FI114870B - Menetelmä ScFv-fragmentteja käsittävien fuusioproteiinien valmistamiseksi transformoidulla homeella - Google Patents

Menetelmä ScFv-fragmentteja käsittävien fuusioproteiinien valmistamiseksi transformoidulla homeella Download PDF

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Publication number
FI114870B
FI114870B FI955446A FI955446A FI114870B FI 114870 B FI114870 B FI 114870B FI 955446 A FI955446 A FI 955446A FI 955446 A FI955446 A FI 955446A FI 114870 B FI114870 B FI 114870B
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FI
Finland
Prior art keywords
ser
scfv
fragment
gly
thr
Prior art date
Application number
FI955446A
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English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI955446A0 (fi
FI955446A (fi
Inventor
Cornelis Theodorus Verrips
Leon Gerardus Joseph Frenken
Gorcom Robert F M Van
Johanna G M Hessing
Den Hondel Cornelis Antoni Van
Wouter Musters
Johannes Maria A Verbakel
Original Assignee
Unilever Nv
Tno
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Unilever Nv, Tno filed Critical Unilever Nv
Publication of FI955446A0 publication Critical patent/FI955446A0/fi
Publication of FI955446A publication Critical patent/FI955446A/fi
Application granted granted Critical
Publication of FI114870B publication Critical patent/FI114870B/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/036—Fusion polypeptide containing a localisation/targetting motif targeting to the medium outside of the cell, e.g. type III secretion
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Endocrinology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FI955446A 1993-06-09 1995-11-13 Menetelmä ScFv-fragmentteja käsittävien fuusioproteiinien valmistamiseksi transformoidulla homeella FI114870B (fi)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
EP93201661 1993-06-09
EP93201660 1993-06-09
EP93201660 1993-06-09
EP93201661 1993-06-09
EP93201706 1993-06-14
EP93201706 1993-06-14
PCT/EP1994/001906 WO1994029457A2 (en) 1993-06-09 1994-06-09 Process for producing fusion proteins comprising scfv fragments by a transformed mould
EP9401906 1994-06-09

Publications (3)

Publication Number Publication Date
FI955446A0 FI955446A0 (fi) 1995-11-13
FI955446A FI955446A (fi) 1995-12-11
FI114870B true FI114870B (fi) 2005-01-14

Family

ID=27235312

Family Applications (1)

Application Number Title Priority Date Filing Date
FI955446A FI114870B (fi) 1993-06-09 1995-11-13 Menetelmä ScFv-fragmentteja käsittävien fuusioproteiinien valmistamiseksi transformoidulla homeella

Country Status (10)

Country Link
EP (1) EP0702721B1 (es)
JP (1) JPH08511160A (es)
AT (1) ATE198490T1 (es)
AU (1) AU7123494A (es)
CA (1) CA2162878A1 (es)
DE (1) DE69426527T2 (es)
DK (1) DK0702721T3 (es)
ES (1) ES2155854T3 (es)
FI (1) FI114870B (es)
WO (1) WO1994029457A2 (es)

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CA2293304A1 (en) 1997-06-13 1998-12-17 Unilever Plc Bleaching enzymes
EP0954978B1 (en) * 1998-03-12 2011-11-30 VHsquared Limited New products comprising inactivated yeasts or moulds provided with active antibodies
ATE535154T1 (de) 1998-03-12 2011-12-15 Vhsquared Ltd Produkten die inaktivierte hefen oder schimmel enthalten, die auf ihrer aussenoberfläche aktive antikörper haben
AU6153100A (en) 1999-07-27 2001-02-13 Davis, Paul James Bleaching detergent compositions
AU2002235761A1 (en) 2000-12-19 2002-07-01 Unilever Plc Stabilization of antibodies or fragments thereof
EP1519747A4 (en) * 2002-01-28 2006-03-29 Medarex Inc HUMAN MONOCLONAL ANTIBODIES AGAINST PROSTATE-SPECIFIC MEMBRANE ANTIGEN (PSMA)
BR122013001996B1 (pt) 2005-05-18 2022-02-01 Ablynx N.V. Nanocorpos melhorados contra fator alfa de necrose tumoral
RU2433139C2 (ru) 2005-05-20 2011-11-10 Аблинкс Н.В. Nanobodies tm для лечения заболеваний, опосредованных агрегацией
EP2115004A2 (en) 2006-12-19 2009-11-11 Ablynx N.V. Amino acid sequences directed against gpcrs and polypeptides comprising the same for the treatment of gpcr-related diseases and disorders
EP2102244A2 (en) 2006-12-19 2009-09-23 Ablynx N.V. Amino acid sequences directed against a metalloproteinase from the adam family and polypeptides comprising the same for the treatment of adam-related diseases and disorders
WO2012130874A1 (en) 2011-03-28 2012-10-04 Ablynx Nv Bispecific anti-cxcr7 immunoglobulin single variable domains
WO2008081031A2 (en) * 2007-01-05 2008-07-10 Novozymes A/S Methods of increasing the production yield of a secreted antibody in a filamentous fungus by overexpression of the chaperone bip
EP2947097A1 (en) 2008-04-07 2015-11-25 Ablynx N.V. Amino acid sequences directed against the Notch pathways and uses thereof
AU2010233658B2 (en) 2009-04-10 2013-11-28 Ablynx Nv Improved amino acid sequences directed against IL-6R and polypeptides comprising the same for the treatment of IL-6R related diseases and disorders
CN102549012B (zh) 2009-05-07 2015-07-01 诺维信生物制药丹麦公司 纯化白蛋白的方法
ES2643034T3 (es) 2009-06-05 2017-11-21 Ablynx N.V. Construcciones de Nanobody contra el virus respiratorio sincicial humano (VRSH) trivalentes para la prevención y/o el tratamiento de infecciones de las vías respiratorias
US9644022B2 (en) 2009-11-30 2017-05-09 Ablynx N.V. Amino acid sequences directed against human respiratory syncytial virus (HRSV) and polypeptides comprising the same for the prevention and/or treatment of respiratory tract infections
EP2513145B1 (en) 2009-12-14 2018-01-24 Ablynx N.V. Single variable domain antibodies against ox40l, constructs and therapeutic use
WO2011083140A1 (en) 2010-01-08 2011-07-14 Ablynx Nv Immunoglobulin single variable domain directed against human cxcr4
US9120855B2 (en) 2010-02-10 2015-09-01 Novartis Ag Biologic compounds directed against death receptor 5
EP2552962B1 (en) 2010-03-26 2016-03-23 Ablynx N.V. Immunoglobulin single variable domains directed against cxcr7
KR20130080790A (ko) 2010-05-20 2013-07-15 아블린쓰 엔.브이. Ｈｅｒ３와 관련된 생물학적 물질들
WO2012042026A1 (en) 2010-09-30 2012-04-05 Ablynx Nv Biological materials related to c-met
EP3575321B1 (en) 2010-11-08 2023-07-26 Ablynx N.V. Cxcr2 binding polypeptides
UA117218C2 (uk) 2011-05-05 2018-07-10 Мерк Патент Гмбх Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f
JP2014525736A (ja) 2011-06-23 2014-10-02 アブリンクス エン．ヴェー． ＩｇＥに対する免疫グロブリン単一可変ドメイン
EP2747783B1 (en) 2011-09-30 2017-06-14 Ablynx N.V. Biological materials related to c-met
US9328174B2 (en) 2012-05-09 2016-05-03 Novartis Ag Chemokine receptor binding polypeptides
WO2014087010A1 (en) 2012-12-07 2014-06-12 Ablynx N.V. IMPROVED POLYPEPTIDES DIRECTED AGAINST IgE
CA2913418C (en) * 2013-05-29 2021-11-23 Vybion, Inc. Single chain intrabodies that alter huntingtin mutant degradation
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US10927186B2 (en) 2015-05-13 2021-02-23 Ablynx N.V. T cell recruiting polypeptides based on TCR alpha/beta reactivity
US11046767B2 (en) 2015-05-13 2021-06-29 Ablynx N.V. T cell recruiting polypeptides based on CD3 reactivity
WO2017013270A1 (en) 2015-07-23 2017-01-26 Universite De Strasbourg Use of leptin signaling inhibitor for protecting kidneys from patients having ciliopathy
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EP3624854A1 (en) 2017-05-16 2020-03-25 Université de Strasbourg Protein-drug conjugates and their use in the treatment of cancers
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KR101875564B1 (ko) * 2018-05-24 2018-07-09 국민대학교산학협력단 포도당 및 글리세롤을 이용한 유가식 배양을 통한 리시놀레산으로 오메가-하이드록시운덱-9-에논산의 생물전환공정
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WO2020245663A1 (en) 2019-06-01 2020-12-10 Institut Pasteur Nanobody-based ns1 assay for the specific diagnosis of acute zika virus infection
MX2022015157A (es) 2020-06-02 2023-01-16 Arcus Biosciences Inc Anticuerpos para tigit.
AU2021402090A1 (en) 2020-12-18 2023-08-03 Ablynx Nv T cell recruiting polypeptides based on tcr alpha/beta reactivity
WO2022238505A1 (en) 2021-05-12 2022-11-17 Universite De Strasbourg Single domain antibody specific for phosphorylated h2ax and its uses
WO2023151894A1 (en) 2022-02-11 2023-08-17 Henkel Ag & Co. Kgaa Process for the synthesis of alpha-methylene-gamma-butyrolactone
WO2024023271A1 (en) 2022-07-27 2024-02-01 Ablynx Nv Polypeptides binding to a specific epitope of the neonatal fc receptor
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WO1993008300A1 (en) * 1991-10-18 1993-04-29 The University Of Calgary Expression-secretion vectors for the production of biologically active fv fragments
IT1270866B (it) * 1993-03-10 1997-05-13 Eniricerche Spa Vettore ricombinante e suo impiego per la preparazione esocellulare di anticorpi in forma di singola molecola da bacillus subtilis

Also Published As

Publication number Publication date
ATE198490T1 (de) 2001-01-15
DE69426527D1 (de) 2001-02-08
CA2162878A1 (en) 1994-12-22
FI955446A0 (fi) 1995-11-13
DK0702721T3 (da) 2001-05-21
ES2155854T3 (es) 2001-06-01
DE69426527T2 (de) 2001-08-30
FI955446A (fi) 1995-12-11
EP0702721B1 (en) 2001-01-03
WO1994029457A2 (en) 1994-12-22
EP0702721A1 (en) 1996-03-27
AU7123494A (en) 1995-01-03
JPH08511160A (ja) 1996-11-26
WO1994029457A3 (en) 1995-03-09

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