DK0566535T3 - Methandiphosphonsyre-præparater med ionbyttere - Google Patents

Methandiphosphonsyre-præparater med ionbyttere

Info

Publication number
DK0566535T3
DK0566535T3 DK93810246T DK93810246T DK0566535T3 DK 0566535 T3 DK0566535 T3 DK 0566535T3 DK 93810246 T DK93810246 T DK 93810246T DK 93810246 T DK93810246 T DK 93810246T DK 0566535 T3 DK0566535 T3 DK 0566535T3
Authority
DK
Denmark
Prior art keywords
diphosphonic acid
ion exchangers
acid preparations
disodium
methane diphosphonic
Prior art date
Application number
DK93810246T
Other languages
Danish (da)
English (en)
Inventor
Satish Chandra Dr Khanna
Jonathan Dr Green
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of DK0566535T3 publication Critical patent/DK0566535T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
    • A61K47/585—Ion exchange resins, e.g. polystyrene sulfonic acid resin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Treatment Of Sludge (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Preventing Corrosion Or Incrustation Of Metals (AREA)
  • Treatment Of Water By Ion Exchange (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Detergent Compositions (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
DK93810246T 1992-04-15 1993-04-06 Methandiphosphonsyre-præparater med ionbyttere DK0566535T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH124792 1992-04-15

Publications (1)

Publication Number Publication Date
DK0566535T3 true DK0566535T3 (da) 2000-03-06

Family

ID=4205927

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93810246T DK0566535T3 (da) 1992-04-15 1993-04-06 Methandiphosphonsyre-præparater med ionbyttere

Country Status (20)

Country Link
US (1) US5344825A (fr)
EP (1) EP0566535B1 (fr)
JP (1) JP3970941B2 (fr)
KR (1) KR100307786B1 (fr)
AT (1) ATE183096T1 (fr)
AU (1) AU665814B2 (fr)
CA (1) CA2093946C (fr)
DE (1) DE59309727D1 (fr)
DK (1) DK0566535T3 (fr)
ES (1) ES2137241T3 (fr)
FI (1) FI110920B (fr)
GR (1) GR3031645T3 (fr)
HU (1) HU219022B (fr)
IL (1) IL105382A (fr)
MX (1) MX9302151A (fr)
NO (1) NO306978B1 (fr)
NZ (1) NZ247398A (fr)
PH (1) PH30733A (fr)
TW (1) TW237386B (fr)
ZA (1) ZA932613B (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6406714B1 (en) 1992-12-02 2002-06-18 Merck & Co., Inc. Dry mix formulation for bisphosphonic acids
US5591730A (en) * 1993-10-12 1997-01-07 The Regents Of The University Of California Inhibition of urinary calculi growth
TW390813B (en) * 1994-04-29 2000-05-21 Merck & Co Inc Wet granulation formulation for bisphosphonic acids
US20010007863A1 (en) * 1998-06-18 2001-07-12 Merck & Co., Inc. Wet granulation formulation for bisphosphonic acids
DE19615812A1 (de) * 1996-04-20 1997-10-23 Boehringer Mannheim Gmbh Pharmazeutische Zubereitung enthaltend Diphosphonsäuren zur oralen Applikation
DE19719680A1 (de) * 1997-05-09 1998-11-19 Boehringer Mannheim Gmbh Verwendung von Diphosphonsäuren zur präventiven Behandlung von Spätfolgen bei Harnblasenerweiterung oder Harnblasenersatz
NZ503946A (en) * 1997-06-11 2003-02-28 Procter & Gamble Oral dosage form in an oval or caplet shape for administration of bisphosphonates and other known medicaments
FI104901B (fi) 1997-10-20 2000-04-28 Leiras Oy Uudet metyleenibisfosfonihappojohdannaiset
US6794536B1 (en) 1998-12-10 2004-09-21 Aesqen, Inc. Method for preparation of disodium pamidronate
US6160165A (en) * 1998-12-10 2000-12-12 Aesgen, Inc. Method for preparation of disodium pamidronate
SE9901272D0 (sv) * 1999-04-09 1999-04-09 Astra Ab New improved formulation
EP1372669B1 (fr) * 2001-01-23 2005-06-15 Gador S.A. Composition comprenant des diphosphonates pour la prevention et/ou le traitement de maladies metaboliques des os, procede de preparation d'une telle composition et son utilisation
CA2347330C (fr) * 2001-05-10 2002-03-12 Pharmaceutical Partners Of Canada Inc. Preparation injectable liquide de pamidronate disodique
US6933127B2 (en) 2001-07-05 2005-08-23 Eucro European Contract Research Gmbh & Co. Kg Substrate for PP2C
WO2003020242A1 (fr) * 2001-08-29 2003-03-13 Srl Technologies, Inc. Preparations a liberation prolongee
CN100479823C (zh) * 2001-12-21 2009-04-22 宝洁公司 双膦酸盐在制造药物套盒中的用途以及用于增加骨质的套盒
PT1506041E (pt) 2002-05-10 2007-12-28 Hoffmann La Roche Ácido ibandrónico para o tratamento e a prevenção da osteoporose
JP2004018524A (ja) * 2002-06-13 2004-01-22 Eucro European Contract Research Gmbh & Co Kg 動脈硬化症を処置するための方法
EP1396263A1 (fr) * 2002-08-09 2004-03-10 Warner-Lambert Company Compositions d'enrobage pour tablettes et caplets
US20040043072A1 (en) * 2002-09-04 2004-03-04 Will Joanne Patricia Alleviation of upper gastrointestinal irritation
DK1596870T4 (da) * 2002-12-20 2011-06-14 Hoffmann La Roche Højdosis-ibandronatformulering
US20050265955A1 (en) * 2004-05-28 2005-12-01 Mallinckrodt Inc. Sustained release preparations
JP4896480B2 (ja) * 2004-10-01 2012-03-14 第一三共ヘルスケア株式会社 陰イオン交換樹脂の粒子状組成物
GB201200868D0 (en) 2012-01-19 2012-02-29 Depuy Int Ltd Bone filler composition
CN111212645A (zh) * 2017-10-02 2020-05-29 得克萨斯大学体系董事会 氯法齐明(Clofazimine)的可吸入组合物及其使用方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2130794C3 (de) 1971-06-22 1974-07-11 Joh. A. Benckiser Gmbh, 6700 Ludwigshafen Verfahren zur Herstellung von l-Hydroxy-S-amino-propan-ljl-diphosphonsäure
DE2405254C2 (de) 1974-02-04 1982-05-27 Henkel KGaA, 4000 Düsseldorf Verwendung von 3-Amino-1-Hydroxypropan-1, 1-diphosphonsäure oder ihrer wasserlöslichen Salze bei der Beeinflußung von Calciumstoffwechselstörungen im menschlichen oder tierischen Körper
JPS57177012A (en) * 1981-04-23 1982-10-30 Sumitomo Chem Co Ltd Preparation of chelate resin
IT1201087B (it) * 1982-04-15 1989-01-27 Gentili Ist Spa Bifosfonati farmacologicamente attivi,procedimento per la loro preparazione e relative composizioni farmaceutiche
US4639338A (en) 1984-08-06 1987-01-27 Ciba-Geigy Corporation Preparation of crystalline disodium 3-amino-1-hydroxypropane-1,1-diphosphonate pentahydrate
US5057505A (en) * 1986-11-21 1991-10-15 Ciba-Geigy Corporation Substituted aminomethanediphosphonic acids and use in medicaments
ES2038693T3 (es) * 1986-11-21 1993-08-01 Ciba-Geigy Ag Nuevos acidos aminometanodifosfonicos substituidos.
DE3822650A1 (de) * 1988-07-05 1990-02-01 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US4996047A (en) * 1988-11-02 1991-02-26 Richardson-Vicks, Inc. Sustained release drug-resin complexes
MX21452A (es) * 1989-07-07 1994-01-31 Ciba Geigy Ag Preparaciones farmaceuticas que se administran en forma topica.
PH27186A (en) * 1989-09-07 1993-04-16 Ciba Geigy Ag Double-coated granules of disodium pamidronate
US5270365A (en) * 1991-12-17 1993-12-14 Merck & Co., Inc. Prevention and treatment of periodontal disease with alendronate

Also Published As

Publication number Publication date
HUT63766A (en) 1993-10-28
US5344825A (en) 1994-09-06
AU665814B2 (en) 1996-01-18
FI931633A0 (fi) 1993-04-08
NZ247398A (en) 1995-07-26
AU3696193A (en) 1993-10-21
NO306978B1 (no) 2000-01-24
KR100307786B1 (ko) 2001-11-30
KR940005268A (ko) 1994-03-21
HU9301088D0 (en) 1993-06-28
PH30733A (en) 1997-10-17
HU219022B (hu) 2001-04-28
EP0566535B1 (fr) 1999-08-11
ATE183096T1 (de) 1999-08-15
FI110920B (fi) 2003-04-30
GR3031645T3 (en) 2000-02-29
CA2093946A1 (fr) 1993-10-16
NO931367L (no) 1993-10-18
MX9302151A (es) 1993-10-01
ZA932613B (en) 1993-10-26
ES2137241T3 (es) 1999-12-16
JP3970941B2 (ja) 2007-09-05
NO931367D0 (no) 1993-04-14
CA2093946C (fr) 2005-07-05
EP0566535A1 (fr) 1993-10-20
JPH069408A (ja) 1994-01-18
IL105382A0 (en) 1993-08-18
IL105382A (en) 1998-06-15
TW237386B (fr) 1995-01-01
DE59309727D1 (de) 1999-09-16
FI931633A (fi) 1993-10-16

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