FI113649B - Uusi menetelmä klonidiinijohdannaisten valmistamiseksi, sekä tioureakompleksi, jota voidaan käyttää menetelmässä - Google Patents

Uusi menetelmä klonidiinijohdannaisten valmistamiseksi, sekä tioureakompleksi, jota voidaan käyttää menetelmässä Download PDF

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Publication number
FI113649B
FI113649B FI954749A FI954749A FI113649B FI 113649 B FI113649 B FI 113649B FI 954749 A FI954749 A FI 954749A FI 954749 A FI954749 A FI 954749A FI 113649 B FI113649 B FI 113649B
Authority
FI
Finland
Prior art keywords
dichloro
nitrophenyl
solvent
converted
thiourea
Prior art date
Application number
FI954749A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI954749A0 (fi
FI954749A (fi
Inventor
Michael E Deason
David R Pierce
William D Dean
Original Assignee
Alcon Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alcon Lab Inc filed Critical Alcon Lab Inc
Publication of FI954749A0 publication Critical patent/FI954749A0/fi
Publication of FI954749A publication Critical patent/FI954749A/fi
Application granted granted Critical
Publication of FI113649B publication Critical patent/FI113649B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D239/08—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms directly attached in position 2
    • C07D239/12—Nitrogen atoms not forming part of a nitro radical
    • C07D239/14—Nitrogen atoms not forming part of a nitro radical with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/04—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
FI954749A 1994-02-08 1995-10-05 Uusi menetelmä klonidiinijohdannaisten valmistamiseksi, sekä tioureakompleksi, jota voidaan käyttää menetelmässä FI113649B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US19331994A 1994-02-08 1994-02-08
US19331994 1994-02-08
US9501641 1995-02-07
PCT/US1995/001641 WO1995021818A1 (en) 1994-02-08 1995-02-07 Novel process for preparation of clonidine derivatives

Publications (3)

Publication Number Publication Date
FI954749A0 FI954749A0 (fi) 1995-10-05
FI954749A FI954749A (fi) 1995-10-05
FI113649B true FI113649B (fi) 2004-05-31

Family

ID=22713139

Family Applications (1)

Application Number Title Priority Date Filing Date
FI954749A FI113649B (fi) 1994-02-08 1995-10-05 Uusi menetelmä klonidiinijohdannaisten valmistamiseksi, sekä tioureakompleksi, jota voidaan käyttää menetelmässä

Country Status (17)

Country Link
US (1) US5684156A (zh)
EP (1) EP0693055B1 (zh)
JP (1) JP2686367B2 (zh)
KR (1) KR100218978B1 (zh)
CN (2) CN1046501C (zh)
AT (1) ATE153330T1 (zh)
AU (1) AU677513B2 (zh)
CA (1) CA2158763C (zh)
DE (1) DE69500313T2 (zh)
DK (1) DK0693055T3 (zh)
ES (1) ES2103151T3 (zh)
FI (1) FI113649B (zh)
GR (1) GR3024164T3 (zh)
HK (1) HK1019742A1 (zh)
NO (1) NO305432B1 (zh)
NZ (1) NZ281460A (zh)
WO (1) WO1995021818A1 (zh)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5612364A (en) * 1995-11-08 1997-03-18 Alcon Laboratories, Inc. Substantially pure apraclonidine
IL151971A0 (en) 2000-03-31 2003-04-10 Tufts College 7-and 9-carbamate, urea, thiourea, thiocarbabamate, and heteroaryl-amino substituted tetracycline compounds
CN100404516C (zh) * 2004-02-13 2008-07-23 大连绿源药业有限责任公司 六氢哒嗪三羧酸酯的制备方法
EP2218442A1 (en) 2005-11-09 2010-08-18 CombinatoRx, Inc. Methods, compositions, and kits for the treatment of ophthalmic disorders
EP2765131B1 (en) 2013-02-08 2016-11-23 Arevipharma GmbH Process for the production of Moxonidine
CN104557716B (zh) * 2014-12-26 2017-12-22 东华大学 一种α2‑肾上腺素能受体激动剂盐酸安普乐定及其制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3236857A (en) * 1961-10-09 1966-02-22 Boehringer Sohn Ingelheim 2-(phenyl-amino)-1, 3-diazacyclopentene-(2) substitution products
DE1568593A1 (de) * 1966-09-22 1970-04-02 Bayer Ag Verfahren zur Herstellung o.o-dihalogensubstituierter aromatischer Senfoele
BE795970A (fr) * 1972-02-29 1973-08-27 Pfizer Nouveaux derives de quinoleine, quinoxaline et quinazoline er composition pharmaceutiques les contenant
US4515800A (en) * 1981-11-20 1985-05-07 Icilio Cavero Method of lowering intraocular pressure using phenylimino-imidazoles
US4517199A (en) * 1981-11-20 1985-05-14 Alcon Laboratories, Inc. Method for lowering intraocular pressure using phenylimino-imidazoles
US4444782A (en) * 1982-12-23 1984-04-24 Smithkline Beckman Corporation 2(4-tert.-Butyl-2,6-dichlorophenyl-imino)imidazolidine and use as an anti-hypertension agent
US4656291A (en) * 1985-03-15 1987-04-07 Mcneilab, Inc. Process for producing amidine sulfonic acids
EP0442878A4 (en) * 1988-04-05 1991-10-23 Abbott Laboratories Derivatives of tryptophan as cck antagonists
US5112822A (en) * 1989-10-12 1992-05-12 Allergan, Inc. (2-imidazolin-2-ylamino) quinoxaline derivatives and methods for using same
US5204347A (en) * 1989-10-12 1993-04-20 Allergan, Inc. Methods for using (2-imidazolin-2-ylamino) tetrahydroquinoxalines
US5077292A (en) * 1989-10-12 1991-12-31 Allergan, Inc. (2-imidazolin-2-ylamino) tetrahydroquinoxalines and methods for using same
US5231096A (en) * 1989-10-12 1993-07-27 Allergan, Inc. Methods for using (2-imidazolin-2-ylamino) quinoxaline derivatives
US5130441A (en) * 1990-02-06 1992-07-14 Allergan, Inc. Method for producing amino-2-imidazoline derivatives

Also Published As

Publication number Publication date
CN1107056C (zh) 2003-04-30
EP0693055A1 (en) 1996-01-24
CA2158763C (en) 2002-10-29
KR960701836A (ko) 1996-03-28
MX9504262A (es) 1997-12-31
FI954749A0 (fi) 1995-10-05
AU1840895A (en) 1995-08-29
US5684156A (en) 1997-11-04
ATE153330T1 (de) 1997-06-15
GR3024164T3 (en) 1997-10-31
HK1019742A1 (en) 2000-02-25
WO1995021818A1 (en) 1995-08-17
NZ281460A (en) 1996-10-28
CA2158763A1 (en) 1995-08-17
CN1220261A (zh) 1999-06-23
NO305432B1 (no) 1999-05-31
DE69500313D1 (de) 1997-06-26
EP0693055B1 (en) 1997-05-21
DK0693055T3 (da) 1997-12-15
JP2686367B2 (ja) 1997-12-08
NO953988D0 (no) 1995-10-06
CN1123026A (zh) 1996-05-22
NO953988L (no) 1995-12-07
AU677513B2 (en) 1997-04-24
FI954749A (fi) 1995-10-05
DE69500313T2 (de) 1997-11-06
ES2103151T3 (es) 1997-08-16
CN1046501C (zh) 1999-11-17
KR100218978B1 (ko) 1999-09-01
JPH08509005A (ja) 1996-09-24

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