ATE161537T1 - Kondensierte pyrimidinderivate und deren verwendung als angiotensin-ii-antagonisten - Google Patents

Kondensierte pyrimidinderivate und deren verwendung als angiotensin-ii-antagonisten

Info

Publication number
ATE161537T1
ATE161537T1 AT92309333T AT92309333T ATE161537T1 AT E161537 T1 ATE161537 T1 AT E161537T1 AT 92309333 T AT92309333 T AT 92309333T AT 92309333 T AT92309333 T AT 92309333T AT E161537 T1 ATE161537 T1 AT E161537T1
Authority
AT
Austria
Prior art keywords
angiotensin
antagonists
pyrimidine derivatives
condensed pyrimidine
condensed
Prior art date
Application number
AT92309333T
Other languages
English (en)
Inventor
John Watson Ellingboe
Madelene Nikaido
Jehan Franroz Bagli
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/782,025 external-priority patent/US5149699A/en
Priority claimed from GB9207560A external-priority patent/GB2265899A/en
Priority claimed from US07/901,485 external-priority patent/US5256654A/en
Application filed by American Home Prod filed Critical American Home Prod
Application granted granted Critical
Publication of ATE161537T1 publication Critical patent/ATE161537T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT92309333T 1991-10-24 1992-10-14 Kondensierte pyrimidinderivate und deren verwendung als angiotensin-ii-antagonisten ATE161537T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/782,025 US5149699A (en) 1991-10-24 1991-10-24 Substituted pyridopyrimidines useful as antgiotensin II antagonists
GB9207560A GB2265899A (en) 1992-04-07 1992-04-07 Substituted pyrimidines
US07/901,485 US5256654A (en) 1991-10-24 1992-06-25 Substituted pyrrolopyrimidines, azepinopyrimidines and pyridopyrimidines useful as angiotensin II antagonists

Publications (1)

Publication Number Publication Date
ATE161537T1 true ATE161537T1 (de) 1998-01-15

Family

ID=27266132

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92309333T ATE161537T1 (de) 1991-10-24 1992-10-14 Kondensierte pyrimidinderivate und deren verwendung als angiotensin-ii-antagonisten

Country Status (21)

Country Link
EP (1) EP0539086B1 (de)
JP (1) JP3240192B2 (de)
KR (1) KR100286624B1 (de)
CN (2) CN1039324C (de)
AT (1) ATE161537T1 (de)
AU (1) AU653635B2 (de)
CA (1) CA2080705C (de)
DE (1) DE69223734T2 (de)
DK (1) DK0539086T3 (de)
ES (1) ES2111617T3 (de)
FI (1) FI103971B (de)
GR (1) GR3025926T3 (de)
HK (1) HK1003031A1 (de)
HU (2) HU218786B (de)
IL (1) IL103436A (de)
LV (1) LV12047B (de)
NO (1) NO301275B1 (de)
SG (1) SG47626A1 (de)
SK (1) SK322192A3 (de)
TW (1) TW226375B (de)
UA (1) UA27748C2 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08500323A (ja) * 1991-11-18 1996-01-16 イー・アイ・デュポン・ドゥ・ヌムール・アンド・カンパニー Ａ▲ｉｉ▼受容体アンタゴニストの合成のためのテトラゾリルフェニルボロン酸中間体
EP0618207B1 (de) * 1993-03-24 1999-01-07 American Home Products Corporation Substituierte Pyridopyrimidine als Antihypertensiva
EP0782996B1 (de) * 1994-09-20 1999-02-17 Wakunaga Seiyaku Kabushiki Kaisha Verfahren zur herstellung von n-biphenylmethylthiadiazolin derivaten oder deren salzen sowie dafür benötigte zwischen verbindungen
IT1292437B1 (it) * 1997-06-30 1999-02-08 Zambon Spa Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti
US6638937B2 (en) 1998-07-06 2003-10-28 Bristol-Myers Squibb Co. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
AR033390A1 (es) 2000-08-22 2003-12-17 Novartis Ag Una composicion farmaceutica que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina, el uso de dicha composicion para la fabricacion de un medicamento y un kit de partes
US8168616B1 (en) 2000-11-17 2012-05-01 Novartis Ag Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
GB0327839D0 (en) 2003-12-01 2003-12-31 Novartis Ag Organic compounds
GB0402262D0 (en) 2004-02-02 2004-03-10 Novartis Ag Process for the manufacture of organic compounds
BRPI0508880A (pt) 2004-03-17 2007-09-04 Novartis Ag uso de compostos orgánicos
JP2008515903A (ja) 2004-10-08 2008-05-15 ノバルティス アクチエンゲゼルシャフト 拡張機能障害または拡張期心不全の予防または処置のためのレニン阻害剤の使用
EP1749828A1 (de) 2005-08-04 2007-02-07 Farmaprojects S.L. Verfahren zur Herstellung eines Angiotensin-II-Antagonisten
ZA200905537B (en) 2007-03-01 2010-10-27 Probiodrug Ag New use of glutaminyl cyclase inhibitors
EP2142514B1 (de) 2007-04-18 2014-12-24 Probiodrug AG Thioharnstoffderivate als glutaminylcyclaseinhibitoren
DK2170930T3 (da) 2007-06-04 2012-11-05 Synergy Pharmaceuticals Inc Agonister af guanylatcyclase, anvendelige til behandlingen af gastrointestinale sygdomme, inflammation, cancer og andre sygdomme
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
RS54459B1 (en) * 2007-06-07 2016-06-30 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. 5BETA, 14BETA ANDROSTAN DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES RESULTING FROM THE BODY FIBROSIS
JP2011522828A (ja) 2008-06-04 2011-08-04 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
ES2548913T3 (es) 2009-09-11 2015-10-21 Probiodrug Ag Derivados heterocíclicos como inhibidores de glutaminil ciclasa
JP6026284B2 (ja) 2010-03-03 2016-11-16 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤
JP5688745B2 (ja) 2010-03-10 2015-03-25 プロビオドルグ エージー グルタミニルシクラーゼ（ｑｃ、ｅｃ２．３．２．５）の複素環阻害剤
WO2011131748A2 (en) 2010-04-21 2011-10-27 Probiodrug Ag Novel inhibitors
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
WO2012123563A1 (en) 2011-03-16 2012-09-20 Probiodrug Ag Benz imidazole derivatives as inhibitors of glutaminyl cyclase
US20130158080A1 (en) 2011-12-15 2013-06-20 Takeda Pharmaceuticals U.S.A., Inc. Methods for treating hypertension in black patients
US9708367B2 (en) 2013-03-15 2017-07-18 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
AU2014235209B2 (en) 2013-03-15 2018-06-14 Bausch Health Ireland Limited Guanylate cyclase receptor agonists combined with other drugs
KR102272746B1 (ko) 2013-06-05 2021-07-08 보슈 헬스 아일랜드 리미티드 구아닐레이트 사이클라제 c의 초순수 작용제, 및 이의 제조 및 사용 방법
EP3461819B1 (de) 2017-09-29 2020-05-27 Probiodrug AG Hemmer der glutaminylcyclase

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0407342A3 (en) * 1989-07-06 1991-07-10 Ciba-Geigy Ag Pyrimidine derivatives
US5100897A (en) * 1989-08-28 1992-03-31 Merck & Co., Inc. Substituted pyrimidinones as angiotensin ii antagonists
EP0415886A3 (en) * 1989-08-30 1991-10-23 Ciba-Geigy Ag Aza compounds
JPH05503530A (ja) * 1990-02-13 1993-06-10 メルク・エンド・カムパニー・インコーポレーテツド 置換ベンジル成分を含むアンギオテンシン２拮抗物質
US5149699A (en) * 1991-10-24 1992-09-22 American Home Products Corporation Substituted pyridopyrimidines useful as antgiotensin II antagonists

Also Published As

Publication number Publication date
KR100286624B1 (ko) 2001-05-02
NO301275B1 (no) 1997-10-06
LV12047A (lv) 1998-05-20
AU653635B2 (en) 1994-10-06
KR930007949A (ko) 1993-05-20
HK1003031A1 (en) 1998-09-30
FI924397A (fi) 1993-04-25
EP0539086B1 (de) 1997-12-29
FI103971B1 (fi) 1999-10-29
NO924121L (no) 1993-04-26
IL103436A0 (en) 1993-03-15
UA27748C2 (uk) 2000-10-16
DK0539086T3 (da) 1998-02-02
JPH05222039A (ja) 1993-08-31
NO924121D0 (no) 1992-10-23
IL103436A (en) 1996-03-31
HUT62893A (en) 1993-06-28
DE69223734D1 (de) 1998-02-05
FI103971B (fi) 1999-10-29
CA2080705A1 (en) 1993-04-25
EP0539086A3 (en) 1993-06-16
HU218786B (hu) 2000-12-28
LV12047B (en) 1998-08-20
CN1175414A (zh) 1998-03-11
SK280292B6 (sk) 1999-11-08
SK322192A3 (en) 1999-11-08
ES2111617T3 (es) 1998-03-16
CN1072682A (zh) 1993-06-02
EP0539086A2 (de) 1993-04-28
JP3240192B2 (ja) 2001-12-17
SG47626A1 (en) 1998-04-17
HU211915A9 (en) 1996-01-29
GR3025926T3 (en) 1998-04-30
HU9203161D0 (en) 1992-12-28
FI924397A0 (fi) 1992-09-30
TW226375B (de) 1994-07-11
CA2080705C (en) 2002-12-03
AU2607992A (en) 1993-04-29
DE69223734T2 (de) 1998-04-16
CN1039324C (zh) 1998-07-29

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee