FI109333B - Förfarande för framställning av ett läkemedelspreparat för lokal behandling - Google Patents

Förfarande för framställning av ett läkemedelspreparat för lokal behandling Download PDF

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Publication number
FI109333B
FI109333B FI922316A FI922316A FI109333B FI 109333 B FI109333 B FI 109333B FI 922316 A FI922316 A FI 922316A FI 922316 A FI922316 A FI 922316A FI 109333 B FI109333 B FI 109333B
Authority
FI
Finland
Prior art keywords
compound
formula
polymeric film
preparation
process according
Prior art date
Application number
FI922316A
Other languages
English (en)
Finnish (fi)
Other versions
FI922316A0 (fi
FI922316A (fi
Inventor
Friedrich Richter
Marianne Roser
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919111210A external-priority patent/GB9111210D0/en
Priority claimed from GB929204472A external-priority patent/GB9204472D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of FI922316A0 publication Critical patent/FI922316A0/fi
Publication of FI922316A publication Critical patent/FI922316A/fi
Application granted granted Critical
Publication of FI109333B publication Critical patent/FI109333B/sv

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q3/00—Manicure or pedicure preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q3/00—Manicure or pedicure preparations
    • A61Q3/02—Nail coatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Birds (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Cosmetics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (8)

1. Förfarande för framställning av ett läkemedelspre-parat för lokal behandling, sasora ett nagellacksprepa-rat för behandling av naglars svampsjukdomar, vilket 5 preparat som verksamt ämne innehäller en förening en-ligt formel I CeC-C(CHj), CH, H / __. I \ / / - \ CB,-N C — C I “ Cty V > och vilken är i form av en fri bas eller ett syraaddi- 15 tionssalt, och ett ämne, som bildar en polymerfilm, vilket valts ur en grupp, vilken omfattar polyvinyl-. : : acetat eller akryl- och metakrylsyraalkylester- *;·«· sampolymerisat med kvaternära ammoniumgrupper, eller I metylvinyleter-maleinsyramonoalkylestersampolymerisat ,·. : 2 0 samt vid behov andra hjälpmedel, känneteck- • s t l n a t därav, att en förening enligt formel (I) , vilken i · är i formen av en fri bas eller ett syraadditionssalt, * * ·’’ blandas med ett lämpligt ämne, som bildar en polymer film, vilket valts ur en grupp, vilken omfattar poly-,'· 25 vinylacetat eller akryl- och metakrylsyra-alkylester- sampolymerisat med kvaternära ammoniumgrupper, eller metylvinyleter-maleinsyramonoalkylestersampolymerisat, samt vid behov med andra konventionella hjälpmedel sä, att blandningsförhällandet mellan föreningen enligt • · « .„·* 30 formel (I) och ämnet som bildar en polymerfilm är ca. 1:0,5 - 1:25 beräknat pä basis av w/w.
2. Förfarande enligt patentkrav 1, känneteck-n a t därav, att ämnet som bildar en polymerfilm är polyvinylacetat. 35
3. Förfarande enligt patentkrav 2, känneteck- n a t därav, att ämnet som bildar en polymerfilm är 109333 ett akryl- och metakrylsyraalkylestersampolymerisat med kvaternära ammoniumgrupper.
4. Förfarande enligt patentkrav 1, känneteck-n a t därav, att ämnet sorti bildar en polymerfilm är 5 ett metylvinyleter-maleinsyramonoalkyles- tersampolymerisat.
5. Preparat enligt patentkrav 1, känneteck-n a t därav, att blandningsförhällandet mellan före-ningen enligt formel (I) och ämnet som bildar en poly- 10 merfilm är ca. 1:1 - 1:20.
6. Preparat enligt patentkrav 5, känneteck-n a t därav, att blandningsförhällandet mellan före-ningen enligt formel (I) och ämnet som bildar en polymerfilm är ca. 1:1 - 1:10. 15
7. Förfarande enligt nägot av patentkraven 1 - 4, kännetecknat därav, att preparatet innehäl-.·, ler ca. 0,5 - 3 0 % av föreningen enligt formel (I) I · · beräknad pä den totala sammansättningen enligt w/w. * ·
8. Förfarande enligt patentkrav 7, känneteck- * * ·[ 20 n a t därav, att preparatet av den totala sammansätt- • · - ningen innehäller ca. 1 - 20 % av föreningen enligt formel (I) . » · · i · • » » t • · « I I · « I · • I · * • » » « * » · • ( * · 1 « 4 • • t t · 4 I I t > t »
FI922316A 1991-05-23 1992-05-21 Förfarande för framställning av ett läkemedelspreparat för lokal behandling FI109333B (sv)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB919111210A GB9111210D0 (en) 1991-05-23 1991-05-23 Pharmaceutical composition
GB9111210 1991-05-23
GB929204472A GB9204472D0 (en) 1992-03-02 1992-03-02 Pharmaceutical composition
GB9204472 1992-03-02

Publications (3)

Publication Number Publication Date
FI922316A0 FI922316A0 (fi) 1992-05-21
FI922316A FI922316A (fi) 1992-11-24
FI109333B true FI109333B (sv) 2002-07-15

Family

ID=26298942

Family Applications (1)

Application Number Title Priority Date Filing Date
FI922316A FI109333B (sv) 1991-05-23 1992-05-21 Förfarande för framställning av ett läkemedelspreparat för lokal behandling

Country Status (31)

Country Link
US (3) US5866105A (sv)
EP (1) EP0515312B1 (sv)
JP (1) JP3527749B2 (sv)
KR (1) KR100367150B1 (sv)
AT (1) AT400518B (sv)
AU (1) AU642090B2 (sv)
CA (1) CA2069153C (sv)
CH (1) CH683237A5 (sv)
CY (1) CY2070B1 (sv)
CZ (1) CZ284232B6 (sv)
DE (1) DE4215677B4 (sv)
DK (1) DK0515312T3 (sv)
ES (1) ES2091441T3 (sv)
FI (1) FI109333B (sv)
FR (1) FR2676647B1 (sv)
GB (1) GB2256138B (sv)
GR (1) GR3021551T3 (sv)
HK (1) HK1000242A1 (sv)
HU (1) HU219480B (sv)
IE (1) IE66476B1 (sv)
IL (1) IL101944A (sv)
IT (1) IT1254571B (sv)
LU (1) LU88117A1 (sv)
MX (1) MX9202407A (sv)
NO (1) NO300084B1 (sv)
NZ (1) NZ242849A (sv)
PH (1) PH31205A (sv)
RO (1) RO112081B1 (sv)
RU (1) RU2110257C1 (sv)
SK (1) SK281130B6 (sv)
ZA (1) ZA923765B (sv)

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Also Published As

Publication number Publication date
ATA105892A (de) 1995-06-15
IE66476B1 (en) 1995-12-27
DK0515312T3 (da) 1996-11-18
GR3021551T3 (en) 1997-02-28
EP0515312A3 (en) 1993-04-14
NO922006L (no) 1992-11-24
AT400518B (de) 1996-01-25
IT1254571B (it) 1995-09-25
EP0515312B1 (en) 1996-08-14
JPH05148136A (ja) 1993-06-15
HU219480B (hu) 2001-04-28
MX9202407A (es) 1992-11-01
CA2069153A1 (en) 1992-11-24
AU1705892A (en) 1992-11-26
HU9201548D0 (en) 1992-07-28
FR2676647B1 (fr) 1995-05-12
ITRM920381A0 (it) 1992-05-22
EP0515312A2 (en) 1992-11-25
US5866105A (en) 1999-02-02
ITRM920381A1 (it) 1993-11-22
US6319509B1 (en) 2001-11-20
FI922316A0 (fi) 1992-05-21
KR100367150B1 (ko) 2003-03-03
GB9210974D0 (en) 1992-07-08
GB2256138B (en) 1995-01-11
HK1000242A1 (en) 1998-02-13
IL101944A (en) 1998-07-15
CZ284232B6 (cs) 1998-09-16
NZ242849A (en) 1993-09-27
JP3527749B2 (ja) 2004-05-17
DE4215677B4 (de) 2008-01-17
IL101944A0 (en) 1992-12-30
NO922006D0 (no) 1992-05-21
CY2070B1 (en) 1998-09-11
FR2676647A1 (fr) 1992-11-27
AU642090B2 (en) 1993-10-07
KR920021140A (ko) 1992-12-18
DE4215677A1 (de) 1992-11-26
US6214360B1 (en) 2001-04-10
LU88117A1 (fr) 1993-12-06
RO112081B1 (ro) 1997-05-30
FI922316A (fi) 1992-11-24
IE921670A1 (en) 1992-12-02
ES2091441T3 (es) 1996-11-01
CH683237A5 (de) 1994-02-15
CA2069153C (en) 2002-12-17
PH31205A (en) 1998-05-05
ZA923765B (en) 1993-11-22
CS153292A3 (en) 1992-12-16
HUT62467A (en) 1993-05-28
RU2110257C1 (ru) 1998-05-10
GB2256138A (en) 1992-12-02
SK281130B6 (sk) 2000-12-11
NO300084B1 (no) 1997-04-07

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MA Patent expired