UA27748C2 - Похідні піримідину, що мають активність антагоністів ангіотензину іі, спосіб їх отримання та фармацевтична композиція - Google Patents

Похідні піримідину, що мають активність антагоністів ангіотензину іі, спосіб їх отримання та фармацевтична композиція

Info

Publication number
UA27748C2
UA27748C2 UA93003129A UA93003129A UA27748C2 UA 27748 C2 UA27748 C2 UA 27748C2 UA 93003129 A UA93003129 A UA 93003129A UA 93003129 A UA93003129 A UA 93003129A UA 27748 C2 UA27748 C2 UA 27748C2
Authority
UA
Ukraine
Prior art keywords
angiotensin
activity
pyrimidine
derivatives
preparation
Prior art date
Application number
UA93003129A
Other languages
English (en)
Russian (ru)
Inventor
Джон Ватсон Еллінгбой
Джон Ватсон Еллингбой
Маделен Нікайдо
Маделен Никайдо
Жак Фрамрос Бажлі
Жак Фрамрос Бажли
Original Assignee
Амерікан Хоум Продактс Корпорейшн
Американ Хоум Продактс Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/782,025 external-priority patent/US5149699A/en
Priority claimed from GB9207560A external-priority patent/GB2265899A/en
Priority claimed from US07/901,485 external-priority patent/US5256654A/en
Application filed by Амерікан Хоум Продактс Корпорейшн, Американ Хоум Продактс Корпорейшн filed Critical Амерікан Хоум Продактс Корпорейшн
Publication of UA27748C2 publication Critical patent/UA27748C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Цей винахід відноситься до заміщених пиримідинів, які можуть використовуватися для лікування гіпертензії. Ця можливість обумовлена таким, що надається ними антагоністичною дією на ангіотензин II, що є активним компонентом ренин-ангіотензинної системи.
UA93003129A 1991-10-24 1993-06-18 Похідні піримідину, що мають активність антагоністів ангіотензину іі, спосіб їх отримання та фармацевтична композиція UA27748C2 (uk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/782,025 US5149699A (en) 1991-10-24 1991-10-24 Substituted pyridopyrimidines useful as antgiotensin II antagonists
GB9207560A GB2265899A (en) 1992-04-07 1992-04-07 Substituted pyrimidines
US07/901,485 US5256654A (en) 1991-10-24 1992-06-25 Substituted pyrrolopyrimidines, azepinopyrimidines and pyridopyrimidines useful as angiotensin II antagonists

Publications (1)

Publication Number Publication Date
UA27748C2 true UA27748C2 (uk) 2000-10-16

Family

ID=27266132

Family Applications (1)

Application Number Title Priority Date Filing Date
UA93003129A UA27748C2 (uk) 1991-10-24 1993-06-18 Похідні піримідину, що мають активність антагоністів ангіотензину іі, спосіб їх отримання та фармацевтична композиція

Country Status (21)

Country Link
EP (1) EP0539086B1 (uk)
JP (1) JP3240192B2 (uk)
KR (1) KR100286624B1 (uk)
CN (2) CN1039324C (uk)
AT (1) ATE161537T1 (uk)
AU (1) AU653635B2 (uk)
CA (1) CA2080705C (uk)
DE (1) DE69223734T2 (uk)
DK (1) DK0539086T3 (uk)
ES (1) ES2111617T3 (uk)
FI (1) FI103971B1 (uk)
GR (1) GR3025926T3 (uk)
HK (1) HK1003031A1 (uk)
HU (2) HU218786B (uk)
IL (1) IL103436A (uk)
LV (1) LV12047B (uk)
NO (1) NO301275B1 (uk)
SG (1) SG47626A1 (uk)
SK (1) SK280292B6 (uk)
TW (1) TW226375B (uk)
UA (1) UA27748C2 (uk)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69233208T2 (de) * 1991-11-18 2004-07-08 E.I. Du Pont De Nemours And Co., Wilmington Tetrazolylphenylborsäureintermediate zur synthese von aii rezeptor antagonisten
ES2126061T3 (es) * 1993-03-24 1999-03-16 American Home Prod Piridopirimidinas substituidas como antihipertensores.
DK0782996T3 (da) * 1994-09-20 1999-09-20 Wakunaga Seiyaku Kk Fremgangsmåde til fremstilling af N-biphenylmethylthiadiazolinderivat eller salt deraf og mellemprodukt til fremstilling af
IT1292437B1 (it) * 1997-06-30 1999-02-08 Zambon Spa Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti
US6638937B2 (en) 1998-07-06 2003-10-28 Bristol-Myers Squibb Co. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
AR033390A1 (es) 2000-08-22 2003-12-17 Novartis Ag Una composicion farmaceutica que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina, el uso de dicha composicion para la fabricacion de un medicamento y un kit de partes
US8168616B1 (en) 2000-11-17 2012-05-01 Novartis Ag Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
GB0327839D0 (en) 2003-12-01 2003-12-31 Novartis Ag Organic compounds
GB0402262D0 (en) 2004-02-02 2004-03-10 Novartis Ag Process for the manufacture of organic compounds
KR20070006774A (ko) 2004-03-17 2007-01-11 노파르티스 아게 치료에서 레닌 억제제의 용도
CA2580862A1 (en) 2004-10-08 2006-04-20 Novartis Ag Use of renin inhibitors for the prevention or treatment of diastolic dysfunction or diastolic heart failure
EP1749828A1 (en) 2005-08-04 2007-02-07 Farmaprojects S.L. Process for preparing an angiotensin II receptor antagonist
CN101668525A (zh) 2007-03-01 2010-03-10 前体生物药物股份公司 谷氨酰胺酰环化酶抑制剂的新用途
EP2142514B1 (en) 2007-04-18 2014-12-24 Probiodrug AG Thiourea derivatives as glutaminyl cyclase inhibitors
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
ES2393885T7 (es) 2007-06-04 2014-01-30 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
RS54459B1 (en) * 2007-06-07 2016-06-30 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. 5BETA, 14BETA ANDROSTAN DERIVATIVES USEFUL FOR THE TREATMENT OF DISEASES RESULTING FROM THE BODY FIBROSIS
ES2522968T3 (es) 2008-06-04 2014-11-19 Synergy Pharmaceuticals Inc. Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
AU2009270833B2 (en) 2008-07-16 2015-02-19 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
SG178953A1 (en) 2009-09-11 2012-04-27 Probiodrug Ag Heterocylcic derivatives as inhibitors of glutaminyl cyclase
ES2586231T3 (es) 2010-03-03 2016-10-13 Probiodrug Ag Inhibidores de glutaminil ciclasa
DK2545047T3 (da) 2010-03-10 2014-07-28 Probiodrug Ag Heterocycliske inhibitorer af glutaminylcyclase (QC, EC 2.3.2.5)
WO2011131748A2 (en) 2010-04-21 2011-10-27 Probiodrug Ag Novel inhibitors
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
ES2570167T3 (es) 2011-03-16 2016-05-17 Probiodrug Ag Derivados de benzimidazol como inhibidores de glutaminil ciclasa
AP2014007766A0 (en) 2011-12-15 2014-07-31 Takeda Pharmaceuticals Usa Inc Combination os azilsartan and chlorthlidone for treating hypertension black patients
CA2905435A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
JP2016514671A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼのアゴニストおよびその使用
US10011637B2 (en) 2013-06-05 2018-07-03 Synergy Pharmaceuticals, Inc. Ultra-pure agonists of guanylate cyclase C, method of making and using same
PL3461819T3 (pl) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitory cyklazy glutaminylowej

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0407342A3 (en) * 1989-07-06 1991-07-10 Ciba-Geigy Ag Pyrimidine derivatives
US5100897A (en) * 1989-08-28 1992-03-31 Merck & Co., Inc. Substituted pyrimidinones as angiotensin ii antagonists
EP0415886A3 (en) * 1989-08-30 1991-10-23 Ciba-Geigy Ag Aza compounds
CA2075627A1 (en) * 1990-02-13 1991-08-14 William J. Greenlee Angiotensin ii antagonists incorporating a substituted benzyl element
US5149699A (en) * 1991-10-24 1992-09-22 American Home Products Corporation Substituted pyridopyrimidines useful as antgiotensin II antagonists

Also Published As

Publication number Publication date
FI103971B (fi) 1999-10-29
FI924397A (fi) 1993-04-25
IL103436A (en) 1996-03-31
KR930007949A (ko) 1993-05-20
EP0539086A3 (en) 1993-06-16
NO301275B1 (no) 1997-10-06
AU653635B2 (en) 1994-10-06
DE69223734T2 (de) 1998-04-16
HU218786B (hu) 2000-12-28
ATE161537T1 (de) 1998-01-15
FI103971B1 (fi) 1999-10-29
NO924121L (no) 1993-04-26
AU2607992A (en) 1993-04-29
SK322192A3 (en) 1999-11-08
DK0539086T3 (da) 1998-02-02
CN1175414A (zh) 1998-03-11
GR3025926T3 (en) 1998-04-30
CA2080705A1 (en) 1993-04-25
FI924397A0 (fi) 1992-09-30
DE69223734D1 (de) 1998-02-05
SK280292B6 (sk) 1999-11-08
KR100286624B1 (ko) 2001-05-02
NO924121D0 (no) 1992-10-23
LV12047A (lv) 1998-05-20
JPH05222039A (ja) 1993-08-31
LV12047B (en) 1998-08-20
CA2080705C (en) 2002-12-03
HU9203161D0 (en) 1992-12-28
TW226375B (uk) 1994-07-11
CN1072682A (zh) 1993-06-02
JP3240192B2 (ja) 2001-12-17
HU211915A9 (en) 1996-01-29
EP0539086A2 (en) 1993-04-28
IL103436A0 (en) 1993-03-15
CN1039324C (zh) 1998-07-29
ES2111617T3 (es) 1998-03-16
HUT62893A (en) 1993-06-28
EP0539086B1 (en) 1997-12-29
HK1003031A1 (en) 1998-09-30
SG47626A1 (en) 1998-04-17

Similar Documents

Publication Publication Date Title
UA27748C2 (uk) Похідні піримідину, що мають активність антагоністів ангіотензину іі, спосіб їх отримання та фармацевтична композиція
UA39158C2 (uk) Похідні n4-оксикарбоніл-5'-дезокси-5-фторцитидину та фармацевтичний препарат на їх основі
YU33802A (sh) Policikloalkilpurini kao antagonisti adenozinskih receptora
UA43348C2 (uk) Водна фармацевтична композиція, що включає фактор росту нерва (варіанти) та ліофілізований фармацевтичний склад
JO1552B1 (en) New pyridizinamine derivatives
EP0209689A3 (en) Use of tetrahydrobiopterins in the treatment of infantile autism
BG101118A (en) Therapeutical compounds
AU3153097A (en) Pharmaceutical for treatment of neurological and neuropsychiatric disorders
NZ502280A (en) Combination therapy comprising atorvastatin and an antihypertensive agent
BG104544A (en) Novel acylguanadine derivatives as inhibitors of bone resorption and as vitronectin receptor antagonists
EP0497258A3 (en) Use of adenosine antagonists in the prevention and treatment of pancreatitis and ulcer
SI0725779T1 (uk)
UA37259C2 (uk) Активна речовина для одержання лікарських засобів при лікуванні дисфункціональних маткових кровотеч
AU9624198A (en) Quinoline and quinazoline derivatives having corticotropin releasing factor (crf) antagonist activity
ZA951974B (en) Bradykinin antagonist peptides incorporating N-subsituted glycines
GEP19981035B (en) 3-cycloalkyl-propanamides, manifesting the anti-inflammatory and immuno-suppressing activity, process for preparation thereof, cyanamide and pharmaceutical composition
EP1032556A4 (en) PHARMACEUTICALLY EFFECTIVE COMPOUNDS AND METHODS OF THEIR APPLICATION
MY106231A (en) Antiviral tetrahydroimidazo [1,4] benzodiazepin-2- thiones.
EP1413299A3 (en) Use of deprenyl analogues to maintain, prevent loss, or recover nerve cell function
JO1589B1 (en) Ketones (quaternary hydroimidazo (4.1) benzo-diazepine-2) anti-viral
HUT41002A (en) Process for preparing anticonvulsives
MXPA01004457A (es) Derivados pirimidina novedosos y procesos para la preparacion de los mismos.
MY115795A (en) Substituted benzenesulfonylureas and -thioureas, processes for their preparation and use of pharmaceutical preparations based on these compounds, and medicaments containing them
ES8403487A1 (es) "procedimiento para la preparacion de n-(2-metoxietil)-noroximorfona".
AP9200443A0 (en) Heterocyclic compounds.