FI106206B - Menetelmä polypeptidin valmistamiseksi - Google Patents

Menetelmä polypeptidin valmistamiseksi Download PDF

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Publication number
FI106206B
FI106206B FI920889A FI920889A FI106206B FI 106206 B FI106206 B FI 106206B FI 920889 A FI920889 A FI 920889A FI 920889 A FI920889 A FI 920889A FI 106206 B FI106206 B FI 106206B
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FI
Finland
Prior art keywords
ala
gly
pro
cys
leu
Prior art date
Application number
FI920889A
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English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI920889A0 (fi
Inventor
Ei Mochida
Akio Uemura
Atsushi Nii
Hideaki Morishita
Original Assignee
Mochida Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mochida Pharm Co Ltd filed Critical Mochida Pharm Co Ltd
Publication of FI920889A0 publication Critical patent/FI920889A0/fi
Application granted granted Critical
Publication of FI106206B publication Critical patent/FI106206B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/7455—Thrombomodulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FI920889A 1990-06-27 1992-02-27 Menetelmä polypeptidin valmistamiseksi FI106206B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP16876690 1990-06-27
JP16876690 1990-06-27
PCT/JP1991/000873 WO1992000325A1 (fr) 1990-06-27 1991-06-27 Polypeptides anticoagulants
JP9100873 1991-06-27

Publications (2)

Publication Number Publication Date
FI920889A0 FI920889A0 (fi) 1992-02-27
FI106206B true FI106206B (fi) 2000-12-15

Family

ID=15874056

Family Applications (1)

Application Number Title Priority Date Filing Date
FI920889A FI106206B (fi) 1990-06-27 1992-02-27 Menetelmä polypeptidin valmistamiseksi

Country Status (8)

Country Link
US (2) US5516659A (fr)
EP (1) EP0489180A4 (fr)
JP (1) JP3189052B2 (fr)
AU (1) AU643306B2 (fr)
CA (1) CA2065409C (fr)
FI (1) FI106206B (fr)
NO (1) NO302527B1 (fr)
WO (1) WO1992000325A1 (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0816495A1 (fr) * 1987-01-08 1998-01-07 Asahi Kasei Kogyo Kabushiki Kaisha ADN codant pour un peptide favorisant l'activation de la protéine C par la thrombine, procédé pour sa préparation
DE69433133T2 (de) * 1993-12-17 2004-04-01 Mochida Pharmaceutical Co. Ltd. Lösliches thrombomodulin enthaltende zubereitung
US6465620B1 (en) * 2000-01-21 2002-10-15 Hyseq, Inc. Methods and materials relating to novel von Willebrand/Thrombospondin-like polypeptides and polynucleotides
US20030092035A1 (en) * 2000-05-04 2003-05-15 Anderson David J. Pain signaling molecules
US7510845B2 (en) * 2000-05-04 2009-03-31 California Institute Of Technology Assay employing G protein-coupled receptor expressed in dorsal root ganglia
US7691604B1 (en) 2000-05-04 2010-04-06 California Institute Of Technology MRG polypeptides and nucleic acids encoding the same
US20030152941A1 (en) * 2000-06-21 2003-08-14 Boyle Bryan J. Nucleic acids encoding novel von Willebrand/Thrombospondin factor-like polypeptides and uses of same
WO2002009647A2 (fr) * 2000-07-28 2002-02-07 Emory University Composant biologique comprenant une membrane artificielle
ATE304021T1 (de) * 2001-05-25 2005-09-15 Vlaams Interuniv Inst Biotech Lektin-ähnliche domäne von thrombomodulin und therapeutische verwendung davon
JP4187141B2 (ja) * 2002-04-12 2008-11-26 興和株式会社 新規なトロンボモジュリン発現促進剤
US20040121410A1 (en) * 2002-12-20 2004-06-24 Anderson David J. Pain signaling molecules
BRPI0720158A2 (pt) 2006-10-06 2014-05-20 Asahi Kasei Pharma Corp Agentes para terapia e/ou melhora de coagulação intravascular disseminada, para reduzir a probabilidade de morte em pacientes sofrendo da mesma, métodos para selecionar pacientes, e, para tratar e/ou melhorar coagulação intravascular disseminada
TW201431872A (zh) 2007-03-23 2014-08-16 Asahi Kasei Pharma Corp 高純度可溶性凝血酶調節素之製造方法
US20120165244A1 (en) * 2008-10-30 2012-06-28 Hua-Lin Wu Methods for binding lewis y antigen
MX2011005005A (es) * 2008-11-12 2011-05-25 Lilly Co Eli Composiciones y metodos de uso para variantes de trombomodulina.
JP2011178687A (ja) * 2010-02-26 2011-09-15 Kochi Univ 造血細胞移植に伴う疼痛の予防および／または治療剤
AU2011246021B2 (en) 2010-04-30 2014-03-13 Asahi Kasei Pharma Corporation High-purity soluble thrombomodulin and method for producing same
AU2011287360A1 (en) 2010-08-05 2013-02-21 Council Of Scientific & Industrial Research Protein fusion constructs possessing thrombolytic and anticoagulant properties
US9592275B2 (en) 2011-11-15 2017-03-14 Asahi Kasei Pharma Corporation Medicament for therapeutic treatment and/or improvement of sepsis
RU2595857C2 (ru) 2012-05-31 2016-08-27 Кинки Юниверсити Средство для профилактического и/или терапевтического лечения периферической нейропатической боли, вызываемой противораковым средством
US11497795B2 (en) 2018-09-28 2022-11-15 Asahi Kasei Pharma Corporation Medicament for mitigating conditions and/or suppressing onset of peripheral neuropathy induced by anti-malignant tumor agent
CA3116686A1 (fr) 2018-10-22 2020-04-30 Asahi Kasei Pharma Corporation Medicament pour le traitement therapeutique et/ou l'amelioration des sepsies accompagnees de coagulopathie
CN114686443B (zh) * 2020-12-31 2023-11-03 广州万孚生物技术股份有限公司 杂交瘤细胞、抗血栓调节蛋白单克隆抗体及其制备方法和应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60199819A (ja) * 1984-03-23 1985-10-09 Kowa Co トロンビン結合性物質およびその製法
JPH0689014B2 (ja) * 1986-01-21 1994-11-09 興和株式会社 トロンビン結合性物質およびその製法
ES2065318T3 (es) * 1986-07-15 1995-02-16 Kowa Co Sustancia que se une a trombina y procedimiento para su preparacion.
JPS63146898A (ja) * 1986-07-15 1988-06-18 Kowa Co トロンビン結合性物質およびその製法
JPS6330423A (ja) * 1986-07-22 1988-02-09 Kowa Co トロンビン結合性物質およびその製法
EP0816495A1 (fr) * 1987-01-08 1998-01-07 Asahi Kasei Kogyo Kabushiki Kaisha ADN codant pour un peptide favorisant l'activation de la protéine C par la thrombine, procédé pour sa préparation
US4912207A (en) * 1987-05-06 1990-03-27 Washington University DNA clone of human thrombomodulin and portions thereof
DK299087D0 (da) * 1987-06-12 1987-06-12 Novo Industri As Proteins and derivatives thereof
JPH0219399A (ja) * 1988-07-05 1990-01-23 Oklahoma Medical Res Found トロンビン結合ポリピペプチド
US5202421A (en) * 1988-12-27 1993-04-13 Mochida Pharmaceutical Co., Ltd. Anticoagulant substance obtained from urine and process for the preparation thereof
US5256770A (en) * 1990-04-09 1993-10-26 Schering Ag Oxidation resistant thrombomodulin analogs
US5273962A (en) * 1990-11-30 1993-12-28 Kowa Co., Ltd. Human urinary thrombomodulin with a modified glycosaminoglycan (GAG) binding site

Also Published As

Publication number Publication date
US5695964A (en) 1997-12-09
EP0489180A1 (fr) 1992-06-10
NO920762D0 (no) 1992-02-26
EP0489180A4 (en) 1993-03-31
FI920889A0 (fi) 1992-02-27
NO302527B1 (no) 1998-03-16
JP3189052B2 (ja) 2001-07-16
AU643306B2 (en) 1993-11-11
CA2065409A1 (fr) 1991-12-28
US5516659A (en) 1996-05-14
NO920762L (no) 1992-04-24
CA2065409C (fr) 2002-05-14
AU8080091A (en) 1992-01-23
WO1992000325A1 (fr) 1992-01-09

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