FI105202B - Menetelmä aktivoitavien fibrinolyyttisten ja veren hyytymistä estävien plasminogeenianalogien valmistamiseksi - Google Patents

Menetelmä aktivoitavien fibrinolyyttisten ja veren hyytymistä estävien plasminogeenianalogien valmistamiseksi Download PDF

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Publication number
FI105202B
FI105202B FI922610A FI922610A FI105202B FI 105202 B FI105202 B FI 105202B FI 922610 A FI922610 A FI 922610A FI 922610 A FI922610 A FI 922610A FI 105202 B FI105202 B FI 105202B
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Finland
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plasminogen
factor
thrombin
protein
arg
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FI922610A
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English (en)
Finnish (fi)
Swedish (sv)
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FI922610A (fi
FI922610A0 (fi
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Keith Martyn Dawson
Richard Mark Edwards
Joan Mabel Forman
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British Biotech Pharm
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C07K14/3153—Streptokinase
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
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    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
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    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
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    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N2800/00—Nucleic acids vectors
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C12N2830/002—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination inducible enhancer/promoter combination, e.g. hypoxia, iron, transcription factor
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/70—Vector systems having a special element relevant for transcription from fungi
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    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/10—Vectors comprising a special translation-regulating system regulates levels of translation
    • C12N2840/107—Vectors comprising a special translation-regulating system regulates levels of translation inhibiting translational read-through

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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Diabetes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
FI922610A 1989-12-07 1992-06-05 Menetelmä aktivoitavien fibrinolyyttisten ja veren hyytymistä estävien plasminogeenianalogien valmistamiseksi FI105202B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB898927722A GB8927722D0 (en) 1989-12-07 1989-12-07 Proteins and nucleic acids
GB8927722 1989-12-07
PCT/GB1990/001912 WO1991009118A2 (en) 1989-12-07 1990-12-07 Activatable fibrinolytic and anti-thrombotic proteins
GB9001912 1990-12-07

Publications (3)

Publication Number Publication Date
FI922610A FI922610A (fi) 1992-06-05
FI922610A0 FI922610A0 (fi) 1992-06-05
FI105202B true FI105202B (fi) 2000-06-30

Family

ID=10667597

Family Applications (2)

Application Number Title Priority Date Filing Date
FI922610A FI105202B (fi) 1989-12-07 1992-06-05 Menetelmä aktivoitavien fibrinolyyttisten ja veren hyytymistä estävien plasminogeenianalogien valmistamiseksi
FI922609A FI922609A (fi) 1989-12-07 1992-06-05 Proteiner och nukleinsyror.

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI922609A FI922609A (fi) 1989-12-07 1992-06-05 Proteiner och nukleinsyror.

Country Status (21)

Country Link
US (2) US5637492A (ko)
EP (2) EP0504241A1 (ko)
JP (2) JPH05502374A (ko)
KR (2) KR100188302B1 (ko)
AT (1) ATE155812T1 (ko)
AU (3) AU644399B2 (ko)
CA (2) CA2069085C (ko)
DE (1) DE69031127T2 (ko)
DK (1) DK0502968T3 (ko)
ES (1) ES2106073T3 (ko)
FI (2) FI105202B (ko)
GB (1) GB8927722D0 (ko)
GR (1) GR3024990T3 (ko)
HU (1) HU211628A9 (ko)
IE (2) IE904416A1 (ko)
IL (2) IL96601A (ko)
NO (2) NO305562B1 (ko)
NZ (2) NZ236330A (ko)
PT (2) PT96104A (ko)
WO (2) WO1991009118A2 (ko)
ZA (2) ZA909854B (ko)

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GB2286190B (en) * 1992-10-29 1996-05-01 British Biotech Pharm Thrombin activatable plasminogen derivatives
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WO1995004823A1 (en) * 1993-08-04 1995-02-16 Ciba-Geigy Ag High molecular weight desulphatohirudin
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US5945403A (en) 1997-05-30 1999-08-31 The Children's Medical Center Corporation Angiostatin fragments and method of use
US5837682A (en) 1996-03-08 1998-11-17 The Children's Medical Center Corporation Angiostatin fragments and method of use
GB9412131D0 (en) * 1994-06-17 1994-08-10 British Bio Technology Thrombolytic composition
DE4440892A1 (de) * 1994-11-17 1996-05-23 Gruenenthal Gmbh Proteine mit fibrinolytischen und gerinnungshemmenden Eigenschaften
DE4442665A1 (de) * 1994-11-30 1996-06-05 Gruenenthal Gmbh Chimäre Proteine mit fibrinolytischen und thrombinhemmenden Eigenschaften
US5854049A (en) * 1995-06-09 1998-12-29 President And Fellows Of Harvard College Plasmin-resistant streptokinase
US5736364A (en) * 1995-12-04 1998-04-07 Genentech, Inc. Factor viia inhibitors
US6461640B1 (en) 1995-12-08 2002-10-08 Board Of Regents, The University Of Texas System Local delivery of fibrinolysis enhancing agents
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US7160540B2 (en) 2000-06-30 2007-01-09 Regents Of The University Of Minnesota Methods for detecting activity of clottings factors
US6423826B1 (en) * 2000-06-30 2002-07-23 Regents Of The University Of Minnesota High molecular weight derivatives of vitamin K-dependent polypeptides
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US9695251B2 (en) 2003-10-31 2017-07-04 The Regents Of The University Of California Activatable cell penetrating peptides with quenched fluorophores
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CN101730740A (zh) * 2006-09-29 2010-06-09 蛋白质组技术公司 用于生产重组纤溶酶原和纤溶酶多肽的方法
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NO305562B1 (no) 1999-06-21
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DE69031127T2 (de) 1998-02-05
KR920703818A (ko) 1992-12-18
CA2069105A1 (en) 1991-06-08
ATE155812T1 (de) 1997-08-15
NO922238L (no) 1992-08-06
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US5434073A (en) 1995-07-18
PT96103B (pt) 1998-08-31
NO922237D0 (no) 1992-06-05
JP2851423B2 (ja) 1999-01-27
ES2106073T3 (es) 1997-11-01
IE904417A1 (en) 1991-06-19
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FI922609A (fi) 1992-06-05
CA2069085A1 (en) 1991-06-08
AU6965691A (en) 1991-07-18
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NO922237L (no) 1992-08-06
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US5637492A (en) 1997-06-10
NZ236330A (en) 1993-05-26
AU643247B2 (en) 1993-11-11
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