FI110920B - Menetelmä metaanidifosfonihappoformulaatioiden valmistamiseksi ioninvaihtajien kanssa - Google Patents

Menetelmä metaanidifosfonihappoformulaatioiden valmistamiseksi ioninvaihtajien kanssa Download PDF

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Publication number
FI110920B
FI110920B FI931633A FI931633A FI110920B FI 110920 B FI110920 B FI 110920B FI 931633 A FI931633 A FI 931633A FI 931633 A FI931633 A FI 931633A FI 110920 B FI110920 B FI 110920B
Authority
FI
Finland
Prior art keywords
diphosphonic acid
preparation
hydroxy
disodium
farmaceutisk
Prior art date
Application number
FI931633A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI931633A0 (fi
FI931633A (fi
Inventor
Satish Chandra Khanna
Jonathan Green
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of FI931633A0 publication Critical patent/FI931633A0/fi
Publication of FI931633A publication Critical patent/FI931633A/fi
Application granted granted Critical
Publication of FI110920B publication Critical patent/FI110920B/fi

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A61K47/585—Ion exchange resins, e.g. polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Organic Chemistry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Treatment Of Sludge (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Preventing Corrosion Or Incrustation Of Metals (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Detergent Compositions (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Treatment Of Water By Ion Exchange (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
FI931633A 1992-04-15 1993-04-08 Menetelmä metaanidifosfonihappoformulaatioiden valmistamiseksi ioninvaihtajien kanssa FI110920B (fi)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH124792 1992-04-15
CH124792 1992-04-15

Publications (3)

Publication Number Publication Date
FI931633A0 FI931633A0 (fi) 1993-04-08
FI931633A FI931633A (fi) 1993-10-16
FI110920B true FI110920B (fi) 2003-04-30

Family

ID=4205927

Family Applications (1)

Application Number Title Priority Date Filing Date
FI931633A FI110920B (fi) 1992-04-15 1993-04-08 Menetelmä metaanidifosfonihappoformulaatioiden valmistamiseksi ioninvaihtajien kanssa

Country Status (20)

Country Link
US (1) US5344825A (fr)
EP (1) EP0566535B1 (fr)
JP (1) JP3970941B2 (fr)
KR (1) KR100307786B1 (fr)
AT (1) ATE183096T1 (fr)
AU (1) AU665814B2 (fr)
CA (1) CA2093946C (fr)
DE (1) DE59309727D1 (fr)
DK (1) DK0566535T3 (fr)
ES (1) ES2137241T3 (fr)
FI (1) FI110920B (fr)
GR (1) GR3031645T3 (fr)
HU (1) HU219022B (fr)
IL (1) IL105382A (fr)
MX (1) MX9302151A (fr)
NO (1) NO306978B1 (fr)
NZ (1) NZ247398A (fr)
PH (1) PH30733A (fr)
TW (1) TW237386B (fr)
ZA (1) ZA932613B (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6406714B1 (en) 1992-12-02 2002-06-18 Merck & Co., Inc. Dry mix formulation for bisphosphonic acids
US5591730A (en) * 1993-10-12 1997-01-07 The Regents Of The University Of California Inhibition of urinary calculi growth
TW390813B (en) * 1994-04-29 2000-05-21 Merck & Co Inc Wet granulation formulation for bisphosphonic acids
US20010007863A1 (en) * 1998-06-18 2001-07-12 Merck & Co., Inc. Wet granulation formulation for bisphosphonic acids
DE19615812A1 (de) * 1996-04-20 1997-10-23 Boehringer Mannheim Gmbh Pharmazeutische Zubereitung enthaltend Diphosphonsäuren zur oralen Applikation
DE19719680A1 (de) 1997-05-09 1998-11-19 Boehringer Mannheim Gmbh Verwendung von Diphosphonsäuren zur präventiven Behandlung von Spätfolgen bei Harnblasenerweiterung oder Harnblasenersatz
CN1274279A (zh) * 1997-06-11 2000-11-22 普罗克特和甘保尔公司 能改进胃肠道上部安全性的膜包衣片剂
FI104901B (fi) 1997-10-20 2000-04-28 Leiras Oy Uudet metyleenibisfosfonihappojohdannaiset
US6160165A (en) 1998-12-10 2000-12-12 Aesgen, Inc. Method for preparation of disodium pamidronate
US6794536B1 (en) 1998-12-10 2004-09-21 Aesqen, Inc. Method for preparation of disodium pamidronate
SE9901272D0 (sv) * 1999-04-09 1999-04-09 Astra Ab New improved formulation
US7560490B2 (en) * 2001-01-23 2009-07-14 Gador S.A. Composition comprising bisphosphonates for prevention and/or treatment of metabolic diseases of bones, process for preparing such composition and use thereof
CA2372450A1 (fr) * 2001-05-10 2001-09-19 Pharmaceutical Partners Of Canada Inc. Preparation injectable liquide de pamidronate disodique
JP4142356B2 (ja) 2001-07-05 2008-09-03 オイクロ ヨーロピアン コントラクト リサーチ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディト ゲゼルシャフト Ｐｐ２ｃの基質
US20030099711A1 (en) * 2001-08-29 2003-05-29 David Meadows Sustained release preparations
HUP0402267A3 (en) * 2001-12-21 2007-05-29 Procter & Gamble Method for treatment of bone disorders
SI1880744T1 (sl) 2002-05-10 2015-04-30 F. Hoffmann-La Roche Ag Bifosfonske kisline za zdravljenje in prepreäśevanje osteoporoze
JP2004018524A (ja) * 2002-06-13 2004-01-22 Eucro European Contract Research Gmbh & Co Kg 動脈硬化症を処置するための方法
EP1396263A1 (fr) * 2002-08-09 2004-03-10 Warner-Lambert Company Compositions d'enrobage pour tablettes et caplets
US20040043072A1 (en) * 2002-09-04 2004-03-04 Will Joanne Patricia Alleviation of upper gastrointestinal irritation
ES2530791T3 (es) * 2002-12-20 2015-03-05 Hoffmann La Roche Formulación de ibandronato de altas dosis
US20050265955A1 (en) * 2004-05-28 2005-12-01 Mallinckrodt Inc. Sustained release preparations
JP4896480B2 (ja) * 2004-10-01 2012-03-14 第一三共ヘルスケア株式会社 陰イオン交換樹脂の粒子状組成物
GB201200868D0 (en) 2012-01-19 2012-02-29 Depuy Int Ltd Bone filler composition
EP3691646A4 (fr) * 2017-10-02 2021-06-30 Board of Regents, The University of Texas System Composition à inhaler de clofazimine et leurs méthodes d'utilisation

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2130794C3 (de) 1971-06-22 1974-07-11 Joh. A. Benckiser Gmbh, 6700 Ludwigshafen Verfahren zur Herstellung von l-Hydroxy-S-amino-propan-ljl-diphosphonsäure
DE2405254C2 (de) 1974-02-04 1982-05-27 Henkel KGaA, 4000 Düsseldorf Verwendung von 3-Amino-1-Hydroxypropan-1, 1-diphosphonsäure oder ihrer wasserlöslichen Salze bei der Beeinflußung von Calciumstoffwechselstörungen im menschlichen oder tierischen Körper
JPS57177012A (en) * 1981-04-23 1982-10-30 Sumitomo Chem Co Ltd Preparation of chelate resin
IT1201087B (it) * 1982-04-15 1989-01-27 Gentili Ist Spa Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche
US4639338A (en) 1984-08-06 1987-01-27 Ciba-Geigy Corporation Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate
US5057505A (en) * 1986-11-21 1991-10-15 Ciba-Geigy Corporation Substituted aminomethanediphosphonic acids and use in medicaments
EP0274346B1 (fr) * 1986-11-21 1991-03-06 Ciba-Geigy Ag Acides aminométhanediphosphoniques substitués
DE3822650A1 (de) * 1988-07-05 1990-02-01 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US4996047A (en) * 1988-11-02 1991-02-26 Richardson-Vicks, Inc. Sustained release drug-resin complexes
MX21452A (es) * 1989-07-07 1994-01-31 Ciba Geigy Ag Preparaciones farmaceuticas que se administran en forma topica.
PH27186A (en) * 1989-09-07 1993-04-16 Ciba Geigy Ag Double-coated granules of disodium pamidronate
US5270365A (en) * 1991-12-17 1993-12-14 Merck & Co., Inc. Prevention and treatment of periodontal disease with alendronate

Also Published As

Publication number Publication date
JP3970941B2 (ja) 2007-09-05
CA2093946A1 (fr) 1993-10-16
IL105382A (en) 1998-06-15
ATE183096T1 (de) 1999-08-15
NO306978B1 (no) 2000-01-24
FI931633A0 (fi) 1993-04-08
KR100307786B1 (ko) 2001-11-30
AU3696193A (en) 1993-10-21
DE59309727D1 (de) 1999-09-16
GR3031645T3 (en) 2000-02-29
AU665814B2 (en) 1996-01-18
ES2137241T3 (es) 1999-12-16
NZ247398A (en) 1995-07-26
ZA932613B (en) 1993-10-26
MX9302151A (es) 1993-10-01
NO931367L (no) 1993-10-18
IL105382A0 (en) 1993-08-18
KR940005268A (ko) 1994-03-21
FI931633A (fi) 1993-10-16
HUT63766A (en) 1993-10-28
DK0566535T3 (da) 2000-03-06
JPH069408A (ja) 1994-01-18
CA2093946C (fr) 2005-07-05
NO931367D0 (no) 1993-04-14
EP0566535A1 (fr) 1993-10-20
US5344825A (en) 1994-09-06
PH30733A (en) 1997-10-17
HU9301088D0 (en) 1993-06-28
HU219022B (hu) 2001-04-28
EP0566535B1 (fr) 1999-08-11
TW237386B (fr) 1995-01-01

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Owner name: NOVARTIS AG