ES2159552T3 - Terapia de sustitucion de hormonas. - Google Patents
Terapia de sustitucion de hormonas.Info
- Publication number
- ES2159552T3 ES2159552T3 ES94909721T ES94909721T ES2159552T3 ES 2159552 T3 ES2159552 T3 ES 2159552T3 ES 94909721 T ES94909721 T ES 94909721T ES 94909721 T ES94909721 T ES 94909721T ES 2159552 T3 ES2159552 T3 ES 2159552T3
- Authority
- ES
- Spain
- Prior art keywords
- substitution therapy
- hormone substitution
- hormone
- estrogen
- therapy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Steroid Compounds (AREA)
- Dental Preparations (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Abstract
UN METODO DE TERAPIA DE SUSTITUCION DE HORMONA INCLUYE LA ADMINISTRACION DE ESTROGENO JUNTO CON UNA CANTIDAD DE ANTIPROGESTINA QUE INHIBE LA PROLIFERACION ENDOMETRIAL INDUCIDA POR ESTROGENO EN UNA MUJER.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/023,692 US5468736A (en) | 1993-02-25 | 1993-02-25 | Hormone replacement therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2159552T3 true ES2159552T3 (es) | 2001-10-16 |
Family
ID=21816657
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES94909721T Expired - Lifetime ES2159552T3 (es) | 1993-02-25 | 1994-02-18 | Terapia de sustitucion de hormonas. |
Country Status (25)
Country | Link |
---|---|
US (1) | US5468736A (es) |
EP (1) | EP0686037B1 (es) |
JP (1) | JP3441459B2 (es) |
KR (1) | KR100248857B1 (es) |
AT (1) | ATE202281T1 (es) |
AU (1) | AU680239B2 (es) |
BG (1) | BG62383B1 (es) |
BR (1) | BR9406667A (es) |
CA (1) | CA2157003C (es) |
CZ (1) | CZ290562B6 (es) |
DE (1) | DE69427529T2 (es) |
DK (1) | DK0686037T3 (es) |
ES (1) | ES2159552T3 (es) |
FI (1) | FI953926A0 (es) |
GR (1) | GR3036649T3 (es) |
HU (1) | HU221169B1 (es) |
NO (1) | NO309456B1 (es) |
NZ (1) | NZ262657A (es) |
PL (1) | PL176796B1 (es) |
PT (1) | PT686037E (es) |
RO (1) | RO115115B1 (es) |
RU (1) | RU2139056C1 (es) |
SK (1) | SK282921B6 (es) |
UA (1) | UA43842C2 (es) |
WO (1) | WO1994018983A1 (es) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX9301121A (es) | 1992-03-02 | 1993-09-01 | Schering Ag | Metodo y equipo para la contracepcion oral y regulacion de la menstruacion con estrogeno/progestina/aniprogestina. |
US7704983B1 (en) | 1992-03-02 | 2010-04-27 | Eastern Virginia Medical School | Antiprogestin method for reducing side effects associated with low dosage HRT and oral contraception |
US6407082B1 (en) | 1996-09-13 | 2002-06-18 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of a vitamin D compound |
DE19610635A1 (de) * | 1996-03-11 | 1997-09-18 | Schering Ag | Sequentielle Estrogen/Progesteronantagonist-Kombination für die Hormonersatz-Therapie |
AU5942700A (en) * | 1996-03-11 | 2000-11-30 | Schering Aktiengesellschaft | Sequential estrogen/progestrone antagonist combination for hormone replacement theapy |
US6511970B1 (en) | 1996-09-13 | 2003-01-28 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium |
US6034074A (en) | 1996-09-13 | 2000-03-07 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of a Vitamin D compound |
US6028064A (en) | 1996-09-13 | 2000-02-22 | New Life Pharmaceuticals Inc. | Prevention of ovarian cancer by administration of progestin products |
US6765002B2 (en) | 2000-03-21 | 2004-07-20 | Gustavo Rodriguez | Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium |
US20060014728A1 (en) * | 1996-11-21 | 2006-01-19 | Kristof Chwalisz | Hormone replacement therapy |
US5855920A (en) * | 1996-12-13 | 1999-01-05 | Chein; Edmund Y. M. | Total hormone replacement therapy |
US7629334B1 (en) | 1999-08-31 | 2009-12-08 | Bayer Schering Pharma Aktiengesellschaft | Mesoprogrestins (progesterone receptor modulations) as a component of compositions for hormone replacement therapy (HRT) |
CA2383659C (en) * | 1999-08-31 | 2009-02-10 | Jenapharm Gmbh & Co. Kg | Mesoprogestins (progesterone receptor modulators) as a component of compositions for hormone replacement therapy (hrt) |
US6432643B1 (en) | 1999-10-22 | 2002-08-13 | Duke University | Method of determining Alzheimer's disease risk using apolipoprotein E4 genotype analysis in combination with decreased estrogen levels |
US20040176336A1 (en) * | 2000-03-21 | 2004-09-09 | Rodriguez Gustavo C. | Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium |
US20010044431A1 (en) * | 2000-03-21 | 2001-11-22 | Rodriguez Gustavo C. | Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium |
US20050113351A1 (en) * | 2000-03-21 | 2005-05-26 | Rodriguez Gustavo C. | Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium |
EP1260225A1 (en) * | 2001-05-18 | 2002-11-27 | Pantarhei Bioscience B.V. | A pharmaceutical composition for use in hormone replacement therapy |
WO2002094276A1 (en) * | 2001-05-18 | 2002-11-28 | Pantarhei Bioscience B.V. | Pharmaceutical composition for use in hormone replacement therapy |
WO2002094278A1 (en) * | 2001-05-23 | 2002-11-28 | Pantarhei Bioscience B.V. | Drug delivery system comprising a tetrahydroxylated estrogen for use in hormonal contraception |
CA2448278C (en) * | 2001-05-23 | 2010-06-08 | Christian Franz Holinka | Drug delivery system comprising a tetrahidroxilated estrogen for use in hormonal contraception |
WO2003018026A1 (en) * | 2001-08-31 | 2003-03-06 | Pantarhei Bioscience B.V. | Use of estrogenic compounds in combination with progestogenic compounds in hormone-replacement therapy |
ES2278925T3 (es) * | 2001-11-15 | 2007-08-16 | Pantarhei Bioscience B.V. | Uso de compuestos estrogenicos en combinacion con compuestos progestogenicos en terapias de sustitucion hormonal. |
DE10206089A1 (de) | 2002-02-13 | 2002-08-14 | Zimmer Ag | Bersteinsatz |
ES2274252T3 (es) * | 2002-06-11 | 2007-05-16 | Pantarhei Bioscience B.V. | Metodo de tratamiento o prevencion de desordenes de medicion inmune y formulacion farmaceutica para su uso en ellos. |
ES2399423T3 (es) * | 2002-06-11 | 2013-04-01 | Pantarhei Bioscience B.V. | Método para tratar la piel humana y una composición para el cuidado de la piel para su uso en tal método |
WO2004006936A1 (en) * | 2002-07-12 | 2004-01-22 | Pantarhei Biosciences B.V. | Pharmaceutical composition comprising estetrol derivatives for use in cancer therapy |
CA2503549C (en) | 2002-10-23 | 2012-07-10 | Pantarhei Bioscience B.V. | Pharmaceutical compositions comprising estetrol derivatives for use in cancer therapy |
ATE340580T1 (de) * | 2003-05-22 | 2006-10-15 | Pantarhei Bioscience Bv | Verwendung von zusammensetzungen enthaltend ein oestrogen zur behandlung und verhinderung von muskelskelettschmerzen |
CA2673128C (en) * | 2006-10-24 | 2018-07-03 | Repros Therapeutics Inc. | Compositions and methods for suppressing endometrial proliferation |
EP2114412B1 (en) * | 2007-01-08 | 2010-07-14 | Pantarhei Bioscience B.V. | Method of treating or preventing infertility in a female mammal and pharmaceutical kit for use in such method |
US20080293683A1 (en) * | 2007-05-24 | 2008-11-27 | University Of Kansas Medical Center | Hormone Replacement Therapy |
US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
BR112014012444B1 (pt) | 2011-11-23 | 2021-12-14 | Therapeuticsmd, Inc | Composição farmacêutica compreendendo estradiol solubilizado, progesterona e um agente de solubilização, bem como usos desta para tratar um sintoma relacionado à menopausa em uma mulher |
US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
JP2017516768A (ja) | 2014-05-22 | 2017-06-22 | セラピューティックスエムディー インコーポレーテッドTherapeuticsmd, Inc. | 天然の併用ホルモン補充療法剤及び療法 |
WO2016090139A1 (en) * | 2014-12-03 | 2016-06-09 | Evestra, Inc. | Combination of estrogens plus antiprogestins with significant partial agonistic effect as an effective treatment of menopausal symptoms and for prevention of the occurrence of breast cancer |
GEP20217243B (en) | 2015-06-18 | 2021-04-26 | Sprl Estetra | Orodispersible dosage unit containing an estetrol component |
US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
EP3435977A4 (en) | 2016-04-01 | 2019-10-16 | Therapeuticsmd, Inc. | PHARMACEUTICAL COMPOSITION OF STEROID HORMONE |
US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3890356A (en) * | 1973-03-26 | 1975-06-17 | Richardson Merrell Inc | 7-Alkyl-{66 {hu 3,5{b -steroids |
US3928398A (en) * | 1973-11-01 | 1975-12-23 | Richardson Merrell Inc | Derivatives of 7{60 -methylestr-4-en-3{60 ,17{62 -diol |
US4416822A (en) * | 1982-07-09 | 1983-11-22 | The Upjohn Company | 17β-Difluoromethyl steroids |
IL68222A (en) * | 1983-03-24 | 1987-02-27 | Yeda Res & Dev | Contraceptive compositions comprising a progesterone antagonist and a blocker of progesterone activity |
AU572589B2 (en) * | 1983-12-14 | 1988-05-12 | Upjohn Company, The | 11(alpha)-difluoromethyl and (e)-and (z)-11-fluoromethylene steroids |
MX9301121A (es) * | 1992-03-02 | 1993-09-01 | Schering Ag | Metodo y equipo para la contracepcion oral y regulacion de la menstruacion con estrogeno/progestina/aniprogestina. |
-
1993
- 1993-02-25 US US08/023,692 patent/US5468736A/en not_active Expired - Lifetime
-
1994
- 1994-02-18 RU RU95118436/14A patent/RU2139056C1/ru active
- 1994-02-18 CA CA002157003A patent/CA2157003C/en not_active Expired - Lifetime
- 1994-02-18 HU HU9502306A patent/HU221169B1/hu unknown
- 1994-02-18 ES ES94909721T patent/ES2159552T3/es not_active Expired - Lifetime
- 1994-02-18 PL PL94310660A patent/PL176796B1/pl unknown
- 1994-02-18 KR KR1019950703613A patent/KR100248857B1/ko not_active IP Right Cessation
- 1994-02-18 JP JP51919494A patent/JP3441459B2/ja not_active Expired - Lifetime
- 1994-02-18 EP EP94909721A patent/EP0686037B1/en not_active Expired - Lifetime
- 1994-02-18 BR BR9406667A patent/BR9406667A/pt not_active Application Discontinuation
- 1994-02-18 DK DK94909721T patent/DK0686037T3/da active
- 1994-02-18 UA UA95083916A patent/UA43842C2/uk unknown
- 1994-02-18 CZ CZ19952048A patent/CZ290562B6/cs not_active IP Right Cessation
- 1994-02-18 PT PT94909721T patent/PT686037E/pt unknown
- 1994-02-18 AT AT94909721T patent/ATE202281T1/de active
- 1994-02-18 DE DE69427529T patent/DE69427529T2/de not_active Expired - Lifetime
- 1994-02-18 WO PCT/US1994/001815 patent/WO1994018983A1/en active IP Right Grant
- 1994-02-18 AU AU62454/94A patent/AU680239B2/en not_active Expired
- 1994-02-18 SK SK1049-95A patent/SK282921B6/sk not_active IP Right Cessation
- 1994-02-18 NZ NZ262657A patent/NZ262657A/en not_active IP Right Cessation
- 1994-02-18 RO RO95-01510A patent/RO115115B1/ro unknown
-
1995
- 1995-08-17 NO NO953243A patent/NO309456B1/no not_active IP Right Cessation
- 1995-08-22 FI FI953926A patent/FI953926A0/fi not_active Application Discontinuation
- 1995-08-23 BG BG99880A patent/BG62383B1/bg unknown
-
2001
- 2001-09-18 GR GR20010401507T patent/GR3036649T3/el unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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