FI103971B1 - Menetelmä terapeuttisesti käyttökelpoisten pyrrolo- ja pyrido[2,3-d]pyrimidinonijohdannaisten valmistamiseksi - Google Patents

Menetelmä terapeuttisesti käyttökelpoisten pyrrolo- ja pyrido[2,3-d]pyrimidinonijohdannaisten valmistamiseksi

Info

Publication number
FI103971B1
FI103971B1 FI924397A FI924397A FI103971B1 FI 103971 B1 FI103971 B1 FI 103971B1 FI 924397 A FI924397 A FI 924397A FI 924397 A FI924397 A FI 924397A FI 103971 B1 FI103971 B1 FI 103971B1
Authority
FI
Finland
Prior art keywords
pyrido
therapeutically useful
pyrrolo
pyrimidinone derivatives
preparing therapeutically
Prior art date
Application number
FI924397A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI103971B (fi
FI924397A (fi
FI924397A0 (fi
Inventor
John Watson Ellingboe
Madelene Nikaido
Jehan Franroz Bagli
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/782,025 external-priority patent/US5149699A/en
Priority claimed from GB9207560A external-priority patent/GB2265899A/en
Priority claimed from US07/901,485 external-priority patent/US5256654A/en
Application filed by American Home Prod filed Critical American Home Prod
Publication of FI924397A0 publication Critical patent/FI924397A0/fi
Publication of FI924397A publication Critical patent/FI924397A/fi
Application granted granted Critical
Publication of FI103971B publication Critical patent/FI103971B/fi
Publication of FI103971B1 publication Critical patent/FI103971B1/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
FI924397A 1991-10-24 1992-09-30 Menetelmä terapeuttisesti käyttökelpoisten pyrrolo- ja pyrido[2,3-d]pyrimidinonijohdannaisten valmistamiseksi FI103971B1 (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US78202591 1991-10-24
US07/782,025 US5149699A (en) 1991-10-24 1991-10-24 Substituted pyridopyrimidines useful as antgiotensin II antagonists
GB9207560A GB2265899A (en) 1992-04-07 1992-04-07 Substituted pyrimidines
GB9207560 1992-04-07
US90148592 1992-06-25
US07/901,485 US5256654A (en) 1991-10-24 1992-06-25 Substituted pyrrolopyrimidines, azepinopyrimidines and pyridopyrimidines useful as angiotensin II antagonists

Publications (4)

Publication Number Publication Date
FI924397A0 FI924397A0 (fi) 1992-09-30
FI924397A FI924397A (fi) 1993-04-25
FI103971B FI103971B (fi) 1999-10-29
FI103971B1 true FI103971B1 (fi) 1999-10-29

Family

ID=27266132

Family Applications (1)

Application Number Title Priority Date Filing Date
FI924397A FI103971B1 (fi) 1991-10-24 1992-09-30 Menetelmä terapeuttisesti käyttökelpoisten pyrrolo- ja pyrido[2,3-d]pyrimidinonijohdannaisten valmistamiseksi

Country Status (21)

Country Link
EP (1) EP0539086B1 (de)
JP (1) JP3240192B2 (de)
KR (1) KR100286624B1 (de)
CN (2) CN1039324C (de)
AT (1) ATE161537T1 (de)
AU (1) AU653635B2 (de)
CA (1) CA2080705C (de)
DE (1) DE69223734T2 (de)
DK (1) DK0539086T3 (de)
ES (1) ES2111617T3 (de)
FI (1) FI103971B1 (de)
GR (1) GR3025926T3 (de)
HK (1) HK1003031A1 (de)
HU (2) HU218786B (de)
IL (1) IL103436A (de)
LV (1) LV12047B (de)
NO (1) NO301275B1 (de)
SG (1) SG47626A1 (de)
SK (1) SK322192A3 (de)
TW (1) TW226375B (de)
UA (1) UA27748C2 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE395341T1 (de) * 1991-11-18 2008-05-15 Du Pont 2-(2'-triphenylmethyl-2'h-tetrazol-5'- yl)phenylborsäure als zwischenprodukt zur synthese von a ii receptorenantagonisten
EP0863143A1 (de) * 1993-03-24 1998-09-09 American Home Products Corporation Zwischenprodukte in der Herstellung von Pyridopyrimidon Angiotensin AII Antagonisten
ATE176784T1 (de) * 1994-09-20 1999-03-15 Wakunaga Seiyaku Kk Verfahren zur herstellung von n- biphenylmethylthiadiazolin derivaten oder deren salzen sowie dafür benötigte zwischen verbindungen
IT1292437B1 (it) * 1997-06-30 1999-02-08 Zambon Spa Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti
US6638937B2 (en) 1998-07-06 2003-10-28 Bristol-Myers Squibb Co. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
PE20020617A1 (es) 2000-08-22 2002-08-05 Novartis Ag Composicion que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina o un sensibilizante a la insulina
US8168616B1 (en) 2000-11-17 2012-05-01 Novartis Ag Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
GB0327839D0 (en) 2003-12-01 2003-12-31 Novartis Ag Organic compounds
GB0402262D0 (en) 2004-02-02 2004-03-10 Novartis Ag Process for the manufacture of organic compounds
SG153831A1 (en) 2004-03-17 2009-07-29 Novartis Ag Use of renin inhibitors in therapy
ATE551052T1 (de) 2004-10-08 2012-04-15 Novartis Ag Verwendung von reninhemmern zur prävention oder behandlung von diastolischer dysfunktion oder diastolischer herzinsuffizienz
EP1749828A1 (de) 2005-08-04 2007-02-07 Farmaprojects S.L. Verfahren zur Herstellung eines Angiotensin-II-Antagonisten
EP2481408A3 (de) 2007-03-01 2013-01-09 Probiodrug AG Neue Verwendung von Inhibitoren der Glutaminyl Cyclase
JP5667440B2 (ja) 2007-04-18 2015-02-12 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのチオ尿素誘導体
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
AU2008261102B2 (en) 2007-06-04 2013-11-28 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
PL2160190T3 (pl) * 2007-06-07 2016-03-31 Cvie Therapeutics Ltd Pochodne 5beta, 14beta-androstanu przydatne w leczeniu chorób będących wynikiem zwłóknienia organu
EP2810951B1 (de) 2008-06-04 2017-03-15 Synergy Pharmaceuticals Inc. Für die Behandlung von gastrointestinalen Erkrankungen, Entzündungen, Krebs und anderen Erkrankungen geeignete Agonisten von Guanylatcyclase
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
SG178953A1 (en) 2009-09-11 2012-04-27 Probiodrug Ag Heterocylcic derivatives as inhibitors of glutaminyl cyclase
JP6026284B2 (ja) 2010-03-03 2016-11-16 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤
ES2481823T3 (es) 2010-03-10 2014-07-31 Probiodrug Ag Inhibidores heterocíclicos de glutaminil ciclasa (QC, EC 2.3.2.5)
JP5945532B2 (ja) 2010-04-21 2016-07-05 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤としてのベンゾイミダゾール誘導体
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
EP2686313B1 (de) 2011-03-16 2016-02-03 Probiodrug AG Benzimidazolderivate als glutaminylcyclase-hemmer
WO2013090196A1 (en) 2011-12-15 2013-06-20 Takeda Pharmaceuticals U.S.A., Inc. Combinations of azilsartan and chlorthalidone for treating hypertension black patients
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
CA2905438A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
KR102272746B1 (ko) 2013-06-05 2021-07-08 보슈 헬스 아일랜드 리미티드 구아닐레이트 사이클라제 c의 초순수 작용제, 및 이의 제조 및 사용 방법
ES2812698T3 (es) 2017-09-29 2021-03-18 Probiodrug Ag Inhibidores de glutaminil ciclasa

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0407342A3 (en) * 1989-07-06 1991-07-10 Ciba-Geigy Ag Pyrimidine derivatives
US5100897A (en) * 1989-08-28 1992-03-31 Merck & Co., Inc. Substituted pyrimidinones as angiotensin ii antagonists
EP0415886A3 (en) * 1989-08-30 1991-10-23 Ciba-Geigy Ag Aza compounds
JPH05504969A (ja) * 1990-02-13 1993-07-29 メルク・エンド・カムパニー・インコーポレーテツド 置換ベンジル要素を含有するアンギオテンシン２アンタゴニスト類
US5149699A (en) * 1991-10-24 1992-09-22 American Home Products Corporation Substituted pyridopyrimidines useful as antgiotensin II antagonists

Also Published As

Publication number Publication date
KR100286624B1 (ko) 2001-05-02
NO924121D0 (no) 1992-10-23
IL103436A (en) 1996-03-31
IL103436A0 (en) 1993-03-15
HU211915A9 (en) 1996-01-29
EP0539086A2 (de) 1993-04-28
KR930007949A (ko) 1993-05-20
CA2080705C (en) 2002-12-03
CA2080705A1 (en) 1993-04-25
HU9203161D0 (en) 1992-12-28
SG47626A1 (en) 1998-04-17
LV12047B (en) 1998-08-20
NO301275B1 (no) 1997-10-06
UA27748C2 (uk) 2000-10-16
FI103971B (fi) 1999-10-29
GR3025926T3 (en) 1998-04-30
FI924397A (fi) 1993-04-25
AU2607992A (en) 1993-04-29
CN1072682A (zh) 1993-06-02
SK280292B6 (sk) 1999-11-08
DK0539086T3 (da) 1998-02-02
LV12047A (lv) 1998-05-20
TW226375B (de) 1994-07-11
EP0539086B1 (de) 1997-12-29
JP3240192B2 (ja) 2001-12-17
HU218786B (hu) 2000-12-28
FI924397A0 (fi) 1992-09-30
HK1003031A1 (en) 1998-09-30
ES2111617T3 (es) 1998-03-16
DE69223734T2 (de) 1998-04-16
HUT62893A (en) 1993-06-28
DE69223734D1 (de) 1998-02-05
JPH05222039A (ja) 1993-08-31
SK322192A3 (en) 1999-11-08
EP0539086A3 (en) 1993-06-16
AU653635B2 (en) 1994-10-06
CN1039324C (zh) 1998-07-29
NO924121L (no) 1993-04-26
ATE161537T1 (de) 1998-01-15
CN1175414A (zh) 1998-03-11

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Legal Events

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MA Patent expired