FI114897B - Silmän sisäistä painetta alentavan aineen käyttö ja silmätipoiksi tehty lääke - Google Patents

Silmän sisäistä painetta alentavan aineen käyttö ja silmätipoiksi tehty lääke Download PDF

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Publication number
FI114897B
FI114897B FI963645A FI963645A FI114897B FI 114897 B FI114897 B FI 114897B FI 963645 A FI963645 A FI 963645A FI 963645 A FI963645 A FI 963645A FI 114897 B FI114897 B FI 114897B
Authority
FI
Finland
Prior art keywords
group
compound
formula
alkyl group
methyl
Prior art date
Application number
FI963645A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI963645A0 (fi
FI963645A (fi
Inventor
Tomihisa Yokoyama
Hiroaki Yanagisawa
Tsunemichi Hosokawa
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of FI963645A0 publication Critical patent/FI963645A0/fi
Publication of FI963645A publication Critical patent/FI963645A/fi
Application granted granted Critical
Publication of FI114897B publication Critical patent/FI114897B/fi

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
FI963645A 1994-03-16 1996-09-16 Silmän sisäistä painetta alentavan aineen käyttö ja silmätipoiksi tehty lääke FI114897B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP4540494 1994-03-16
JP4540494 1994-03-16
PCT/JP1995/000444 WO1995024902A1 (fr) 1994-03-16 1995-03-16 Reducteur de tension oculaire
JP9500444 1995-03-16

Publications (3)

Publication Number Publication Date
FI963645A0 FI963645A0 (fi) 1996-09-16
FI963645A FI963645A (fi) 1996-11-14
FI114897B true FI114897B (fi) 2005-01-31

Family

ID=12718322

Family Applications (2)

Application Number Title Priority Date Filing Date
FI963645A FI114897B (fi) 1994-03-16 1996-09-16 Silmän sisäistä painetta alentavan aineen käyttö ja silmätipoiksi tehty lääke
FI20041236A FI115197B (fi) 1994-03-16 2004-09-24 Yhdisteen käyttö silmälääkkeen valmistamiseksi yhdistelmänä beta-salpaajan kanssa ja silmätipoiksi tehty, silmissä paikallisesti käytettävä lääke

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI20041236A FI115197B (fi) 1994-03-16 2004-09-24 Yhdisteen käyttö silmälääkkeen valmistamiseksi yhdistelmänä beta-salpaajan kanssa ja silmätipoiksi tehty, silmissä paikallisesti käytettävä lääke

Country Status (20)

Country Link
US (1) US5925664A (es)
EP (2) EP1110551B1 (es)
KR (1) KR100211446B1 (es)
CN (2) CN1104898C (es)
AT (2) ATE266402T1 (es)
AU (1) AU684916B2 (es)
CZ (1) CZ284395B6 (es)
DE (2) DE69533045T2 (es)
DK (2) DK1110551T3 (es)
ES (2) ES2221872T3 (es)
FI (2) FI114897B (es)
GR (1) GR3036989T3 (es)
HK (1) HK1000551A1 (es)
HU (1) HUT74734A (es)
MX (1) MX9604109A (es)
NO (1) NO311068B1 (es)
NZ (1) NZ282485A (es)
PT (2) PT1110551E (es)
RU (1) RU2123847C1 (es)
WO (1) WO1995024902A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1198650C (zh) * 1999-06-11 2005-04-27 三共株式会社 局部给药用眼压降低组合物
JP4000505B2 (ja) * 1999-12-01 2007-10-31 第一三共株式会社 緑内障を治療するための併用剤
GR20000100281A (el) * 2000-08-17 2002-05-24 Ιωαννης Ματσουκας Ανταγωνιστες του υποδοχεα της αγγεοτενσινης ιι και συνθετικες μεθοδοι για την θεραπεια της υπερτασης και καρδιοαγγειακων ασθενειων
AU2002218527A1 (en) * 2000-12-05 2002-06-18 Sankyo Company Limited Ocular tension-lowering compositions for topical administration
BRPI0409293A (pt) * 2003-04-15 2006-04-11 Sankyo Co medicamento para a prevenção ou tratamento de doenças angiogênicas intraoculares

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6323868A (ja) * 1986-07-11 1988-02-01 イー・アイ・デュポン・ドゥ・ヌムール・アンド・カンパニー アンギオテンシン２受容体遮断性イミダゾ−ル
US5138069A (en) * 1986-07-11 1992-08-11 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking imidazoles
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
US4820843A (en) * 1987-05-22 1989-04-11 E. I. Du Pont De Nemours And Company Tetrazole intermediates to antihypertensive compounds
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
RU2099330C1 (ru) * 1989-06-30 1997-12-20 Е.И.Дюпон Де Немур Энд Компани Замещенные имидазолы или их фармацевтически приемлемые соли и фармацевтическая композиция
WO1991015206A1 (en) * 1990-04-05 1991-10-17 E.I. Du Pont De Nemours And Company Treatment of glaucoma and ocular hypertension with imidazole angiotensin-ii receptor antagonists
US5196444A (en) * 1990-04-27 1993-03-23 Takeda Chemical Industries, Ltd. 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof
US5126342A (en) * 1990-10-01 1992-06-30 Merck & Co., Inc. Imidazole angiotensin ii antagonists incorporating acidic functional groups
FI112942B3 (fi) * 1991-02-21 2012-03-13 Daiichi Sankyo Co Ltd Menetelmä kohonneen verenpaineen hoitoon ja ennaltaehkäisyyn käyttökelpoisten 4'-(1H-imidatsol-1-yylimetyyli)-1,1' -bifenyylijohdannaisten valmistamiseksi
US5616599A (en) * 1991-02-21 1997-04-01 Sankyo Company, Limited Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use
US5219856A (en) * 1992-04-06 1993-06-15 E. I. Du Pont De Nemours And Company Angiotensin-II receptor blocking, heterocycle substituted imidazoles
DK0573218T3 (da) * 1992-06-02 2001-06-18 Sankyo Co 4-carboxyimidazolderivater som angiotensin-II antagonister og deres terapeutiske anvendelse
US5310929A (en) * 1992-08-06 1994-05-10 E. I. Du Pont De Nemours And Company Prodrugs of imidazole carboxylic acids as angiotensin II receptor antagonists
CZ283315B6 (cs) * 1992-12-17 1998-02-18 Sankyo Company Limited Bifenylové deriváty, způsob výroby a farmaceutické prostředky k léčení hypertense a srdečních onemocnění, které tyto deriváty obsahují
CZ154994A3 (en) * 1993-07-02 1995-09-13 Senju Pharma Co Visual hypotensive agent
AU1423795A (en) * 1994-02-08 1995-08-29 Novartis Ag Treatment of normotensive glaucoma with angiotensin ii antagonists

Also Published As

Publication number Publication date
DE69533045T2 (de) 2005-01-27
EP1110551A3 (en) 2001-08-16
NO963854D0 (no) 1996-09-13
EP0795326B1 (en) 2001-09-26
CN1202819C (zh) 2005-05-25
ES2221872T3 (es) 2005-01-16
FI963645A0 (fi) 1996-09-16
WO1995024902A1 (fr) 1995-09-21
PT795326E (pt) 2002-01-30
EP1110551B1 (en) 2004-05-12
FI20041236A (fi) 2004-09-24
DE69522955T2 (de) 2002-05-29
CN1104898C (zh) 2003-04-09
HU9602534D0 (en) 1996-11-28
FI963645A (fi) 1996-11-14
DK1110551T3 (da) 2004-06-07
NO963854L (no) 1996-11-14
HUT74734A (en) 1997-02-28
CZ269496A3 (en) 1996-12-11
PT1110551E (pt) 2004-07-30
EP1110551A2 (en) 2001-06-27
DE69522955D1 (de) 2001-10-31
US5925664A (en) 1999-07-20
ATE206050T1 (de) 2001-10-15
CZ284395B6 (cs) 1998-11-11
CN1387846A (zh) 2003-01-01
DK0795326T3 (da) 2001-11-26
KR100211446B1 (ko) 1999-08-02
ES2163501T3 (es) 2002-02-01
DE69533045D1 (de) 2004-06-17
AU684916B2 (en) 1998-01-08
NZ282485A (en) 1997-06-24
FI115197B (fi) 2005-03-31
RU2123847C1 (ru) 1998-12-27
NO311068B1 (no) 2001-10-08
EP0795326A4 (es) 1997-09-17
EP0795326A1 (en) 1997-09-17
ATE266402T1 (de) 2004-05-15
MX9604109A (es) 1997-09-30
KR970701542A (ko) 1997-04-12
HK1000551A1 (en) 2002-04-12
CN1148809A (zh) 1997-04-30
AU1960295A (en) 1995-10-03
GR3036989T3 (en) 2002-01-31

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