FI114709B - Förfarande för framställning av farmakologiskt akvit polymorf A av N-t-butyl-androst-3,5-dien 17b-karboxamid-3-karboxylsyra - Google Patents
Förfarande för framställning av farmakologiskt akvit polymorf A av N-t-butyl-androst-3,5-dien 17b-karboxamid-3-karboxylsyra Download PDFInfo
- Publication number
- FI114709B FI114709B FI944414A FI944414A FI114709B FI 114709 B FI114709 B FI 114709B FI 944414 A FI944414 A FI 944414A FI 944414 A FI944414 A FI 944414A FI 114709 B FI114709 B FI 114709B
- Authority
- FI
- Finland
- Prior art keywords
- polymorph
- carboxamide
- diene
- butyl
- carboxylic acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0066—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by a carbon atom forming part of an amide group
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (5)
1. Förfarande för framställning av en farmakologiskt aktiv förening med strukturen 5 °\ \^-N(H)C(CH3)3 o väsentligen i polymorf A -form och med det i figur 1 visade infrarödspektrumet, I kännetecknat av att en uppslamning av rä N-t-butyl-androst-3,5-dien-17P- 25 karboxamid-3-karboxylsyra i etylacetat uppvärms vid en temperatur överstigande omgivningstemperaturen, företrädesvis vid en temperatur överstigande 60 °C, varefter uppslamningen avkyls tili en temperatur understigande omgivningstemperaturen, företrädesvis tili 0-5 °C, och polymorf A isoleras. 30
2. Förfarande enligt patentkrav 1, kännetecknat av att nämnda uppslamning är en 12-40-viktprocentig, företrädesvis en 14-20-viktprocentig uppslamning.
·· ; 3. Förfarande enligt patentkrav 1 eller 2, kännetecknat av att nämnda uppslam- ·· : ning uppvärms under cirka en timme eller över en timme vid nämnda temperatur . :' 35 överstigande omgivningstemperaturen.
4. Förfarande enligt nägot av föregäende patentkrav, kännetecknat av att den : · framställda polymorf en A har det i figur 2 visade infrarödspektrumet. 40
5. Förfarande enligt nägot av föregäende patentkrav, kännetecknat av att den : framställda polymorfen A har den i tabell 1 visade röntgendiffraktionsmönsterlistan. * ·
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929206413A GB9206413D0 (en) | 1992-03-24 | 1992-03-24 | N-t-butyl-androst-3,5-diene-17b-carboxamide-3-carboxylic acid polymorph a |
| GB9206413 | 1992-03-24 | ||
| PCT/US1993/002974 WO1993019081A1 (en) | 1992-03-24 | 1993-03-24 | N-T-BUTYL-ANDROST-3,5-DIENE-17β-CARBOXAMIDE-3-CARBOXYLIC ACID POLYMORPH A |
| US9302974 | 1993-03-24 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI944414A0 FI944414A0 (sv) | 1994-09-23 |
| FI944414A FI944414A (sv) | 1994-09-23 |
| FI114709B true FI114709B (sv) | 2004-12-15 |
Family
ID=10712749
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI944414A FI114709B (sv) | 1992-03-24 | 1994-09-23 | Förfarande för framställning av farmakologiskt akvit polymorf A av N-t-butyl-androst-3,5-dien 17b-karboxamid-3-karboxylsyra |
Country Status (29)
| Country | Link |
|---|---|
| EP (1) | EP0633892B1 (sv) |
| JP (1) | JP2736169B2 (sv) |
| CN (1) | CN1078723A (sv) |
| AP (1) | AP403A (sv) |
| AT (1) | ATE180490T1 (sv) |
| AU (1) | AU669522B2 (sv) |
| BG (1) | BG99062A (sv) |
| BR (1) | BR9306139A (sv) |
| CA (1) | CA2132535A1 (sv) |
| CZ (1) | CZ286266B6 (sv) |
| DE (1) | DE69325094T2 (sv) |
| DK (1) | DK0633892T3 (sv) |
| ES (1) | ES2134260T3 (sv) |
| FI (1) | FI114709B (sv) |
| GB (1) | GB9206413D0 (sv) |
| GR (1) | GR3030779T3 (sv) |
| HU (1) | HUT68120A (sv) |
| IL (1) | IL105102A (sv) |
| MA (1) | MA22841A1 (sv) |
| MX (1) | MX9301656A (sv) |
| NO (1) | NO943547L (sv) |
| NZ (1) | NZ252008A (sv) |
| OA (1) | OA10100A (sv) |
| PL (1) | PL172523B1 (sv) |
| RU (1) | RU94041839A (sv) |
| SI (1) | SI9300140A (sv) |
| SK (1) | SK113894A3 (sv) |
| WO (1) | WO1993019081A1 (sv) |
| ZA (1) | ZA932014B (sv) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4910226A (en) * | 1987-04-29 | 1990-03-20 | Smithkline Beckman Corporation | Steroid 5-alpha-reductase inhibitors |
| IL104602A (en) * | 1992-02-07 | 1997-07-13 | Smithkline Beecham Corp | Process for the preparation of 3-carbonylandrostadiene- 17-carboxamides and intermediates for this process |
-
1992
- 1992-03-24 GB GB929206413A patent/GB9206413D0/en active Pending
-
1993
- 1993-03-18 IL IL10510293A patent/IL105102A/xx not_active IP Right Cessation
- 1993-03-18 AP APAP/P/1993/000497A patent/AP403A/en active
- 1993-03-22 ZA ZA932014A patent/ZA932014B/xx unknown
- 1993-03-23 MA MA23136A patent/MA22841A1/fr unknown
- 1993-03-23 SI SI19939300140A patent/SI9300140A/sl unknown
- 1993-03-24 EP EP93911567A patent/EP0633892B1/en not_active Expired - Lifetime
- 1993-03-24 CA CA002132535A patent/CA2132535A1/en not_active Abandoned
- 1993-03-24 AT AT93911567T patent/ATE180490T1/de not_active IP Right Cessation
- 1993-03-24 CZ CZ19942319A patent/CZ286266B6/cs not_active IP Right Cessation
- 1993-03-24 WO PCT/US1993/002974 patent/WO1993019081A1/en active IP Right Grant
- 1993-03-24 MX MX9301656A patent/MX9301656A/es unknown
- 1993-03-24 JP JP5516858A patent/JP2736169B2/ja not_active Expired - Fee Related
- 1993-03-24 HU HU9402740A patent/HUT68120A/hu unknown
- 1993-03-24 AU AU40448/93A patent/AU669522B2/en not_active Ceased
- 1993-03-24 DE DE69325094T patent/DE69325094T2/de not_active Expired - Fee Related
- 1993-03-24 SK SK1138-94A patent/SK113894A3/sk unknown
- 1993-03-24 CN CN 93103518 patent/CN1078723A/zh active Pending
- 1993-03-24 RU RU94041839/04A patent/RU94041839A/ru unknown
- 1993-03-24 PL PL93305206A patent/PL172523B1/pl unknown
- 1993-03-24 NZ NZ252008A patent/NZ252008A/en unknown
- 1993-03-24 ES ES93911567T patent/ES2134260T3/es not_active Expired - Lifetime
- 1993-03-24 DK DK93911567T patent/DK0633892T3/da active
- 1993-03-24 BR BR9306139A patent/BR9306139A/pt not_active Application Discontinuation
-
1994
- 1994-09-20 OA OA60561A patent/OA10100A/en unknown
- 1994-09-23 FI FI944414A patent/FI114709B/sv active
- 1994-09-23 NO NO943547A patent/NO943547L/no unknown
- 1994-09-26 BG BG99062A patent/BG99062A/xx unknown
-
1999
- 1999-07-14 GR GR990401866T patent/GR3030779T3/el unknown
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