FI109333B - Förfarande för framställning av ett läkemedelspreparat för lokal behandling - Google Patents
Förfarande för framställning av ett läkemedelspreparat för lokal behandling Download PDFInfo
- Publication number
- FI109333B FI109333B FI922316A FI922316A FI109333B FI 109333 B FI109333 B FI 109333B FI 922316 A FI922316 A FI 922316A FI 922316 A FI922316 A FI 922316A FI 109333 B FI109333 B FI 109333B
- Authority
- FI
- Finland
- Prior art keywords
- compound
- formula
- polymeric film
- preparation
- process according
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q3/00—Manicure or pedicure preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q3/00—Manicure or pedicure preparations
- A61Q3/02—Nail coatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Birds (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (8)
1. Förfarande för framställning av ett läkemedelspre-parat för lokal behandling, sasora ett nagellacksprepa-rat för behandling av naglars svampsjukdomar, vilket 5 preparat som verksamt ämne innehäller en förening en-ligt formel I CeC-C(CHj), CH, H / __. I \ / / - \ CB,-N C — C I “ Cty V > och vilken är i form av en fri bas eller ett syraaddi- 15 tionssalt, och ett ämne, som bildar en polymerfilm, vilket valts ur en grupp, vilken omfattar polyvinyl-. : : acetat eller akryl- och metakrylsyraalkylester- *;·«· sampolymerisat med kvaternära ammoniumgrupper, eller I metylvinyleter-maleinsyramonoalkylestersampolymerisat ,·. : 2 0 samt vid behov andra hjälpmedel, känneteck- • s t l n a t därav, att en förening enligt formel (I) , vilken i · är i formen av en fri bas eller ett syraadditionssalt, * * ·’’ blandas med ett lämpligt ämne, som bildar en polymer film, vilket valts ur en grupp, vilken omfattar poly-,'· 25 vinylacetat eller akryl- och metakrylsyra-alkylester- sampolymerisat med kvaternära ammoniumgrupper, eller metylvinyleter-maleinsyramonoalkylestersampolymerisat, samt vid behov med andra konventionella hjälpmedel sä, att blandningsförhällandet mellan föreningen enligt • · « .„·* 30 formel (I) och ämnet som bildar en polymerfilm är ca. 1:0,5 - 1:25 beräknat pä basis av w/w.
2. Förfarande enligt patentkrav 1, känneteck-n a t därav, att ämnet som bildar en polymerfilm är polyvinylacetat. 35
3. Förfarande enligt patentkrav 2, känneteck- n a t därav, att ämnet som bildar en polymerfilm är 109333 ett akryl- och metakrylsyraalkylestersampolymerisat med kvaternära ammoniumgrupper.
4. Förfarande enligt patentkrav 1, känneteck-n a t därav, att ämnet sorti bildar en polymerfilm är 5 ett metylvinyleter-maleinsyramonoalkyles- tersampolymerisat.
5. Preparat enligt patentkrav 1, känneteck-n a t därav, att blandningsförhällandet mellan före-ningen enligt formel (I) och ämnet som bildar en poly- 10 merfilm är ca. 1:1 - 1:20.
6. Preparat enligt patentkrav 5, känneteck-n a t därav, att blandningsförhällandet mellan före-ningen enligt formel (I) och ämnet som bildar en polymerfilm är ca. 1:1 - 1:10. 15
7. Förfarande enligt nägot av patentkraven 1 - 4, kännetecknat därav, att preparatet innehäl-.·, ler ca. 0,5 - 3 0 % av föreningen enligt formel (I) I · · beräknad pä den totala sammansättningen enligt w/w. * ·
8. Förfarande enligt patentkrav 7, känneteck- * * ·[ 20 n a t därav, att preparatet av den totala sammansätt- • · - ningen innehäller ca. 1 - 20 % av föreningen enligt formel (I) . » · · i · • » » t • · « I I · « I · • I · * • » » « * » · • ( * · 1 « 4 • • t t · 4 I I t > t »
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB919111210A GB9111210D0 (en) | 1991-05-23 | 1991-05-23 | Pharmaceutical composition |
GB9111210 | 1991-05-23 | ||
GB929204472A GB9204472D0 (en) | 1992-03-02 | 1992-03-02 | Pharmaceutical composition |
GB9204472 | 1992-03-02 |
Publications (3)
Publication Number | Publication Date |
---|---|
FI922316A0 FI922316A0 (fi) | 1992-05-21 |
FI922316A FI922316A (fi) | 1992-11-24 |
FI109333B true FI109333B (sv) | 2002-07-15 |
Family
ID=26298942
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI922316A FI109333B (sv) | 1991-05-23 | 1992-05-21 | Förfarande för framställning av ett läkemedelspreparat för lokal behandling |
Country Status (31)
Country | Link |
---|---|
US (3) | US5866105A (sv) |
EP (1) | EP0515312B1 (sv) |
JP (1) | JP3527749B2 (sv) |
KR (1) | KR100367150B1 (sv) |
AT (1) | AT400518B (sv) |
AU (1) | AU642090B2 (sv) |
CA (1) | CA2069153C (sv) |
CH (1) | CH683237A5 (sv) |
CY (1) | CY2070B1 (sv) |
CZ (1) | CZ284232B6 (sv) |
DE (1) | DE4215677B4 (sv) |
DK (1) | DK0515312T3 (sv) |
ES (1) | ES2091441T3 (sv) |
FI (1) | FI109333B (sv) |
FR (1) | FR2676647B1 (sv) |
GB (1) | GB2256138B (sv) |
GR (1) | GR3021551T3 (sv) |
HK (1) | HK1000242A1 (sv) |
HU (1) | HU219480B (sv) |
IE (1) | IE66476B1 (sv) |
IL (1) | IL101944A (sv) |
IT (1) | IT1254571B (sv) |
LU (1) | LU88117A1 (sv) |
MX (1) | MX9202407A (sv) |
NO (1) | NO300084B1 (sv) |
NZ (1) | NZ242849A (sv) |
PH (1) | PH31205A (sv) |
RO (1) | RO112081B1 (sv) |
RU (1) | RU2110257C1 (sv) |
SK (1) | SK281130B6 (sv) |
ZA (1) | ZA923765B (sv) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HU219480B (hu) * | 1991-05-23 | 2001-04-28 | Novartis Ag. | Eljárás gombás körömmegbetegségek ellen helyileg alkalmazható, allil-amin-származékot tartalmazó gyógyászati készítmények előállítására |
US5464610A (en) * | 1992-10-15 | 1995-11-07 | Schering-Plough Healthcare Products, Inc. | Method for treating onychomycosis |
DK128494A (da) * | 1994-11-08 | 1996-05-09 | Edel K Seidenschnur | Behandling af keratinøse og psoriatiske sygdomstilstande med neglelak indeholdende vitamin D metabolit, eller derivat, og/eller vitamin A derivat |
DE19643831A1 (de) | 1996-10-30 | 1998-05-07 | Hoechst Ag | Verwendung von 1-Hydroxy-2-pyridonen zur Behandlung von schwer therapierbaren Schleimhauterkrankungen |
WO1997034644A1 (de) * | 1996-03-16 | 1997-09-25 | Hoechst Aktiengesellschaft | Topische formulierungen zur behandlung von nagel-psoriasis |
DE19639817A1 (de) | 1996-09-27 | 1998-04-02 | Hoechst Ag | Verwendung von 1-Hydroxy-2-pyridonen zur Behandlung von Hautinfektionen |
DE19639816A1 (de) * | 1996-09-27 | 1998-04-02 | Hoechst Ag | Antimykotische Mittel mit hoher Wirkstofffreisetzung |
US20040039030A1 (en) * | 1996-09-27 | 2004-02-26 | Hoechst Akeengesellschaft | Use of 1-hydroxy-2-pyridones for the treatment of seborrheic dermatitis |
RO118174B1 (ro) * | 1997-08-21 | 2003-03-28 | Aventis Pharma Deutschland Gmbh | Lac de unghii şi utilizarea acestuia |
US6605751B1 (en) * | 1997-11-14 | 2003-08-12 | Acrymed | Silver-containing compositions, devices and methods for making |
US6727401B1 (en) | 1998-02-12 | 2004-04-27 | Watson Pharmaceuticals, Inc. | Pressure sensitive adhesive matrix patch for the treatment of onychomycosis |
IL138889A0 (en) * | 1998-04-17 | 2001-11-25 | Bertek Pharm Inc | Topical formulations for the treatment of nail fungal diseases |
AU3753700A (en) * | 1999-03-16 | 2000-10-04 | Mark Yezbick | A fingernail coating composition |
US6403063B1 (en) | 1999-07-26 | 2002-06-11 | Kenneth I. Sawyer | Method of treating nail fungus |
DE19949517A1 (de) * | 1999-10-14 | 2001-04-19 | Henkel Kgaa | Festigende Haarreinigungsmittel |
ATE327779T1 (de) | 1999-12-30 | 2006-06-15 | Acrymed | Methode und zusammensetzungen für verbesserte abgabevorrichtungen |
DE10011081A1 (de) * | 2000-03-09 | 2001-09-13 | Aventis Pharma Gmbh | Antiinfektive Wirkstoffkombinationen und ihre Verwendung zur topischen Behandlung von Pilzerkrankungen der Fuß- und Fingernägel |
GB0014448D0 (en) * | 2000-06-13 | 2000-08-09 | Novartis Ag | Organic compounds |
DE10035991A1 (de) | 2000-07-24 | 2002-02-14 | Polichem Sa | Nagellackzusammensetzung |
GB0019283D0 (en) * | 2000-08-04 | 2000-09-27 | Novartis Ag | Organic compounds |
JP4803511B2 (ja) * | 2000-08-25 | 2011-10-26 | 株式会社ポーラファルマ | 抗真菌医薬組成物 |
GB0103046D0 (en) | 2001-02-07 | 2001-03-21 | Novartis Ag | Organic Compounds |
US6585963B1 (en) * | 2001-02-15 | 2003-07-01 | Watson Pharmaceuticals, Inc. | Nail compositions and methods of administering same |
US6878365B2 (en) * | 2001-03-10 | 2005-04-12 | James Edward Brehove | Topical application for treating toenail fungus |
US7244703B2 (en) * | 2001-06-22 | 2007-07-17 | Bentley Pharmaceuticals, Inc. | Pharmaceutical compositions and methods for peptide treatment |
CA2459399C (en) * | 2001-09-04 | 2009-06-30 | Trommsdorff Gmbh & Co. Kg Arzneimittel | Plaster for the treatment of dysfunctions and disorders of nails, comprising sertaconazole |
US6921529B2 (en) * | 2002-07-29 | 2005-07-26 | Joseph C. Maley | Treatment modality and method for fungal nail infection |
US8486426B2 (en) | 2002-07-29 | 2013-07-16 | Kimberly-Clark Worldwide, Inc. | Methods and compositions for treatment of dermal conditions |
US20030049307A1 (en) * | 2002-08-15 | 2003-03-13 | Gyurik Robert J. | Pharmaceutical composition |
JP2006501223A (ja) * | 2002-08-20 | 2006-01-12 | ピネル,ドーレン・エム | 真菌感染を治療する方法 |
US20040126343A1 (en) * | 2002-12-26 | 2004-07-01 | Garshowitz Solomon David | Nail drug delivery |
ES2366273T3 (es) * | 2003-03-21 | 2011-10-18 | Nexmed Holdings, Inc. | Esmalte de uñas antifúngico y procedimiento de utilización. |
US7112561B2 (en) | 2003-12-08 | 2006-09-26 | Bentley Pharmaceuticals, Inc. | Pharmaceutical compositions and methods for insulin treatment |
EP2789235B1 (en) | 2004-07-30 | 2015-12-23 | Avent, Inc. | Method of preparing silver nanoparticles |
US8361553B2 (en) | 2004-07-30 | 2013-01-29 | Kimberly-Clark Worldwide, Inc. | Methods and compositions for metal nanoparticle treated surfaces |
EP1781098B1 (en) * | 2004-07-30 | 2015-10-07 | Avent, Inc. | Antimicrobial devices and compositions |
EP1809264B1 (en) * | 2004-09-20 | 2016-04-13 | Avent, Inc. | Antimicrobial amorphous compositions |
FR2878157B1 (fr) * | 2004-11-23 | 2007-03-02 | Durlin France Sa | Composition de vernis a base de solvant a base de solvant d'origine vegetale |
US20060165747A1 (en) * | 2005-01-24 | 2006-07-27 | David Rolf | Antifungal composition, method and kit for topically treating onychomycosis |
CN101262848B (zh) * | 2005-09-29 | 2011-05-11 | 诺瓦提斯公司 | 抗真菌组合物 |
BRPI0616765A2 (pt) | 2005-09-29 | 2011-06-28 | Novartis Ag | composição antifúngica tópica adaptada para tratar uma infecção fúngica da pele, método para tratar uma infecção da pele por dermatófito, método para tratar infecção da pele e processo para a fabricação de uma composição farmacêutica tópica |
KR20080098596A (ko) * | 2006-01-02 | 2008-11-11 | 티엘티 메디컬 리미티드 | 조갑 질환 치료용 약학적 조성물 |
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GB0720716D0 (en) * | 2007-10-23 | 2007-12-05 | York Pharma Plc | Novel formulation |
JP5638534B2 (ja) * | 2008-11-24 | 2014-12-10 | キンバリー クラーク ワールドワイド インコーポレイテッド | 抗菌積層構造体 |
WO2010069519A1 (en) * | 2008-12-18 | 2010-06-24 | Merz Pharma Gmbh & Co. Kgaa | Topical compositions comprising at least one active ingredient poorly soluble in water and biopolymers such as hyaluronic acid with a pka-value between 5-7 |
ES2468540T3 (es) * | 2009-02-13 | 2014-06-16 | Topica Pharmaceuticals, Inc | Formulación antif�ngica |
FR2942716B1 (fr) * | 2009-03-06 | 2011-04-15 | Galderma Res & Dev | Methode de solubilisation d'agent antifongique et compositions a haute concentration en agent antifongique applicables sur l'ongle |
JP5992324B2 (ja) * | 2009-03-20 | 2016-09-14 | スティーフェル ラボラトリーズ インコーポレイテッド | 脂肪酸モノグリセリド組成物 |
US9345774B2 (en) | 2012-07-06 | 2016-05-24 | Leo Pharma A/S | Topical composition comprising a film-forming polymer for delivering an active ingredient to skin |
US8697753B1 (en) * | 2013-02-07 | 2014-04-15 | Polichem Sa | Method of treating onychomycosis |
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LU86924A1 (fr) * | 1987-06-19 | 1989-03-08 | Oreal | Vernis a ongles anhydres |
US4920109A (en) * | 1988-04-18 | 1990-04-24 | Merck & Co., Inc. | Antifungal compositions and method of controlling mycotic infections |
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US5116603A (en) * | 1989-01-31 | 1992-05-26 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Oral antifungal preventative, and method of use |
CA2008775C (en) * | 1989-02-24 | 1998-12-22 | Alberto Ferro | Nail lacquer |
FR2646603B1 (fr) * | 1989-05-03 | 1991-07-12 | Oreal | Composition nettoyante |
CA2020888A1 (en) * | 1989-07-27 | 1991-01-28 | Philippe Guerry | Substituted aminoalkoxybenzene derivatives |
FR2666962B1 (fr) | 1990-09-26 | 1996-06-14 | Oreal | Composition antifongique sous forme de spray sec. |
FR2673537B1 (fr) | 1991-03-08 | 1993-06-11 | Oreal | Utilisation d'agents de penetration hydrophiles dans les compositions dermatologiques pour le traitement des onychomycoses, et compositions correspondantes. |
HU223343B1 (hu) | 1991-05-20 | 2004-06-28 | Novartis Ag. | Allil-amin-származékot tartalmazó gyógyászati készítmények és eljárás azok előállítására |
HU219480B (hu) * | 1991-05-23 | 2001-04-28 | Novartis Ag. | Eljárás gombás körömmegbetegségek ellen helyileg alkalmazható, allil-amin-származékot tartalmazó gyógyászati készítmények előállítására |
-
1992
- 1992-05-08 HU HU9201548A patent/HU219480B/hu unknown
- 1992-05-13 DE DE4215677A patent/DE4215677B4/de not_active Expired - Lifetime
- 1992-05-15 FR FR9206025A patent/FR2676647B1/fr not_active Expired - Lifetime
- 1992-05-19 LU LU88117A patent/LU88117A1/fr unknown
- 1992-05-19 CH CH1598/92A patent/CH683237A5/de not_active IP Right Cessation
- 1992-05-20 DK DK92810380.3T patent/DK0515312T3/da active
- 1992-05-20 PH PH44373A patent/PH31205A/en unknown
- 1992-05-20 EP EP92810380A patent/EP0515312B1/en not_active Expired - Lifetime
- 1992-05-20 ES ES92810380T patent/ES2091441T3/es not_active Expired - Lifetime
- 1992-05-21 SK SK1532-92A patent/SK281130B6/sk not_active IP Right Cessation
- 1992-05-21 CZ CS921532A patent/CZ284232B6/cs not_active IP Right Cessation
- 1992-05-21 NZ NZ242849A patent/NZ242849A/xx not_active IP Right Cessation
- 1992-05-21 AU AU17058/92A patent/AU642090B2/en not_active Expired
- 1992-05-21 MX MX9202407A patent/MX9202407A/es unknown
- 1992-05-21 FI FI922316A patent/FI109333B/sv not_active IP Right Cessation
- 1992-05-21 CA CA002069153A patent/CA2069153C/en not_active Expired - Lifetime
- 1992-05-21 IL IL10194492A patent/IL101944A/en not_active IP Right Cessation
- 1992-05-21 NO NO922006A patent/NO300084B1/no not_active IP Right Cessation
- 1992-05-21 RO RO92-200709A patent/RO112081B1/ro unknown
- 1992-05-22 GB GB9210974A patent/GB2256138B/en not_active Expired - Lifetime
- 1992-05-22 ZA ZA923765A patent/ZA923765B/xx unknown
- 1992-05-22 JP JP13066592A patent/JP3527749B2/ja not_active Expired - Lifetime
- 1992-05-22 AT AT0105892A patent/AT400518B/de not_active IP Right Cessation
- 1992-05-22 IT ITRM920381A patent/IT1254571B/it active
- 1992-05-22 KR KR1019920008688A patent/KR100367150B1/ko not_active IP Right Cessation
- 1992-05-22 RU SU5052122A patent/RU2110257C1/ru active
- 1992-07-01 IE IE921670A patent/IE66476B1/en not_active IP Right Cessation
-
1995
- 1995-06-06 US US08/466,490 patent/US5866105A/en not_active Expired - Fee Related
-
1996
- 1996-11-06 GR GR960402925T patent/GR3021551T3/el unknown
-
1997
- 1997-09-20 HK HK97101807A patent/HK1000242A1/xx not_active IP Right Cessation
-
1998
- 1998-09-11 CY CY9802070A patent/CY2070B1/xx unknown
- 1998-12-18 US US09/215,398 patent/US6214360B1/en not_active Expired - Lifetime
-
2000
- 2000-10-18 US US09/691,485 patent/US6319509B1/en not_active Expired - Fee Related
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