-07 Emory University Method for the treatment of central nervous system cancers and compositions related thereto
CN103648482B (zh) * 2011-07-15 2018-01-02 根特大学 阴道内递送系统
US8951996B2 (en) 2011-07-28 2015-02-10 Lipocine Inc. 17-hydroxyprogesterone ester-containing oral compositions and related methods
BR112014012444B1 (pt) 2011-11-23 2021-12-14 Therapeuticsmd, Inc Composição farmacêutica compreendendo estradiol solubilizado, progesterona e um agente de solubilização, bem como usos desta para tratar um sintoma relacionado à menopausa em uma mulher
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
BR112014018439A8 (pt) * 2012-01-26 2017-07-11 Therapeuticsmd Inc Terapias de reposição de hormônio transdérmica
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US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
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US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
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CN103239389A (zh) * 2013-06-03 2013-08-14 南京泽恒医药技术开发有限公司 一种治疗先兆性流产的黄体酮缓释凝胶的制备方法
JP2017516768A (ja) 2014-05-22 2017-06-22 セラピューティックスエムディー インコーポレーテッドＴｈｅｒａｐｅｕｔｉｃｓｍｄ， Ｉｎｃ． 天然の併用ホルモン補充療法剤及び療法
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BR112017027688A2 (pt) 2015-06-22 2018-09-04 Lipocine Inc Composições orais que contêm éster de 17- hidroxiprogesterona e métodos relacionados
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Also Published As

Publication number Publication date
NO961044L (no) 1996-05-14
CO4290332A1 (es) 1996-04-17
CA2171939A1 (en) 1995-03-23
FI115444B (fi) 2005-05-13
ZA947073B (en) 1995-05-02
BR9407475A (pt) 1996-11-12
DE69415543T2 (de) 1999-06-17
RU2148393C1 (ru) 2000-05-10
UA37244C2 (uk) 2001-05-15
JP3143474B2 (ja) 2001-03-07
LV11527A (lv) 1996-10-20
HUT76824A (en) 1997-11-28
KR100278553B1 (ko) 2001-01-15
AU7726194A (en) 1995-04-03
FI961221A0 (fi) 1996-03-15
ES2126783T3 (es) 1999-04-01
EP0719146B1 (de) 1998-12-23
EP0719146A1 (de) 1996-07-03
CA2171939C (en) 2002-01-01
AU689133B2 (en) 1998-03-26
LV11527B (en) 1997-02-20
FI961221A (fi) 1996-05-14
NO961044D0 (no) 1996-03-14
NZ273816A (en) 2007-09-28
US5543150A (en) 1996-08-06
LT4072B (en) 1996-11-25
LT96027A (en) 1996-07-25
HU221583B (hu) 2002-11-28
DK0719146T3 (da) 1999-08-23
IL110972A0 (en) 1994-11-28
PH30813A (en) 1997-10-17
GR3029314T3 (en) 1999-05-28
HU9600669D0 (en) 1996-05-28
IL110972A (en) 1998-03-10
NO308585B1 (no) 2000-10-02
PE50795A1 (es) 1996-01-19
MA23329A1 (fr) 1995-04-01
MY111484A (en) 2000-06-30
ATE174796T1 (de) 1999-01-15
JPH09502724A (ja) 1997-03-18
WO1995007699A1 (en) 1995-03-23

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Legal Events

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