FI108643B - Stereoselektiivinen glykosylaatiomenetelmä beta-anomeerilla rikastetun nukleosidin valmistamiseksi - Google Patents

Stereoselektiivinen glykosylaatiomenetelmä beta-anomeerilla rikastetun nukleosidin valmistamiseksi Download PDF

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Publication number
FI108643B
FI108643B FI932869A FI932869A FI108643B FI 108643 B FI108643 B FI 108643B FI 932869 A FI932869 A FI 932869A FI 932869 A FI932869 A FI 932869A FI 108643 B FI108643 B FI 108643B
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FI
Finland
Prior art keywords
group
anomer
nhw
alkyl
deoxy
Prior art date
Application number
FI932869A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI932869A (fi
FI932869A0 (fi
Inventor
Charles David Jones
Larry Wayne Hertel
Cora Sue Grossman
Ta-Sen Chou
Laurie Michelle Poteet
Douglas Patton Kjell
Richard Elmer Holmes
Thomas Edward Mabry
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27583678&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI108643(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US07/902,312 external-priority patent/US5371210A/en
Priority claimed from US08/044,312 external-priority patent/US5426183A/en
Priority claimed from US08/044,996 external-priority patent/US5821357A/en
Priority claimed from US08/044,345 external-priority patent/US5594124A/en
Priority claimed from US08/044,343 external-priority patent/US5401838A/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of FI932869A0 publication Critical patent/FI932869A0/fi
Publication of FI932869A publication Critical patent/FI932869A/fi
Application granted granted Critical
Publication of FI108643B publication Critical patent/FI108643B/fi

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heat Sensitive Colour Forming Recording (AREA)
FI932869A 1992-06-22 1993-06-21 Stereoselektiivinen glykosylaatiomenetelmä beta-anomeerilla rikastetun nukleosidin valmistamiseksi FI108643B (fi)

Applications Claiming Priority (24)

Application Number Priority Date Filing Date Title
US90231392A 1992-06-22 1992-06-22
US90211292A 1992-06-22 1992-06-22
US90230292A 1992-06-22 1992-06-22
US90215092A 1992-06-22 1992-06-22
US90213592A 1992-06-22 1992-06-22
US90231392 1992-06-22
US07/902,312 US5371210A (en) 1992-06-22 1992-06-22 Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US90211292 1992-06-22
US90231292 1992-06-22
US90215092 1992-06-22
US90213592 1992-06-22
US90230292 1992-06-22
US4430993A 1993-04-07 1993-04-07
US4431593A 1993-04-07 1993-04-07
US4499693 1993-04-07
US4430993 1993-04-07
US4431593 1993-04-07
US4431293 1993-04-07
US4434393 1993-04-07
US08/044,312 US5426183A (en) 1992-06-22 1993-04-07 Catalytic stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US08/044,996 US5821357A (en) 1992-06-22 1993-04-07 Stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoropurine and triazole nucleosides
US08/044,345 US5594124A (en) 1992-06-22 1993-04-07 Stereoselective glycosylation process for preparing 2'-Deoxy-2',2'-difluoropyrimidine nucleosides and 2'-deoxy-2'-fluoropyrimidine nucleosides and intermediates thereof
US4434593 1993-04-07
US08/044,343 US5401838A (en) 1992-06-22 1993-04-07 Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides

Publications (3)

Publication Number Publication Date
FI932869A0 FI932869A0 (fi) 1993-06-21
FI932869A FI932869A (fi) 1993-12-23
FI108643B true FI108643B (fi) 2002-02-28

Family

ID=27583678

Family Applications (1)

Application Number Title Priority Date Filing Date
FI932869A FI108643B (fi) 1992-06-22 1993-06-21 Stereoselektiivinen glykosylaatiomenetelmä beta-anomeerilla rikastetun nukleosidin valmistamiseksi

Country Status (20)

Country Link
EP (1) EP0577303B1 (ja)
JP (1) JP3313191B2 (ja)
KR (1) KR100252452B1 (ja)
AT (1) ATE158799T1 (ja)
BR (1) BR9302434A (ja)
CA (1) CA2098881C (ja)
CY (1) CY2067A (ja)
DE (1) DE69314239C5 (ja)
DK (1) DK0577303T3 (ja)
ES (1) ES2107624T3 (ja)
FI (1) FI108643B (ja)
GR (1) GR3025689T3 (ja)
HU (2) HUT64358A (ja)
IL (1) IL106071A (ja)
MX (1) MX9303707A (ja)
MY (1) MY115775A (ja)
NO (1) NO180235B3 (ja)
NZ (1) NZ247939A (ja)
PL (1) PL172348B1 (ja)
UA (1) UA41261C2 (ja)

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US5606048A (en) * 1992-06-22 1997-02-25 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-Deoxy-2', 2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5424416A (en) * 1993-08-25 1995-06-13 Eli Lilly And Company Process for preparation of 2-deoxy-2,2-difluoro-D-ribofuranosyl-3,5-hydroxy protected-1-alkyl and aryl sulfonates and their use in preparation of 2',2'-difluoro-2'-deoxy nucleosides
US5637688A (en) * 1994-12-13 1997-06-10 Eli Lilly And Company Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride
US5559222A (en) * 1995-02-03 1996-09-24 Eli Lilly And Company Preparation of 1-(2'-deoxy-2',2'-difluoro-D-ribo-pentofuranosyl)-cytosine from 2-deoxy-2,2-difluoro-β-D-ribo-pentopyranose
EP0779275A2 (en) 1995-12-13 1997-06-18 Eli Lilly And Company Alpha, Alpha - Difluoro-beta -hydroxy thiol esters and their synthesis
US6326507B1 (en) 1998-06-19 2001-12-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
AU2001238516B2 (en) 2000-02-18 2005-08-04 Southern Research Institute Methods for synthesizing 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H- purin-6-amine
US7435755B2 (en) 2000-11-28 2008-10-14 The Trustees Of Dartmouth College CDDO-compounds and combination therapies thereof
DE60226447D1 (de) * 2001-08-02 2008-06-19 Ilex Oncology Inc Verfahren zur herstellung von purinnukleosiden
EP1465615B1 (en) 2002-01-15 2012-08-01 Trustees of Dartmouth College Tricyclic-bis-enone derivatives and methods of use thereof
US6884880B2 (en) * 2002-08-21 2005-04-26 Ash Stevens, Inc. Process for the preparation of 9-β-anomeric nucleoside analogs
US7265096B2 (en) 2002-11-04 2007-09-04 Xenoport, Inc. Gemcitabine prodrugs, pharmaceutical compositions and uses thereof
CN100384862C (zh) 2003-05-22 2008-04-30 独立行政法人科学技术振兴机构 α-选择性糖基化反应方法
WO2006070985A1 (en) 2004-12-30 2006-07-06 Hanmi Pharm. Co., Ltd. METHOD FOR THE PREPARATION OF 2#-DEOXY-2#,2#-DIFLUOROCYTIDINE
DE602005019626D1 (de) 2005-03-04 2010-04-08 Fresenius Kabi Oncology Ltd Zwischenprodukt und verfahren zur herstellung von an beta-anomeren angereicherten 2'-desoxy,2',2'-difluor-d-ribufuranosylnukleosiden
US7572898B2 (en) * 2005-06-03 2009-08-11 Scinopharm Taiwan, Ltd. Process of making an alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonate and use thereof for making a beta nucleoside
CN100391966C (zh) * 2005-06-17 2008-06-04 华东师范大学 一种2’-脱氧-2’，2’-二氟-胞苷合成的方法
WO2008064132A2 (en) 2006-11-17 2008-05-29 Trustees Of Dartmouth College Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
JP2010510243A (ja) 2006-11-17 2010-04-02 トラスティーズ オブ ダートマス カレッジ 三環系−ビス−エノン（ｔｂｅ）の合成および生物学的活性
US8921340B2 (en) 2006-11-17 2014-12-30 Trustees Of Dartmouth College Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions
US20080262215A1 (en) * 2007-04-23 2008-10-23 Chemagis Ltd. Gemcitabine production process
CN100475832C (zh) 2007-05-31 2009-04-08 南京卡文迪许生物工程技术有限公司 一种新颖的高立体选择性合成吉西他滨工艺及中间体
EP2048151A1 (en) * 2007-10-10 2009-04-15 Cilag AG Method for producing nucleosides by direct glycosylation of the nucleoside base
EP2050757A1 (en) * 2007-10-10 2009-04-22 Cilag AG Method of producing 2' -deoxy-5-azacytidine (Decitabine)
RS58486B1 (sr) 2008-01-11 2019-04-30 Reata Pharmaceuticals Inc Sintetički triterpenoidi i metode njihove upotrebe u tretmanu bolesti
CN102164941B (zh) 2008-04-18 2015-05-27 里亚塔医药公司 抗氧化剂炎症调节剂:具有饱和c环的齐墩果酸衍生物
CN102066397B (zh) 2008-04-18 2013-09-11 里亚塔医药公司 包含抗炎症药效团的化合物以及使用方法
PL2276493T3 (pl) 2008-04-18 2019-05-31 Reata Pharmaceuticals Inc Antyoksydacyjne modulatory stanu zapalnego: pochodne kwasu oleanolowego z amino- i innymi modyfikacjami przy C-17
BRPI0911422B8 (pt) 2008-04-18 2021-05-25 Reata Pharmaceuticals Inc compostos moduladores inflamatórios antioxidantes, composição farmacêutica e usos dos mesmos
TW201004627A (en) 2008-04-18 2010-02-01 Reata Pharmaceuticals Inc Antioxidant inflammation modulators: novel derivatives of oleanolic acid
EA031986B1 (ru) 2012-04-04 2019-03-29 Галозим, Инк. Способ и комбинация для лечения солидной раковой опухоли и набор, содержащий комбинацию
US8921419B2 (en) 2012-05-08 2014-12-30 Trustees Of Dartmouth College Triterpenoids and compositions containing the same
CA2906284A1 (en) * 2013-03-15 2014-09-18 Epigenetics Pharma Llc Fluorinated pyrimidine analogs and methods of use thereof
EP3618837A4 (en) 2017-04-26 2020-11-04 Thomas I. Kalman MULTI-DIRECTIONAL NUCLEOSIDE DERIVATIVES
WO2019222435A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20

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CA1295998C (en) * 1985-07-29 1992-02-18 Sai P. Sunkara Nucleosides and their use as antineoplastic agents
EP0688783B1 (en) * 1987-08-28 2001-06-13 Eli Lilly And Company Method for preparing 2'-deoxy-2',2'-difluornucleosides
JPH0217199A (ja) * 1988-07-05 1990-01-22 Japan Tobacco Inc ２’−デオキシ−β−アデノシンの製造方法
GB8816345D0 (en) * 1988-07-08 1988-08-10 Hoffmann La Roche Purine derivatives
HU906976D0 (en) * 1989-11-13 1991-05-28 Bristol Myers Squibb Co Process for producing 2', 3'-didesoxy-2'-fluoarabinonucleoside analogues
AU7558491A (en) * 1990-04-04 1991-10-30 Nycomed Imaging As Nucleoside derivatives
US5817799A (en) * 1990-07-23 1998-10-06 The United States Of America As Represented By The Department Of Health And Human Services 2'-Fluorofuranosyl derivatives and methods for preparing 2'-fluoropyrimidine and 2'-fluoropurine nucleosides
US5256798A (en) * 1992-06-22 1993-10-26 Eli Lilly And Company Process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates
US5371210A (en) * 1992-06-22 1994-12-06 Eli Lilly And Company Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides

Also Published As

Publication number Publication date
ATE158799T1 (de) 1997-10-15
FI932869A (fi) 1993-12-23
ES2107624T3 (es) 1997-12-01
JP3313191B2 (ja) 2002-08-12
IL106071A (en) 2006-08-20
CA2098881C (en) 2005-06-07
HUT64358A (en) 1993-12-28
NO932288A (no) 1993-12-23
EP0577303B1 (en) 1997-10-01
BR9302434A (pt) 1994-02-16
NO932288D0 (no) 1993-06-21
DE69314239T2 (de) 1998-02-19
HU0201196D0 (ja) 2002-06-29
IL106071A0 (en) 1993-10-20
NO180235B3 (no) 2007-10-01
NO180235B (no) 1996-12-02
FI932869A0 (fi) 1993-06-21
NZ247939A (en) 1996-02-27
EP0577303A1 (en) 1994-01-05
GR3025689T3 (en) 1998-03-31
HU223837B1 (hu) 2005-02-28
JPH06157570A (ja) 1994-06-03
DE69314239C5 (de) 2012-11-29
MY115775A (en) 2003-09-30
PL299415A1 (en) 1994-03-07
KR100252452B1 (en) 2000-04-15
CY2067A (en) 1993-06-21
HU9301822D0 (en) 1993-09-28
MX9303707A (es) 1994-06-30
UA41261C2 (uk) 2001-09-17
DK0577303T3 (da) 1997-10-27
NO180235C (no) 1997-03-12
KR940005658A (ko) 1994-03-22
DE69314239D1 (de) 1997-11-06
CA2098881A1 (en) 1993-12-23
PL172348B1 (pl) 1997-09-30

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