ES2111617T3 - Derivados de pirimidina condensados y su utilizacion como antagonistas de la angiotensina ii. - Google Patents

Derivados de pirimidina condensados y su utilizacion como antagonistas de la angiotensina ii.

Info

Publication number
ES2111617T3
ES2111617T3 ES92309333T ES92309333T ES2111617T3 ES 2111617 T3 ES2111617 T3 ES 2111617T3 ES 92309333 T ES92309333 T ES 92309333T ES 92309333 T ES92309333 T ES 92309333T ES 2111617 T3 ES2111617 T3 ES 2111617T3
Authority
ES
Spain
Prior art keywords
angiotensin
antagonists
condensed
pirimidine derivatives
pirimidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92309333T
Other languages
English (en)
Inventor
John Watson Ellingboe
Madelene Nikaido
Jehan Franroz Bagli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/782,025 external-priority patent/US5149699A/en
Priority claimed from GB9207560A external-priority patent/GB2265899A/en
Priority claimed from US07/901,485 external-priority patent/US5256654A/en
Application filed by American Home Products Corp filed Critical American Home Products Corp
Application granted granted Critical
Publication of ES2111617T3 publication Critical patent/ES2111617T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

ESTA INVENCION SE REFIERE A PIRROLO-, PIRIDOY AZOCINOPIRIMIDINAS DE LA FORMULA GENERAL I UTILES PARA EL TRATAMIENTO DE LA HIPERTENSION O DE ATAQUES CARDIACOS CONGESTIVOS Y PARA PREVENIR O TRATAR LA RESTENOSIS QUE SIGUE A LA ANGIOPLASTIA, A COMPOSICIONES FARMACEUTICAS Y A METODOS PARA LA PRODUCCION DE LAS MISMAS.
ES92309333T 1991-10-24 1992-10-14 Derivados de pirimidina condensados y su utilizacion como antagonistas de la angiotensina ii. Expired - Lifetime ES2111617T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/782,025 US5149699A (en) 1991-10-24 1991-10-24 Substituted pyridopyrimidines useful as antgiotensin II antagonists
GB9207560A GB2265899A (en) 1992-04-07 1992-04-07 Substituted pyrimidines
US07/901,485 US5256654A (en) 1991-10-24 1992-06-25 Substituted pyrrolopyrimidines, azepinopyrimidines and pyridopyrimidines useful as angiotensin II antagonists

Publications (1)

Publication Number Publication Date
ES2111617T3 true ES2111617T3 (es) 1998-03-16

Family

ID=27266132

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92309333T Expired - Lifetime ES2111617T3 (es) 1991-10-24 1992-10-14 Derivados de pirimidina condensados y su utilizacion como antagonistas de la angiotensina ii.

Country Status (21)

Country Link
EP (1) EP0539086B1 (es)
JP (1) JP3240192B2 (es)
KR (1) KR100286624B1 (es)
CN (2) CN1039324C (es)
AT (1) ATE161537T1 (es)
AU (1) AU653635B2 (es)
CA (1) CA2080705C (es)
DE (1) DE69223734T2 (es)
DK (1) DK0539086T3 (es)
ES (1) ES2111617T3 (es)
FI (1) FI103971B1 (es)
GR (1) GR3025926T3 (es)
HK (1) HK1003031A1 (es)
HU (2) HU218786B (es)
IL (1) IL103436A (es)
LV (1) LV12047B (es)
NO (1) NO301275B1 (es)
SG (1) SG47626A1 (es)
SK (1) SK322192A3 (es)
TW (1) TW226375B (es)
UA (1) UA27748C2 (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE250043T1 (de) * 1991-11-18 2003-10-15 Du Pont Tetrazolylphenylborsäureintermediate zur synthese von aii rezeptor antagonisten
ES2126061T3 (es) * 1993-03-24 1999-03-16 American Home Prod Piridopirimidinas substituidas como antihipertensores.
WO1996009301A1 (fr) * 1994-09-20 1996-03-28 Wakunaga Seiyaku Kabushiki Kaisha Procede de production d'un derive de n-biphenylmethylthiadiazoline ou un sel de celui-ci et son intermediaire de production
IT1292437B1 (it) * 1997-06-30 1999-02-08 Zambon Spa Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti
US6638937B2 (en) 1998-07-06 2003-10-28 Bristol-Myers Squibb Co. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
AR033390A1 (es) 2000-08-22 2003-12-17 Novartis Ag Una composicion farmaceutica que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina, el uso de dicha composicion para la fabricacion de un medicamento y un kit de partes
US8168616B1 (en) 2000-11-17 2012-05-01 Novartis Ag Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
GB0327839D0 (en) 2003-12-01 2003-12-31 Novartis Ag Organic compounds
GB0402262D0 (en) 2004-02-02 2004-03-10 Novartis Ag Process for the manufacture of organic compounds
RU2426532C2 (ru) 2004-03-17 2011-08-20 Новартис Аг Применение органических соединений
CA2580862A1 (en) 2004-10-08 2006-04-20 Novartis Ag Use of renin inhibitors for the prevention or treatment of diastolic dysfunction or diastolic heart failure
EP1749828A1 (en) 2005-08-04 2007-02-07 Farmaprojects S.L. Process for preparing an angiotensin II receptor antagonist
JP5930573B2 (ja) 2007-03-01 2016-06-15 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤の新規使用
ES2533484T3 (es) 2007-04-18 2015-04-10 Probiodrug Ag Derivados de tiourea como inhibidores de la glutaminil ciclasa
US8034782B2 (en) 2008-07-16 2011-10-11 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CA3089569C (en) 2007-06-04 2023-12-05 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
JP5579058B2 (ja) * 2007-06-07 2014-08-27 シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ 血管形成または内部粥腫切除術後の再狭窄および臓器線維症を原因とする疾患の処置に有用な５β，１４β−アンドロスタン誘導体
CA2930674A1 (en) 2008-06-04 2009-12-10 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
DK2475428T3 (en) 2009-09-11 2015-09-28 Probiodrug Ag Heterocyclic derivatives as glutaminylcyklaseinhibitorer
US9181233B2 (en) 2010-03-03 2015-11-10 Probiodrug Ag Inhibitors of glutaminyl cyclase
BR112012022478B1 (pt) 2010-03-10 2021-09-21 Probiodrug Ag Inibidores heterocíclicos de glutaminil ciclase (qc, ec 2.3.2.5), seu processo de preparação, e composição farmacêutica
EP2560953B1 (en) 2010-04-21 2016-01-06 Probiodrug AG Inhibitors of glutaminyl cyclase
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
DK2686313T3 (en) 2011-03-16 2016-05-02 Probiodrug Ag Benzimidazole derivatives as inhibitors of glutaminyl cyclase
WO2013090196A1 (en) 2011-12-15 2013-06-20 Takeda Pharmaceuticals U.S.A., Inc. Combinations of azilsartan and chlorthalidone for treating hypertension black patients
EP2968439A2 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
AU2014235215A1 (en) 2013-03-15 2015-10-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
JP6606491B2 (ja) 2013-06-05 2019-11-13 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法
DK3461819T3 (da) 2017-09-29 2020-08-10 Probiodrug Ag Inhibitorer af glutaminylcyklase

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0407342A3 (en) * 1989-07-06 1991-07-10 Ciba-Geigy Ag Pyrimidine derivatives
US5100897A (en) * 1989-08-28 1992-03-31 Merck & Co., Inc. Substituted pyrimidinones as angiotensin ii antagonists
EP0415886A3 (en) * 1989-08-30 1991-10-23 Ciba-Geigy Ag Aza compounds
EP0515535A4 (en) * 1990-02-13 1996-01-17 Merck & Co Inc Angiotensin ii antagonists incorporating a substituted benzyl element
US5149699A (en) * 1991-10-24 1992-09-22 American Home Products Corporation Substituted pyridopyrimidines useful as antgiotensin II antagonists

Also Published As

Publication number Publication date
HU218786B (hu) 2000-12-28
DE69223734T2 (de) 1998-04-16
EP0539086A2 (en) 1993-04-28
CA2080705C (en) 2002-12-03
JPH05222039A (ja) 1993-08-31
KR100286624B1 (ko) 2001-05-02
UA27748C2 (uk) 2000-10-16
ATE161537T1 (de) 1998-01-15
LV12047A (lv) 1998-05-20
IL103436A (en) 1996-03-31
TW226375B (es) 1994-07-11
IL103436A0 (en) 1993-03-15
HUT62893A (en) 1993-06-28
HK1003031A1 (en) 1998-09-30
LV12047B (en) 1998-08-20
FI924397A (fi) 1993-04-25
HU211915A9 (en) 1996-01-29
SK280292B6 (sk) 1999-11-08
EP0539086B1 (en) 1997-12-29
CN1175414A (zh) 1998-03-11
SG47626A1 (en) 1998-04-17
FI103971B (fi) 1999-10-29
DE69223734D1 (de) 1998-02-05
NO924121D0 (no) 1992-10-23
DK0539086T3 (da) 1998-02-02
KR930007949A (ko) 1993-05-20
AU653635B2 (en) 1994-10-06
AU2607992A (en) 1993-04-29
EP0539086A3 (en) 1993-06-16
CN1072682A (zh) 1993-06-02
NO924121L (no) 1993-04-26
NO301275B1 (no) 1997-10-06
FI103971B1 (fi) 1999-10-29
JP3240192B2 (ja) 2001-12-17
FI924397A0 (fi) 1992-09-30
CA2080705A1 (en) 1993-04-25
HU9203161D0 (en) 1992-12-28
SK322192A3 (en) 1999-11-08
CN1039324C (zh) 1998-07-29
GR3025926T3 (en) 1998-04-30

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