NO302527B1 - Fremgangsmåte ved fremstilling av polypeptid med antikoagulerende aktivitet - Google Patents
Fremgangsmåte ved fremstilling av polypeptid med antikoagulerende aktivitet Download PDFInfo
- Publication number
- NO302527B1 NO302527B1 NO920762A NO920762A NO302527B1 NO 302527 B1 NO302527 B1 NO 302527B1 NO 920762 A NO920762 A NO 920762A NO 920762 A NO920762 A NO 920762A NO 302527 B1 NO302527 B1 NO 302527B1
- Authority
- NO
- Norway
- Prior art keywords
- polypeptide
- amino acid
- dna fragment
- thrombomodulin
- dna
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/7455—Thrombomodulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16876690 | 1990-06-27 | ||
| PCT/JP1991/000873 WO1992000325A1 (fr) | 1990-06-27 | 1991-06-27 | Polypeptides anticoagulants |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO920762D0 NO920762D0 (no) | 1992-02-26 |
| NO920762L NO920762L (no) | 1992-04-24 |
| NO302527B1 true NO302527B1 (no) | 1998-03-16 |
Family
ID=15874056
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO920762A NO302527B1 (no) | 1990-06-27 | 1992-02-26 | Fremgangsmåte ved fremstilling av polypeptid med antikoagulerende aktivitet |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US5516659A (fr) |
| EP (1) | EP0489180A4 (fr) |
| JP (1) | JP3189052B2 (fr) |
| AU (1) | AU643306B2 (fr) |
| CA (1) | CA2065409C (fr) |
| FI (1) | FI106206B (fr) |
| NO (1) | NO302527B1 (fr) |
| WO (1) | WO1992000325A1 (fr) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0816495A1 (fr) * | 1987-01-08 | 1998-01-07 | Asahi Kasei Kogyo Kabushiki Kaisha | ADN codant pour un peptide favorisant l'activation de la protéine C par la thrombine, procédé pour sa préparation |
| DE69433133T2 (de) * | 1993-12-17 | 2004-04-01 | Mochida Pharmaceutical Co. Ltd. | Lösliches thrombomodulin enthaltende zubereitung |
| US6465620B1 (en) * | 2000-01-21 | 2002-10-15 | Hyseq, Inc. | Methods and materials relating to novel von Willebrand/Thrombospondin-like polypeptides and polynucleotides |
| US20030092035A1 (en) * | 2000-05-04 | 2003-05-15 | Anderson David J. | Pain signaling molecules |
| US7510845B2 (en) * | 2000-05-04 | 2009-03-31 | California Institute Of Technology | Assay employing G protein-coupled receptor expressed in dorsal root ganglia |
| US7691604B1 (en) | 2000-05-04 | 2010-04-06 | California Institute Of Technology | MRG polypeptides and nucleic acids encoding the same |
| US20030152941A1 (en) * | 2000-06-21 | 2003-08-14 | Boyle Bryan J. | Nucleic acids encoding novel von Willebrand/Thrombospondin factor-like polypeptides and uses of same |
| WO2002009647A2 (fr) * | 2000-07-28 | 2002-02-07 | Emory University | Composant biologique comprenant une membrane artificielle |
| ATE304021T1 (de) * | 2001-05-25 | 2005-09-15 | Vlaams Interuniv Inst Biotech | Lektin-ähnliche domäne von thrombomodulin und therapeutische verwendung davon |
| JP4187141B2 (ja) * | 2002-04-12 | 2008-11-26 | 興和株式会社 | 新規なトロンボモジュリン発現促進剤 |
| US20040121410A1 (en) * | 2002-12-20 | 2004-06-24 | Anderson David J. | Pain signaling molecules |
| BRPI0720158A2 (pt) | 2006-10-06 | 2014-05-20 | Asahi Kasei Pharma Corp | Agentes para terapia e/ou melhora de coagulação intravascular disseminada, para reduzir a probabilidade de morte em pacientes sofrendo da mesma, métodos para selecionar pacientes, e, para tratar e/ou melhorar coagulação intravascular disseminada |
| TW201431872A (zh) | 2007-03-23 | 2014-08-16 | Asahi Kasei Pharma Corp | 高純度可溶性凝血酶調節素之製造方法 |
| US20120165244A1 (en) * | 2008-10-30 | 2012-06-28 | Hua-Lin Wu | Methods for binding lewis y antigen |
| MX2011005005A (es) * | 2008-11-12 | 2011-05-25 | Lilly Co Eli | Composiciones y metodos de uso para variantes de trombomodulina. |
| JP2011178687A (ja) * | 2010-02-26 | 2011-09-15 | Kochi Univ | 造血細胞移植に伴う疼痛の予防および／または治療剤 |
| AU2011246021B2 (en) | 2010-04-30 | 2014-03-13 | Asahi Kasei Pharma Corporation | High-purity soluble thrombomodulin and method for producing same |
| AU2011287360A1 (en) | 2010-08-05 | 2013-02-21 | Council Of Scientific & Industrial Research | Protein fusion constructs possessing thrombolytic and anticoagulant properties |
| US9592275B2 (en) | 2011-11-15 | 2017-03-14 | Asahi Kasei Pharma Corporation | Medicament for therapeutic treatment and/or improvement of sepsis |
| RU2595857C2 (ru) | 2012-05-31 | 2016-08-27 | Кинки Юниверсити | Средство для профилактического и/или терапевтического лечения периферической нейропатической боли, вызываемой противораковым средством |
| US11497795B2 (en) | 2018-09-28 | 2022-11-15 | Asahi Kasei Pharma Corporation | Medicament for mitigating conditions and/or suppressing onset of peripheral neuropathy induced by anti-malignant tumor agent |
| CA3116686A1 (fr) | 2018-10-22 | 2020-04-30 | Asahi Kasei Pharma Corporation | Medicament pour le traitement therapeutique et/ou l'amelioration des sepsies accompagnees de coagulopathie |
| CN114686443B (zh) * | 2020-12-31 | 2023-11-03 | 广州万孚生物技术股份有限公司 | 杂交瘤细胞、抗血栓调节蛋白单克隆抗体及其制备方法和应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS60199819A (ja) * | 1984-03-23 | 1985-10-09 | Kowa Co | トロンビン結合性物質およびその製法 |
| JPH0689014B2 (ja) * | 1986-01-21 | 1994-11-09 | 興和株式会社 | トロンビン結合性物質およびその製法 |
| ES2065318T3 (es) * | 1986-07-15 | 1995-02-16 | Kowa Co | Sustancia que se une a trombina y procedimiento para su preparacion. |
| JPS63146898A (ja) * | 1986-07-15 | 1988-06-18 | Kowa Co | トロンビン結合性物質およびその製法 |
| JPS6330423A (ja) * | 1986-07-22 | 1988-02-09 | Kowa Co | トロンビン結合性物質およびその製法 |
| EP0816495A1 (fr) * | 1987-01-08 | 1998-01-07 | Asahi Kasei Kogyo Kabushiki Kaisha | ADN codant pour un peptide favorisant l'activation de la protéine C par la thrombine, procédé pour sa préparation |
| US4912207A (en) * | 1987-05-06 | 1990-03-27 | Washington University | DNA clone of human thrombomodulin and portions thereof |
| DK299087D0 (da) * | 1987-06-12 | 1987-06-12 | Novo Industri As | Proteins and derivatives thereof |
| JPH0219399A (ja) * | 1988-07-05 | 1990-01-23 | Oklahoma Medical Res Found | トロンビン結合ポリピペプチド |
| US5202421A (en) * | 1988-12-27 | 1993-04-13 | Mochida Pharmaceutical Co., Ltd. | Anticoagulant substance obtained from urine and process for the preparation thereof |
| US5256770A (en) * | 1990-04-09 | 1993-10-26 | Schering Ag | Oxidation resistant thrombomodulin analogs |
| US5273962A (en) * | 1990-11-30 | 1993-12-28 | Kowa Co., Ltd. | Human urinary thrombomodulin with a modified glycosaminoglycan (GAG) binding site |
-
1991
- 1991-06-27 AU AU80800/91A patent/AU643306B2/en not_active Ceased
- 1991-06-27 JP JP51114691A patent/JP3189052B2/ja not_active Expired - Fee Related
- 1991-06-27 WO PCT/JP1991/000873 patent/WO1992000325A1/fr not_active Application Discontinuation
- 1991-06-27 EP EP19910912069 patent/EP0489180A4/en not_active Withdrawn
- 1991-06-27 CA CA002065409A patent/CA2065409C/fr not_active Expired - Fee Related
-
1992
- 1992-02-26 NO NO920762A patent/NO302527B1/no unknown
- 1992-02-27 FI FI920889A patent/FI106206B/fi active
-
1994
- 1994-09-19 US US08/307,444 patent/US5516659A/en not_active Expired - Fee Related
-
1996
- 1996-01-17 US US08/587,389 patent/US5695964A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US5695964A (en) | 1997-12-09 |
| EP0489180A1 (fr) | 1992-06-10 |
| NO920762D0 (no) | 1992-02-26 |
| EP0489180A4 (en) | 1993-03-31 |
| FI920889A0 (fi) | 1992-02-27 |
| JP3189052B2 (ja) | 2001-07-16 |
| AU643306B2 (en) | 1993-11-11 |
| CA2065409A1 (fr) | 1991-12-28 |
| US5516659A (en) | 1996-05-14 |
| FI106206B (fi) | 2000-12-15 |
| NO920762L (no) | 1992-04-24 |
| CA2065409C (fr) | 2002-05-14 |
| AU8080091A (en) | 1992-01-23 |
| WO1992000325A1 (fr) | 1992-01-09 |
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