FI103971B1 - Förfarande för framställning av terapeutiskt användbara pyrrolo- och pyrido[3,2-d]pyrimidinonderivat - Google Patents

Förfarande för framställning av terapeutiskt användbara pyrrolo- och pyrido[3,2-d]pyrimidinonderivat

Info

Publication number
FI103971B1
FI103971B1 FI924397A FI924397A FI103971B1 FI 103971 B1 FI103971 B1 FI 103971B1 FI 924397 A FI924397 A FI 924397A FI 924397 A FI924397 A FI 924397A FI 103971 B1 FI103971 B1 FI 103971B1
Authority
FI
Finland
Prior art keywords
pyrido
therapeutically useful
pyrrolo
pyrimidinone derivatives
preparing therapeutically
Prior art date
Application number
FI924397A
Other languages
English (en)
Finnish (fi)
Other versions
FI924397A (fi
FI924397A0 (fi
FI103971B (sv
Inventor
John Watson Ellingboe
Madelene Nikaido
Jehan Franroz Bagli
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/782,025 external-priority patent/US5149699A/en
Priority claimed from GB9207560A external-priority patent/GB2265899A/en
Priority claimed from US07/901,485 external-priority patent/US5256654A/en
Application filed by American Home Prod filed Critical American Home Prod
Publication of FI924397A0 publication Critical patent/FI924397A0/fi
Publication of FI924397A publication Critical patent/FI924397A/fi
Application granted granted Critical
Publication of FI103971B publication Critical patent/FI103971B/sv
Publication of FI103971B1 publication Critical patent/FI103971B1/sv

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
FI924397A 1991-10-24 1992-09-30 Förfarande för framställning av terapeutiskt användbara pyrrolo- och pyrido[3,2-d]pyrimidinonderivat FI103971B1 (sv)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US07/782,025 US5149699A (en) 1991-10-24 1991-10-24 Substituted pyridopyrimidines useful as antgiotensin II antagonists
US78202591 1991-10-24
GB9207560 1992-04-07
GB9207560A GB2265899A (en) 1992-04-07 1992-04-07 Substituted pyrimidines
US07/901,485 US5256654A (en) 1991-10-24 1992-06-25 Substituted pyrrolopyrimidines, azepinopyrimidines and pyridopyrimidines useful as angiotensin II antagonists
US90148592 1992-06-25

Publications (4)

Publication Number Publication Date
FI924397A0 FI924397A0 (fi) 1992-09-30
FI924397A FI924397A (fi) 1993-04-25
FI103971B FI103971B (sv) 1999-10-29
FI103971B1 true FI103971B1 (sv) 1999-10-29

Family

ID=27266132

Family Applications (1)

Application Number Title Priority Date Filing Date
FI924397A FI103971B1 (sv) 1991-10-24 1992-09-30 Förfarande för framställning av terapeutiskt användbara pyrrolo- och pyrido[3,2-d]pyrimidinonderivat

Country Status (21)

Country Link
EP (1) EP0539086B1 (sv)
JP (1) JP3240192B2 (sv)
KR (1) KR100286624B1 (sv)
CN (2) CN1039324C (sv)
AT (1) ATE161537T1 (sv)
AU (1) AU653635B2 (sv)
CA (1) CA2080705C (sv)
DE (1) DE69223734T2 (sv)
DK (1) DK0539086T3 (sv)
ES (1) ES2111617T3 (sv)
FI (1) FI103971B1 (sv)
GR (1) GR3025926T3 (sv)
HK (1) HK1003031A1 (sv)
HU (2) HU218786B (sv)
IL (1) IL103436A (sv)
LV (1) LV12047B (sv)
NO (1) NO301275B1 (sv)
SG (1) SG47626A1 (sv)
SK (1) SK322192A3 (sv)
TW (1) TW226375B (sv)
UA (1) UA27748C2 (sv)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1384717B1 (en) * 1991-11-18 2008-05-14 E.I. Dupont De Nemours And Company 2-(2'-triphenylmethyl-2'H-tetrazol-5'-yl)phenylboronic acid intermediates for the synthesis of A II receptor antagonists
EP0863143A1 (en) * 1993-03-24 1998-09-09 American Home Products Corporation Intermediates useful in the production of pyridopyrimidone angiotensin AII antagonists
EP0782996B1 (en) * 1994-09-20 1999-02-17 Wakunaga Seiyaku Kabushiki Kaisha Process for producing n-biphenylmethylthiadiazoline derivative or salt thereof and intermediate for producing the same
IT1292437B1 (it) * 1997-06-30 1999-02-08 Zambon Spa Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti
US6638937B2 (en) 1998-07-06 2003-10-28 Bristol-Myers Squibb Co. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
PE20020617A1 (es) 2000-08-22 2002-08-05 Novartis Ag Composicion que comprende un antagonista del receptor at1 y un potenciador de la secrecion de insulina o un sensibilizante a la insulina
US8168616B1 (en) 2000-11-17 2012-05-01 Novartis Ag Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
GB0327839D0 (en) 2003-12-01 2003-12-31 Novartis Ag Organic compounds
GB0402262D0 (en) 2004-02-02 2004-03-10 Novartis Ag Process for the manufacture of organic compounds
CA2558020A1 (en) 2004-03-17 2005-09-29 Novartis Ag Use of renin inhibitors in therapy
AU2005294318A1 (en) 2004-10-08 2006-04-20 Novartis Ag Use of renin inhibitors for the prevention or treatment of diastolic dysfunction or diastolic heart failure
EP1749828A1 (en) 2005-08-04 2007-02-07 Farmaprojects S.L. Process for preparing an angiotensin II receptor antagonist
KR20090115951A (ko) 2007-03-01 2009-11-10 프로비오드룩 아게 글루타미닐 사이클라제 저해제의 신규 용도
US9656991B2 (en) 2007-04-18 2017-05-23 Probiodrug Ag Inhibitors of glutaminyl cyclase
ES2393885T7 (es) 2007-06-04 2014-01-30 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EP2160190B1 (en) * 2007-06-07 2015-11-04 SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. 5beta, 14beta-androstane derivatives useful for the treatment of diseases due to organ fibrosis
WO2009149279A2 (en) 2008-06-04 2009-12-10 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
ES2624828T3 (es) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros
JP5934645B2 (ja) 2009-09-11 2016-06-15 プロビオドルグ エージー グルタミニルシクラーゼ阻害剤としてのヘテロ環式誘導体
JP6026284B2 (ja) 2010-03-03 2016-11-16 プロビオドルグ エージー グルタミニルシクラーゼの阻害剤
EP2545047B9 (en) 2010-03-10 2015-06-10 Probiodrug AG Heterocyclic inhibitors of glutaminyl cyclase (qc, ec 2.3.2.5)
EP2560953B1 (en) 2010-04-21 2016-01-06 Probiodrug AG Inhibitors of glutaminyl cyclase
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
US8530670B2 (en) 2011-03-16 2013-09-10 Probiodrug Ag Inhibitors
BR112014014527A2 (pt) 2011-12-15 2017-06-13 Takeda Pharmaceuticals Usa Inc combinações de azilsartan e clorotalidona para tratar hipertensão em pacientes negros
WO2014151206A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
WO2014151200A2 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions useful for the treatment of gastrointestinal disorders
RS65632B1 (sr) 2013-06-05 2024-07-31 Bausch Health Ireland Ltd Ultra-prečišćeni agonisti guanilat-ciklaze c, postupak njihove pripreme i upotrebe
DK3461819T3 (da) 2017-09-29 2020-08-10 Probiodrug Ag Inhibitorer af glutaminylcyklase

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0407342A3 (en) * 1989-07-06 1991-07-10 Ciba-Geigy Ag Pyrimidine derivatives
US5100897A (en) * 1989-08-28 1992-03-31 Merck & Co., Inc. Substituted pyrimidinones as angiotensin ii antagonists
EP0415886A3 (en) * 1989-08-30 1991-10-23 Ciba-Geigy Ag Aza compounds
WO1991011999A1 (en) * 1990-02-13 1991-08-22 Merck & Co., Inc. Angiotensin ii antagonists incorporating a substituted benzyl element
US5149699A (en) * 1991-10-24 1992-09-22 American Home Products Corporation Substituted pyridopyrimidines useful as antgiotensin II antagonists

Also Published As

Publication number Publication date
SK280292B6 (sk) 1999-11-08
DE69223734T2 (de) 1998-04-16
ES2111617T3 (es) 1998-03-16
SG47626A1 (en) 1998-04-17
AU653635B2 (en) 1994-10-06
CN1175414A (zh) 1998-03-11
HU211915A9 (en) 1996-01-29
CN1072682A (zh) 1993-06-02
FI924397A (fi) 1993-04-25
HUT62893A (en) 1993-06-28
HU218786B (hu) 2000-12-28
FI924397A0 (fi) 1992-09-30
JPH05222039A (ja) 1993-08-31
GR3025926T3 (en) 1998-04-30
CA2080705C (en) 2002-12-03
FI103971B (sv) 1999-10-29
HK1003031A1 (en) 1998-09-30
CA2080705A1 (en) 1993-04-25
SK322192A3 (en) 1999-11-08
LV12047A (lv) 1998-05-20
EP0539086A2 (en) 1993-04-28
EP0539086B1 (en) 1997-12-29
DE69223734D1 (de) 1998-02-05
CN1039324C (zh) 1998-07-29
KR930007949A (ko) 1993-05-20
ATE161537T1 (de) 1998-01-15
UA27748C2 (uk) 2000-10-16
NO924121L (no) 1993-04-26
KR100286624B1 (ko) 2001-05-02
TW226375B (sv) 1994-07-11
EP0539086A3 (en) 1993-06-16
LV12047B (en) 1998-08-20
NO924121D0 (no) 1992-10-23
IL103436A (en) 1996-03-31
JP3240192B2 (ja) 2001-12-17
AU2607992A (en) 1993-04-29
HU9203161D0 (en) 1992-12-28
DK0539086T3 (da) 1998-02-02
NO301275B1 (no) 1997-10-06
IL103436A0 (en) 1993-03-15

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Legal Events

Date Code Title Description
MA Patent expired