FI102965B - Menetelmä uusien kondensoituneiden heterosyklisten yhdisteiden valmist amiseksi - Google Patents

Menetelmä uusien kondensoituneiden heterosyklisten yhdisteiden valmist amiseksi

Info

Publication number
FI102965B
FI102965B FI915488A FI915488A FI102965B FI 102965 B FI102965 B FI 102965B FI 915488 A FI915488 A FI 915488A FI 915488 A FI915488 A FI 915488A FI 102965 B FI102965 B FI 102965B
Authority
FI
Finland
Prior art keywords
substituted
condensed heterocyclic
preparation
heterocyclic compounds
whole number
Prior art date
Application number
FI915488A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI102965B1 (fi
FI915488A0 (fi
FI915488L (fi
Inventor
Giichi Goto
Yuji Ishihara
Masaomi Miyamoto
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of FI915488A0 publication Critical patent/FI915488A0/fi
Publication of FI915488L publication Critical patent/FI915488L/fi
Application granted granted Critical
Publication of FI102965B1 publication Critical patent/FI102965B1/fi
Publication of FI102965B publication Critical patent/FI102965B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Containers Having Bodies Formed In One Piece (AREA)
  • Hydrogenated Pyridines (AREA)
FI915488A 1990-11-22 1991-11-21 Menetelmä uusien kondensoituneiden heterosyklisten yhdisteiden valmist amiseksi FI102965B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP31989790 1990-11-22
JP7028691 1991-01-14
JP20935891 1991-08-21
JP24376891 1991-09-24

Publications (4)

Publication Number Publication Date
FI915488A0 FI915488A0 (fi) 1991-11-21
FI915488L FI915488L (fi) 1992-05-23
FI102965B1 FI102965B1 (fi) 1999-03-31
FI102965B true FI102965B (fi) 1999-03-31

Family

ID=27465225

Family Applications (2)

Application Number Title Priority Date Filing Date
FI915488A FI102965B (fi) 1990-11-22 1991-11-21 Menetelmä uusien kondensoituneiden heterosyklisten yhdisteiden valmist amiseksi
FI982436A FI982436A7 (fi) 1990-11-22 1991-11-21 Kondensoituneet heterosykliset yhdisteet

Family Applications After (1)

Application Number Title Priority Date Filing Date
FI982436A FI982436A7 (fi) 1990-11-22 1991-11-21 Kondensoituneet heterosykliset yhdisteet

Country Status (19)

Country Link
US (1) US5273974A (enExample)
EP (1) EP0487071B1 (enExample)
JP (1) JP2650537B2 (enExample)
KR (1) KR100211437B1 (enExample)
CN (1) CN1036458C (enExample)
AT (1) ATE124695T1 (enExample)
AU (1) AU643337B2 (enExample)
CA (1) CA2055947C (enExample)
DE (1) DE69111029T2 (enExample)
DK (1) DK0487071T3 (enExample)
ES (1) ES2074205T3 (enExample)
FI (2) FI102965B (enExample)
GR (1) GR3017366T3 (enExample)
HU (2) HU214573B (enExample)
IE (1) IE68346B1 (enExample)
NO (1) NO179868C (enExample)
NZ (1) NZ240676A (enExample)
RU (1) RU2095361C1 (enExample)
TW (1) TW197435B (enExample)

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US5965574A (en) * 1996-08-13 1999-10-12 Chen; Yuhpyng Liang Heteroaryl amines as novel acetylcholinesterase inhibitors
TW263504B (enExample) * 1991-10-03 1995-11-21 Pfizer
US5462934A (en) * 1992-03-09 1995-10-31 Takeda Chemical Industries Condensed heterocyclic ketone derivatives and their use
TW218875B (enExample) * 1992-03-09 1994-01-11 Takeda Pharm Industry Co Ltd
DE69329084T2 (de) 1992-04-24 2000-12-21 Takeda Chemical Industries, Ltd. Benzoxazepin-Derivate als Cholinesterase-Inhibitoren
TW248556B (enExample) * 1993-01-18 1995-06-01 Takeda Pharm Industry Co
US5620973A (en) * 1993-11-30 1997-04-15 Takeda Chemical Industries, Ltd. Tetracyclic condensed heterocyclic compounds and their use
CA2196054C (en) * 1994-07-27 2001-04-17 Michael Wiard Scherz Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US5674891A (en) * 1994-07-27 1997-10-07 The Procter & Gamble Company Dihydrobenzothiophene compounds useful as anti-inflammatory agents
US5672620A (en) * 1996-02-01 1997-09-30 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
US5684031A (en) * 1996-02-01 1997-11-04 The Procter & Gamble Company Dihydrobenzofuran and related compounds useful as anti-inflammatory agents
ATE377585T1 (de) 1996-12-18 2007-11-15 Teva Pharma Aminoindanderivate
US6251938B1 (en) 1996-12-18 2001-06-26 Teva Pharmaceutical Industries, Ltd., Phenylethylamine derivatives
US5962535A (en) * 1997-01-17 1999-10-05 Takeda Chemical Industries, Ltd. Composition for alzheimer's disease
WO1998031356A1 (en) * 1997-01-17 1998-07-23 Takeda Chemical Industries, Ltd. Idebenone containing combination agent for treating alzheimer's disease
US6534496B1 (en) 1997-04-17 2003-03-18 Takeda Chemical Industries, Inc. Thermogenic composition and benzazepine thermogenics
RU2222815C2 (ru) * 1997-10-09 2004-01-27 Дексел Фарма Текнолоджис Элтиди. Лекарственная форма для доставки и непосредственного локализованного освобождения желаемого агента в желудочно-кишечном тракте животного и способ доставки желаемого агента в желудочно-кишечный тракт животного (варианты)
BR9814300A (pt) * 1997-12-19 2002-02-05 Searle & Co Método de preparação de óxidos de tetraidrobenzotiepina enanciomericamente enriquecidos
EP1079816A2 (en) 1998-04-23 2001-03-07 Takeda Chemical Industries, Ltd. Pharmaceutical composition for neurotrophic action
HUP0104493A3 (en) 1998-09-30 2002-12-28 Takeda Pharmaceutical Drugs for improving vesical excretory strength
KR100694682B1 (ko) 1999-03-03 2007-03-13 에자이 알앤드디 매니지먼트 가부시키가이샤 4-치환 피페리딘 유도체 불화물
CA2414976A1 (en) * 2000-07-04 2002-01-10 Takeda Chemical Industries, Ltd. Gpr14 antagonistic agent
US20040053826A1 (en) * 2000-08-10 2004-03-18 Yoshio Matsumoto Uses of polypeptides
CN1317276C (zh) * 2000-09-29 2007-05-23 中国科学院上海药物研究所 一类吲哚基哌啶类化合物及其制备方法和用途
JP3878178B2 (ja) 2001-12-28 2007-02-07 武田薬品工業株式会社 排尿障害予防治療剤
US20040010038A1 (en) * 2002-02-27 2004-01-15 Eran Blaugrund Propargylamino indan derivatives and propargylamino tetralin derivatives as brain-selective MAO inhibitors
DE60331114D1 (de) * 2002-04-16 2010-03-11 Schering Corp Trizyklische Thrombinrezeptorantagonisten
EP2389937B1 (en) 2002-06-14 2018-08-15 Toyama Chemical Co., Ltd. Medicinal composition for improving brain function
NZ540148A (en) 2002-12-20 2007-11-30 Glaxo Group Ltd Benzazepine derivatives for the treatment of neurological disorders
US20080045500A1 (en) * 2004-07-01 2008-02-21 Eisai R&D Management Co., Ltd. Nerve Regeneration Stimulator
US20080188510A1 (en) * 2005-05-23 2008-08-07 Eisai R & D Management Co., Ltd. Novel methods using zonisamide
AU2006326642B2 (en) * 2005-12-09 2012-05-03 Technion Research And Development Foundation Ltd. Use of low-dose ladostigil for neuroprotection
TW200744576A (en) * 2006-02-24 2007-12-16 Teva Pharma Propargylated aminoindans, processes for preparation, and uses thereof
CA2731196A1 (en) * 2008-07-18 2010-01-21 Takeda Pharmaceuticals Company Limited Benzazepine derivatives and their use as hstamine h3 antagonists
CN109662964A (zh) 2010-02-09 2019-04-23 约翰斯.霍普金斯大学 用于改善认知功能的方法和组合物
JP6440625B2 (ja) 2012-11-14 2018-12-19 ザ・ジョンズ・ホプキンス・ユニバーシティー 精神分裂病を処置するための方法および組成物
WO2014144663A1 (en) 2013-03-15 2014-09-18 The Johns Hopkins University Methods and compositions for improving cognitive function
CN105142623A (zh) 2013-03-15 2015-12-09 艾吉因生物股份有限公司 用于改善认知功能的方法和组合物
NZ738682A (en) 2015-05-22 2022-01-28 Agenebio Inc Extended release pharmaceutical compositions of levetiracetam
CN109880635B (zh) * 2019-03-19 2021-02-02 石家庄晶奥量新材料有限公司 含有二苯并呋喃并含氧杂环类液晶化合物和组合物及应用

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Publication number Priority date Publication date Assignee Title
FR2334358A1 (fr) * 1975-12-12 1977-07-08 Sogeras Nouveaux medicaments derives de l'indole
US4208417A (en) * 1978-06-29 1980-06-17 Pharmindustrie Indole derivatives and their use as anxiolytics
DK623586A (da) * 1985-12-27 1987-06-28 Eisai Co Ltd Piperidinderivater eller salte deraf og farmaceutiske kompositioner indeholdende forbindelserne
KR910006138B1 (ko) * 1986-09-30 1991-08-16 에자이 가부시끼가이샤 환상아민 유도체
FI95572C (fi) * 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
FR2640266B2 (fr) * 1988-07-12 1992-07-10 Synthelabo Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2, quinoleinones-2, benzo(b)azepinones-2 et benzimidazolones-2, leur preparation et leur application en therapeutique
JP2969359B2 (ja) * 1989-01-13 1999-11-02 武田薬品工業株式会社 環状アミン化合物
CA2023492A1 (en) * 1989-08-31 1991-03-01 Barry Clifford Lange Herbicidal glutarimides
US5109002A (en) * 1989-09-08 1992-04-28 Du Pont Merck Pharmaceutical Company Antipsychotic 1-cycloalkylpiperidines

Also Published As

Publication number Publication date
NO914558L (no) 1992-05-25
FI102965B1 (fi) 1999-03-31
GR3017366T3 (en) 1995-12-31
NO179868B (no) 1996-09-23
CN1062143A (zh) 1992-06-24
ATE124695T1 (de) 1995-07-15
FI915488A0 (fi) 1991-11-21
HUT59676A (en) 1992-06-29
US5273974A (en) 1993-12-28
JPH05140149A (ja) 1993-06-08
IE914053A1 (en) 1992-06-03
JP2650537B2 (ja) 1997-09-03
EP0487071B1 (en) 1995-07-05
TW197435B (enExample) 1993-01-01
CA2055947C (en) 2002-03-12
FI982436A0 (fi) 1998-11-10
HU214573B (hu) 2000-04-28
IE68346B1 (en) 1996-06-12
NO179868C (no) 1997-01-02
FI982436L (fi) 1998-11-10
DK0487071T3 (da) 1995-10-30
DE69111029T2 (de) 1995-12-14
HU211130A9 (en) 1995-10-30
HU913643D0 (en) 1992-02-28
KR920009823A (ko) 1992-06-25
EP0487071A1 (en) 1992-05-27
AU8804591A (en) 1992-05-28
NZ240676A (en) 1993-05-26
FI982436A7 (fi) 1998-11-10
AU643337B2 (en) 1993-11-11
FI915488L (fi) 1992-05-23
NO914558D0 (no) 1991-11-21
KR100211437B1 (ko) 1999-08-02
RU2095361C1 (ru) 1997-11-10
ES2074205T3 (es) 1995-09-01
CA2055947A1 (en) 1992-05-23
CN1036458C (zh) 1997-11-19
DE69111029D1 (de) 1995-08-10

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