FI111716B - Menetelmä uusien terapeuttisesti käyttökelpoisten 9-amino-7-(substituoitu)-6-demetyyli-6-deoksitetrasykliinien valmistamiseksi - Google Patents

Menetelmä uusien terapeuttisesti käyttökelpoisten 9-amino-7-(substituoitu)-6-demetyyli-6-deoksitetrasykliinien valmistamiseksi Download PDF

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Publication number
FI111716B
FI111716B FI924453A FI924453A FI111716B FI 111716 B FI111716 B FI 111716B FI 924453 A FI924453 A FI 924453A FI 924453 A FI924453 A FI 924453A FI 111716 B FI111716 B FI 111716B
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FI
Finland
Prior art keywords
group
amino
dimethylamino
dioxo
tetrahydroxy
Prior art date
Application number
FI924453A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI924453A0 (fi
FI924453A (fi
Inventor
Phaik-Eng Sum
Ving J Lee
Joseph J Hlavka
Yakov Gluzman
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of FI924453A0 publication Critical patent/FI924453A0/fi
Publication of FI924453A publication Critical patent/FI924453A/fi
Application granted granted Critical
Publication of FI111716B publication Critical patent/FI111716B/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
FI924453A 1991-10-04 1992-10-02 Menetelmä uusien terapeuttisesti käyttökelpoisten 9-amino-7-(substituoitu)-6-demetyyli-6-deoksitetrasykliinien valmistamiseksi FI111716B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77169791 1991-10-04
US07/771,697 US5281628A (en) 1991-10-04 1991-10-04 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines

Publications (3)

Publication Number Publication Date
FI924453A0 FI924453A0 (fi) 1992-10-02
FI924453A FI924453A (fi) 1993-04-05
FI111716B true FI111716B (fi) 2003-09-15

Family

ID=25092681

Family Applications (1)

Application Number Title Priority Date Filing Date
FI924453A FI111716B (fi) 1991-10-04 1992-10-02 Menetelmä uusien terapeuttisesti käyttökelpoisten 9-amino-7-(substituoitu)-6-demetyyli-6-deoksitetrasykliinien valmistamiseksi

Country Status (25)

Country Link
US (3) US5281628A (da)
EP (1) EP0535346B1 (da)
JP (1) JP3183729B2 (da)
KR (1) KR100261528B1 (da)
CN (1) CN1053182C (da)
AT (1) ATE129697T1 (da)
AU (1) AU651734B2 (da)
CA (1) CA2079703C (da)
CZ (1) CZ285015B6 (da)
DE (1) DE69205792T2 (da)
DK (1) DK0535346T3 (da)
ES (1) ES2081005T3 (da)
FI (1) FI111716B (da)
GR (1) GR3017978T3 (da)
HK (1) HK1000319A1 (da)
HU (2) HU211214B (da)
IL (1) IL103319A (da)
MX (1) MX9205573A (da)
NO (1) NO300129B1 (da)
NZ (1) NZ244556A (da)
PH (1) PH30343A (da)
PL (2) PL170939B1 (da)
SK (1) SK281113B6 (da)
TW (1) TW222616B (da)
ZA (1) ZA927608B (da)

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MXPA03000055A (es) * 2000-07-07 2003-07-14 Tufts College Compuestos de monociclina sustituidos en posicion 9..
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US20060194773A1 (en) * 2001-07-13 2006-08-31 Paratek Pharmaceuticals, Inc. Tetracyline compounds having target therapeutic activities
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IL163931A0 (en) * 2002-03-08 2005-12-18 Paratek Pharm Innc Amino-methyl substituted tetracyline compounds
CN1653037A (zh) 2002-03-21 2005-08-10 帕拉特克药品公司 取代的四环素化合物
EA012136B1 (ru) 2002-07-12 2009-08-28 Пэрэтек Фамэсьютикэлс, Инк. Замещенные соединения тетрациклина, фармацевтическая композиция и способ лечения чувствительного к тетрациклину состояния у субъекта
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AR057032A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos de preparacion
AR057033A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos para preparar 9-nitrominociclina
AR057034A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Metodos para purificar tigeciclina
AR057324A1 (es) * 2005-05-27 2007-11-28 Wyeth Corp Tigeciclina y metodos para preparar 9-aminominociclina
JP2009502809A (ja) * 2005-07-21 2009-01-29 パラテック ファーマシューティカルズ インコーポレイテッド １０−置換テトラサイクリンおよびその使用方法
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US8198470B2 (en) * 2006-04-24 2012-06-12 Teva Pharmaceutical Industries Ltd. Crystalline form II of tigecycline and processes for preparation thereof
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EP2537934A3 (en) 2006-05-15 2013-04-10 Paratek Pharmaceuticals, Inc. Methods of regulating expression of genes or of gene products using substituted tetracycline compounds
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Also Published As

Publication number Publication date
PL170933B1 (pl) 1997-02-28
HU211214B (en) 1995-11-28
MX9205573A (es) 1993-05-01
CN1053182C (zh) 2000-06-07
CZ285015B6 (cs) 1999-05-12
DE69205792T2 (de) 1996-06-20
GR3017978T3 (en) 1996-02-29
AU651734B2 (en) 1994-07-28
CA2079703A1 (en) 1993-04-05
CZ297292A3 (en) 1993-04-14
KR930007895A (ko) 1993-05-20
ATE129697T1 (de) 1995-11-15
SK297292A3 (en) 1994-12-07
EP0535346A1 (en) 1993-04-07
ZA927608B (en) 1993-04-13
ES2081005T3 (es) 1996-02-16
EP0535346B1 (en) 1995-11-02
HU211922A9 (en) 1996-01-29
PH30343A (en) 1997-04-02
NO923856L (no) 1993-04-05
FI924453A0 (fi) 1992-10-02
DE69205792D1 (de) 1995-12-07
IL103319A (en) 1996-07-23
JP3183729B2 (ja) 2001-07-09
CN1071415A (zh) 1993-04-28
US5401863A (en) 1995-03-28
NZ244556A (en) 1994-06-27
TW222616B (da) 1994-04-21
PL170939B1 (pl) 1997-02-28
US5281628A (en) 1994-01-25
DK0535346T3 (da) 1995-12-04
FI924453A (fi) 1993-04-05
SK281113B6 (sk) 2000-12-11
HK1000319A1 (en) 1998-02-27
IL103319A0 (en) 1993-03-15
CA2079703C (en) 2004-07-20
HU9203143D0 (en) 1992-12-28
NO923856D0 (no) 1992-10-02
US5326759A (en) 1994-07-05
PL296140A1 (en) 1993-11-02
JPH05239006A (ja) 1993-09-17
HUT64298A (en) 1993-12-28
NO300129B1 (no) 1997-04-14
AU2618292A (en) 1993-04-08
KR100261528B1 (ko) 2000-07-15

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